LOCUS       NM_182919               2684 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens TIR domain containing adaptor molecule 1 (TICAM1),
            transcript variant 1, mRNA.
ACCESSION   NM_182919
VERSION     NM_182919.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2684)
  AUTHORS   Braga,M., Shiga,M.A.S., Silva,P.E.S., Yamanaka,A.H.U., Souza,V.H.,
            Grava,S., Simao,A.N.C., Neves,J.S.F., de Lima Neto,Q.A.,
            Zacarias,J.M.V. and Visentainer,J.E.L.
  TITLE     Association between polymorphisms in TLR3, TICAM1 and IFNA1 genes
            and covid-19 severity in Southern Brazil
  JOURNAL   Expert Rev Mol Diagn 24 (6), 525-531 (2024)
   PUBMED   38864429
  REMARK    GeneRIF: Association between polymorphisms in TLR3, TICAM1 and
            IFNA1 genes and covid-19 severity in Southern Brazil.
REFERENCE   2  (bases 1 to 2684)
  AUTHORS   Yang,Y., Yang,S.Y., Chen,Z.B. and Liu,L.
  TITLE     [Association of gene polymorphisms of MyD88 and TICAM1 and their
            interactions with community-acquired pneumonia in children]
  JOURNAL   Zhongguo Dang Dai Er Ke Za Zhi 25 (8), 791-799 (2023)
   PUBMED   37668025
  REMARK    GeneRIF: [Association of gene polymorphisms of MyD88 and TICAM1 and
            their interactions with community-acquired pneumonia in children].
REFERENCE   3  (bases 1 to 2684)
  AUTHORS   Bierwagen,J., Wiegand,M., Laakmann,K., Danov,O., Limburg,H.,
            Herbel,S.M., Heimerl,T., Dorna,J., Jonigk,D., Preusser,C.,
            Bertrams,W., Braun,A., Sewald,K., Schulte,L.N., Bauer,S., Pogge von
            Strandmann,E., Bottcher-Friebertshauser,E., Schmeck,B. and
            Jung,A.L.
  TITLE     Bacterial vesicles block viral replication in macrophages via
            TLR4-TRIF-axis
  JOURNAL   Cell Commun Signal 21 (1), 65 (2023)
   PUBMED   36978183
  REMARK    GeneRIF: Bacterial vesicles block viral replication in macrophages
            via TLR4-TRIF-axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2684)
  AUTHORS   Youn,S.E., Jiang,F., Won,H.Y., Hong,D.E., Kang,T.H., Park,Y.Y. and
            Koh,S.S.
  TITLE     PAUF Induces Migration of Human Pancreatic Cancer Cells Exclusively
            via the TLR4/MyD88/NF-kappaB Signaling Pathway
  JOURNAL   Int J Mol Sci 23 (19), 11414 (2022)
   PUBMED   36232715
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2684)
  AUTHORS   Cagliero,J., Vernel-Pauillac,F., Murray,G., Adler,B., Matsui,M. and
            Werts,C.
  TITLE     Pathogenic Leptospires Limit Dendritic Cell Activation Through
            Avoidance of TLR4 and TRIF Signaling
  JOURNAL   Front Immunol 13, 911778 (2022)
   PUBMED   35812397
  REMARK    GeneRIF: Pathogenic Leptospires Limit Dendritic Cell Activation
            Through Avoidance of TLR4 and TRIF Signaling.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2684)
  AUTHORS   Bin,L.H., Xu,L.G. and Shu,H.B.
  TITLE     TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing
            adapter protein involved in TIR signaling
  JOURNAL   J Biol Chem 278 (27), 24526-24532 (2003)
   PUBMED   12721283
REFERENCE   7  (bases 1 to 2684)
  AUTHORS   Jiang,Z., Zamanian-Daryoush,M., Nie,H., Silva,A.M., Williams,B.R.
            and Li,X.
  TITLE     Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation
            of NFkappa B and MAP kinase is through an interleukin-1
            receptor-associated kinase (IRAK)-independent pathway employing the
            signaling components TLR3-TRAF6-TAK1-TAB2-PKR
  JOURNAL   J Biol Chem 278 (19), 16713-16719 (2003)
   PUBMED   12609980
  REMARK    Erratum:[J Biol Chem. 2003 Jun 20;278(5):23212]
REFERENCE   8  (bases 1 to 2684)
  AUTHORS   Fitzgerald,K.A., McWhirter,S.M., Faia,K.L., Rowe,D.C., Latz,E.,
            Golenbock,D.T., Coyle,A.J., Liao,S.M. and Maniatis,T.
  TITLE     IKKepsilon and TBK1 are essential components of the IRF3 signaling
            pathway
  JOURNAL   Nat Immunol 4 (5), 491-496 (2003)
   PUBMED   12692549
REFERENCE   9  (bases 1 to 2684)
  AUTHORS   Oshiumi,H., Matsumoto,M., Funami,K., Akazawa,T. and Seya,T.
  TITLE     TICAM-1, an adaptor molecule that participates in Toll-like
            receptor 3-mediated interferon-beta induction
  JOURNAL   Nat Immunol 4 (2), 161-167 (2003)
   PUBMED   12539043
  REMARK    GeneRIF: identified an alternative adaptor, designated
            Toll-interleukin 1 receptor domain (TIR)-containing adaptor
            molecule (TICAM)-1, that can physically bind the TIR domain of TLR3
REFERENCE   10 (bases 1 to 2684)
  AUTHORS   Yamamoto,M., Sato,S., Mori,K., Hoshino,K., Takeuchi,O., Takeda,K.
            and Akira,S.
  TITLE     Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter
            that preferentially activates the IFN-beta promoter in the
            Toll-like receptor signaling
  JOURNAL   J Immunol 169 (12), 6668-6672 (2002)
   PUBMED   12471095
  REMARK    GeneRIF: TRIF is identified and characterized as a novel adaptor
            protein containing the Toll/IL-1 receptor domain, with a specific
            role in TLR3 signaling.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DR000002.1, BC035331.1,
            AB086380.1 and BX349282.2.
            
            On Feb 27, 2020 this sequence version replaced NM_182919.3.
            
            Summary: This gene encodes an adaptor protein containing a
            Toll/interleukin-1 receptor (TIR) homology domain, which is an
            intracellular signaling domain that mediates protein-protein
            interactions between the Toll-like receptors (TLRs) and
            signal-transduction components. This protein is involved in native
            immunity against invading pathogens. It specifically interacts with
            toll-like receptor 3, but not with other TLRs, and this association
            mediates dsRNA induction of interferon-beta through activation of
            nuclear factor kappa-B, during an antiviral immune response.
            Mutations in this gene are associated with encephalopathy, acute,
            infection-induced. [provided by RefSeq, Jul 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035331.1, SRR14038191.3946913.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2151358
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in immune response or antiviral
                                      activity
            MANE Ensembl match     :: ENST00000248244.6/ ENSP00000248244.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 DR000002.1         22-29
            9-249               BC035331.1         1-241
            250-2636            AB086380.1         74-2460
            2637-2684           BX349282.2         81-128
FEATURES             Location/Qualifiers
     source          1..2684
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2684
                     /gene="TICAM1"
                     /gene_synonym="IIAE6; MyD88-3; PRVTIRB; TICAM-1; TRIF"
                     /note="TIR domain containing adaptor molecule 1"
                     /db_xref="GeneID:148022"
                     /db_xref="HGNC:HGNC:18348"
                     /db_xref="MIM:607601"
     exon            1..99
                     /gene="TICAM1"
                     /gene_synonym="IIAE6; MyD88-3; PRVTIRB; TICAM-1; TRIF"
                     /inference="alignment:Splign:2.1.0"
     exon            100..2684
                     /gene="TICAM1"
                     /gene_synonym="IIAE6; MyD88-3; PRVTIRB; TICAM-1; TRIF"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..2377
                     /gene="TICAM1"
                     /gene_synonym="IIAE6; MyD88-3; PRVTIRB; TICAM-1; TRIF"
                     /note="isoform 1 is encoded by transcript variant 1; TIR
                     domain-containing adapter molecule 1; TIR domain
                     containing adaptor inducing interferon-beta; putative
                     NF-kappa-B-activating protein 502H; TIR domain-containing
                     adapter protein inducing IFN-beta; proline-rich, vinculin
                     and TIR domain-containing protein B; toll-interleukin-1
                     receptor domain-containing adapter protein inducing
                     interferon beta; toll like receptor adaptor molecule 1"
                     /codon_start=1
                     /product="TIR domain-containing adapter molecule 1 isoform
                     1"
                     /protein_id="NP_891549.1"
                     /db_xref="CCDS:CCDS12136.1"
                     /db_xref="GeneID:148022"
                     /db_xref="HGNC:HGNC:18348"
                     /db_xref="MIM:607601"
                     /translation="MACTGPSLPSAFDILGAAGQDKLLYLKHKLKTPRPGCQGQDLLH
                     AMVLLKLGQETEARISLEALKADAVARLVARQWAGVDSTEDPEEPPDVSWAVARLYHL
                     LAEEKLCPASLRDVAYQEAVRTLSSRDDHRLGELQDEARNRCGWDIAGDPGSIRTLQS
                     NLGCLPPSSALPSGTRSLPRPIDGVSDWSQGCSLRSTGSPASLASNLEISQSPTMPFL
                     SLHRSPHGPSKLCDDPQASLVPEPVPGGCQEPEEMSWPPSGEIASPPELPSSPPPGLP
                     EVAPDATSTGLPDTPAAPETSTNYPVECTEGSAGPQSLPLPILEPVKNPCSVKDQTPL
                     QLSVEDTTSPNTKPCPPTPTTPETSPPPPPPPPSSTPCSAHLTPSSLFPSSLESSSEQ
                     KFYNFVILHARADEHIALRVREKLEALGVPDGATFCEDFQVPGRGELSCLQDAIDHSA
                     FIILLLTSNFDCRLSLHQVNQAMMSNLTRQGSPDCVIPFLPLESSPAQLSSDTASLLS
                     GLVRLDEHSQIFARKVANTFKPHRLQARKAMWRKEQDTRALREQSQHLDGERMQAAAL
                     NAAYSAYLQSYLSYQAQMEQLQVAFGSHMSFGTGAPYGARMPFGGQVPLGAPPPFPTW
                     PGCPQPPPLHAWQAGTPPPPSPQPAAFPQSLPFPQSPAFPTASPAPPQSPGLQPLIIH
                     HAQMVQLGLNNHMWNQRGSQAPEDKTQEAE"
     regulatory      2664..2669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TICAM1"
                     /gene_synonym="IIAE6; MyD88-3; PRVTIRB; TICAM-1; TRIF"
                     /note="hexamer: AATAAA"
     polyA_site      2684
                     /gene="TICAM1"
                     /gene_synonym="IIAE6; MyD88-3; PRVTIRB; TICAM-1; TRIF"
                     /note="major polyA site"
ORIGIN      
        1 agcgccctca gcgcgctacg gtccgcgggc aactccgcag aagccccagc ccccaggacc
       61 ccaggaccca gtggcgcagc cggcagcccc ggatccctga tctgcttggg cagctcctgc
      121 agaacctgga acagtgaatg ggtaggggac actgggcgtg cagaaggcgg ggggcagtgt
      181 ggaacatgcc ttcaccacct ccagcttctg ctgccggagg ctgcacccac ctgtgcccat
      241 ggcctgcaca ggcccatcac ttcctagcgc cttcgacatt ctaggtgcag caggccagga
      301 caagctcttg tatctgaagc acaaactgaa gaccccacgc ccaggctgcc aggggcagga
      361 cctcctgcat gccatggttc tcctgaagct gggccaggaa actgaggcca ggatctctct
      421 agaggcattg aaggccgatg cggtggcccg gctggtggcc cgccagtggg ctggcgtgga
      481 cagcaccgag gacccagagg agcccccaga tgtgtcctgg gctgtggccc gcttgtacca
      541 cctgctggct gaggagaagc tgtgccccgc ctcgctgcgg gacgtggcct accaggaagc
      601 cgtccgcacc ctcagctcca gggacgacca ccggctgggg gaacttcagg atgaggcccg
      661 aaaccggtgt gggtgggaca ttgctgggga tccagggagc atccggacgc tccagtccaa
      721 tctgggctgc ctcccaccat cctcggcttt gccctctggg accaggagcc tcccacgccc
      781 cattgacggt gtttcggact ggagccaagg gtgctccctg cgatccactg gcagccctgc
      841 ctccctggcc agcaacttgg aaatcagcca gtcccctacc atgcccttcc tcagcctgca
      901 ccgcagccca catgggccca gcaagctctg tgacgacccc caggccagct tggtgcccga
      961 gcctgtcccc ggtggctgcc aggagcctga ggagatgagc tggccgccat cgggggagat
     1021 tgccagccca ccagagctgc caagcagccc acctcctggg cttcccgaag tggccccaga
     1081 tgcaacctcc actggcctcc ctgatacccc cgcagctcca gaaaccagca ccaactaccc
     1141 agtggagtgc accgaggggt ctgcaggccc ccagtctctc cccttgccta ttctggagcc
     1201 ggtcaaaaac ccctgctctg tcaaagacca gacgccactc caactttctg tagaagatac
     1261 cacctctcca aataccaagc cgtgcccacc tactcccacc accccagaaa catcccctcc
     1321 tcctcctcct cctcctcctt catctactcc ttgttcagct cacctgaccc cctcctccct
     1381 gttcccttcc tccctggaat catcatcgga acagaaattc tataactttg tgatcctcca
     1441 cgccagggca gacgaacaca tcgccctgcg ggttcgggag aagctggagg cccttggcgt
     1501 gcccgacggg gccaccttct gcgaggattt ccaggtgccg gggcgcgggg agctgagctg
     1561 cctgcaggac gccatagacc actcagcttt catcatccta cttctcacct ccaacttcga
     1621 ctgtcgcctg agcctgcacc aggtgaacca agccatgatg agcaacctca cgcgacaggg
     1681 gtcgccagac tgtgtcatcc ccttcctgcc cctggagagc tccccggccc agctcagctc
     1741 cgacacggcc agcctgctct ccgggctggt gcggctggac gaacactccc agatcttcgc
     1801 caggaaggtg gccaacacct tcaagcccca caggcttcag gcccgaaagg ccatgtggag
     1861 gaaggaacag gacacccgag ccctgcggga acagagccaa cacctggacg gtgagcggat
     1921 gcaggcggcg gcactgaacg cagcctactc agcctacctc cagagctact tgtcctacca
     1981 ggcacagatg gagcagctcc aggtggcttt tgggagccac atgtcatttg ggactggggc
     2041 gccctatggg gctcgaatgc cctttggggg ccaggtgccc ctgggagccc cgccaccctt
     2101 tcccacttgg ccggggtgcc cgcagccgcc acccctgcac gcatggcagg ctggcacccc
     2161 cccaccgccc tccccacagc cagcagcctt tccacagtca ctgcccttcc cgcagtcccc
     2221 agccttccct acggcctcac ccgcaccccc tcagagccca gggctgcaac ccctcattat
     2281 ccaccacgca cagatggtac agctggggct gaacaaccac atgtggaacc agagagggtc
     2341 ccaggcgccc gaggacaaga cgcaggaggc agaatgaccg cgtgtccttg cctgaccacc
     2401 tggggaacac ccctggaccc aggcatcggc caggacccca tagagcaccc cggtctgccc
     2461 tgtgccctgt ggacagtgga agatgaggtc atctgccact ttcaggacat tgtccgggag
     2521 cccttcattt aggacaaaac gggcgcgatg atgccctggc tttcagggtg gtcagaactg
     2581 gatacggtgt ttacaattcc aatctctcta tttctgggtg aagggtcttg gtggtggggg
     2641 tattgctacg gtcttttaat tataataaat atttattgaa tgct
//
