LOCUS       NM_152259               6788 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens TOPBP1 interacting checkpoint and replication
            regulator (TICRR), transcript variant 2, mRNA.
ACCESSION   NM_152259
VERSION     NM_152259.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6788)
  AUTHORS   Chen,J., Sun,M., Chen,C., Jiang,B. and Fang,Y.
  TITLE     Identification of hub genes and their correlation with infiltration
            of immune cells in MYCN positive neuroblastoma based on WGCNA and
            LASSO algorithm
  JOURNAL   Front Immunol 13, 1016683 (2022)
   PUBMED   36311753
  REMARK    GeneRIF: Identification of hub genes and their correlation with
            infiltration of immune cells in MYCN positive neuroblastoma based
            on WGCNA and LASSO algorithm.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6788)
  AUTHORS   Zhu,T., Cen,Y., Chen,Z., Zhang,Y., Zhao,L., Wang,J., Lu,W., Xie,X.
            and Wang,X.
  TITLE     Oncogenic circTICRR suppresses autophagy via binding to HuR protein
            and stabilizing GLUD1 mRNA in cervical cancer
  JOURNAL   Cell Death Dis 13 (5), 479 (2022)
   PUBMED   35595754
  REMARK    GeneRIF: Oncogenic circTICRR suppresses autophagy via binding to
            HuR protein and stabilizing GLUD1 mRNA in cervical cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6788)
  AUTHORS   Ferreira,P., Sanchez-Pulido,L., Marko,A., Ponting,C.P. and Boos,D.
  TITLE     Refining the domain architecture model of the replication origin
            firing factor Treslin/TICRR
  JOURNAL   Life Sci Alliance 5 (5), e202101088 (2022)
   PUBMED   35091422
  REMARK    GeneRIF: Refining the domain architecture model of the replication
            origin firing factor Treslin/TICRR.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6788)
  AUTHORS   Wittig,K.A., Sansam,C.G., Noble,T.D., Goins,D. and Sansam,C.L.
  TITLE     The CRL4DTL E3 ligase induces degradation of the DNA replication
            initiation factor TICRR/TRESLIN specifically during S phase
  JOURNAL   Nucleic Acids Res 49 (18), 10507-10523 (2021)
   PUBMED   34534348
  REMARK    GeneRIF: The CRL4DTL E3 ligase induces degradation of the DNA
            replication initiation factor TICRR/TRESLIN specifically during S
            phase.
REFERENCE   5  (bases 1 to 6788)
  AUTHORS   Yang,L., Cui,Y., Sun,X. and Wang,Y.
  TITLE     Overexpression of TICRR and PPIF confer poor prognosis in
            endometrial cancer identified by gene co-expression network
            analysis
  JOURNAL   Aging (Albany NY) 13 (3), 4564-4589 (2021)
   PUBMED   33495413
  REMARK    GeneRIF: Overexpression of TICRR and PPIF confer poor prognosis in
            endometrial cancer identified by gene co-expression network
            analysis.
REFERENCE   6  (bases 1 to 6788)
  AUTHORS   Boos,D., Sanchez-Pulido,L., Rappas,M., Pearl,L.H., Oliver,A.W.,
            Ponting,C.P. and Diffley,J.F.
  TITLE     Regulation of DNA replication through Sld3-Dpb11 interaction is
            conserved from yeast to humans
  JOURNAL   Curr Biol 21 (13), 1152-1157 (2011)
   PUBMED   21700459
REFERENCE   7  (bases 1 to 6788)
  AUTHORS   Kumagai,A., Shevchenko,A., Shevchenko,A. and Dunphy,W.G.
  TITLE     Direct regulation of Treslin by cyclin-dependent kinase is
            essential for the onset of DNA replication
  JOURNAL   J Cell Biol 193 (6), 995-1007 (2011)
   PUBMED   21646402
  REMARK    GeneRIF: Results indicate that Cdk-mediated phosphorylation of
            Treslin during S phase is necessary for both its effective
            association with TopBP1 and its ability to promote DNA replication
            in human cells.
REFERENCE   8  (bases 1 to 6788)
  AUTHORS   Sanchez-Pulido,L., Diffley,J.F. and Ponting,C.P.
  TITLE     Homology explains the functional similarities of Treslin/Ticrr and
            Sld3
  JOURNAL   Curr Biol 20 (12), R509-R510 (2010)
   PUBMED   20620901
REFERENCE   9  (bases 1 to 6788)
  AUTHORS   Kumagai,A., Shevchenko,A., Shevchenko,A. and Dunphy,W.G.
  TITLE     Treslin collaborates with TopBP1 in triggering the initiation of
            DNA replication
  JOURNAL   Cell 140 (3), 349-359 (2010)
   PUBMED   20116089
  REMARK    GeneRIF: Results indicate that Treslin and TopBP1 collaborate in
            the Cdk2-mediated loading of Cdc45 onto replication origins;
            treslin regulates a pivotal step in the initiation of DNA
            replication in vertebrates.
REFERENCE   10 (bases 1 to 6788)
  AUTHORS   Sansam,C.L., Cruz,N.M., Danielian,P.S., Amsterdam,A., Lau,M.L.,
            Hopkins,N. and Lees,J.A.
  TITLE     A vertebrate gene, ticrr, is an essential checkpoint and
            replication regulator
  JOURNAL   Genes Dev 24 (2), 183-194 (2010)
   PUBMED   20080954
  REMARK    GeneRIF: TICRR acts in association with TopBP1 and plays an
            essential role in preinitiation complex formation [TICRR =
            TopBP1-interacting, checkpoint, and replication regulator]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC013391.12, DR731357.1, DR731358.1, CN285632.1, AK123612.1,
            BX538335.1 and AW627706.1.
            
            On May 17, 2019 this sequence version replaced NM_152259.3.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region compared to variant 1. The
            encoded isoform (2) is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1968968 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000268138.12/ ENSP00000268138.7
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AC013391.12        16405-16522         c
            119-572             AC013391.12        15951-16404         c
            573-976             DR731357.1         57-460
            977-977             AC013391.12        9101-9101           c
            978-1124            DR731357.1         462-608
            1125-1188           AC013391.12        7570-7633           c
            1189-1844           DR731358.1         1-656               c
            1845-2018           CN285632.1         19-192
            2019-3142           AK123612.1         1-1124
            3143-3341           BX538335.1         326-524
            3342-4234           AK123612.1         1324-2216
            4235-4484           BX538335.1         1418-1667
            4485-6784           AK123612.1         2467-4766
            6785-6788           AW627706.1         19-22               c
FEATURES             Location/Qualifiers
     source          1..6788
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.1"
     gene            1..6788
                     /gene="TICRR"
                     /gene_synonym="C15orf42; SLD3; Treslin"
                     /note="TOPBP1 interacting checkpoint and replication
                     regulator"
                     /db_xref="GeneID:90381"
                     /db_xref="HGNC:HGNC:28704"
                     /db_xref="MIM:613298"
     exon            1..772
                     /gene="TICRR"
                     /gene_synonym="C15orf42; SLD3; Treslin"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..5851
                     /gene="TICRR"
                     /gene_synonym="C15orf42; SLD3; Treslin"
                     /note="isoform 2 is encoded by transcript variant 2;
                     topBP1-interacting replication-stimulating protein;
                     topBP1-interacting checkpoint and replication regulator"
                     /codon_start=1
                     /product="treslin isoform 2"
                     /protein_id="NP_689472.3"
                     /db_xref="CCDS:CCDS10352.2"
                     /db_xref="GeneID:90381"
                     /db_xref="HGNC:HGNC:28704"
                     /db_xref="MIM:613298"
                     /translation="MACCHKVMLLLDTAGGAARHSRVRRAALRLLTYLSCRFGLARVH
                     WAFKFFDSQGARSRPSRVSDFRELGSRSWEDFEEELEARLEDRAHLPGPAPRATHTHG
                     ALMETLLDYQWDRPEITSPTKPILRSSGRRLLDVESEAKEAEAALGGLVNAVFLLAPC
                     PHSQRELLQFVSGCEAQAQRLPPTPKQVMEKLLPKRVREVMVARKITFYWVDTTEWSK
                     LWESPDHLGYWTVCELLHHGGGTVLPSESFSWDFAQAGEMLLRSGIKLSSEPHLSPWI
                     SMLPTDATLNRLLYNSPEYEASFPRMEGMLFLPVEAGKEIQETWTVTLEPLAMHQRHF
                     QKPVRIFLKGSVAQWSLPTSSTLGTDSWMLGSPEESTATQRLLFQQLVSRLTAEELHL
                     VADVDPGEGRPPITGVISPLSASAMILTVCRTKEAEFQRHVLQTAVADSPRDTASLFS
                     DVVDSILNQTHDSLADTASAASPVPEWAQQELGHTTPWSPAVVEKWFPFCNISGASSD
                     LMESFGLLQAASANKEESSKTEGELIHCLAELYQRKSREESTIAHQEDSKKKRGVPRT
                     PVRQKMNTMCRSLKMLNVARLNVKAQKLHPDGSPDVAGEKGIQKIPSGRTVDKLEDRG
                     RTLRSSKPKDFKTEEELLSYIRENYQKTVATGEIMLYACARNMISTVKMFLKSKGTKE
                     LEVNCLNQVKSSLLKTSKSLRQNLGKKLDKEDKVRECQLQVFLRLEMCLQCPSINEST
                     DDMEQVVEEVTDLLRMVCLTEDSAYLAEFLEEILRLYIDSIPKTLGNLYNSLGFVIPQ
                     KLAGVLPTDFFSDDSMTQENKSPLLSVPFLSSARRSVSGSPESDELQELRTRSAKKRR
                     KNALIRHKSIAEVSQNLRQIEIPKVSKRATKKENSHPAPQQPSQPVKDTVQEVTKVRR
                     NLFNQELLSPSKRSLKRGLPRSHSVSAVDGLEDKLDNFKKNKGYHKLLTKSVAETPVH
                     KQISKRLLHRQIKGRSSDPGPDIGVVEESPEKGDEISLRRSPRIKQLSFSRTHSASFY
                     SVSQPKSRSVQRVHSFQQDKSDQRENSPVQSIRSPKSLLFGAMSEMISPSEKGSARMK
                     KRSRNTLDSEVPAAYQTPKKSHQKSLSFSKTTPRRISHTPQTPLYTPERLQKSPAKMT
                     PTKQAAFKESLKDSSSPGHDSPLDSKITPQKRHTQAGEGTSLETKTPRTPKRQGTQPP
                     GFLPNCTWPHSVNSSPESPSCPAPPTSSTAQPRRECLTPIRDPLRTPPRAAAFMGTPQ
                     NQTHQQPHVLRAARAEEPAQKLKDKAIKTPKRPGNSTVTSSPPVTPKKLFTSPLCDVS
                     KKSPFRKSKIECPSPGELDQKEPQMSPSVAASLSCPVPSTPPELSQRATLDTVPPPPP
                     SKVGKRCRKTSDPRRSIVECQPDASATPGVGTADSPAAPTDSRDDQKGLSLSPQSPPE
                     RRGYPGPGLRSDWHASSPLLITSDTEHVTLLSEAEHHGIGDLKSNVLSVEEGEGLRTA
                     DAEKSSLSHPGIPPSPPSCGPGSPLMPSRDVHCTTDGRQCQASAQLDNLPASAWHSTD
                     SASPQTYEVELEMQASGLPKLRIKKIDPSSSLEAEPLSKEESSLGEESFLPALSMPRA
                     SRSLSKPEPTYVSPPCPRLSHSTPGKSRGQTYICQACTPTHGPSSTPSPFQTDGVPWT
                     PSPKHSGKTTPDIIKDWPRRKRAVGCGAGSSSGRGEVGADLPGSLSLLESEGKDHGLE
                     LSIHRTPILEDFELEGVCQLPDQSPPRNSMPKAEEASSWGQFGLSSRKRVLLAKEEAD
                     RGAKRICDLREDSEVSKSKEGSPSWSAWQLPSTGDEEVFVSGSTPPPSCAVRSCLSAS
                     ALQALTQSPLLFQGKTPSSQSKDPRDEDVDVLPSTVEDSPFSRAFSRRRPISRTYTRK
                     KLMGTWLEDL"
     exon            773..1052
                     /gene="TICRR"
                     /gene_synonym="C15orf42; SLD3; Treslin"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1294
                     /gene="TICRR"
                     /gene_synonym="C15orf42; SLD3; Treslin"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1529
                     /gene="TICRR"
                     /gene_synonym="C15orf42; SLD3; Treslin"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1659
                     /gene="TICRR"
                     /gene_synonym="C15orf42; SLD3; Treslin"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1799
                     /gene="TICRR"
                     /gene_synonym="C15orf42; SLD3; Treslin"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..2018
                     /gene="TICRR"
                     /gene_synonym="C15orf42; SLD3; Treslin"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2170
                     /gene="TICRR"
                     /gene_synonym="C15orf42; SLD3; Treslin"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2271
                     /gene="TICRR"
                     /gene_synonym="C15orf42; SLD3; Treslin"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..2365
                     /gene="TICRR"
                     /gene_synonym="C15orf42; SLD3; Treslin"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2445
                     /gene="TICRR"
                     /gene_synonym="C15orf42; SLD3; Treslin"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2685
                     /gene="TICRR"
                     /gene_synonym="C15orf42; SLD3; Treslin"
                     /inference="alignment:Splign:2.1.0"
     exon            2686..2782
                     /gene="TICRR"
                     /gene_synonym="C15orf42; SLD3; Treslin"
                     /inference="alignment:Splign:2.1.0"
     exon            2783..2840
                     /gene="TICRR"
                     /gene_synonym="C15orf42; SLD3; Treslin"
                     /inference="alignment:Splign:2.1.0"
     exon            2841..2987
                     /gene="TICRR"
                     /gene_synonym="C15orf42; SLD3; Treslin"
                     /inference="alignment:Splign:2.1.0"
     exon            2988..3078
                     /gene="TICRR"
                     /gene_synonym="C15orf42; SLD3; Treslin"
                     /inference="alignment:Splign:2.1.0"
     exon            3079..3137
                     /gene="TICRR"
                     /gene_synonym="C15orf42; SLD3; Treslin"
                     /inference="alignment:Splign:2.1.0"
     exon            3138..3272
                     /gene="TICRR"
                     /gene_synonym="C15orf42; SLD3; Treslin"
                     /inference="alignment:Splign:2.1.0"
     exon            3273..3430
                     /gene="TICRR"
                     /gene_synonym="C15orf42; SLD3; Treslin"
                     /inference="alignment:Splign:2.1.0"
     exon            3431..5594
                     /gene="TICRR"
                     /gene_synonym="C15orf42; SLD3; Treslin"
                     /inference="alignment:Splign:2.1.0"
     exon            5595..5720
                     /gene="TICRR"
                     /gene_synonym="C15orf42; SLD3; Treslin"
                     /inference="alignment:Splign:2.1.0"
     exon            5721..6788
                     /gene="TICRR"
                     /gene_synonym="C15orf42; SLD3; Treslin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6763..6768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TICRR"
                     /gene_synonym="C15orf42; SLD3; Treslin"
                     /note="hexamer: ATTAAA"
     polyA_site      6788
                     /gene="TICRR"
                     /gene_synonym="C15orf42; SLD3; Treslin"
                     /note="major polyA site"
ORIGIN      
        1 agcctttcga ccagggtccc aaaggaaagc agtgagtggt gctgtttccc tgaaggaagg
       61 gactaaggga cggtggcgcg ggcccggacc ggggccccgg ggcggcggca cggccgatat
      121 ggcatgctgt cacaaagtaa tgctgctgct ggacaccgcg ggcggcgccg cccgccacag
      181 ccgggtccgg cgggccgccc tgcgcctcct cacctatctg agttgccgat tcggcctggc
      241 cagggtccac tgggccttca agttctttga ctcgcagggg gcgcggagcc ggccgtcccg
      301 cgtgtctgac ttccgcgagc tggggtcccg ctcgtgggag gactttgagg aggagctgga
      361 ggccaggctc gaggatcgcg cccacctgcc cggcccggcg cccagggcca cccacacgca
      421 cggcgccctg atggagacgc tgctagacta ccagtgggac cggcccgaga tcacgtcgcc
      481 cacgaagccg atcctgcgga gcagcgggag gagactgctg gacgtggaga gcgaggccaa
      541 ggaggccgag gccgcgctcg ggggcttggt gaacgccgtc ttcctcctgg ccccctgtcc
      601 gcactcgcag agggagctgc tgcagttcgt gtctgggtgc gaggcccagg cccagcgcct
      661 gccgcccacc cctaagcagg tgatggagaa gttgttgccc aagagagtcc gggaagtcat
      721 ggtcgcccga aaaatcacct tctactgggt ggataccacc gaatggtcta agttgtggga
      781 atccccagac caccttggat actggactgt ttgtgaactg ctccaccacg gaggtggcac
      841 tgtcttgcca tctgaatctt tcagctggga ttttgctcaa gctggggaaa tgctgctcag
      901 gagtggaata aagctgtcaa gtgaacctca tctttctccg tggatttcaa tgctgccaac
      961 tgatgccact ttaaaccgtt tgctctacaa ttctcctgag tatgaggcct cgtttccacg
     1021 aatggaagga atgttatttc tccctgttga agcaggcaaa gagattcaag aaacatggac
     1081 agtcacccta gagcccttgg ccatgcatca gagacatttt cagaaaccag tcagaatttt
     1141 tctaaaaggc tcagtggccc agtggtctct cccaacgagc agcactttgg gcactgacag
     1201 ctggatgcta ggaagtccag aggagagcac agcaactcaa aggctgttat ttcagcagtt
     1261 ggtaagcagg ctgactgctg aagagttaca cctggttgct gatgtggacc ctggtgaagg
     1321 ccggcccccc atcactggag ttatttcccc actctctgcc agtgctatga tcctcactgt
     1381 gtgccgcacc aaggaggctg aatttcaacg acatgttctc caaacagctg tggctgacag
     1441 cccccgggac acagcttccc ttttctcaga tgttgtggat agtatattga atcagactca
     1501 tgattcgctt gcagatactg cttctgctgc ttctcctgtt ccagagtggg cccagcagga
     1561 gcttggccac accactccct ggagtccagc tgttgtggaa aagtggtttc ctttctgtaa
     1621 catcagtggt gccagttccg atttgatgga gtcatttggg ttactacagg ctgcctcagc
     1681 taataaggaa gagtcttcca aaactgaagg cgaattaata cattgccttg ccgagctcta
     1741 ccagagaaaa tctcgtgaag aatccactat agctcatcaa gaagacagca aaaagaaacg
     1801 aggggtccct cgtactccag tgagacagaa gatgaatacc atgtgccgtt ccttaaagat
     1861 gttgaatgtc gcaaggctga atgtgaaggc ccagaagtta catccagatg gcagtccgga
     1921 tgtggctggg gagaaaggaa tccaaaagat acctagtggg agaacagtgg ataaattgga
     1981 agacagagga agaacactaa gaagttctaa acctaaagat tttaaaactg aggaagagct
     2041 gctatcatat atacgtgaaa attaccaaaa gactgtggcc acaggagaaa tcatgttgta
     2101 tgcatgtgct cgaaacatga tctcaaccgt taaaatgttc ctaaaatcaa aaggcaccaa
     2161 ggaattagaa gtgaactgcc tgaatcaagt aaaaagtagt ctcttaaaaa ctagtaaaag
     2221 tcttcgacag aatctaggaa aaaaactgga taaggaagac aaagttagag agtgccagct
     2281 tcaggtattt cttcgtttgg agatgtgtct gcaatgccct tcaataaatg aaagtacaga
     2341 tgatatggaa caagtagtgg aggaggtgac agatttgctg cgcatggtgt gtttaactga
     2401 ggattcagcg tacctagcag agtttctgga ggaaattttg agattgtata ttgactctat
     2461 cccaaagaca cttggaaatc tttacaacag cctagggttt gtgattcctc agaagctggc
     2521 tggtgtcctt cctacagatt ttttcagtga tgactccatg acacaagaga acaaatcacc
     2581 acttctttct gtgccttttt tgtcaagtgc tcgtagatca gtgtcaggca gccctgaatc
     2641 tgatgaactg caggaacttc gtaccagatc agccaagaag agaaggaaaa atgcattaat
     2701 aagacataaa agcattgctg aggtttcaca gaatcttcga caaattgaaa ttcctaaagt
     2761 gtcaaagaga gctacgaaaa aagagaactc tcaccctgct cctcagcagc cttcccagcc
     2821 agtgaaagat acagtgcaag aagtgaccaa agttcgaaga aatcttttca accaggaatt
     2881 gctttcccct tcaaagagat cactaaagcg ggggttgcct agaagccatt ctgtgtcagc
     2941 tgtggatggt ctagaggata aacttgacaa cttcaagaag aacaaaggtt atcacaaact
     3001 gctgactaag agtgtggccg agactccagt gcataagcag atctccaaaa ggctgctgca
     3061 cagacaaatc aagggcaggt cctctgatcc tggtcctgat attggtgttg ttgaagagtc
     3121 ccctgaaaaa ggagatgaaa taagtctgag acgaagtcct cgaatcaagc agttgtcatt
     3181 tagcaggaca cattctgcct ccttctattc tgtgtctcag ccgaagtctc gaagtgtgca
     3241 aagagtccac tctttccagc aagataagtc agaccaaaga gaaaattctc cagtccaaag
     3301 tattcggtct cccaagagtc ttctttttgg ggcaatgtct gagatgatca gcccctcaga
     3361 aaagggttca gctcgaatga aaaagcgttc aagaaacact ttggattcgg aggtacctgc
     3421 agcttaccag actcccaaga agagtcacca gaaatctctg agcttttcta aaactacacc
     3481 aagaaggatc tctcatacac cacaaactcc gttgtatact ccagaaaggc tgcagaagtc
     3541 ccctgcaaaa atgaccccta caaagcaggc agcttttaag gagtccttaa aagactcctc
     3601 ctcacccggc catgactcac cattggattc aaaaatcact cctcaaaaac gacataccca
     3661 ggcaggagaa ggtacctctc ttgaaacgaa gacaccaaga actcctaaga ggcaaggtac
     3721 tcagccgcct gggtttttgc caaactgtac ttggccacat tcagtgaatt ccagtccaga
     3781 aagcccctcc tgtccagccc ctccaacttc atcgactgcc cagcccagga gagagtgtct
     3841 cactcccatc agagaccctc tcagaacacc tccgagagca gcagccttca tgggcacgcc
     3901 tcagaatcaa acacaccaac agccccatgt cctcagagct gctcgggcag aggaaccagc
     3961 ccagaaacta aaggataaag ctatcaaaac tccaaaaaga ccagggaatt caactgtgac
     4021 ttcttcccca cctgttacgc caaagaaact gtttacctct cctttatgtg atgtctccaa
     4081 gaagagtcca tttaggaaat ctaaaataga gtgtccttcc ccaggagaac tggatcagaa
     4141 agagccccag atgtcaccca gcgtagctgc atctctctcc tgccctgttc cctcaactcc
     4201 ccctgaactc tcacagagag ctacattgga caccgtccct cctccacccc cttctaaagt
     4261 tgggaaacgg tgtagaaaga cctctgatcc cagaaggagc atcgtggagt gtcagcctga
     4321 tgcctccgct actcctgggg ttggcacagc tgacagccca gctgccccca cagactctag
     4381 agatgaccag aagggactga gcctctctcc tcagtctcct cctgaaagac ggggctaccc
     4441 aggccctggt ctcaggagtg attggcatgc atcctctcct ctgctcatta caagtgacac
     4501 agagcatgtc actctcctca gtgaagccga acaccatggc attggtgact tgaaaagtaa
     4561 cgtcttatca gtggaagagg gtgaggggct aaggacagca gatgctgaga agtcttctct
     4621 gtctcaccct gggattcccc catctcctcc ttcctgtggg cctggctctc ctctgatgcc
     4681 ttcccgtgac gtgcactgta ccacagatgg gagacagtgc caggcttcgg cacaactaga
     4741 caacctgcca gcatcagctt ggcattccac agactctgcc agcccacaga cctatgaggt
     4801 tgagctggag atgcaagctt ctggccttcc caaacttcga attaagaaga tagaccccag
     4861 ctcttcatta gaggctgagc ccctcagcaa ggaggagagc tctctgggag aagagagctt
     4921 cctccctgct ctcagcatgc ccagggccag caggtcctta agcaaacctg aacccaccta
     4981 tgtgtcaccc ccctgccccc gcctctccca cagcacacct ggcaagagca gggggcaaac
     5041 ctacatctgc caggcctgta cccccaccca cggcccttct agtaccccct ctccatttca
     5101 aacagatggg gttccttgga caccatcccc caagcacagt gggaagacaa ctccagacat
     5161 aattaaagac tggcccagga ggaagagggc ggtgggctgt ggcgccggct cctcttccgg
     5221 gaggggcgag gtcggtgcag accttcctgg gagcctgtca ctgcttgagt cagagggcaa
     5281 ggaccacggc cttgaactca gcatccacag gacgcccatc ttggaggatt ttgagctcga
     5341 gggagtgtgc cagctcccag accagtcgcc tcccaggaac agcatgccta aggccgagga
     5401 agcctcttcc tggggacagt ttgggttgag ttccaggaag agagtcctgt tggccaagga
     5461 agaagctgac cgtggagcca aaaggatctg tgacctgaga gaagattcag aagttagtaa
     5521 gagtaaagag gggtctccaa gttggagtgc atggcagcta ccctccacgg gagacgaaga
     5581 ggtgtttgtt tccggctcca ccccacctcc cagctgtgcc gtgcggagct gcctctctgc
     5641 cagtgccctc caggctctga cccagtctcc gctgctgttc caggggaaaa caccttcctc
     5701 tcagagcaaa gaccccagag atgaggatgt ggatgttctt ccctccactg tagaagactc
     5761 tcctttcagt cgcgctttct ccaggaggcg ccccatcagc agaacttata cacggaagaa
     5821 gctcatggga acctggctgg aggacttata gccacaaaca ttactgagcc caaaagatca
     5881 aggagtcagc caggaccctg tggacataaa gaagttggat gcctggtccc aagcctcttt
     5941 tgccatggtc agtgttcaga ttgccattag aatgccttag ggttttctaa ttccccttat
     6001 ggatccaatc catctcctgg ccctgcccct tgttggggaa gttgcaggag gagaggtgga
     6061 tggcaatgtg attggtgcta taactcaggc agcctgggag tcaggaaccc agacaaggaa
     6121 tcccattcca gcctcacccc aaccatgacc ttggcaagtc agggggccac tctgcctcat
     6181 ttatgcaaat ggagaaaggc gccctccctg gggtcccttg agctgctgta aggctgggct
     6241 gctgcgacac aggcagcgct ttgtaaactg tgaagccata tacgtgaaac tgaagagtgc
     6301 attgggcagt ggaagctatt ttttgccttc cctgtgtaac agtaaaatca tctctagtga
     6361 ctgagcactc agtacatttt tgtttaatgt tgggcctgag gttaactgtg accatggtcc
     6421 agcttgagtg gcttctggag cagccacatt ttcaaggact gtccaagagc cagccagttc
     6481 agggctcagg cctcacccat tgcccactcc tggggagacc atcacctggc tcatcgtttc
     6541 caccaagagt gccccacagg agtgccccac agacccgctg gaccagcctg ctgcgggtcc
     6601 tggccagggg tctggctaac ggtgagggct gactctgaac tgtctctcag tctccagaaa
     6661 gtgttcaagc ctgttgtgtt cccaaatctg attcctccta ttgtcttgta aatcaaactc
     6721 taagtgaaaa cttcccattt gtcccttcaa agattttttt ttattaaatg gttttttaag
     6781 atcctaaa
//
