LOCUS       XM_047445629            4984 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens TIA1 cytotoxic granule associated RNA
            binding protein (TIA1), transcript variant X6, mRNA.
ACCESSION   XM_047445629
VERSION     XM_047445629.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4984
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..4984
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /note="TIA1 cytotoxic granule associated RNA binding
                     protein; Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 1 mRNA, 27 ESTs, 1780 long SRA
                     reads, 3 Proteins, and 100% coverage of the annotated
                     genomic feature by RNAseq alignments, including 161
                     samples with support for all annotated introns"
                     /db_xref="GeneID:7072"
                     /db_xref="HGNC:HGNC:11802"
                     /db_xref="MIM:603518"
     CDS             852..1709
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /codon_start=1
                     /product="cytotoxic granule associated RNA binding protein
                     TIA1 isoform X4"
                     /protein_id="XP_047301585.1"
                     /db_xref="GeneID:7072"
                     /db_xref="HGNC:HGNC:11802"
                     /db_xref="MIM:603518"
                     /translation="MQDHFHVFVGDLSPEITTEDIKAAFAPFGRISDARVVKDMATGK
                     SKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTNWATRKPPAPKSTYESNTKQLSYD
                     EVVNQSSPSNCTVYCGGVTSGLTEQLMRQTFSPFGQIMEIRVFPDKGYSFVRFNSHES
                     AAHAIVSVNGTTIEGHVVKCYWGKETLDMINPVQQQNQIGYPQPYGQWGQWYGNAQQI
                     GQYMPNGWQVPAYGMYGQAWNQQGFNQTQSSAPWMGPNYGVQPPQGQNGSMLPNQPSG
                     YRVAGYETQ"
ORIGIN      
        1 gcctataaac atcatacatg tttgcagtaa tgttttgatc gttatcctaa gatatgattg
       61 aatgtgtttg tgttaataaa tttaagaaca aatctaatct ttgtcatcag gtagtaccgt
      121 tgtcagcaca cagcgttcac aaggtaattg tatcttctta aacataaaat gaaatctctt
      181 gaaagggtat tcactaacca cctgaagttt ttttgtttga tatttggggg aggggggcgg
      241 gaggagatat tatttctatt tgtctctcta gcaatacttt tctcccttct cagtgttgac
      301 caagtataac ttgtccgcta ctttggtgct agttcaagct ttctgacccg tttggtagca
      361 gctgatgcct tagaactact ttcaccaact aaggggcaaa ataccctcct ttcttgaggt
      421 caccatttgg gcttcatacc cagatcttcc aaatgcttga gttgctcctc aaattttgtt
      481 tcccaaagag caatccaaaa tgttgtttaa ggcctgtcaa atatgggtaa cttttctttc
      541 caaatatgct ttgtcaaatt gatgtatgtg tccattttaa agtgttggtc caacaatttt
      601 gcatttttaa agtgtttctt tttttgataa ttgtcttttt taaaaacttc agatatgggt
      661 tggttatttc tctccaatgc ttttttaatg gttctgatat aaagtgaagg gattactgtt
      721 ttcattctgt tgccttcagt cttagttcac ttgcacatgg attcacataa actgaatggt
      781 gtaatgtctg ggcaaccaaa actgttggct tttgagaaaa ctgtcaaata ctttaacatc
      841 aaactgttgc aatgcaagat catttccatg tctttgttgg tgatctcagc ccagaaatta
      901 caactgaaga tataaaagct gcttttgcac catttggaag aatatcagat gcccgagtgg
      961 taaaagacat ggcaacagga aagtctaagg gatatggctt tgtctccttt ttcaacaaat
     1021 gggatgctga aaacgccatt caacagatgg gtggccagtg gcttggtgga agacaaatca
     1081 gaactaactg ggcaacccga aagcctcccg ctccaaagag tacatatgag tcaaatacca
     1141 aacagctatc atatgatgag gttgtaaatc agtctagtcc aagcaactgt actgtatact
     1201 gtggaggtgt tacttctggg ctaacagaac aactaatgcg tcagactttt tcaccatttg
     1261 gacaaataat ggaaattcga gtctttccag ataaaggata ttcatttgtt cggttcaatt
     1321 cccatgaaag tgcagcacat gcaattgttt ctgttaatgg tactaccatt gaaggtcatg
     1381 ttgtgaaatg ctattggggc aaagaaactc ttgatatgat aaatcccgtg caacagcaga
     1441 atcaaattgg atatccccaa ccttatggcc agtggggcca gtggtatgga aatgcacaac
     1501 aaattggcca gtatatgcct aatggttggc aagttcctgc atatggaatg tatggccagg
     1561 catggaacca gcaaggattt aatcagacac agtcttctgc accatggatg ggaccaaatt
     1621 atggagtgca accgcctcaa gggcaaaatg gcagcatgtt gcccaatcag ccttctgggt
     1681 atcgagtggc agggtatgaa acccagtgaa taaggactcc agaatctaaa gccagtggct
     1741 tgaggctaca gggagtgtag taaagccgtt gtttacttaa agatttatca aatcagtcag
     1801 tgcaaatgtc agatacaatg tatttattta aaagattcat ttttaatcat gaaattactt
     1861 atcatccaca ttgttttaaa aagaaacaag atgctggatg tctgccaatt tttgccttca
     1921 ttaccttttt tgataaagtt tctcagatcc ttgtttcaaa cacaaatgca gggattgctg
     1981 ccacttttta actattaaga ggcagaaaat tgcacaatat tgaacttttt tccactgaag
     2041 tagtgtgcag ttctagtttg cattcctgat atgatttaaa acatgtaata taaagatgtt
     2101 aaaaaaaaaa accaaaactg tgcagagtct agaagttgtt tgtcatcttc agcttgtgca
     2161 caattctgtt ttaggttaaa aaaaggcatt gtttgagctg tcccatctcc actgttatcc
     2221 ctttggggtt ttttaatata aattattagt ttacatcatt tttgtatcta catctttttt
     2281 cacaaatttg tcttgcctta ttaaagttct gtaaaatata cttaaatgga aaaaatgatg
     2341 ttcatttaga ttgaaaactt ttctcagatg gattgataat tgcattcatc ttgtgtttta
     2401 tatgagaagg tgcctcaaga atttcctgtt ggatttgttt aaaaggattt ttatctttcg
     2461 tgataaactt tgctgtgtac caggaactat aaaaacaaaa acttgttact aaagaaaata
     2521 tctgaaatgt gataagttct tatgccatgt taatttcatg tgtcaacttc aacatttaca
     2581 tgtattattt cattatgtaa aatgttttag caatttaata ttttgcacag ttagcaaact
     2641 ttgtatgtca tttccttcaa ggcatcatgc agagttgaca tgagatttat aaggttttaa
     2701 gttgtttgca tgtgaaaatc aaatacatac tttggtagtc tttgaataca aagtcatctg
     2761 ctcttgtttt tcaagaattt tgagacacaa agttgtatgt aaaggaatat attaatttgc
     2821 cgttttctag gtagatttgc tcaaaaagag tgaatcaact taatatgtac aaatgatagc
     2881 tgtgaaactg tagaatatct ttgtgtcagg cttggagttc attgtgacct ccaaattttg
     2941 cctgaaggac cagctgggca aagcatcttt taaatgttca gaggccaaaa gataaacaaa
     3001 aaaaaaacct taaaatccta cctctttaaa cagccttcag ataagagaat cctcagtgca
     3061 atcattattt tgattcgttt ggtacctgtt ttcctggagt tcccgatttt attattttgg
     3121 ggtggctcca agcattaaga ggtttaatct ttgatggcat tgttctagtt ttgaaatttc
     3181 tagtatattt cagagtctct tagaagactt gtgtgggaag tttcactttg ttttcagtga
     3241 agatcacaaa cctccttctt cctttactca agaggaaagg tcccagtata catatttgaa
     3301 tggttgatgg ttttcaagac cttcagggag ctccctgcat tttacctaga aacagaaaag
     3361 gcccgcaaaa tcttaagttt cctggcctgc atttcccggg taggggcaaa tgactccaag
     3421 ctggtctcta agccaatacc cttataaacc agagcccagg aaagacagct cgagtgtata
     3481 attctctgga gctcaattct atgcagttgt gctgatattt cattaagtca ctgtgtattt
     3541 ttaagtgttg atacattaaa agtcgcttta tggaagatga gtaaattttt taaatacttg
     3601 gaaattttat ttccttgtta acttctacag atcagggcat gcaaccaaaa gcagcttaaa
     3661 tgaaatattt taaaataaaa tatcaggaag ctatttttag atttcttctg gcttatgttt
     3721 ctactttagg accctcattg ttctcttatt aaaaaaaatt atttcctgtg catctcatgg
     3781 actgcagggt aaattatttg ggcataaata atttaaatag ttttctttca ttttgactat
     3841 ctccagtaat aacagttttt attatccagc atattggctt attgcacaaa tcttaaaatg
     3901 tacattgact actttctgag aagaaagtgg tatcagtact catgatgaaa aggttactac
     3961 tgaacaaatt cacatttcag gaacacctct atctttggtt taaatcttac tcttagtttt
     4021 tccgtctaaa aatcatactg gtattagtat caggtaagga aattaaagtt tttaaaatgg
     4081 tttcattctc tgcaatatgc aaaatttaga ttttactttc tggtactgta aagaacctga
     4141 agtgatttac acttaatggg tgattaatcc agtattcttt accctgaatg tttggatatt
     4201 aaagttcctt tatgttttct ataacctgtg ggatcttctt gcagtgatta ttgtgtgtga
     4261 gatttttttt ctttttggtc tatccatatt gttatattca ctcaggtatt ttttttttaa
     4321 tcttattcca gaatcagtgg tttatattgg gttactgttt aacaccaaat ggaattggca
     4381 ttctgcagat ttaattaatt atgaaaccag ggtctcattt tccttgctga tacttgttga
     4441 aaatgagatt cacattctag tctttatttt cctcctgttt tgtccctgtg cttgtacatc
     4501 ttccttttat ttgtgtgtta tagttctatt ccatttgaga aggcagttgg taagaactag
     4561 attgcatgta caaagacagg tttactaagt gctgtacagt ggtcctgagg ttacagttga
     4621 attagaaaaa cgaaatgtac ttacaggaaa taagaaagca aacctttcaa atgagagtga
     4681 tgatttcttt aaaaaaaatc agtttttttc tctcaaataa tgttctttat ttcacgaaat
     4741 cgtcaatctt aagcatgagc agggataaac aactcctaga aggaactcaa ttcattcttc
     4801 ctggattttc tctgttgtta aatcacaaaa atgatagtcc ccaatcgttt ctttatagga
     4861 ggttattaca tttcattaca gtcactgcat tttgactgtt gtgtttagaa tttgaatgta
     4921 catccaaaat gatgagtttc aatttaagag ccttaataaa atgtgtgagt gtgtctcaat
     4981 tgaa
//
