LOCUS       NM_001351524            4629 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens TIA1 cytotoxic granule associated RNA binding protein
            (TIA1), transcript variant 19, mRNA.
ACCESSION   NM_001351524 XM_017004799
VERSION     NM_001351524.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4629)
  AUTHORS   Panos-Basterra,P., Theuriet,J., Nadaj-Pakleza,A., Magot,A.,
            Lannes,B., Marcorelles,P., Behin,A., Masingue,M., Caillon,F.,
            Malek,Y., Fenouil,T., Bas,J., Menassa,R., Michel-Calemard,L.,
            Streichenberger,N., Simon,J.P., Bouhour,F., Evangelista,T.,
            Metay,C., Pegat,A., Stojkovic,T. and Fernandez-Eulate,G.
  TITLE     Defining the landscape of TIA1 and SQSTM1 digenic myopathy
  JOURNAL   Neuromuscul Disord 42, 43-52 (2024)
   PUBMED   39142003
  REMARK    GeneRIF: Defining the landscape of TIA1 and SQSTM1 digenic
            myopathy.
REFERENCE   2  (bases 1 to 4629)
  AUTHORS   Tak,H., Cha,S., Hong,Y., Jung,M., Ryu,S., Han,S., Jeong,S.M.,
            Kim,W. and Lee,E.K.
  TITLE     The miR-30-5p/TIA-1 axis directs cellular senescence by regulating
            mitochondrial dynamics
  JOURNAL   Cell Death Dis 15 (6), 404 (2024)
   PUBMED   38858355
  REMARK    GeneRIF: The miR-30-5p/TIA-1 axis directs cellular senescence by
            regulating mitochondrial dynamics.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4629)
  AUTHORS   Wang,S., Xu,C., Shan,Y. and Zhang,Y.
  TITLE     RAMP2-AS1 stabilized RAPM2 mRNA through TIA1 to inhibit the
            progression of non-small cell lung cancer
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (14), 9-14 (2023)
   PUBMED   38279501
  REMARK    GeneRIF: RAMP2-AS1 stabilized RAPM2 mRNA through TIA1 to inhibit
            the progression of non-small cell lung cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4629)
  AUTHORS   Bermejo-Guerrero,L., de Fuenmayor Fernandez-de la Hoz,C.P.,
            Gonzalez-Quereda,L., Segarra-Casas,A., Nedkova,V., Gallano,P.,
            Martin-Jimenez,P., Hernandez-Lain,A., Olive,M., Arteche-Lopez,A.
            and Dominguez-Gonzalez,C.
  TITLE     Distal myopathy due to digenic inheritance of TIA1 and SQSTM1
            variants in two unrelated Spanish patients
  JOURNAL   Neuromuscul Disord 33 (12), 983-987 (2023)
   PUBMED   38016875
  REMARK    GeneRIF: Distal myopathy due to digenic inheritance of TIA1 and
            SQSTM1 variants in two unrelated Spanish patients.
REFERENCE   5  (bases 1 to 4629)
  AUTHORS   Zhang,D., Qiao,L., Lei,X., Dong,X., Tong,Y., Wang,J., Wang,Z. and
            Zhou,R.
  TITLE     Mutagenesis and structural studies reveal the basis for the
            specific binding of SARS-CoV-2 SL3 RNA element with human TIA1
            protein
  JOURNAL   Nat Commun 14 (1), 3715 (2023)
   PUBMED   37349329
  REMARK    GeneRIF: Mutagenesis and structural studies reveal the basis for
            the specific binding of SARS-CoV-2 SL3 RNA element with human TIA1
            protein.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4629)
  AUTHORS   Tian,Q., Taupin,J., Elledge,S., Robertson,M. and Anderson,P.
  TITLE     Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1
            during Fas-mediated apoptosis
  JOURNAL   J Exp Med 182 (3), 865-874 (1995)
   PUBMED   7544399
REFERENCE   7  (bases 1 to 4629)
  AUTHORS   Herve-Minvielle,A. and Sara,S.J.
  TITLE     Rapid habituation of auditory responses of locus coeruleus cells in
            anaesthetized and awake rats
  JOURNAL   Neuroreport 6 (10), 1363-1368 (1995)
   PUBMED   7488725
REFERENCE   8  (bases 1 to 4629)
  AUTHORS   Kawakami,A., Tian,Q., Streuli,M., Poe,M., Edelhoff,S.,
            Disteche,C.M. and Anderson,P.
  TITLE     Intron-exon organization and chromosomal localization of the human
            TIA-1 gene
  JOURNAL   J Immunol 152 (10), 4937-4945 (1994)
   PUBMED   8176212
REFERENCE   9  (bases 1 to 4629)
  AUTHORS   Tian,Q., Streuli,M., Saito,H., Schlossman,S.F. and Anderson,P.
  TITLE     A polyadenylate binding protein localized to the granules of
            cytolytic lymphocytes induces DNA fragmentation in target cells
  JOURNAL   Cell 67 (3), 629-639 (1991)
   PUBMED   1934064
REFERENCE   10 (bases 1 to 4629)
  AUTHORS   Anderson,P., Nagler-Anderson,C., O'Brien,C., Levine,H., Watkins,S.,
            Slayter,H.S., Blue,M.L. and Schlossman,S.F.
  TITLE     A monoclonal antibody reactive with a 15-kDa cytoplasmic
            granule-associated protein defines a subpopulation of CD8+ T
            lymphocytes
  JOURNAL   J Immunol 144 (2), 574-582 (1990)
   PUBMED   2104899
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC016700.8.
            
            On May 31, 2019 this sequence version replaced NM_001351524.1.
            
            Summary: The product encoded by this gene is a member of a
            RNA-binding protein family and possesses nucleolytic activity
            against cytotoxic lymphocyte (CTL) target cells. It has been
            suggested that this protein may be involved in the induction of
            apoptosis as it preferentially recognizes poly(A) homopolymers and
            induces DNA fragmentation in CTL targets. The major
            granule-associated species is a 15-kDa protein that is thought to
            be derived from the carboxyl terminus of the 40-kDa product by
            proteolytic processing. Alternative splicing resulting in different
            isoforms has been found for this gene. [provided by RefSeq, May
            2017].
            
            Transcript Variant: This variant (19), as well as variant 20,
            encodes isoform 19.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.853113.1,
                                           SRR14038195.1202226.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-224               AC016700.8         164752-164975       c
            225-321             AC016700.8         152426-152522       c
            322-415             AC016700.8         147108-147201       c
            416-470             AC016700.8         145611-145665       c
            471-503             AC016700.8         145406-145438       c
            504-591             AC016700.8         144082-144169       c
            592-667             AC016700.8         140901-140976       c
            668-776             AC016700.8         133233-133341       c
            777-872             AC016700.8         132751-132846       c
            873-957             AC016700.8         132555-132639       c
            958-1081            AC016700.8         131718-131841       c
            1082-1227           AC016700.8         130696-130841       c
            1228-4629           AC016700.8         125791-129192       c
FEATURES             Location/Qualifiers
     source          1..4629
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.3"
     gene            1..4629
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /note="TIA1 cytotoxic granule associated RNA binding
                     protein"
                     /db_xref="GeneID:7072"
                     /db_xref="HGNC:HGNC:11802"
                     /db_xref="MIM:603518"
     exon            1..224
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /inference="alignment:Splign:2.1.0"
     exon            225..321
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /inference="alignment:Splign:2.1.0"
     exon            322..415
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /inference="alignment:Splign:2.1.0"
     exon            416..470
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /inference="alignment:Splign:2.1.0"
     exon            471..503
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /inference="alignment:Splign:2.1.0"
     exon            504..591
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /inference="alignment:Splign:2.1.0"
     exon            592..667
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /inference="alignment:Splign:2.1.0"
     CDS             614..1354
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /note="isoform 19 is encoded by transcript variant 19;
                     p40-TIA-1 (containing p15-TIA-1); T-cell-restricted
                     intracellular antigen-1; cytotoxic granule associated RNA
                     binding protein TIA1"
                     /codon_start=1
                     /product="cytotoxic granule associated RNA binding protein
                     TIA1 isoform 19"
                     /protein_id="NP_001338453.1"
                     /db_xref="GeneID:7072"
                     /db_xref="HGNC:HGNC:11802"
                     /db_xref="MIM:603518"
                     /translation="MATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTNWATR
                     KPPAPKSTYESNTKQLSYDEVVNQSSPSNCTVYCGGVTSGLTEQLMRQTFSPFGQIME
                     IRVFPDKGYSFVRFNSHESAAHAIVSVNGTTIEGHVVKCYWGKETLDMINPVQQQNQI
                     GYPQPYGQWGQWYGNAQQIGQYMPNGWQVPAYGMYGQAWNQQGFNQTQSSAPWMGPNY
                     GVQPPQGQNGSMLPNQPSGYRVAGYETQ"
     exon            668..776
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /inference="alignment:Splign:2.1.0"
     exon            777..872
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /inference="alignment:Splign:2.1.0"
     exon            873..957
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1081
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1227
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..4629
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2367..2372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /note="hexamer: AATACA"
     polyA_site      2391
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /note="major polyA site"
     regulatory      3843..3848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /note="hexamer: ATTAAA"
     polyA_site      3869
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /note="major polyA site"
     regulatory      4600..4605
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
                     /note="hexamer: AATAAA"
     polyA_site      4629
                     /gene="TIA1"
                     /gene_synonym="ALS26; TIA-1; WDM"
ORIGIN      
        1 gccgccatct tgtattgggg tttcattgtt cccgctgggc cgggcggttt agtgtaattg
       61 ccgccggagg aggaggcgga gtaacctctg gtcagccgag aaaccccact atcctgtagc
      121 cataaccgct taaacgattt gggaggtagt gaagggcagg gagctggacc tggaggcgcc
      181 gccgcgacag cagcagccat ggaggacgag atgcccaaga ctctatacgt cggtaacctt
      241 tccagagatg tgacagaagc tctaattctg caactcttta gccagattgg accttgtaaa
      301 aactgcaaaa tgattatgga tacagctgga aatgatccct attgttttgt ggagtttcat
      361 gagcatcgtc atgcagctgc agcattagct gctatgaatg gacggaagat aatgggaagt
      421 caaagtgaat tgggcaacaa cccctagcag tcaaaagaaa gatacaagca gtagtaccgt
      481 tgtcagcaca cagcgttcac aagatcattt ccatgtcttt gttggtgatc tcagcccaga
      541 aattacaact gaagatataa aagctgcttt tgcaccattt ggaagaatat cagatgcccg
      601 agtggtaaaa gacatggcaa caggaaagtc taagggatat ggctttgtct cctttttcaa
      661 caaatgggat gctgaaaacg ccattcaaca gatgggtggc cagtggcttg gtggaagaca
      721 aatcagaact aactgggcaa cccgaaagcc tcccgctcca aagagtacat atgagtcaaa
      781 taccaaacag ctatcatatg atgaggttgt aaatcagtct agtccaagca actgtactgt
      841 atactgtgga ggtgttactt ctgggctaac agaacaacta atgcgtcaga ctttttcacc
      901 atttggacaa ataatggaaa ttcgagtctt tccagataaa ggatattcat ttgttcggtt
      961 caattcccat gaaagtgcag cacatgcaat tgtttctgtt aatggtacta ccattgaagg
     1021 tcatgttgtg aaatgctatt ggggcaaaga aactcttgat atgataaatc ccgtgcaaca
     1081 gcagaatcaa attggatatc cccaacctta tggccagtgg ggccagtggt atggaaatgc
     1141 acaacaaatt ggccagtata tgcctaatgg ttggcaagtt cctgcatatg gaatgtatgg
     1201 ccaggcatgg aaccagcaag gatttaatca gacacagtct tctgcaccat ggatgggacc
     1261 aaattatgga gtgcaaccgc ctcaagggca aaatggcagc atgttgccca atcagccttc
     1321 tgggtatcga gtggcagggt atgaaaccca gtgaataagg actccagaat ctaaagccag
     1381 tggcttgagg ctacagggag tgtagtaaag ccgttgttta cttaaagatt tatcaaatca
     1441 gtcagtgcaa atgtcagata caatgtattt atttaaaaga ttcattttta atcatgaaat
     1501 tacttatcat ccacattgtt ttaaaaagaa acaagatgct ggatgtctgc caatttttgc
     1561 cttcattacc ttttttgata aagtttctca gatccttgtt tcaaacacaa atgcagggat
     1621 tgctgccact ttttaactat taagaggcag aaaattgcac aatattgaac ttttttccac
     1681 tgaagtagtg tgcagttcta gtttgcattc ctgatatgat ttaaaacatg taatataaag
     1741 atgttaaaaa aaaaaaccaa aactgtgcag agtctagaag ttgtttgtca tcttcagctt
     1801 gtgcacaatt ctgttttagg ttaaaaaaag gcattgtttg agctgtccca tctccactgt
     1861 tatccctttg gggtttttta atataaatta ttagtttaca tcatttttgt atctacatct
     1921 tttttcacaa atttgtcttg ccttattaaa gttctgtaaa atatacttaa atggaaaaaa
     1981 tgatgttcat ttagattgaa aacttttctc agatggattg ataattgcat tcatcttgtg
     2041 ttttatatga gaaggtgcct caagaatttc ctgttggatt tgtttaaaag gatttttatc
     2101 tttcgtgata aactttgctg tgtaccagga actataaaaa caaaaacttg ttactaaaga
     2161 aaatatctga aatgtgataa gttcttatgc catgttaatt tcatgtgtca acttcaacat
     2221 ttacatgtat tatttcatta tgtaaaatgt tttagcaatt taatattttg cacagttagc
     2281 aaactttgta tgtcatttcc ttcaaggcat catgcagagt tgacatgaga tttataaggt
     2341 tttaagttgt ttgcatgtga aaatcaaata catactttgg tagtctttga atacaaagtc
     2401 atctgctctt gtttttcaag aattttgaga cacaaagttg tatgtaaagg aatatattaa
     2461 tttgccgttt tctaggtaga tttgctcaaa aagagtgaat caacttaata tgtacaaatg
     2521 atagctgtga aactgtagaa tatctttgtg tcaggcttgg agttcattgt gacctccaaa
     2581 ttttgcctga aggaccagct gggcaaagca tcttttaaat gttcagaggc caaaagataa
     2641 acaaaaaaaa aaccttaaaa tcctacctct ttaaacagcc ttcagataag agaatcctca
     2701 gtgcaatcat tattttgatt cgtttggtac ctgttttcct ggagttcccg attttattat
     2761 tttggggtgg ctccaagcat taagaggttt aatctttgat ggcattgttc tagttttgaa
     2821 atttctagta tatttcagag tctcttagaa gacttgtgtg ggaagtttca ctttgttttc
     2881 agtgaagatc acaaacctcc ttcttccttt actcaagagg aaaggtccca gtatacatat
     2941 ttgaatggtt gatggttttc aagaccttca gggagctccc tgcattttac ctagaaacag
     3001 aaaaggcccg caaaatctta agtttcctgg cctgcatttc ccgggtaggg gcaaatgact
     3061 ccaagctggt ctctaagcca atacccttat aaaccagagc ccaggaaaga cagctcgagt
     3121 gtataattct ctggagctca attctatgca gttgtgctga tatttcatta agtcactgtg
     3181 tatttttaag tgttgataca ttaaaagtcg ctttatggaa gatgagtaaa ttttttaaat
     3241 acttggaaat tttatttcct tgttaacttc tacagatcag ggcatgcaac caaaagcagc
     3301 ttaaatgaaa tattttaaaa taaaatatca ggaagctatt tttagatttc ttctggctta
     3361 tgtttctact ttaggaccct cattgttctc ttattaaaaa aaattatttc ctgtgcatct
     3421 catggactgc agggtaaatt atttgggcat aaataattta aatagttttc tttcattttg
     3481 actatctcca gtaataacag tttttattat ccagcatatt ggcttattgc acaaatctta
     3541 aaatgtacat tgactacttt ctgagaagaa agtggtatca gtactcatga tgaaaaggtt
     3601 actactgaac aaattcacat ttcaggaaca cctctatctt tggtttaaat cttactctta
     3661 gtttttccgt ctaaaaatca tactggtatt agtatcaggt aaggaaatta aagtttttaa
     3721 aatggtttca ttctctgcaa tatgcaaaat ttagatttta ctttctggta ctgtaaagaa
     3781 cctgaagtga tttacactta atgggtgatt aatccagtat tctttaccct gaatgtttgg
     3841 atattaaagt tcctttatgt tttctataac ctgtgggatc ttcttgcagt gattattgtg
     3901 tgtgagattt tttttctttt tggtctatcc atattgttat attcactcag gtattttttt
     3961 tttaatctta ttccagaatc agtggtttat attgggttac tgtttaacac caaatggaat
     4021 tggcattctg cagatttaat taattatgaa accagggtct cattttcctt gctgatactt
     4081 gttgaaaatg agattcacat tctagtcttt attttcctcc tgttttgtcc ctgtgcttgt
     4141 acatcttcct tttatttgtg tgttatagtt ctattccatt tgagaaggca gttggtaaga
     4201 actagattgc atgtacaaag acaggtttac taagtgctgt acagtggtcc tgaggttaca
     4261 gttgaattag aaaaacgaaa tgtacttaca ggaaataaga aagcaaacct ttcaaatgag
     4321 agtgatgatt tctttaaaaa aaatcagttt ttttctctca aataatgttc tttatttcac
     4381 gaaatcgtca atcttaagca tgagcaggga taaacaactc ctagaaggaa ctcaattcat
     4441 tcttcctgga ttttctctgt tgttaaatca caaaaatgat agtccccaat cgtttcttta
     4501 taggaggtta ttacatttca ttacagtcac tgcattttga ctgttgtgtt tagaatttga
     4561 atgtacatcc aaaatgatga gtttcaattt aagagcctta ataaaatgtg tgagtgtgtc
     4621 tcaattgaa
//
