LOCUS       NM_006288               4502 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens Thy-1 cell surface antigen (THY1), transcript variant
            1, mRNA.
ACCESSION   NM_006288 NM_033209
VERSION     NM_006288.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4502)
  AUTHORS   Rohan,P., Dos Santos,E.C., Abdelhay,E. and Binato,R.
  TITLE     High Expression of THY1 in Intestinal Gastric Cancer as a Key
            Factor in Tumor Biology: A Poor Prognosis-Independent Marker
            Related to the Epithelial-Mesenchymal Transition Profile
  JOURNAL   Genes (Basel) 15 (1), 28 (2023)
   PUBMED   38254918
  REMARK    GeneRIF: High Expression of THY1 in Intestinal Gastric Cancer as a
            Key Factor in Tumor Biology: A Poor Prognosis-Independent Marker
            Related to the Epithelial-Mesenchymal Transition Profile.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4502)
  AUTHORS   ElMenshawy,N., El-Chennawi,F., Darwish,A., Foda,A., Atita,D. and
            Eissa,M.
  TITLE     CD44, CD90 and CD96 expression in immune thrombocytopenia purpura
            (ITP) patients
  JOURNAL   J Immunoassay Immunochem 44 (4), 326-337 (2023)
   PUBMED   36949573
  REMARK    GeneRIF: CD44, CD90 and CD96 expression in immune thrombocytopenia
            purpura (ITP) patients.
REFERENCE   3  (bases 1 to 4502)
  AUTHORS   Wang,J., Du,M., Meng,L., Yang,Y., He,S., Zhu,Y., Ren,X., Wei,M.,
            Dong,R., Zheng,S. and Chen,G.
  TITLE     Integrative analysis implicates the significance of m6A in the
            liver fibrosis of biliary atresia by regulating THY1
  JOURNAL   Hepatol Commun 7 (1), e0004 (2023)
   PUBMED   36633486
  REMARK    GeneRIF: Integrative analysis implicates the significance of m6A in
            the liver fibrosis of biliary atresia by regulating THY1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4502)
  AUTHORS   Hwang,H.S., Yoo,J.E., Han,D.H., Choi,J.S., Lee,J.G., Joo,D.J.,
            Kim,M.S., Kim,S.I., Choi,G.H. and Park,Y.N.
  TITLE     Circulating Cancer Stem Cells Expressing EpCAM/CD90 in
            Hepatocellular Carcinoma: A Pilot Study for Predicting Tumor
            Recurrence after Living Donor Liver Transplantation
  JOURNAL   Gut Liver 16 (3), 443-455 (2022)
   PUBMED   34737243
  REMARK    GeneRIF: Circulating Cancer Stem Cells Expressing EpCAM/CD90 in
            Hepatocellular Carcinoma: A Pilot Study for Predicting Tumor
            Recurrence after Living Donor Liver Transplantation.
REFERENCE   5  (bases 1 to 4502)
  AUTHORS   Leyton,L. and Hagood,J.S.
  TITLE     Thy-1 modulates neurological cell-cell and cell-matrix interactions
            through multiple molecular interactions
  JOURNAL   Adv Neurobiol 8, 3-20 (2014)
   PUBMED   25300130
  REMARK    Review article
REFERENCE   6  (bases 1 to 4502)
  AUTHORS   Fivenson,D.P., Douglass,M.C. and Nickoloff,B.J.
  TITLE     Cutaneous expression of Thy-1 in mycosis fungoides
  JOURNAL   Am J Pathol 141 (6), 1373-1380 (1992)
   PUBMED   1281618
REFERENCE   7  (bases 1 to 4502)
  AUTHORS   Thomas,P.M. and Samelson,L.E.
  TITLE     The glycophosphatidylinositol-anchored Thy-1 molecule interacts
            with the p60fyn protein tyrosine kinase in T cells
  JOURNAL   J Biol Chem 267 (17), 12317-12322 (1992)
   PUBMED   1351058
REFERENCE   8  (bases 1 to 4502)
  AUTHORS   Mahanthappa,N.K. and Patterson,P.H.
  TITLE     Thy-1 multimerization is correlated with neurite outgrowth
  JOURNAL   Dev Biol 150 (1), 60-71 (1992)
   PUBMED   1347022
REFERENCE   9  (bases 1 to 4502)
  AUTHORS   Seki,T., Spurr,N., Obata,F., Goyert,S., Goodfellow,P. and Silver,J.
  TITLE     The human Thy-1 gene: structure and chromosomal location
  JOURNAL   Proc Natl Acad Sci U S A 82 (19), 6657-6661 (1985)
   PUBMED   2864690
REFERENCE   10 (bases 1 to 4502)
  AUTHORS   Moriuchi,T., Chang,H.C., Denome,R. and Silver,J.
  TITLE     Thy-1 cDNA sequence suggests a novel regulatory mechanism
  JOURNAL   Nature 301 (5895), 80-82 (1983)
   PUBMED   6130472
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP003396.1.
            
            On Aug 5, 2019 this sequence version replaced NM_006288.4.
            
            Summary: This gene encodes a cell surface glycoprotein and member
            of the immunoglobulin superfamily of proteins. The encoded protein
            is involved in cell adhesion and cell communication in numerous
            cell types, but particularly in cells of the immune and nervous
            systems. The encoded protein is widely used as a marker for
            hematopoietic stem cells. This gene may function as a tumor
            suppressor in nasopharyngeal carcinoma. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Jul
            2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.375953.1,
                                           SRR14038194.3765363.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000284240.10/ ENSP00000284240.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AP003396.1         89646-89705         c
            61-121              AP003396.1         87402-87462         c
            122-457             AP003396.1         86584-86919         c
            458-4502            AP003396.1         82009-86053         c
FEATURES             Location/Qualifiers
     source          1..4502
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..4502
                     /gene="THY1"
                     /gene_synonym="CD90; CDw90"
                     /note="Thy-1 cell surface antigen"
                     /db_xref="GeneID:7070"
                     /db_xref="HGNC:HGNC:11801"
                     /db_xref="MIM:188230"
     exon            1..60
                     /gene="THY1"
                     /gene_synonym="CD90; CDw90"
                     /inference="alignment:Splign:2.1.0"
     exon            61..121
                     /gene="THY1"
                     /gene_synonym="CD90; CDw90"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..570
                     /gene="THY1"
                     /gene_synonym="CD90; CDw90"
                     /EC_number="3.1.26.4"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; Thy-1 T-cell antigen; Thy-1 membrane
                     glycoprotein; thy-1 antigen"
                     /codon_start=1
                     /product="thy-1 membrane glycoprotein isoform 1
                     preproprotein"
                     /protein_id="NP_006279.2"
                     /db_xref="CCDS:CCDS8424.1"
                     /db_xref="GeneID:7070"
                     /db_xref="HGNC:HGNC:11801"
                     /db_xref="MIM:188230"
                     /translation="MNLAISIALLLTVLQVSRGQKVTSLTACLVDQSLRLDCRHENTS
                     SSPIQYEFSLTRETKKHVLFGTVGVPEHTYRSRTNFTSKYNMKVLYLSAFTSKDEGTY
                     TCALHHSGHSPPISSQNVTVLRDKLVKCEGISLLAQNTSWLLLLLLSLSLLQATDFMS
                     L"
     exon            122..457
                     /gene="THY1"
                     /gene_synonym="CD90; CDw90"
                     /inference="alignment:Splign:2.1.0"
     exon            458..4502
                     /gene="THY1"
                     /gene_synonym="CD90; CDw90"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1777..1782
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THY1"
                     /gene_synonym="CD90; CDw90"
                     /note="hexamer: AATAAA"
     polyA_site      1801
                     /gene="THY1"
                     /gene_synonym="CD90; CDw90"
                     /note="major polyA site"
     regulatory      2007..2012
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THY1"
                     /gene_synonym="CD90; CDw90"
                     /note="hexamer: AATAAA"
     polyA_site      2033
                     /gene="THY1"
                     /gene_synonym="CD90; CDw90"
     regulatory      4473..4478
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THY1"
                     /gene_synonym="CD90; CDw90"
                     /note="hexamer: AATAAA"
     polyA_site      4502
                     /gene="THY1"
                     /gene_synonym="CD90; CDw90"
ORIGIN      
        1 agcaaccgga ggcggcggcg cgtctggagg aggctgcagc agcggaagac cccagtccag
       61 atccaggact gagatcccag aaccatgaac ctggccatca gcatcgctct cctgctaaca
      121 gtcttgcagg tctcccgagg gcagaaggtg accagcctaa cggcctgcct agtggaccag
      181 agccttcgtc tggactgccg ccatgagaat accagcagtt cacccatcca gtacgagttc
      241 agcctgaccc gtgagacaaa gaagcacgtg ctctttggca ctgtgggggt gcctgagcac
      301 acataccgct cccgaaccaa cttcaccagc aaatacaaca tgaaggtcct ctacttatcc
      361 gccttcacta gcaaggacga gggcacctac acgtgtgcac tccaccactc tggccattcc
      421 ccacccatct cctcccagaa cgtcacagtg ctcagagaca aactggtcaa gtgtgagggc
      481 atcagcctgc tggctcagaa cacctcgtgg ctgctgctgc tcctgctctc cctctccctc
      541 ctccaggcca cggatttcat gtccctgtga ctggtggggc ccatggagga gacaggaagc
      601 ctcaagttcc agtgcagaga tcctacttct ctgagtcagc tgaccccctc cccccaatcc
      661 ctcaaacctt gaggagaagt ggggacccca cccctcatca ggagttccag tgctgcatgc
      721 gattatctac ccacgtccac gcggccacct caccctctcc gcacacctct ggctgtcttt
      781 ttgtactttt tgttccagag ctgcttctgt ctggtttatt taggttttat ccttcctttt
      841 ctttgagagt tcgtgaagag ggaagccagg attggggacc tgatggagag tgagagcatg
      901 tgaggggtag tgggatggtg gggtaccagc cactggaggg gtcatccttg cccatcggga
      961 ccagaaacct gggagagact tggatgagga gtggttgggc tgtgcctggg cctagcacgg
     1021 acatggtctg tcctgacagc actcctcggc aggcatggct ggtgcctgaa gaccccagat
     1081 gtgagggcac caccaagaat ttgtggccta ccttgtgagg gagagaactg agcatctcca
     1141 gcattctcag ccacaaccaa aaaaaaataa aaagggcagc cctccttacc actgtggaag
     1201 tccctcagag gccttggggc atgacccagt gaagatgcag gtttgaccag gaaagcagcg
     1261 ctagtggagg gttggagaag gaggtaaagg atgagggttc atcatccctc cctgcctaag
     1321 gaagctaaaa gcatggccct gctgcccctc cctgcctcca cccacagtgg agagggctac
     1381 aaaggaggac aagaccctct caggctgtcc caagctccca agagcttcca gagctctgac
     1441 ccacagcctc caagtcaggt ggggtggagt cccagagctg cacagggttt ggcccaagtt
     1501 tctaagggag gcacttcctc ccctcgccca tcagtgccag cccctgctgg ctggtgcctg
     1561 agcccctcag acagccccct gccccgcagg cctgccttct cagggacttc tgcggggcct
     1621 gaggcaagcc atggagtgag acccaggagc cggacacttc tcaggaaatg gcttttccca
     1681 acccccagcc cccacccggt ggttcttcct gttctgtgac tgtgtatagt gccaccacag
     1741 cttatggcat ctcattgagg acaaagaaaa ctgcacaata aaaccaagcc tctggaatct
     1801 gtcctcgtgt ccacctggcc ttcgctcctc cagcagtgcc tgcctgcccc cgcttcgctg
     1861 gggtctccac gggtgaggct ggggaacgcc acctcttcct cttccctgac ttctccccaa
     1921 ccacttagta gcaacgctac cccaggggct aatgactgca cactgggctt cttttcagaa
     1981 tgaccctaac gagacacatt tgcccaaata aacgaacatc ccatgtctgc tgactcacct
     2041 ggctggaaca acatgcttac tgccaacatg tgggccgaac cacatggccc tggctctgga
     2101 atgcacaagt ggctttgcgt gaatctgcgc taagctatgc agtctgcttt ttcttctcag
     2161 ctctggtagt tcttcagaaa tgtaccctcc aggcacatcc actattgcga gggtgagcac
     2221 gaagggtggg agatgcccat gtcctcaagg catcacttcc taaatccaaa agcatcggca
     2281 ggagaaagga ctggggacaa atactgtccc ttcgggagta gggagggaac actgaggccc
     2341 atccctggct ccttccctaa aagtagagta aaatggaagc gagcatcctg ggattggggg
     2401 caagaggggg accgcagggt agctgtgggt tccaactgct gtcagagtca gagaggcagc
     2461 cccaagccag cctccctgct ttgccaggga atttggggga ggaaggtgac agctgcccag
     2521 aggctgactc atctgatatt tagcactggg taggatgatt gtttctgagc atttttctta
     2581 aaggcctcag atctaaatta tgccaccggc tcccactctt gctacctccc gtcaacttct
     2641 ctgccttgcc ttccacccct gtagttacca tacacagagg aggaggagct gtccttgtcc
     2701 caggttggga ggctgacaac cccttagcaa gatgctgcca gcccagagct ctccaagggg
     2761 aggaacaccc ctgagactca ggcccctctc cttcagccct gcttgggctg caagcgccgt
     2821 gccaaggaaa ggcatcttgg tgagaagagc tgctgtgggg gaagggagat caaatgccag
     2881 agaaatgtgg ggtgccccac cctcaggata gtaaaagagt atggaggtat ttctggaagg
     2941 aaatgagcgg cactgtgtga agcctcgcac ctgtgtgaca cttcctatgg ggtctttgtc
     3001 acactctagt actatgtccc tgaagagttt agcagccaca ctcttagaag ggtgctggga
     3061 gatggtgttg ccctctgcag ccatgtttag gggagcggaa cctgaggccc acagtgggtg
     3121 agattagctc aagaagccac agaggccacc agagggccac ggacttcgga aaggagaaga
     3181 gaagaacagg gcatcaggcc tcacaacgca aacctaccca gagatgggca cagtggctca
     3241 tgcctgtaat cccaccactt tgggaagagg cggatcgctt gaggtcagga gttcgagact
     3301 agcctcgaaa ccctatctct actaaaaata caaaaattag ccaggcatgg tggcctgcgc
     3361 ctgtaatccc agctactcag gaggctgagg caggagaatc acttgaaccc gggaggcgga
     3421 ggttgcagtg agccaagatt gcaccactgc actccagcct gggagataga gtgagactcc
     3481 atctcaaaaa aataaaaaat aaaataaacc tacccggaat gaccatgctg aggactggga
     3541 gcccgcagac tttcagccac aggccgcgac agccgtgggt ccctccctgg tcaagtcagc
     3601 aggccttgtg gaggctgtgg ggtatctgtg gtgactcagg taattataga gggctggccc
     3661 ccagccctgg ttcctgtaca catgccccaa ccccatcccc atccactccc tcgccagtcc
     3721 taacctcttt cctgggtccc cccccttcag cacctaagtc catacctagg gccgtggaat
     3781 tcccgctcaa gagcaacaga agcccctctc tgcaccccca tttctggact ggattgtcca
     3841 ctgagacgcg caatgtctgc atctctgaca tctagaggct tcctcgggaa gggcatgggg
     3901 atctccgtga gatgtgggga ctttcactgg ccaaccaaga aatctacaca gcgtccgggg
     3961 acctgtgaca cacatccctc ccgcctcctc aacctgatgt ccctctctga atctgcagct
     4021 ttcgtgctgt gaaggtgtct ttacatgtga aacaaacaaa cccaagtcaa gagtaaatca
     4081 tctcatttac tagtgagaaa atgttggagc tggagtcctt cagagagtcc tggccaggca
     4141 agagggccat cagctctctt ctgctcaaca ggggctctca gcctcaggac actctcaggc
     4201 ctggaatgtc cccaacacac tcaaggagaa acatgtcctg tgcagaccca caggaggcat
     4261 ctttgcccgg cacaaggaag agctggggtc agtgggacct gtagatgtag acacatcata
     4321 tggagggtgg gtaggaccaa tgtggcagct tcatggaggc caagtgtggc tctgcaccag
     4381 gaaggggctg tgatggctgg aggtgcccag cagtgcaggc ggggagtgcc tggcagtggc
     4441 gtggccaggt ggaggccacc tgtcaagttt gcaataaagc agtttcctga atttggtgag
     4501 aa
//
