LOCUS       NM_003252               3827 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens TIA1 cytotoxic granule associated RNA binding protein
            like 1 (TIAL1), transcript variant 1, mRNA.
ACCESSION   NM_003252 XM_941936 XM_945550 XM_945552 XM_945554 XM_945556
            XM_945560 XM_945564 XM_945566 XM_945569 XM_945570 XM_945572
            XM_945573
VERSION     NM_003252.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3827)
  AUTHORS   Zhang,T., Zheng,H., Lu,D., Guan,G., Li,D., Zhang,J., Liu,S.,
            Zhao,J., Guo,J.T., Lu,F. and Chen,X.
  TITLE     RNA binding protein TIAR modulates HBV replication by tipping the
            balance of pgRNA translation
  JOURNAL   Signal Transduct Target Ther 8 (1), 346 (2023)
   PUBMED   37699883
  REMARK    GeneRIF: RNA binding protein TIAR modulates HBV replication by
            tipping the balance of pgRNA translation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3827)
  AUTHORS   Wang,L., Sola,I., Enjuanes,L. and Zuniga,S.
  TITLE     MOV10 Helicase Interacts with Coronavirus Nucleocapsid Protein and
            Has Antiviral Activity
  JOURNAL   mBio 12 (5), e0131621 (2021)
   PUBMED   34517762
REFERENCE   3  (bases 1 to 3827)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3827)
  AUTHORS   Guo,X., Sun,Y., Azad,T., Janse van Rensburg,H.J., Luo,J., Yang,S.,
            Liu,P., Lv,Z., Zhan,M., Lu,L., Zhou,Y., Ma,X., Zhang,X., Yang,X.
            and Xue,L.
  TITLE     Rox8 promotes microRNA-dependent yki messenger RNA decay
  JOURNAL   Proc Natl Acad Sci U S A 117 (48), 30520-30530 (2020)
   PUBMED   33203680
REFERENCE   5  (bases 1 to 3827)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3827)
  AUTHORS   Jin,K., Li,W., Nagayama,T., He,X., Sinor,A.D., Chang,J., Mao,X.,
            Graham,S.H., Simon,R.P. and Greenberg,D.A.
  TITLE     Expression of the RNA-binding protein TIAR is increased in neurons
            after ischemic cerebral injury
  JOURNAL   J Neurosci Res 59 (6), 767-774 (2000)
   PUBMED   10700014
REFERENCE   7  (bases 1 to 3827)
  AUTHORS   Doi,T., Minami,T., Itoh,M., Aburatani,H., Kawabe,Y., Kodama,T.,
            Kondo,N., Satoh,Y., Asayama,T. and Imanishi,T.
  TITLE     An alternative form of nucleolysin binds to a T-cluster DNA in the
            silencer element of platelet factor 4 gene
  JOURNAL   Biochem Biophys Res Commun 235 (3), 625-630 (1997)
   PUBMED   9207209
REFERENCE   8  (bases 1 to 3827)
  AUTHORS   Dember,L.M., Kim,N.D., Liu,K.Q. and Anderson,P.
  TITLE     Individual RNA recognition motifs of TIA-1 and TIAR have different
            RNA binding specificities
  JOURNAL   J Biol Chem 271 (5), 2783-2788 (1996)
   PUBMED   8576255
REFERENCE   9  (bases 1 to 3827)
  AUTHORS   Taupin,J.L., Tian,Q., Kedersha,N., Robertson,M. and Anderson,P.
  TITLE     The RNA-binding protein TIAR is translocated from the nucleus to
            the cytoplasm during Fas-mediated apoptotic cell death
  JOURNAL   Proc Natl Acad Sci U S A 92 (5), 1629-1633 (1995)
   PUBMED   7533298
REFERENCE   10 (bases 1 to 3827)
  AUTHORS   Kawakami,A., Tian,Q., Duan,X., Streuli,M., Schlossman,S.F. and
            Anderson,P.
  TITLE     Identification and functional characterization of a TIA-1-related
            nucleolysin
  JOURNAL   Proc Natl Acad Sci U S A 89 (18), 8681-8685 (1992)
   PUBMED   1326761
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL833106.1, BC030025.1,
            AC012468.10, AK125264.1 and AA972022.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 11, 2020 this sequence version replaced NM_003252.3.
            
            Summary: The protein encoded by this gene is a member of a family
            of RNA-binding proteins, has three RNA recognition motifs (RRMs),
            and binds adenine and uridine-rich elements in mRNA and pre-mRNAs
            of a wide range of genes. It regulates various activities including
            translational control, splicing and apoptosis. Alternate
            transcriptional splice variants, encoding different isoforms, have
            been characterized. The different isoforms have been show to
            function differently with respect to post-transcriptional
            silencing. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.296620.1,
                                           SRR14038193.2006134.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000436547.7/ ENSP00000394902.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-728               AL833106.1         2-729
            729-870             BC030025.1         799-940
            871-1236            AL833106.1         872-1237
            1237-1360           AC012468.10        37686-37809         c
            1361-1500           AC012468.10        37217-37356         c
            1501-1850           AC012468.10        36048-36397         c
            1851-3594           AK125264.1         19-1762
            3595-3827           AA972022.1         3-235               c
FEATURES             Location/Qualifiers
     source          1..3827
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.11"
     gene            1..3827
                     /gene="TIAL1"
                     /gene_synonym="TCBP; TIAR"
                     /note="TIA1 cytotoxic granule associated RNA binding
                     protein like 1"
                     /db_xref="GeneID:7073"
                     /db_xref="HGNC:HGNC:11804"
                     /db_xref="MIM:603413"
     exon            1..531
                     /gene="TIAL1"
                     /gene_synonym="TCBP; TIAR"
                     /inference="alignment:Splign:2.1.0"
     CDS             500..1627
                     /gene="TIAL1"
                     /gene_synonym="TCBP; TIAR"
                     /note="isoform 1 is encoded by transcript variant 1;
                     TIA-1-related nucleolysin; T-cluster binding protein;
                     nucleolysin TIAR; aging-associated gene 7 protein; TIA1
                     related"
                     /codon_start=1
                     /product="nucleolysin TIAR isoform 1"
                     /protein_id="NP_003243.1"
                     /db_xref="CCDS:CCDS7613.1"
                     /db_xref="GeneID:7073"
                     /db_xref="HGNC:HGNC:11804"
                     /db_xref="MIM:603413"
                     /translation="MMEDDGQPRTLYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEH
                     TSNDPYCFVEFYEHRDAAAALAAMNGRKILGKEVKVNWATTPSSQKKDTSNHFHVFVG
                     DLSPEITTEDIKSAFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGG
                     QWLGGRQIRTNWATRKPPAPKSTQENNTKQLRFEDVVNQSSPKNCTVYCGGIASGLTD
                     QLMRQTFSPFGQIMEIRVFPEKGYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYWGK
                     ESPDMTKNFQQVDYSQWGQWSQVYGNPQQYGQYMANGWQVPPYGVYGQPWNQQGFGVD
                     QSPSAAWMGGFGAQPPQGQAPPPVIPPPNQAGYGMASYQTQ"
     exon            532..628
                     /gene="TIAL1"
                     /gene_synonym="TCBP; TIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            629..727
                     /gene="TIAL1"
                     /gene_synonym="TCBP; TIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            728..782
                     /gene="TIAL1"
                     /gene_synonym="TCBP; TIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            783..870
                     /gene="TIAL1"
                     /gene_synonym="TCBP; TIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            871..946
                     /gene="TIAL1"
                     /gene_synonym="TCBP; TIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1055
                     /gene="TIAL1"
                     /gene_synonym="TCBP; TIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1151
                     /gene="TIAL1"
                     /gene_synonym="TCBP; TIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1236
                     /gene="TIAL1"
                     /gene_synonym="TCBP; TIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1360
                     /gene="TIAL1"
                     /gene_synonym="TCBP; TIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1500
                     /gene="TIAL1"
                     /gene_synonym="TCBP; TIAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..3827
                     /gene="TIAL1"
                     /gene_synonym="TCBP; TIAR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1861..1866
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIAL1"
                     /gene_synonym="TCBP; TIAR"
                     /note="hexamer: AATAAA"
     regulatory      1870..1875
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIAL1"
                     /gene_synonym="TCBP; TIAR"
                     /note="hexamer: AATAAA"
     polyA_site      1880
                     /gene="TIAL1"
                     /gene_synonym="TCBP; TIAR"
     polyA_site      1893
                     /gene="TIAL1"
                     /gene_synonym="TCBP; TIAR"
                     /note="major polyA site"
     regulatory      3790..3795
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIAL1"
                     /gene_synonym="TCBP; TIAR"
                     /note="hexamer: AATAAA"
     polyA_site      3827
                     /gene="TIAL1"
                     /gene_synonym="TCBP; TIAR"
ORIGIN      
        1 gcagaagtgc ttccctctct catttccagg accacaattc ccagagactt cggcttcacg
       61 acgtttctct ttttgcccga tctctcccgg agctggctgg gcttcggccg gccagaggcc
      121 cacagcgacg acgtgatccg tcgtgagcgg gtcccagggt ttcctcggcg gccctttttt
      181 ctctcccctc ggtcgtcccc cttgcaggct gtcgcggctg gcctgagcgg tgacctggcg
      241 ggtcgcgcct gcgctctgcc ctgtttcctg cctggctggt ggcggcggcc attttgttca
      301 tcctcctcct cctcctgctc ctcctggttg gagcgcagtg tccggagcgg gctgggggga
      361 gagagcccga gagcagggtt cggtgccttt tcctctgtcc ccagccggtg cccagagccc
      421 ccctcccctt cctccccacc ccctcccctc cccaaccctg ccctccccct tgtcccggga
      481 tcgctccgtc gcacccacca tgatggaaga cgacgggcag ccccggactc tatacgtagg
      541 taacctttcc agagatgtga cagaagtcct tatacttcag ttgttcagtc agattggacc
      601 ctgtaaaagc tgtaaaatga taacagagca tacaagcaat gacccatatt gctttgtgga
      661 attttatgaa cacagagatg cagctgctgc attagctgct atgaatggga gaaaaatttt
      721 gggaaaggag gtcaaagtaa actgggcaac cacaccaagt agccagaaaa aagatacttc
      781 caatcacttc catgtgtttg ttggggattt gagtccagaa attacaacag aagatatcaa
      841 atcagcattt gccccctttg gtaaaatatc ggatgcccgg gtagttaaag acatggcaac
      901 tggaaaatcc aaaggctatg gttttgtatc tttttataac aaactggatg cagaaaatgc
      961 gattgtgcat atgggcggtc agtggttggg tggtcgtcaa atccgaacca attgggccac
     1021 tcgtaaacca cctgcaccta aaagtacaca agaaaacaac actaagcagt tgagatttga
     1081 agatgtagta aaccagtcaa gtccaaaaaa ttgtactgtg tactgtggag gaattgcgtc
     1141 tgggttaaca gatcagctta tgagacagac attctcacca tttggacaaa ttatggaaat
     1201 aagagttttc ccagaaaagg gctattcatt tgtcagattt tcaacccatg aaagtgcagc
     1261 ccatgccatt gtttcggtga acggtactac gattgaagga catgtggtta aatgctattg
     1321 gggtaaagaa tctcctgata tgactaaaaa cttccaacag gttgactata gtcaatgggg
     1381 ccaatggagc caagtgtatg gaaacccaca acagtatgga cagtatatgg caaatgggtg
     1441 gcaagtaccg ccttatggag tatacgggca accatggaat caacaaggat ttggagtaga
     1501 tcaatcacct tctgctgctt ggatgggtgg atttggtgct cagcctcccc aaggacaagc
     1561 tcctccccct gtaatacctc ctcctaacca agccggatat ggtatggcaa gttaccaaac
     1621 acagtgagcc gggactctaa aaaaaaattg taattcatga taggcttcga tttcctgtga
     1681 cactctgaag acatgaaagt agacatcgga aaatgaaaat atttatttta aaaattgaaa
     1741 tgtttggaac ctttagcaca gatttgcttt ggtgaaggac acgtgtcttc tagttctgcc
     1801 tttttaagtt tttgttcatg atggatatga acatgatttt tctttatgta caaaaactaa
     1861 aataaagtca ataaagacaa ttctgactac aaattttgat ataataggaa aaatggctaa
     1921 tacattttga ttcttagata ctattccatt tttatcttgc tgttcagtat tttaactcac
     1981 tgtgttttta aaagagcaaa aaagggagga tcgtgaaaac ctgggaatca catataagtt
     2041 catcctgaat cctgatactc ccctcccctt ccctgaggtg gaccacattt gaagtcagca
     2101 gagaaaaagt gtgatattca gaagaaatgc gtgattttgg agtcgctttg gaggaaatat
     2161 tttctttctc tatgcctaaa gaaactgaag ccagactgaa gttttgcacc ctaaaaaagg
     2221 aacagcattg tttgagttac ttgagcaaat gttggtggtc cacgttaaga catattttta
     2281 aaacttccaa aagtgtcgat tattaaaatt gtagtatttt acatttcatt ttggggggaa
     2341 atccaagtat ggtgtttgta ttgaagtcag acagtcatac ttgtgctttt acatgaagtt
     2401 taaatgatac atattgtaaa tattcaataa ctacagtgtt taaaaagcat gcttcaacat
     2461 agaagtagca gcaatgtaat tatttgaagt aacacttaac acactccgct gcattgaatg
     2521 cagtggattg atcagaatgt taagactgac atttccaagg ttggctacta tgtaaaatta
     2581 aaattacaca aattgtgcag aaaaagcctt aattttaatt tcatacaatc tttgatgcat
     2641 tagtatgttc taaaatgtca ttgggaatta gttttttgtt tttgtttttt tttttttttt
     2701 tttttgcttt acattacttg gtatgtaaat accttgatta aaaccttgta aaccaatttc
     2761 aaggttacta taagttgtat agtacaagtg ttttttaaaa atcttggggt gtttttaaaa
     2821 attaagatat attttgccca agaatttttt taacaagatt gctaaaaaca tcttatttag
     2881 acacttcaat gtaccaattt ataattggat attcagttta aatagtacac agagttgtgg
     2941 cttttatttt caattaattt ttttccttgt gggcagtgtg catggtataa taagcctgag
     3001 cagaggctta agttgtatgt gtgcagagtt tgtaaaggaa tcaattggaa gatgcagaag
     3061 accgaggttt gctttcaagg tatttttcag gctgtgtggg taaaatttgc ctcaaatttc
     3121 tatcaaacag gaatgtaaaa tagataaaat cctatgtatt tgaattgtca gagctaggga
     3181 gtgcaaatgt tttggcaatg tattcaaaat gctggcctgg gcaccaaaga gaaaatagcc
     3241 ttttacagtt acatagtaag atgcgattag tacccacaaa ttactgtttt ctaaacattt
     3301 gaagttttac gattagcttt aaaataatga ttttataaat tggtggtcac aataattttg
     3361 gtattacttt cctccttttc ccacttagca atatagccaa atgtattcaa cataaaaatt
     3421 catagggtct gaaattcata gctgggccaa attttttatg gcaccttagt tttaccataa
     3481 tggtcatcta ttacactctt ctgttataaa atataccctt atttcttttg tttatagtat
     3541 ctttgaggaa tgtttttgga aaagttaatt tatattttat agggagaaca ctcaataaat
     3601 tatgttaact gtgcccccga gttaaaaatt ttatgagtat atgtgaaact tgaacaactg
     3661 aagacttttt ttaattgata aaaatgctta gtatgcctgt tttggtctgc cagtaaatta
     3721 agtagcttat tgagataact aacagctaaa tatagctgta gtgtttcctg actgtatatt
     3781 ctatgattta ataaaattat ccagactagt tatattgcca cagtaaa
//
