LOCUS       NM_022173               4634 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens TIA1 cytotoxic granule associated RNA binding protein
            (TIA1), transcript variant 2, mRNA.
ACCESSION   NM_022173
VERSION     NM_022173.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4634)
  AUTHORS   Panos-Basterra,P., Theuriet,J., Nadaj-Pakleza,A., Magot,A.,
            Lannes,B., Marcorelles,P., Behin,A., Masingue,M., Caillon,F.,
            Malek,Y., Fenouil,T., Bas,J., Menassa,R., Michel-Calemard,L.,
            Streichenberger,N., Simon,J.P., Bouhour,F., Evangelista,T.,
            Metay,C., Pegat,A., Stojkovic,T. and Fernandez-Eulate,G.
  TITLE     Defining the landscape of TIA1 and SQSTM1 digenic myopathy
  JOURNAL   Neuromuscul Disord 42, 43-52 (2024)
   PUBMED   39142003
  REMARK    GeneRIF: Defining the landscape of TIA1 and SQSTM1 digenic
            myopathy.
REFERENCE   2  (bases 1 to 4634)
  AUTHORS   Tak,H., Cha,S., Hong,Y., Jung,M., Ryu,S., Han,S., Jeong,S.M.,
            Kim,W. and Lee,E.K.
  TITLE     The miR-30-5p/TIA-1 axis directs cellular senescence by regulating
            mitochondrial dynamics
  JOURNAL   Cell Death Dis 15 (6), 404 (2024)
   PUBMED   38858355
  REMARK    GeneRIF: The miR-30-5p/TIA-1 axis directs cellular senescence by
            regulating mitochondrial dynamics.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4634)
  AUTHORS   Wang,S., Xu,C., Shan,Y. and Zhang,Y.
  TITLE     RAMP2-AS1 stabilized RAPM2 mRNA through TIA1 to inhibit the
            progression of non-small cell lung cancer
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (14), 9-14 (2023)
   PUBMED   38279501
  REMARK    GeneRIF: RAMP2-AS1 stabilized RAPM2 mRNA through TIA1 to inhibit
            the progression of non-small cell lung cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4634)
  AUTHORS   Bermejo-Guerrero,L., de Fuenmayor Fernandez-de la Hoz,C.P.,
            Gonzalez-Quereda,L., Segarra-Casas,A., Nedkova,V., Gallano,P.,
            Martin-Jimenez,P., Hernandez-Lain,A., Olive,M., Arteche-Lopez,A.
            and Dominguez-Gonzalez,C.
  TITLE     Distal myopathy due to digenic inheritance of TIA1 and SQSTM1
            variants in two unrelated Spanish patients
  JOURNAL   Neuromuscul Disord 33 (12), 983-987 (2023)
   PUBMED   38016875
  REMARK    GeneRIF: Distal myopathy due to digenic inheritance of TIA1 and
            SQSTM1 variants in two unrelated Spanish patients.
REFERENCE   5  (bases 1 to 4634)
  AUTHORS   Zhang,D., Qiao,L., Lei,X., Dong,X., Tong,Y., Wang,J., Wang,Z. and
            Zhou,R.
  TITLE     Mutagenesis and structural studies reveal the basis for the
            specific binding of SARS-CoV-2 SL3 RNA element with human TIA1
            protein
  JOURNAL   Nat Commun 14 (1), 3715 (2023)
   PUBMED   37349329
  REMARK    GeneRIF: Mutagenesis and structural studies reveal the basis for
            the specific binding of SARS-CoV-2 SL3 RNA element with human TIA1
            protein.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4634)
  AUTHORS   Tian,Q., Taupin,J., Elledge,S., Robertson,M. and Anderson,P.
  TITLE     Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1
            during Fas-mediated apoptosis
  JOURNAL   J Exp Med 182 (3), 865-874 (1995)
   PUBMED   7544399
REFERENCE   7  (bases 1 to 4634)
  AUTHORS   Herve-Minvielle,A. and Sara,S.J.
  TITLE     Rapid habituation of auditory responses of locus coeruleus cells in
            anaesthetized and awake rats
  JOURNAL   Neuroreport 6 (10), 1363-1368 (1995)
   PUBMED   7488725
REFERENCE   8  (bases 1 to 4634)
  AUTHORS   Kawakami,A., Tian,Q., Streuli,M., Poe,M., Edelhoff,S.,
            Disteche,C.M. and Anderson,P.
  TITLE     Intron-exon organization and chromosomal localization of the human
            TIA-1 gene
  JOURNAL   J Immunol 152 (10), 4937-4945 (1994)
   PUBMED   8176212
REFERENCE   9  (bases 1 to 4634)
  AUTHORS   Tian,Q., Streuli,M., Saito,H., Schlossman,S.F. and Anderson,P.
  TITLE     A polyadenylate binding protein localized to the granules of
            cytolytic lymphocytes induces DNA fragmentation in target cells
  JOURNAL   Cell 67 (3), 629-639 (1991)
   PUBMED   1934064
REFERENCE   10 (bases 1 to 4634)
  AUTHORS   Anderson,P., Nagler-Anderson,C., O'Brien,C., Levine,H., Watkins,S.,
            Slayter,H.S., Blue,M.L. and Schlossman,S.F.
  TITLE     A monoclonal antibody reactive with a 15-kDa cytoplasmic
            granule-associated protein defines a subpopulation of CD8+ T
            lymphocytes
  JOURNAL   J Immunol 144 (2), 574-582 (1990)
   PUBMED   2104899
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC016700.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_022173.3.
            
            Summary: The product encoded by this gene is a member of a
            RNA-binding protein family and possesses nucleolytic activity
            against cytotoxic lymphocyte (CTL) target cells. It has been
            suggested that this protein may be involved in the induction of
            apoptosis as it preferentially recognizes poly(A) homopolymers and
            induces DNA fragmentation in CTL targets. The major
            granule-associated species is a 15-kDa protein that is thought to
            be derived from the carboxyl terminus of the 40-kDa product by
            proteolytic processing. Alternative splicing resulting in different
            isoforms has been found for this gene. [provided by RefSeq, May
            2017].
            
            Transcript Variant: This variant (2) includes exon 5, which is
            missing in transcript variant 1, resulting in the longer isoform
            (2).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.155662.1,
                                           SRR18074967.1238969.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000433529.7/ ENSP00000401371.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-224               AC016700.8         164752-164975       c
            225-321             AC016700.8         152426-152522       c
            322-420             AC016700.8         147103-147201       c
            421-475             AC016700.8         145611-145665       c
            476-508             AC016700.8         145406-145438       c
            509-596             AC016700.8         144082-144169       c
            597-672             AC016700.8         140901-140976       c
            673-781             AC016700.8         133233-133341       c
            782-877             AC016700.8         132751-132846       c
            878-962             AC016700.8         132555-132639       c
            963-1086            AC016700.8         131718-131841       c
            1087-1232           AC016700.8         130696-130841       c
            1233-4634           AC016700.8         125791-129192       c
FEATURES             Location/Qualifiers
     source          1..4634
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.3"
     gene            1..4634
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /note="TIA1 cytotoxic granule associated RNA binding
                     protein"
                     /db_xref="GeneID:7072"
                     /db_xref="HGNC:HGNC:11802"
                     /db_xref="MIM:603518"
     exon            1..224
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..1359
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /note="isoform 2 is encoded by transcript variant 2;
                     p40-TIA-1 (containing p15-TIA-1); T-cell-restricted
                     intracellular antigen-1; cytotoxic granule associated RNA
                     binding protein TIA1"
                     /codon_start=1
                     /product="cytotoxic granule associated RNA binding protein
                     TIA1 isoform 2"
                     /protein_id="NP_071505.2"
                     /db_xref="CCDS:CCDS1901.1"
                     /db_xref="GeneID:7072"
                     /db_xref="HGNC:HGNC:11802"
                     /db_xref="MIM:603518"
                     /translation="MEDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDTAG
                     NDPYCFVEFHEHRHAAAALAAMNGRKIMGKEVKVNWATTPSSQKKDTSSSTVVSTQRS
                     QDHFHVFVGDLSPEITTEDIKAAFAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDA
                     ENAIQQMGGQWLGGRQIRTNWATRKPPAPKSTYESNTKQLSYDEVVNQSSPSNCTVYC
                     GGVTSGLTEQLMRQTFSPFGQIMEIRVFPDKGYSFVRFNSHESAAHAIVSVNGTTIEG
                     HVVKCYWGKETLDMINPVQQQNQIGYPQPYGQWGQWYGNAQQIGQYMPNGWQVPAYGM
                     YGQAWNQQGFNQTQSSAPWMGPNYGVQPPQGQNGSMLPNQPSGYRVAGYETQ"
     exon            225..321
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /inference="alignment:Splign:2.1.0"
     exon            322..420
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /inference="alignment:Splign:2.1.0"
     exon            421..475
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /inference="alignment:Splign:2.1.0"
     exon            476..508
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /inference="alignment:Splign:2.1.0"
     exon            509..596
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /inference="alignment:Splign:2.1.0"
     exon            597..672
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /inference="alignment:Splign:2.1.0"
     exon            673..781
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /inference="alignment:Splign:2.1.0"
     exon            782..877
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /inference="alignment:Splign:2.1.0"
     exon            878..962
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1086
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1232
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..4634
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2372..2377
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /note="hexamer: AATACA"
     polyA_site      2396
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /note="major polyA site"
     regulatory      3848..3853
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /note="hexamer: ATTAAA"
     polyA_site      3874
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /note="major polyA site"
     regulatory      4605..4610
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /note="hexamer: AATAAA"
     polyA_site      4634
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
ORIGIN      
        1 gccgccatct tgtattgggg tttcattgtt cccgctgggc cgggcggttt agtgtaattg
       61 ccgccggagg aggaggcgga gtaacctctg gtcagccgag aaaccccact atcctgtagc
      121 cataaccgct taaacgattt gggaggtagt gaagggcagg gagctggacc tggaggcgcc
      181 gccgcgacag cagcagccat ggaggacgag atgcccaaga ctctatacgt cggtaacctt
      241 tccagagatg tgacagaagc tctaattctg caactcttta gccagattgg accttgtaaa
      301 aactgcaaaa tgattatgga tacagctgga aatgatccct attgttttgt ggagtttcat
      361 gagcatcgtc atgcagctgc agcattagct gctatgaatg gacggaagat aatgggtaag
      421 gaagtcaaag tgaattgggc aacaacccct agcagtcaaa agaaagatac aagcagtagt
      481 accgttgtca gcacacagcg ttcacaagat catttccatg tctttgttgg tgatctcagc
      541 ccagaaatta caactgaaga tataaaagct gcttttgcac catttggaag aatatcagat
      601 gcccgagtgg taaaagacat ggcaacagga aagtctaagg gatatggctt tgtctccttt
      661 ttcaacaaat gggatgctga aaacgccatt caacagatgg gtggccagtg gcttggtgga
      721 agacaaatca gaactaactg ggcaacccga aagcctcccg ctccaaagag tacatatgag
      781 tcaaatacca aacagctatc atatgatgag gttgtaaatc agtctagtcc aagcaactgt
      841 actgtatact gtggaggtgt tacttctggg ctaacagaac aactaatgcg tcagactttt
      901 tcaccatttg gacaaataat ggaaattcga gtctttccag ataaaggata ttcatttgtt
      961 cggttcaatt cccatgaaag tgcagcacat gcaattgttt ctgttaatgg tactaccatt
     1021 gaaggtcatg ttgtgaaatg ctattggggc aaagaaactc ttgatatgat aaatcccgtg
     1081 caacagcaga atcaaattgg atatccccaa ccttatggcc agtggggcca gtggtatgga
     1141 aatgcacaac aaattggcca gtatatgcct aatggttggc aagttcctgc atatggaatg
     1201 tatggccagg catggaacca gcaaggattt aatcagacac agtcttctgc accatggatg
     1261 ggaccaaatt atggagtgca accgcctcaa gggcaaaatg gcagcatgtt gcccaatcag
     1321 ccttctgggt atcgagtggc agggtatgaa acccagtgaa taaggactcc agaatctaaa
     1381 gccagtggct tgaggctaca gggagtgtag taaagccgtt gtttacttaa agatttatca
     1441 aatcagtcag tgcaaatgtc agatacaatg tatttattta aaagattcat ttttaatcat
     1501 gaaattactt atcatccaca ttgttttaaa aagaaacaag atgctggatg tctgccaatt
     1561 tttgccttca ttaccttttt tgataaagtt tctcagatcc ttgtttcaaa cacaaatgca
     1621 gggattgctg ccacttttta actattaaga ggcagaaaat tgcacaatat tgaacttttt
     1681 tccactgaag tagtgtgcag ttctagtttg cattcctgat atgatttaaa acatgtaata
     1741 taaagatgtt aaaaaaaaaa accaaaactg tgcagagtct agaagttgtt tgtcatcttc
     1801 agcttgtgca caattctgtt ttaggttaaa aaaaggcatt gtttgagctg tcccatctcc
     1861 actgttatcc ctttggggtt ttttaatata aattattagt ttacatcatt tttgtatcta
     1921 catctttttt cacaaatttg tcttgcctta ttaaagttct gtaaaatata cttaaatgga
     1981 aaaaatgatg ttcatttaga ttgaaaactt ttctcagatg gattgataat tgcattcatc
     2041 ttgtgtttta tatgagaagg tgcctcaaga atttcctgtt ggatttgttt aaaaggattt
     2101 ttatctttcg tgataaactt tgctgtgtac caggaactat aaaaacaaaa acttgttact
     2161 aaagaaaata tctgaaatgt gataagttct tatgccatgt taatttcatg tgtcaacttc
     2221 aacatttaca tgtattattt cattatgtaa aatgttttag caatttaata ttttgcacag
     2281 ttagcaaact ttgtatgtca tttccttcaa ggcatcatgc agagttgaca tgagatttat
     2341 aaggttttaa gttgtttgca tgtgaaaatc aaatacatac tttggtagtc tttgaataca
     2401 aagtcatctg ctcttgtttt tcaagaattt tgagacacaa agttgtatgt aaaggaatat
     2461 attaatttgc cgttttctag gtagatttgc tcaaaaagag tgaatcaact taatatgtac
     2521 aaatgatagc tgtgaaactg tagaatatct ttgtgtcagg cttggagttc attgtgacct
     2581 ccaaattttg cctgaaggac cagctgggca aagcatcttt taaatgttca gaggccaaaa
     2641 gataaacaaa aaaaaaacct taaaatccta cctctttaaa cagccttcag ataagagaat
     2701 cctcagtgca atcattattt tgattcgttt ggtacctgtt ttcctggagt tcccgatttt
     2761 attattttgg ggtggctcca agcattaaga ggtttaatct ttgatggcat tgttctagtt
     2821 ttgaaatttc tagtatattt cagagtctct tagaagactt gtgtgggaag tttcactttg
     2881 ttttcagtga agatcacaaa cctccttctt cctttactca agaggaaagg tcccagtata
     2941 catatttgaa tggttgatgg ttttcaagac cttcagggag ctccctgcat tttacctaga
     3001 aacagaaaag gcccgcaaaa tcttaagttt cctggcctgc atttcccggg taggggcaaa
     3061 tgactccaag ctggtctcta agccaatacc cttataaacc agagcccagg aaagacagct
     3121 cgagtgtata attctctgga gctcaattct atgcagttgt gctgatattt cattaagtca
     3181 ctgtgtattt ttaagtgttg atacattaaa agtcgcttta tggaagatga gtaaattttt
     3241 taaatacttg gaaattttat ttccttgtta acttctacag atcagggcat gcaaccaaaa
     3301 gcagcttaaa tgaaatattt taaaataaaa tatcaggaag ctatttttag atttcttctg
     3361 gcttatgttt ctactttagg accctcattg ttctcttatt aaaaaaaatt atttcctgtg
     3421 catctcatgg actgcagggt aaattatttg ggcataaata atttaaatag ttttctttca
     3481 ttttgactat ctccagtaat aacagttttt attatccagc atattggctt attgcacaaa
     3541 tcttaaaatg tacattgact actttctgag aagaaagtgg tatcagtact catgatgaaa
     3601 aggttactac tgaacaaatt cacatttcag gaacacctct atctttggtt taaatcttac
     3661 tcttagtttt tccgtctaaa aatcatactg gtattagtat caggtaagga aattaaagtt
     3721 tttaaaatgg tttcattctc tgcaatatgc aaaatttaga ttttactttc tggtactgta
     3781 aagaacctga agtgatttac acttaatggg tgattaatcc agtattcttt accctgaatg
     3841 tttggatatt aaagttcctt tatgttttct ataacctgtg ggatcttctt gcagtgatta
     3901 ttgtgtgtga gatttttttt ctttttggtc tatccatatt gttatattca ctcaggtatt
     3961 ttttttttaa tcttattcca gaatcagtgg tttatattgg gttactgttt aacaccaaat
     4021 ggaattggca ttctgcagat ttaattaatt atgaaaccag ggtctcattt tccttgctga
     4081 tacttgttga aaatgagatt cacattctag tctttatttt cctcctgttt tgtccctgtg
     4141 cttgtacatc ttccttttat ttgtgtgtta tagttctatt ccatttgaga aggcagttgg
     4201 taagaactag attgcatgta caaagacagg tttactaagt gctgtacagt ggtcctgagg
     4261 ttacagttga attagaaaaa cgaaatgtac ttacaggaaa taagaaagca aacctttcaa
     4321 atgagagtga tgatttcttt aaaaaaaatc agtttttttc tctcaaataa tgttctttat
     4381 ttcacgaaat cgtcaatctt aagcatgagc agggataaac aactcctaga aggaactcaa
     4441 ttcattcttc ctggattttc tctgttgtta aatcacaaaa atgatagtcc ccaatcgttt
     4501 ctttatagga ggttattaca tttcattaca gtcactgcat tttgactgtt gtgtttagaa
     4561 tttgaatgta catccaaaat gatgagtttc aatttaagag ccttaataaa atgtgtgagt
     4621 gtgtctcaat tgaa
//
