LOCUS       NM_014174               1304 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens thymocyte nuclear protein 1 (THYN1), transcript
            variant 1, mRNA.
ACCESSION   NM_014174
VERSION     NM_014174.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1304)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1304)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 1304)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   4  (bases 1 to 1304)
  AUTHORS   Yu,F., Song,A., Xu,C., Sun,L., Li,J., Tang,L., Yu,M., Yeates,T.O.,
            Hu,H. and He,J.
  TITLE     Determining the DUF55-domain structure of human thymocyte nuclear
            protein 1 from crystals partially twinned by tetartohedry
  JOURNAL   Acta Crystallogr D Biol Crystallogr 65 (Pt 3), 212-219 (2009)
   PUBMED   19237743
  REMARK    GeneRIF: The 2.3A-resolution structure revealed only one 2-fold
            axis of rotational pseudosymmetry. A potential RNA-binding domain
            from human YTH-domain-containing protein 2 has the most similar 3-D
            fold to that of the DUF55 domain; it may be an RNA-related domain.
REFERENCE   5  (bases 1 to 1304)
  AUTHORS   Song,A.X., Chang,Y.G., Gao,Y.G., Lin,X.J., Shi,Y.H., Lin,D.H.,
            Hang,Q.H. and Hu,H.Y.
  TITLE     Identification, expression, and purification of a unique stable
            domain from human HSPC144 protein
  JOURNAL   Protein Expr Purif 42 (1), 146-152 (2005)
   PUBMED   15939300
  REMARK    GeneRIF: HSPC144 was expressed and purified, and a stable fragment
            (residues 44-225) was identified by limited proteolysis method.
REFERENCE   6  (bases 1 to 1304)
  AUTHORS   Jiang,X., Toyota,H., Takada,E., Yoshimoto,T., Kitamura,T.,
            Yamada,J. and Mizuguchi,J.
  TITLE     Modulation of mThy28 nuclear protein expression during thymocyte
            development
  JOURNAL   Tissue Cell 35 (6), 471-478 (2003)
   PUBMED   14580360
REFERENCE   7  (bases 1 to 1304)
  AUTHORS   Jiang,X.Z., Toyota,H., Yoshimoto,T., Takada,E., Asakura,H. and
            Mizuguchi,J.
  TITLE     Anti-IgM-induced down-regulation of nuclear Thy28 protein
            expression in Ramos B lymphoma cells
  JOURNAL   Apoptosis 8 (5), 509-519 (2003)
   PUBMED   14601557
REFERENCE   8  (bases 1 to 1304)
  AUTHORS   Miyaji,H., Yoshimoto,T., Asakura,H., Komachi,A., Kamiya,S.,
            Takasaki,M. and Mizuguchi,J.
  TITLE     Molecular cloning and characterization of the mouse thymocyte
            protein gene
  JOURNAL   Gene 297 (1-2), 189-196 (2002)
   PUBMED   12384300
  REMARK    GeneRIF: Studies of the mouse counterpart.
REFERENCE   9  (bases 1 to 1304)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Ray,S., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human retina for the NEIBank
            Project: retbindin, an abundant, novel retinal cDNA and alternative
            splicing of other retina-preferred gene transcripts
  JOURNAL   Mol Vis 8, 196-204 (2002)
   PUBMED   12107411
  REMARK    Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ959408.1 and AF161493.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014174.2.
            
            Summary: This gene encodes a protein that is highly conserved among
            vertebrates and plant species and may be involved in the induction
            of apoptosis. Alternatively spliced transcript variants encoding
            different isoforms have been described. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Isoform 1 is also
            encoded by variants 3 and 5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.609278.1,
                                           SRR5189655.25842.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341541.8/ ENSP00000341657.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-609               BQ959408.1         18-626
            610-1304            AF161493.1         586-1280
FEATURES             Location/Qualifiers
     source          1..1304
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q25"
     gene            1..1304
                     /gene="THYN1"
                     /gene_synonym="HSPC144; MDS012; MY105; THY28; THY28KD"
                     /note="thymocyte nuclear protein 1"
                     /db_xref="GeneID:29087"
                     /db_xref="HGNC:HGNC:29560"
                     /db_xref="MIM:613739"
     exon            1..513
                     /gene="THYN1"
                     /gene_synonym="HSPC144; MDS012; MY105; THY28; THY28KD"
                     /inference="alignment:Splign:2.1.0"
     CDS             471..1148
                     /gene="THYN1"
                     /gene_synonym="HSPC144; MDS012; MY105; THY28; THY28KD"
                     /note="isoform 1 is encoded by transcript variant 1;
                     thymocyte protein thy28"
                     /codon_start=1
                     /product="thymocyte nuclear protein 1 isoform 1"
                     /protein_id="NP_054893.1"
                     /db_xref="CCDS:CCDS8496.1"
                     /db_xref="GeneID:29087"
                     /db_xref="HGNC:HGNC:29560"
                     /db_xref="MIM:613739"
                     /translation="MSRPRKRLAGTSGSDKGLSGKRTKTENSGEALAKVEDSNPQKTS
                     ATKNCLKNLSSHWLMKSEPESRLEKGVDVKFSIEDLKAQPKQTTCWDGVRNYQARNFL
                     RAMKLGEEAFFYHSNCKEPGIAGLMKIVKEAYPDHTQFEKNNPHYDPSSKEDNPKWSM
                     VDVQFVRMMKRFIPLAELKSYHQAHKATGGPLKNMVLFTRQRLSIQPLTQEEFDFVLS
                     LEEKEPS"
     exon            514..692
                     /gene="THYN1"
                     /gene_synonym="HSPC144; MDS012; MY105; THY28; THY28KD"
                     /inference="alignment:Splign:2.1.0"
     exon            693..761
                     /gene="THYN1"
                     /gene_synonym="HSPC144; MDS012; MY105; THY28; THY28KD"
                     /inference="alignment:Splign:2.1.0"
     exon            762..854
                     /gene="THYN1"
                     /gene_synonym="HSPC144; MDS012; MY105; THY28; THY28KD"
                     /inference="alignment:Splign:2.1.0"
     exon            855..950
                     /gene="THYN1"
                     /gene_synonym="HSPC144; MDS012; MY105; THY28; THY28KD"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1101
                     /gene="THYN1"
                     /gene_synonym="HSPC144; MDS012; MY105; THY28; THY28KD"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1304
                     /gene="THYN1"
                     /gene_synonym="HSPC144; MDS012; MY105; THY28; THY28KD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1285..1290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THYN1"
                     /gene_synonym="HSPC144; MDS012; MY105; THY28; THY28KD"
                     /note="hexamer: AATAAA"
     polyA_site      1304
                     /gene="THYN1"
                     /gene_synonym="HSPC144; MDS012; MY105; THY28; THY28KD"
                     /note="major polyA site"
ORIGIN      
        1 gcacagcctg cggcgcagcg gaggcggacc gcagtcgagt ctgcagagtg ttgggtctgt
       61 agccagcaaa ttacttcatc atctagatta tccattcagt tgatcctaat tagcaaggat
      121 aacaaggtaa cacaaggctt acttatattc acccaacaaa agtgtctctg tggagccact
      181 tcccagtgaa ctacatactg agataggggt tcctggatga gaaggaccaa ggacagaacc
      241 gagaagagtt taggggcagg ttatgcgaga tggaaatggc gcagataacg gagggaagga
      301 tttgagggct caaacgtagg cgtctgtgtt tcgcaaaagt tggagacgtt ctaggctgcc
      361 tctcgttgcc tccatctcgc tctgcgcggg ttttggagga cattagcatt ctttcttgta
      421 tctccgttga ttccagaatc gtccgcacta aagtcccctg cagcgtgacc atgtcgagac
      481 cccggaagag gctggctggg acttctggtt cagacaaggg actatcagga aaacgcacca
      541 aaactgagaa ctcaggtgag gcattagcta aagtggagga ctccaaccct cagaagactt
      601 cagccactaa aaactgtttg aagaatctaa gcagccactg gctgatgaag tcagagccag
      661 agagccgcct agagaaaggt gtagatgtga agttcagcat tgaggatctc aaagcacagc
      721 ccaaacagac aacatgctgg gatggtgttc gtaactacca ggctcggaac ttccttagag
      781 ccatgaagct gggagaagaa gccttcttct accatagcaa ctgcaaagag ccaggcatcg
      841 caggactcat gaagatcgtg aaagaggctt acccagacca cacacagttt gagaaaaaca
      901 atccccatta tgacccatct agcaaagagg acaaccctaa gtggtccatg gtggatgtac
      961 agtttgttcg gatgatgaaa cgtttcattc ccctggctga gctcaaatcc tatcatcaag
     1021 ctcacaaagc tactggtggc cccttaaaaa atatggttct cttcactcgc cagagattat
     1081 caatccagcc cctgacccag gaagagtttg attttgtttt gagcctggag gaaaaggaac
     1141 caagttaact gagatactgc tgctggaatg ggcgagacat tgctgcaaag aagtcaagct
     1201 tttttcagac aaaaggtgtg agggggcttg cttggtatgc ttacctgggc ttgtgtacct
     1261 cagtggtttt tgtgtacttt tttcaataaa atatcaaagt tgaa
//
