LOCUS       NM_052864               4163 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens TRAF interacting protein with forkhead associated
            domain (TIFA), mRNA.
ACCESSION   NM_052864
VERSION     NM_052864.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4163)
  AUTHORS   Li,Y., Zhang,J., Zhai,P., Hu,C., Suo,J., Wang,J., Liu,C. and
            Peng,Z.
  TITLE     The potential biomarker TIFA regulates pyroptosis in sepsis-induced
            acute kidney injury
  JOURNAL   Int Immunopharmacol 115, 109580 (2023)
   PUBMED   36586274
  REMARK    GeneRIF: The potential biomarker TIFA regulates pyroptosis in
            sepsis-induced acute kidney injury.
REFERENCE   2  (bases 1 to 4163)
  AUTHORS   Shen,W., Du,W., Li,Y., Huang,Y., Jiang,X., Yang,C., Tang,J.,
            Liu,H., Luo,N., Zhang,X. and Zhang,Z.
  TITLE     TIFA promotes colorectal cancer cell proliferation in an RSK- and
            PRAS40-dependent manner
  JOURNAL   Cancer Sci 113 (9), 3018-3031 (2022)
   PUBMED   35635239
  REMARK    GeneRIF: TIFA promotes colorectal cancer cell proliferation in an
            RSK- and PRAS40-dependent manner.
REFERENCE   3  (bases 1 to 4163)
  AUTHORS   Maubach,G., Lim,M.C.C., Sokolova,O., Backert,S., Meyer,T.F. and
            Naumann,M.
  TITLE     TIFA has dual functions in Helicobacter pylori-induced classical
            and alternative NF-kappaB pathways
  JOURNAL   EMBO Rep 22 (9), e52878 (2021)
   PUBMED   34328245
  REMARK    GeneRIF: TIFA has dual functions in Helicobacter pylori-induced
            classical and alternative NF-kappaB pathways.
REFERENCE   4  (bases 1 to 4163)
  AUTHORS   Chang,H.C., Wei,T.W., Wu,P.Y., Tsai,M.D., Yu,W.C., Chen,C.H. and
            Sung,S.H.
  TITLE     TIFA protein expression is associated with pulmonary arterial
            hypertension
  JOURNAL   Sci Rep 11 (1), 14140 (2021)
   PUBMED   34238983
  REMARK    GeneRIF: TIFA protein expression is associated with pulmonary
            arterial hypertension.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4163)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 4163)
  AUTHORS   Pachathundikandi,K. and Backert,S.
  TITLE     Heptose 1,7-Bisphosphate Directed TIFA Oligomerization: A Novel
            PAMP-Recognizing Signaling Platform in the Control of Bacterial
            Infections
  JOURNAL   Gastroenterology 154 (4), 778-783 (2018)
   PUBMED   29337150
REFERENCE   7  (bases 1 to 4163)
  AUTHORS   Ea,C.K., Sun,L., Inoue,J. and Chen,Z.J.
  TITLE     TIFA activates IkappaB kinase (IKK) by promoting oligomerization
            and ubiquitination of TRAF6
  JOURNAL   Proc Natl Acad Sci U S A 101 (43), 15318-15323 (2004)
   PUBMED   15492226
  REMARK    GeneRIF: TIFA induces the oligomerization and polyubiquitination of
            TRAF6, which leads to the activation of TAK1 and IKK through a
            proteasome-independent mechanism
REFERENCE   8  (bases 1 to 4163)
  AUTHORS   Matsumura,T., Semba,K., Azuma,S., Ikawa,S., Gohda,J., Akiyama,T.
            and Inoue,J.
  TITLE     TIFAB inhibits TIFA, TRAF-interacting protein with a
            forkhead-associated domain
  JOURNAL   Biochem Biophys Res Commun 317 (1), 230-234 (2004)
   PUBMED   15047173
REFERENCE   9  (bases 1 to 4163)
  AUTHORS   Takatsuna,H., Kato,H., Gohda,J., Akiyama,T., Moriya,A., Okamoto,Y.,
            Yamagata,Y., Otsuka,M., Umezawa,K., Semba,K. and Inoue,J.
  TITLE     Identification of TIFA as an adapter protein that links tumor
            necrosis factor receptor-associated factor 6 (TRAF6) to
            interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1
            receptor signaling
  JOURNAL   J Biol Chem 278 (14), 12144-12150 (2003)
   PUBMED   12566447
REFERENCE   10 (bases 1 to 4163)
  AUTHORS   Kanamori,M., Suzuki,H., Saito,R., Muramatsu,M. and Hayashizaki,Y.
  TITLE     T2BP, a novel TRAF2 binding protein, can activate NF-kappaB and
            AP-1 without TNF stimulation
  JOURNAL   Biochem Biophys Res Commun 290 (3), 1108-1113 (2002)
   PUBMED   11798190
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC109347.3, AB097011.1,
            BM718895.1, CA772080.1 and BM680110.1.
            
            On Nov 22, 2018 this sequence version replaced NM_052864.2.
            
            Summary: This gene encodes an adapter protein involved in adaptive
            and innate immunity. This protein includes a forkhead-associated
            (FHA) domain that specifically binds to phosphorylated serine and
            threonine residues. In response to bacterial infection, the encoded
            host cell protein undergoes an intermolecular interaction between
            the FHA domain and a phosphorylated threonine that leads to protein
            oligomerization and stimulation of the NF-kappa B and other
            downstream signaling pathways. This protein exhibits reduced
            expression in hepatocellular carcinoma and may suppress
            hepatocellular carcinoma progression. This protein may also play a
            role in the DNA damage response. [provided by RefSeq, Jun 2018].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.199802.1,
                                           SRR1803615.158334.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361717.4/ ENSP00000354911.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC109347.3         106756-106756       c
            2-1616              AB097011.1         3-1617
            1617-2167           BM718895.1         58-608
            2168-2681           CA772080.1         1-514               c
            2682-3074           BM680110.1         18-410              c
            3075-4163           AC109347.3         95389-96477         c
FEATURES             Location/Qualifiers
     source          1..4163
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q25"
     gene            1..4163
                     /gene="TIFA"
                     /gene_synonym="T2BP; T6BP; TIFAA"
                     /note="TRAF interacting protein with forkhead associated
                     domain"
                     /db_xref="GeneID:92610"
                     /db_xref="HGNC:HGNC:19075"
                     /db_xref="MIM:609028"
     exon            1..265
                     /gene="TIFA"
                     /gene_synonym="T2BP; T6BP; TIFAA"
                     /inference="alignment:Splign:2.1.0"
     exon            266..4163
                     /gene="TIFA"
                     /gene_synonym="T2BP; T6BP; TIFAA"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..838
                     /gene="TIFA"
                     /gene_synonym="T2BP; T6BP; TIFAA"
                     /note="TRAF2 binding protein; TRAF-interacting protein
                     with a forkhead-associated domain; TRAF6 binding protein;
                     putative MAPK-activating protein PM14; putative
                     NF-kappa-B-activating protein 20"
                     /codon_start=1
                     /product="TRAF-interacting protein with FHA
                     domain-containing protein A"
                     /protein_id="NP_443096.1"
                     /db_xref="CCDS:CCDS34051.1"
                     /db_xref="GeneID:92610"
                     /db_xref="HGNC:HGNC:19075"
                     /db_xref="MIM:609028"
                     /translation="MTSFEDADTEETVTCLQMTVYHPGQLQCGIFQSISFNREKLPSS
                     EVVKFGRNSNICHYTFQDKQVSRVQFSLQLFKKFNSSVLSFEIKNMSKKTNLIVDSRE
                     LGYLNKMDLPYRCMVRFGEYQFLMEKEDGESLEFFETQFILSPRSLLQENNWPPHRPI
                     PEYGTYSLCSSQSSSPTEMDENES"
     regulatory      1594..1599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIFA"
                     /gene_synonym="T2BP; T6BP; TIFAA"
                     /note="hexamer: AATAAA"
     polyA_site      1618
                     /gene="TIFA"
                     /gene_synonym="T2BP; T6BP; TIFAA"
                     /note="major polyA site"
     regulatory      1758..1763
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIFA"
                     /gene_synonym="T2BP; T6BP; TIFAA"
                     /note="hexamer: AATAAA"
     polyA_site      1782
                     /gene="TIFA"
                     /gene_synonym="T2BP; T6BP; TIFAA"
     regulatory      3057..3062
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIFA"
                     /gene_synonym="T2BP; T6BP; TIFAA"
                     /note="hexamer: ATTAAA"
     polyA_site      3074
                     /gene="TIFA"
                     /gene_synonym="T2BP; T6BP; TIFAA"
     regulatory      3989..3994
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIFA"
                     /gene_synonym="T2BP; T6BP; TIFAA"
                     /note="hexamer: AATAAA"
     regulatory      3993..3998
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIFA"
                     /gene_synonym="T2BP; T6BP; TIFAA"
                     /note="hexamer: AATATA"
     polyA_site      4009
                     /gene="TIFA"
                     /gene_synonym="T2BP; T6BP; TIFAA"
     polyA_site      4015
                     /gene="TIFA"
                     /gene_synonym="T2BP; T6BP; TIFAA"
     polyA_site      4163
                     /gene="TIFA"
                     /gene_synonym="T2BP; T6BP; TIFAA"
ORIGIN      
        1 ctttacaaag gccccgggcg cgagaggacg tgctctgcca gccagtggga aggcaggccg
       61 cgcgcgcggg agcgcgggag gatcggcggc tcgcggtcac tggtccctgg ctcggttccc
      121 cgcaccccgg ggctcacact tacccgcgcg gaggagcagc ggccgggtgt ccacccccat
      181 cctgcgccca gtctcctcga ttcccctcgc tctgagccgg gagagccgaa cagctgaaga
      241 gagttcactg actccccagc cccaggtggg ccttgtgcac atcatgacca gttttgaaga
      301 tgctgacaca gaagagacag taacttgtct ccagatgacg gtttaccatc ctggccagtt
      361 gcagtgtgga atatttcagt caataagttt taacagagag aaactccctt ccagcgaagt
      421 ggtgaaattt ggccgaaatt ccaacatctg tcattatact tttcaggaca aacaggtttc
      481 ccgagttcag ttttctctgc agctgtttaa aaaattcaac agctcagttc tctcctttga
      541 aataaaaaat atgagtaaaa agaccaatct gatcgtggac agcagagagc tgggctacct
      601 aaataaaatg gacctgccat acaggtgcat ggtcagattc ggagagtatc agtttctgat
      661 ggagaaggaa gatggcgagt cattggaatt ttttgagact caatttattt tatctccaag
      721 atcactcttg caagaaaaca actggccacc acacaggccc ataccggagt atggcactta
      781 ttcgctctgc tcctcccaaa gcagttctcc gacagaaatg gatgaaaatg agtcatgaac
      841 acagaaagtc taagaggaga aatatgatgg atgaagagct ctgtagatgc tgtatagaca
      901 ctaaataaga gttgattagg gtagtatatt atagtcatct gttatgctgt gaaatttgga
      961 attcagtatt atcattttga agtctgtaaa ttgtgttagt cattaactta gtcacctgtt
     1021 gtattctgga tctacacaaa attattttaa ctgctcttat taatctgtga ggattaatat
     1081 acaaaaagta tcctttgaga tgaagtcgtg ttctcaaaat aaggttatat tattttcttt
     1141 ttctgcttga ttttcatctt gtgttttgct ttgtttttgt aaggaaccat ctcttggttt
     1201 ggtcacatca gttcacaaca gccatttgtt ttcaaggtca aggctccagg caggttgtta
     1261 ctggtgtttg cagcctgtca gtacttgcag tactggaata ggttctaggc tagtgtctgc
     1321 gcgtcactgt ggttttagca tgggaggact tatttgagaa atactacctt acttttctat
     1381 gatttctttt tacagagtta tagtgtgttt actcctaaga tgacagttct ctttgtctat
     1441 attcagcatc taagacaaat atttaaacat tttaaagaac cactgtgtta agtttaggat
     1501 tatttactta ccaaattaga agtttgactt ttatgtgtta tacacaatct taaaatttca
     1561 cgaattcacc tttttaatag tatccatgta cataataaaa tcaaagttta attagccatt
     1621 ttctttgaat ttttttctaa ataagggaaa taactgttct tgggccactt tacagagata
     1681 aatgtatgtg aatgtttatg ataaacgctt aaatatttct aaaatattaa cttcaaaaaa
     1741 gtctttttca gttcttaaat aaaaatttat ttatttaaga tacttattcg acttatctta
     1801 actaaggtag ctatgaatgt taagtagatg aggtaaccat tcagttaagt taaattgtag
     1861 cattgccagg tagtgaggct cactgtacaa ttttccaggt aaatgaaatt tcctgtagta
     1921 agaggtccgt atttttgtaa cagcctttta aaaatgcttt tgggaaccct ccagcctctt
     1981 accaaaagag gctttaaacc tcatcttgat tcagactgtc agtctattcc tgggcagtag
     2041 tatgtgatgt ccagcaccct aaccccgact ccccagccct gggactattc cagtagagtg
     2101 aaatatttgt ccctgtacaa agtggcctga atgactgttg gagttcctgt gtctggtttt
     2161 cctgtttatt ccctgtgatg cccagagtaa tggcccatcc aaagatgtcc agatgtccat
     2221 gtgctagtct ccagaacttg taactgtgtt gttatgtggc aaaggggaat gaaggctgca
     2281 gatggaagta aaatagatta tgctggatta tctgggtgtg cccaattgat caccggatcc
     2341 gtaaaagtgg aagagaggca gatcaggatg tcagcgtgat gaggtgtgag acagacttga
     2401 cttgctgttg ctgggaggaa ggggaggtca tgagccaagg aatgtggaca gtctcttgaa
     2461 gctggaaagt gtgcattgga catctggaag ccagaaaaga caaagaaata tccagaaagg
     2521 aacaaagtct tgtggacacc ttgattttgg tccagtgaga atatgtttga cttgttaacc
     2581 tacaaaactt tatgatgata aatttgtgtt ggtcgtaagc cactaaatca cagtaatttg
     2641 ttatagcagc agatagaaaa ctaatatact ccctttaata taaggttatc tactattgat
     2701 tctttctagg attttagctt ctggtctgat gtgggtttac agccagatca cccggcttga
     2761 attgcttaca gtgtgtagtc tcatggtaaa ggcgttctat gagtgaagtg tatatacttt
     2821 aatgtgtgta tactgtcaca ttttgactat tttggaagac tttcacctct gtttcttgtc
     2881 tttgaggctg atgaatgtgt ttctaagtta taaatttaat attaagggat tcatgtatta
     2941 ttgttattga atccaaacaa tgtgttaagt aatatttagg gccagaaaaa tcttgtacag
     3001 aataatgatt tctcctaatg taaatcttgg aaagggtttt gttcaacttg agaaatatta
     3061 aattttttat tctattttct tttcttcaaa gattggcaaa ggagagagtg ggttgctaaa
     3121 agtttatatt gttctccaaa gaatagaaac actttccata gcccaactcc ggtagtaaat
     3181 aataatgaac gctttaataa tgaaagagca attggttagt attagaattg ttttgattac
     3241 aaagttagca tctctgcctg agctacccaa ccccaaagcg gggttgttag aggaaagcta
     3301 ccatatttca tagaaccgag gaaggaatgc agcagacctc aggtgagatt cgaatgctct
     3361 ggctctgacc ctcaatgcat attggctcca tggccacctg tagctcccaa gttttacacg
     3421 ttattgatcc cccaaagaga cctgatctct tgatttcagt tccagggacg ggtcagcttg
     3481 ggtcaggtgc ccaccccttc accaatcaac ttgtctcagg taacgcagtc acattatata
     3541 atggctgctc tggtcagtga tcatgtggat agatacagca ttttctcaaa aaaatggtca
     3601 caggggtggg ggtggggcaa acaaaaatat tggtgtttga tacaaggtac tgaagctaag
     3661 atgtgaaacc ttccatatac actttaagga cttctttgtc cctggaaagt gatttttctg
     3721 gggctcctta ggtagagagg tgtattaatg gtgccagtgt tagaatcctt ggcagtctct
     3781 tcttgaacct gcaactccag tggttaaatc tcataggcca tataaccatt ttctagagaa
     3841 ttctgttcct actatctaat gcagtaactg acttaaaagt aagtattact gttagactct
     3901 aacataagtg gtggtatttg ttttaatgga ggtgggatca ggtatgtgtt cacttaagct
     3961 ttacattaaa aaaaaattta tatgtgtaaa taaatatata tgccttgtag aaaaattagc
     4021 cataatctta ctaccagaag agaactactg ttaactttgt gtgtgtgtat atgtggtgga
     4081 tggttttatg ttacctcctg gctcttttta tgtttccaat tctctaacac ttgtttaatt
     4141 aattacttat attattaaga taa
//
