LOCUS       NM_001099221            5867 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens TIFA inhibitor (TIFAB), mRNA.
ACCESSION   NM_001099221 XM_928467 XM_938912
VERSION     NM_001099221.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5867)
  AUTHORS   Niederkorn,M., Agarwal,P. and Starczynowski,D.T.
  TITLE     TIFA and TIFAB: FHA-domain proteins involved in inflammation,
            hematopoiesis, and disease
  JOURNAL   Exp Hematol 90, 18-29 (2020)
   PUBMED   32910997
  REMARK    GeneRIF: TIFA and TIFAB: FHA-domain proteins involved in
            inflammation, hematopoiesis, and disease.
            Review article
REFERENCE   2  (bases 1 to 5867)
  AUTHORS   Niederkorn,M., Hueneman,K., Choi,K., Varney,M.E., Romano,L.,
            Pujato,M.A., Greis,K.D., Inoue,J.I., Meetei,R. and
            Starczynowski,D.T.
  TITLE     TIFAB Regulates USP15-Mediated p53 Signaling during Stressed and
            Malignant Hematopoiesis
  JOURNAL   Cell Rep 30 (8), 2776-2790 (2020)
   PUBMED   32101751
  REMARK    GeneRIF: TIFAB Regulates USP15-Mediated p53 Signaling during
            Stressed and Malignant Hematopoiesis.
REFERENCE   3  (bases 1 to 5867)
  AUTHORS   Varney,M.E., Niederkorn,M., Konno,H., Matsumura,T., Gohda,J.,
            Yoshida,N., Akiyama,T., Christie,S., Fang,J., Miller,D., Jerez,A.,
            Karsan,A., Maciejewski,J.P., Meetei,R.A., Inoue,J. and
            Starczynowski,D.T.
  TITLE     Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through
            derepression of Toll-like receptor-TRAF6 signaling
  JOURNAL   J Exp Med 212 (11), 1967-1985 (2015)
   PUBMED   26458771
  REMARK    GeneRIF: TIFAB loss increases TRAF6 protein and the dynamic range
            of TLR4 signaling
REFERENCE   4  (bases 1 to 5867)
  AUTHORS   Schroder,J.C., Lassig,A.K., Galetzka,D., Peters,A., Castle,J.C.,
            Diederich,S., Zechner,U., Muller-Forell,W., Keilmann,A. and
            Bartsch,O.
  TITLE     A boy with homozygous microdeletion of NEUROG1 presents with a
            congenital cranial dysinnervation disorder [Moebius syndrome
            variant]
  JOURNAL   Behav Brain Funct 9, 7 (2013)
   PUBMED   23419067
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5867)
  AUTHORS   Matsumura,T., Semba,K., Azuma,S., Ikawa,S., Gohda,J., Akiyama,T.
            and Inoue,J.
  TITLE     TIFAB inhibits TIFA, TRAF-interacting protein with a
            forkhead-associated domain
  JOURNAL   Biochem Biophys Res Commun 317 (1), 230-234 (2004)
   PUBMED   15047173
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB161513.1, AK131088.1, BX119085.1 and AC022092.8.
            
            On Nov 22, 2018 this sequence version replaced NM_001099221.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131088.1, AB161513.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000537858.2/ ENSP00000440509.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               AB161513.1         49-240
            193-765             AK131088.1         140-712
            766-1225            BX119085.1         13-472              c
            1226-5867           AC022092.8         60104-64745         c
FEATURES             Location/Qualifiers
     source          1..5867
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..5867
                     /gene="TIFAB"
                     /note="TIFA inhibitor"
                     /db_xref="GeneID:497189"
                     /db_xref="HGNC:HGNC:34024"
                     /db_xref="MIM:612663"
     exon            1..143
                     /gene="TIFAB"
                     /inference="alignment:Splign:2.1.0"
     exon            144..5867
                     /gene="TIFAB"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..639
                     /gene="TIFAB"
                     /note="TIFA-related protein TIFAB; TIFA-like protein;
                     TRAF-interacting protein with forkhead-associated domain,
                     family member B"
                     /codon_start=1
                     /product="TRAF-interacting protein with FHA
                     domain-containing protein B"
                     /protein_id="NP_001092691.1"
                     /db_xref="CCDS:CCDS43365.1"
                     /db_xref="GeneID:497189"
                     /db_xref="HGNC:HGNC:34024"
                     /db_xref="MIM:612663"
                     /translation="MEKPLTVLRVSLYHPTLGPSAFANVPPRLQHDTSPLLLGRGQDA
                     HLQLQLPRLSRRHLSLEPYLEKGSALLAFCLKALSRKGCVWVNGLTLRYLEQVPLSTV
                     NRVSFSGIQMLVRVEEGTSLEAFVCYFHVSPSPLIYRPEAEETDEWEGISQGQPPPGS
                     G"
     regulatory      5847..5852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIFAB"
                     /note="hexamer: ATTAAA"
     polyA_site      5867
                     /gene="TIFAB"
                     /note="major polyA site"
ORIGIN      
        1 aagaatgcaa caaaactgaa gtatgttctg ccacgttcct gaactgcagc cataggagcc
       61 ctcccagccc tacccaaacc agcctactcc ctctcaagag ctcacagctg caggactaga
      121 gccagatgtg ccccggcaat aaggacttct tccatggaga agcccctcac cgtcctgcga
      181 gtgagcctgt accatcccac gctgggccca tctgcctttg ccaatgtccc accacggctg
      241 cagcatgata ccagccctct gcttctcgga cgggggcagg acgcccacct ccagctgcag
      301 ctccctcgcc tctcccgccg tcacctgtcc ctggagccct acctggagaa aggcagtgcc
      361 ctgctggcct tctgcctcaa ggccctgagc cgcaagggct gtgtgtgggt caatgggctg
      421 acgctgaggt acctggagca ggtccccctg agcaccgtca acagggtctc cttctcaggc
      481 atccagatgc tggttcgcgt agaagaaggc acatccctgg aggcttttgt ctgctatttc
      541 catgtcagcc cttcacccct gatttacaga cctgaggctg aggaaactga cgaatgggaa
      601 ggcatctccc aggggcagcc tccccctggt tcagggtagc agatccaggt tgcctggggt
      661 ttctccacgg cccttcccag acttgggaca gccctctcca gccaagacct ggaggaggaa
      721 cagaaataca gctccagagg gaacccccag acagtgcact ctgctagccc tgccactaga
      781 gcaagccttt gctagatgaa acaggatttg aaatacttga gctgcatcat gcaaggttga
      841 caagcaaaac ccactggctg ccttgctcat aatgaaccaa ttctgcaaac accgaacaaa
      901 cagcccaggg gggagaagca ccctctgtgg ccagagctat gcaatgtaat gggaacatca
      961 tatactttta gaggccctga ggggttctgg ggagcctctc tcagcatttc cacacatttc
     1021 tccctgttgt ctgactagga gttactttat gtggttcatt ttgtgtgctg cttaagagca
     1081 ggagtttgag gttgcaccag gaatgcgtgg acacatgtaa caattacatt tgtggtagct
     1141 tggggttacc ttcagctttc aaatacccac aggcacgcgg ggcttaggaa agcctgagtg
     1201 taataaactg caagtatttc attaagctgg catacccaat aggattccct gatccccaga
     1261 tgggccacat gcacgccacg ctgtcatgca gacgtggggg tgggaaatat agacgaggtg
     1321 taagaggaaa ttggaaaggt gggactcaca tttctggaaa ggatgcaggc agggctcagg
     1381 gtttcctgag gatgggagct gggagctggg cctgcctgga aattcattgt cccccttatc
     1441 atcctcatcc tcacactccg cattctctgt cacttctgga tcaaggcctt ggttgacttg
     1501 agggcaaggt ctttagggaa tgaggggatg gggtgggggt ttgtgtaaga actcagccca
     1561 gcagttattt cgctcagggt gagtcacaca ccaatggggg tgggggaatt ccttccaaat
     1621 aagggactcg ttaggagcca ggtacgccaa gggcaggagg attttctcgg tgaacaaggg
     1681 cagcagctat ttgccacgcc atgctgagaa ggggagagtg tggtttagaa acaacgttca
     1741 ctagtgtgat gcagggaggg atctacatgg tcaccatgat cccagacccc actctccagg
     1801 gaatctgagg caccaagggc acagccctgt tcccctggct gactcgaatc tctgggtctg
     1861 tagctgtcaa caatttctgt tttctgccca aaaggatgat cgttttgcac ccagggcaag
     1921 ctacaaggag gtccaacttc actcacaggc cctgagcatc ttctccatca ggaaaacaga
     1981 ggtgggcaag acccaggctt gccctggtgt gggaagcttc ctctccaata gggatgaagc
     2041 aaaaacactc agatcacagc cacaaggcag ggagagcagg gctgctagga aggggctctc
     2101 tgatgctgtg aatgacccct tgggaccccc aaagcagttc ctcattcatt cagcaaacct
     2161 tcaccaagca cccaccttgt gccagatctg tgcaaagcca cggaactgaa ccagaagtga
     2221 ataaggcaaa ctccctcagg gagtttacct tgcactcagg aaagtcaagc attcaggagt
     2281 gcattactta tttgatcact actatgatta gtgctatagt cattgtattt ttctctctcc
     2341 tccagctggg ctcacattct cttgttaagt ggccttgcct gttgagtgcc taccatgtgc
     2401 ttagcactct gctaggtgct gtgtgtatta actgcactta acagataagg aaactgagac
     2461 ttggaaaggt tacatatctt gcccaacatc acaccatcag tagctatgcg atttgggcaa
     2521 gtgatttagt ctgctcttgc ctctatttct cccgctggaa aatgggtaag ataatagtac
     2581 tacctgctag agttacgagg gtcttagaag gtgacacctg taaagcattc aatcagtgcc
     2641 cagcacacac ttaataaggg ttagctacta tcatgagacc tgagagagga gggctcacca
     2701 tccacacgga gctaaggaag actcacaccc cagtaagctg gctccagaac ccaagggctt
     2761 acctgtgctc tgtgattccc caactaggga tttagttgta gccacggacc tggtaggcaa
     2821 cagggagggg attttaatct gctccttgca tcagaaggtc caataggcag ggttagtata
     2881 atgggagatg ccctggtagg gctggcaagg agaagaagcc acatgtattt tggtctgatg
     2941 aaaagcagca gtgatctgtc actgaccaaa atggtccccc aactatgcat tacggagcag
     3001 caacccacat acagaactcg agaagccacg gcctggagac tgtacctgga caccaaagac
     3061 tggagagagg agctggtggg gaaaccccag agttcccagg gtgccactcc ccagctccac
     3121 cagagaactt tgggaatgag ctgctgcccc tgagtgcccc tctccagggc ctcagtgagg
     3181 gtctctaccc tccagggagg aacaaaacct tgccagctgg ggtcctgcga gagggggcag
     3241 ttcaattcct ccacagggga ctctgcaact ccaatctttc gagtgaagca tctgcgaggc
     3301 cctcagggac ccaggatgaa ctgcatagca gcagaaggaa gacaggccag accaggcggg
     3361 agggagcccg gaaacatctg gtttgtagtt tcagactcta cccgttcaca gttcacacag
     3421 tctcaccggg aaactcacac cttgccctgt accaagtttt taaggcagtt aagctctgcc
     3481 catccgagac ttcatttttc ttgagtagaa aatcactgaa atcatcagat ccatggcacc
     3541 caccttcact ttctcctaac agctggaacc gtcaggctgg cttcagggcc tggtcttcgc
     3601 acttgatatc actatccctc acctgctcag acagccagag caggcgggtg agttcctccc
     3661 aacaacctcc actgcattct ctcagctccc accgcagggc agcccacgtg cctgagtgaa
     3721 catgtgtgcg tgtgcacaca cgcaagtatg cacagacata cactaaacac gaacatacag
     3781 tgcacatgaa cgctgctccc agctagggcc ctctggtcag actgctgcct gggttagaat
     3841 tcttgtcccc acccccactt actatagttc tgtgatcctg gacaagtaac tgaatctctc
     3901 cgtgccacag tttcttcttg tagaaaacgg gaaagttcac agtacttacc tccttagagt
     3961 cattgtgaag gtcagtttga ggcatcacaa atttaaggca cccagacata agggtcaaca
     4021 gggttagcta tcactgtcca gtttggtggg aggaactgaa tgcatgtagg cacatggacc
     4081 cagtctacac tcaggcacaa aaggagctac attagttaca ttcaggcata ccccagagca
     4141 ctacaattct ctgagacatt gtctggaaat ctagaaatca tctccttgcc ctttaaggta
     4201 ttttaaccct cgcattcctc tgcttttcca agaatgtgaa tcttgccaag ctgtccgtga
     4261 gagacacggg ctcccctcga gggagacttg caaatgctcc ataaacagcc acagtgtggg
     4321 gctctgccat gaggaagtca cagcagacac gctagacagc atagtcctgg atgcaacctg
     4381 gaggaaggga ggcccatggt ggagcactca ctccgtgcct gtctgcccgg tgagacctca
     4441 agttccttgc agacaaaggc catgggttgt tggctcttgt gttcccggtg gcctttccag
     4501 agctgaacag aggacagatg cacagacggg ggggctctgg tggtcaaggc agcagtcccc
     4561 ttggatacta aagtctgagc caggcccctc aggcccggca tgggcagtgc gaggcccata
     4621 gtggtgggaa gccagttggc cagctggggt gagaaggccg cgaagccatg ggcagacagg
     4681 aagtggaggt gaatgtctct gcctcctgta ggcctcagca gggacagcac agaccctctg
     4741 gctggggcag cgcagaccct ctagctgggg cagaacaagg ctggtgcttc cttctagtcc
     4801 ttgagacttt gtagctctaa ctcaagcaga accctggggt tttgggattc tgtgtggtga
     4861 ctgctgagga aggtttatgg atttgacagg gtgcatgtca cagagagaca gttctcagtc
     4921 agcacttcct gtcccctgca gaggctcata ggggacagcc cctgccaagg agaccctgga
     4981 ggggctctga ggatagcaat cagaggttgg gctggctgga ctgagcccag gcctgttgcc
     5041 caccaagtct ccataggttc tagtctgacc cctctctcca cccctgggct atgcaggcca
     5101 gcccgtgcag accacccccg acgcgtccac ttgcaacacc cgcctcactg tgccaacact
     5161 ccatccacac aggaaaggac tgagaacgtg atgcttaacc caaaggagtg agtttcatag
     5221 gatgggtggc tttaacagtt tcacagcagg acactgaggg aatatttccc tatcccttca
     5281 aatggacggt cactacagaa acgtgtagag caagactttg tcaaggggct gtttccaggt
     5341 ctcccggtgt ctaaatagca gagctggaat gggaactgag aaccgattct ttccacaacc
     5401 gcccactgag cagcaaggct gcagccagca aagaggtgcg gaggcaagca agctccatgt
     5461 ggtggggaca gcgcattgcg acctccacca cccctgcagt gggctgccag ctgagccacc
     5521 tgtcttccac tgtatctact gtacgaactt ctccagctct gctctgtttt ctcttcctca
     5581 gcatccaccc cgtgacacgt agtggtggct gatgtcgcca cagtaccatg aggttaacag
     5641 gtcctccctc cagcttccct catggtggca gcctaacctg cattgcagcc gttcaccgga
     5701 caccgcacca gaccctcaaa acccatccaa gactgtggga ggagtaaaca acccagccca
     5761 gttaagagga gatgccgaat ttaatgaacc ctatttgaat tgcagggctg tgattcctct
     5821 tacctttaac gtgaactcac aggcggatta aagtgaaata aaaccta
//
