LOCUS       NM_001316349            6112 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens thrombospondin type 1 domain containing 7B (THSD7B),
            mRNA.
ACCESSION   NM_001316349 XM_005263802
VERSION     NM_001316349.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6112)
  AUTHORS   Yao,Z., Lin,A., Yi,Y., Shen,W., Zhang,J. and Luo,P.
  TITLE     THSD7B Mutation Induces Platinum Resistance in Small Cell Lung
            Cancer Patients
  JOURNAL   Drug Des Devel Ther 16, 1679-1695 (2022)
   PUBMED   35685767
  REMARK    GeneRIF: THSD7B Mutation Induces Platinum Resistance in Small Cell
            Lung Cancer Patients.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6112)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 6112)
  AUTHORS   Haga,S., Nakaoka,H., Yamaguchi,T., Yamamoto,K., Kim,Y.I.,
            Samoto,H., Ohno,T., Katayama,K., Ishida,H., Park,S.B., Kimura,R.,
            Maki,K. and Inoue,I.
  TITLE     A genome-wide association study of third molar agenesis in Japanese
            and Korean populations
  JOURNAL   J Hum Genet 58 (12), 799-803 (2013)
   PUBMED   24172245
REFERENCE   4  (bases 1 to 6112)
  AUTHORS   Park,T.J., Hwang,J.Y., Go,M.J., Lee,H.J., Jang,H.B., Choi,Y.,
            Kang,J.H., Park,K.H., Choi,M.G., Song,J., Kim,B.J. and Lee,J.Y.
  TITLE     Genome-wide association study of liver enzymes in korean children
  JOURNAL   Genomics Inform 11 (3), 149-154 (2013)
   PUBMED   24124411
REFERENCE   5  (bases 1 to 6112)
  AUTHORS   Yazar,S., Mishra,A., Ang,W., Kearns,L.S., Mountain,J.A.,
            Pennell,C., Montgomery,G.W., Young,T.L., Hammond,C.J.,
            Macgregor,S., Mackey,D.A. and Hewitt,A.W.
  TITLE     Interrogation of the platelet-derived growth factor receptor alpha
            locus and corneal astigmatism in Australians of Northern European
            ancestry: results of a genome-wide association study
  JOURNAL   Mol Vis 19, 1238-1246 (2013)
   PUBMED   23761726
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6112)
  AUTHORS   Lee,Y., Yoon,K.A., Joo,J., Lee,D., Bae,K., Han,J.Y. and Lee,J.S.
  TITLE     Prognostic implications of genetic variants in advanced non-small
            cell lung cancer: a genome-wide association study
  JOURNAL   Carcinogenesis 34 (2), 307-313 (2013)
   PUBMED   23144319
REFERENCE   7  (bases 1 to 6112)
  AUTHORS   Fox,C.S., Liu,Y., White,C.C., Feitosa,M., Smith,A.V.,
            Heard-Costa,N., Lohman,K., Johnson,A.D., Foster,M.C.,
            Greenawalt,D.M., Griffin,P., Ding,J., Newman,A.B., Tylavsky,F.,
            Miljkovic,I., Kritchevsky,S.B., Launer,L., Garcia,M.,
            Eiriksdottir,G., Carr,J.J., Gudnason,V., Harris,T.B., Cupples,L.A.
            and Borecki,I.B.
  CONSRTM   GIANT Consortium; MAGIC Consortium; GLGC Consortium
  TITLE     Genome-wide association for abdominal subcutaneous and visceral
            adipose reveals a novel locus for visceral fat in women
  JOURNAL   PLoS Genet 8 (5), e1002695 (2012)
   PUBMED   22589738
REFERENCE   8  (bases 1 to 6112)
  AUTHORS   Wang,K.S., Liu,X., Zhang,Q., Pan,Y., Aragam,N. and Zeng,M.
  TITLE     A meta-analysis of two genome-wide association studies identifies 3
            new loci for alcohol dependence
  JOURNAL   J Psychiatr Res 45 (11), 1419-1425 (2011)
   PUBMED   21703634
  REMARK    GeneRIF: Several flanking SNPs of the top hits in the meta-analysis
            demonstrated borderline associations with alcohol dependence in the
            family sample for KIAA0040, NRD1 and THSD7B, respectively.
REFERENCE   9  (bases 1 to 6112)
  AUTHORS   Low,S.K., Kuchiba,A., Zembutsu,H., Saito,A., Takahashi,A., Kubo,M.,
            Daigo,Y., Kamatani,N., Chiku,S., Totsuka,H., Ohnami,S., Hirose,H.,
            Shimada,K., Okusaka,T., Yoshida,T., Nakamura,Y. and Sakamoto,H.
  TITLE     Genome-wide association study of pancreatic cancer in Japanese
            population
  JOURNAL   PLoS One 5 (7), e11824 (2010)
   PUBMED   20686608
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010100.13, AC010873.12, AC011231.7, AC012000.3, AC019067.9,
            AC017082.4 and AC016679.9.
            
            On Nov 23, 2018 this sequence version replaced NM_001316349.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2159931,
                              SAMN03267780 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000409968.6/ ENSP00000387145.1
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               AC010100.13        44051-44193         c
            144-317             AC010873.12        107823-107996       c
            318-1128            AC011231.7         51915-52725         c
            1129-1377           AC011231.7         14024-14272         c
            1378-1547           AC012000.3         188124-188293       c
            1548-1703           AC012000.3         143049-143204       c
            1704-1901           AC012000.3         132479-132676       c
            1902-2093           AC012000.3         72182-72373         c
            2094-2328           AC012000.3         70284-70518         c
            2329-2444           AC012000.3         60845-60960         c
            2445-2574           AC012000.3         30755-30884         c
            2575-2678           AC012000.3         27391-27494         c
            2679-2873           AC019067.9         65538-65732         c
            2874-3137           AC019067.9         59473-59736         c
            3138-3316           AC019067.9         20322-20500         c
            3317-3450           AC017082.4         89774-89907         c
            3451-3601           AC017082.4         80572-80722         c
            3602-3743           AC017082.4         36812-36953         c
            3744-3859           AC017082.4         34621-34736         c
            3860-3977           AC017082.4         32402-32519         c
            3978-4123           AC017082.4         10495-10640         c
            4124-4283           AC016679.9         4374-4533
            4284-4457           AC016679.9         5669-5842
            4458-4553           AC016679.9         5938-6033
            4554-4636           AC016679.9         8537-8619
            4637-4829           AC016679.9         12256-12448
            4830-4917           AC016679.9         16647-16734
            4918-6112           AC016679.9         25397-26591
FEATURES             Location/Qualifiers
     source          1..6112
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q22.1"
     gene            1..6112
                     /gene="THSD7B"
                     /note="thrombospondin type 1 domain containing 7B"
                     /db_xref="GeneID:80731"
                     /db_xref="HGNC:HGNC:29348"
     exon            1..143
                     /gene="THSD7B"
                     /inference="alignment:Splign:2.1.0"
     exon            144..317
                     /gene="THSD7B"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..4999
                     /gene="THSD7B"
                     /note="thrombospondin type-1 domain-containing protein 7B;
                     thrombospondin, type I, domain containing 7B"
                     /codon_start=1
                     /product="thrombospondin type-1 domain-containing protein
                     7B precursor"
                     /protein_id="NP_001303278.1"
                     /db_xref="CCDS:CCDS82515.1"
                     /db_xref="GeneID:80731"
                     /db_xref="HGNC:HGNC:29348"
                     /translation="MFPKSNLTVTCWVWRSMRKLFLLLSLLLSHAAHLEGKKDNQFIW
                     KPGPWGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSCFRVCDWHSD
                     LFQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICE
                     HFALQPPTEQACLIPCPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGGLQCP
                     NLTESRACDAPISCPLGEEEYTFSLKVGPWSKCRLPHLKEINPSGRTVLDFNSDSNER
                     VTFKHQSYKAHHHSKSWAIEIGYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCIMP
                     KDCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVEG
                     ELLQQCPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAA
                     ALRAKEVSRPVEKALCVGPAPLPSQLCNIPCSTDCIVSSWSAWGLCIHENCHDPQGKK
                     GFRTRQRHVLMESTGPAGHCPHLVESVPCEDPMCYRWLASEGICFPDHGKCGLGHRIL
                     KAVCQNDRGEDVSGSLCPVPPPPERKSCEIPCRMDCVLSEWTEWSSCSQSCSNKNSDG
                     KQTRSRTILALAGEGGKPCPPSQALQEHRLCNDHSCMQLHWETSPWGPCSEDTLVTAL
                     NATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRPETVRPCFLPCKKDCIV
                     TAFSEWTPCPRMCQAGNATVKQSRYRIIIQEAANGGQECPDTLYEERECEDVSLCPVY
                     RWKPQKWSPCILVPESVWQGITGSSEACGKGLQTRAVSCISDDNRSAEMMECLKQTNG
                     MPLLVQECTVPCREDCTFTAWSKFTPCSTNCEATKSRRRQLTGKSRKKEKCQDSDLYP
                     LVETELCPCDEFISQPYGNWSDCILPEGRREPHRGLRVQADSKECGEGLRFRAVACSD
                     KNGRPVDPSFCSSSGYIQEKCVIPCPFDCKLSDWSSWGSCSSSCGIGVRIRSKWLKEK
                     PYNGGRPCPKLDLKNQVHEAVPCYSECNQYSWVVEHWSSCKINNELRSLRCGGGTQSR
                     KIRCVNTADGEGGAVDSNLCNQDEIPPETQSCSLMCPNECVMSEWGLWSKCPQSCDPH
                     TMQRRTRHLLRPSLNSRTCAEDSQVQPCLLNENCFQFQYNLTEWSTCQLSENAPCGQG
                     VRTRLLSCVCSDGKPVSMDQCEQHNLEKPQRMSIPCLVECVVNCQLSGWTAWTECSQT
                     CGHGGRMSRTRFIIMPTQGEGRPCPTELTQEKTCPVTPCYSWVLGNWSACKLEGGDCG
                     EGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQDSILKQLCSVPCPGDCHLTEWSE
                     WSTCELTCIDGRSFETVGRQSRSRTFIIQSFENQDSCPQQVLETRPCTGGKCYHYTWK
                     ASLWNNNERTVWCQRSDGVNVTGGCSPQARPAAIRQCIPACRKPFSYCTQGGVCGCEK
                     GYTEIMKSNGFLDYCMKVPGSEDKKADVKNLSGKNRPVNSKIHDIFKGWSLQPLDPDG
                     RVKIWVYGVSGGAFLIMIFLIFTSYLVCKKPKPHQSTPPQQKPLTLAYDGDLDM"
     exon            318..1128
                     /gene="THSD7B"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1377
                     /gene="THSD7B"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1547
                     /gene="THSD7B"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1703
                     /gene="THSD7B"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1901
                     /gene="THSD7B"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2093
                     /gene="THSD7B"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2328
                     /gene="THSD7B"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2444
                     /gene="THSD7B"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..2574
                     /gene="THSD7B"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..2678
                     /gene="THSD7B"
                     /inference="alignment:Splign:2.1.0"
     exon            2679..2873
                     /gene="THSD7B"
                     /inference="alignment:Splign:2.1.0"
     exon            2874..3137
                     /gene="THSD7B"
                     /inference="alignment:Splign:2.1.0"
     exon            3138..3316
                     /gene="THSD7B"
                     /inference="alignment:Splign:2.1.0"
     exon            3317..3450
                     /gene="THSD7B"
                     /inference="alignment:Splign:2.1.0"
     exon            3451..3601
                     /gene="THSD7B"
                     /inference="alignment:Splign:2.1.0"
     exon            3602..3743
                     /gene="THSD7B"
                     /inference="alignment:Splign:2.1.0"
     exon            3744..3859
                     /gene="THSD7B"
                     /inference="alignment:Splign:2.1.0"
     exon            3860..3977
                     /gene="THSD7B"
                     /inference="alignment:Splign:2.1.0"
     exon            3978..4123
                     /gene="THSD7B"
                     /inference="alignment:Splign:2.1.0"
     exon            4124..4283
                     /gene="THSD7B"
                     /inference="alignment:Splign:2.1.0"
     exon            4284..4457
                     /gene="THSD7B"
                     /inference="alignment:Splign:2.1.0"
     exon            4458..4553
                     /gene="THSD7B"
                     /inference="alignment:Splign:2.1.0"
     exon            4554..4636
                     /gene="THSD7B"
                     /inference="alignment:Splign:2.1.0"
     exon            4637..4829
                     /gene="THSD7B"
                     /inference="alignment:Splign:2.1.0"
     exon            4830..4917
                     /gene="THSD7B"
                     /inference="alignment:Splign:2.1.0"
     exon            4918..6112
                     /gene="THSD7B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6090..6095
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THSD7B"
                     /note="hexamer: AATAAA"
     polyA_site      6112
                     /gene="THSD7B"
                     /note="major polyA site"
ORIGIN      
        1 agtgctgagg agccagagtc gccgccgggt tgccagacgc tggaatgggt ggtcttccga
       61 cacacaccac catctttctt gcgctcggga agctcggggc tcagcggctc ccagaggtta
      121 cggcggcggc tctggcgaga cgggaatagg caagtcaaga ggctgaaaaa tctgaagcat
      181 gtttccaaag agcaacctaa cagtcacttg ctgggtatgg aggagcatga ggaagctctt
      241 tctattgctt tctctcttgc tgtcccatgc agctcatttg gaaggcaaaa aggataatca
      301 gttcatctgg aaaccaggtc cgtggggaag gtgtacagga gactgtggtc ccggaggagt
      361 ccagagtcgg gcagtgtggt gttttcatgt tgacgggtgg acaagtcacc tgtctaactg
      421 tggtgagagc aacaggcctc caaaggaaag aagttgtttc cgagtttgtg actggcacag
      481 tgacctcttt cagtgggagg tttctgactg gcaccactgt gtgcttgttc cttacgctcg
      541 cggtgaagtc aagcctcgga ctgcagagtg tgtgacggct cagcatggac tgcagcaccg
      601 gatggtgcgc tgcattcaga agctgaaccg aactgtggtt gcaaatgaaa tatgcgaaca
      661 ctttgccctt cagcctccta cagaacaggc ttgcctcatt ccttgtcccc gggattgtgt
      721 agtatctgag ttcttaccat ggtccaactg tagcaaggga tgtgggaaga aattgcagca
      781 tagaactcgc gcggtcatag ctccccctct ctttggtggt ttgcaatgtc caaatctgac
      841 tgagtcaaga gcctgtgatg ctcccatttc ctgtcctctt ggggaagagg aatatacatt
      901 tagccttaag gttggaccat ggagtaaatg cagactgcct catcttaaag aaattaatcc
      961 aagcggaaga actgttctgg attttaactc tgattcaaat gagcgagtca cctttaaaca
     1021 tcaaagttac aaagcacatc atcattcgaa gtcttgggca atagagatag gttatcaaac
     1081 ccggcaggtt tcgtgtacaa gaagtgatgg acaaaatgct atgttaagcc tttgccttca
     1141 agattccttc ccattgactg ttcagtcctg catcatgccc aaagactgtg aaacctccca
     1201 gtggtcctcc tggagcccct gctccaagac atgccgttca gggagtctct tgccaggatt
     1261 taggagcagg agccggaacg tgaagcacat ggctattgga ggtggaaagg agtgtcctga
     1321 acttcttgag aaagaggcct gcattgttga aggagaactt ctgcagcaat gtcccaggta
     1381 ttcctggaga acttctgaat ggaaagaatg ccaagtctct ctcctcctcg agcagcagga
     1441 tccccactgg catgtgacgg gacccgtgtg tggcggtggg atccagaccc gggaggtgta
     1501 ctgtgcccag agcgtaccag cagctgccgc actgagggcc aaggaagtct ctagacctgt
     1561 ggaaaaggca ttatgtgtgg gacccgcccc gttgccctct cagctctgca atatcccttg
     1621 ctctacggac tgcatagtat cttcctggtc agcctggggc ctgtgcatcc atgaaaactg
     1681 tcatgatcct caggggaaaa aaggatttag aacgaggcag cgccatgtcc tcatggaatc
     1741 tacagggcct gcagggcatt gccctcattt ggtggagtct gttccttgtg aggatccaat
     1801 gtgctaccga tggctggcat cagaagggat ctgtttccct gatcatggaa aatgtggcct
     1861 gggacatcgt attctgaagg ccgtctgcca gaatgaccgc ggagaagatg tatcagggag
     1921 tctttgccca gttccccctc ctcctgagag gaagtcttgt gaaattccct gccgaatgga
     1981 ctgtgtgctg agcgagtgga cggagtggtc atcctgttcc cagtcctgtt caaataaaaa
     2041 ctcagatggg aaacagacca ggtcaagaac tatcctggca ctggctgggg aaggtggaaa
     2101 gccatgtccc cctagtcagg ctctccaaga gcatcgtttg tgtaatgacc attcctgtat
     2161 gcagcttcac tgggagacat cgccttgggg cccttgttct gaggacacat tggtaactgc
     2221 ccttaatgca accattggct ggaatggaga agccacgtgt ggtgtaggca ttcagactcg
     2281 gagagtcttc tgtgtcaaga gtcacgtggg acaagtaatg accaaaagat gtccagattc
     2341 tactcgacct gaaactgtgc gcccctgttt tctcccatgc aaaaaagact gtattgtgac
     2401 tgctttcagt gagtggacac cctgcccaag gatgtgccaa gcaggaaatg ccacagtaaa
     2461 acagtctcga tacagaatca tcatccaaga agcagccaat ggaggccagg aatgcccaga
     2521 taccttatat gaggagagag agtgtgaaga tgtttccttg tgtcctgtat atcggtggaa
     2581 gccacagaaa tggagccctt gcatcttagt gccagagtct gtctggcagg gaataacggg
     2641 cagcagtgaa gcctgtggaa aggggttaca aacaagagct gtctcatgca tctctgatga
     2701 caaccggtca gcagaaatga tggaatgcct caagcagaca aacggcatgc ctctccttgt
     2761 gcaagaatgc acagtcccat gtcgagaaga ctgcaccttc actgcttggt ccaagtttac
     2821 gccctgctcc acgaactgtg aagccacaaa aagtaggcgg cgacagctca cagggaaaag
     2881 cagaaagaag gagaaatgcc aggattctga cctttaccct ctagtggaga cagaactatg
     2941 tccttgtgat gaatttatat cccaacctta tggaaactgg tcagattgca ttcttccaga
     3001 aggcagaagg gagcctcacc gaggactgcg ggtacaagca gacagcaaag aatgtggaga
     3061 aggcctgcgc tttcgagcag tagcctgttc tgataaaaat ggaagacctg ttgacccctc
     3121 cttctgcagc agctctggtt acattcaaga aaaatgtgtc attccctgcc catttgattg
     3181 caagttaagc gattggtcta gttgggggtc ttgcagttca tcttgtggaa ttggagtgag
     3241 aattcgatcc aaatggctaa aagaaaaacc ttacaatgga ggacgaccat gtcccaaact
     3301 ggatctcaag aatcaggtac atgaggcagt cccatgttac agtgagtgca atcagtattc
     3361 ctgggttgta gaacactggt cttcatgcaa aatcaacaat gagctgaggt ccctgcgctg
     3421 tggaggagga acacaatcta ggaaaatcag atgtgtgaat actgcggatg gtgaaggtgg
     3481 agcagtggat agcaacctgt gcaaccagga tgaaattccc ccagaaaccc agtcctgttc
     3541 tcttatgtgt cccaatgagt gtgtcatgtc tgagtgggga ctttggagca aatgcccaca
     3601 gtcatgcgat ccccacacaa tgcagagaag aactcgccac ctgctaagac catcactgaa
     3661 ctcaaggact tgtgctgaag actcacaggt gcagccttgc ctcctgaatg aaaattgctt
     3721 ccagttccag tacaatctaa cagagtggag cacatgccag ctgagtgaaa acgcaccctg
     3781 tggtcaaggc gtcaggaccc gcctgctaag ctgtgtgtgc agtgatggca agccagtcag
     3841 catggaccaa tgtgagcagc ataatttgga gaagccccag agaatgagca ttccctgctt
     3901 ggtggaatgc gtggtcaact gtcagctctc agggtggacg gcttggacag agtgttcaca
     3961 gacctgtggc catggaggtc gaatgagccg gactcgattt atcattatgc caacccaagg
     4021 agaaggacgg ccatgcccca cagagcttac ccaggagaaa acctgcccag tgaccccctg
     4081 ctacagctgg gtccttggca actggtctgc atgtaaattg gagggtggag actgtgggga
     4141 aggagttcag atccgcagcc tttcctgcat ggtccacagt ggttcaatat ctcatgcagc
     4201 tggacgtgtc gaggatgcac tgtgtggaga aatgcccttt caggacagca tcctgaagca
     4261 gctgtgttct gtgccttgcc caggagactg ccatttaaca gaatggtcag agtggagcac
     4321 atgtgaatta acctgcattg atggaagaag ctttgagact gtgggccgcc agtctagatc
     4381 aaggactttt ataattcagt cttttgagaa ccaagacagc tgcccccaac aggttctaga
     4441 aacacgccct tgtacaggag gcaaatgtta tcactacaca tggaaagcaa gtctttggaa
     4501 caataacgaa cgaactgtat ggtgccagcg ttcagatggc gttaatgtca caggaggctg
     4561 ctcccctcag gcccgtcctg ctgccattcg gcagtgcatt ccagcctgca gaaaaccttt
     4621 ctcctactgt acacagggtg gagtctgtgg ttgtgagaag ggctatacag agataatgaa
     4681 atcaaatggt ttcctggatt actgcatgaa agtaccaggc tcagaggata aaaaagctga
     4741 tgtgaaaaac ctttctggga aaaacagacc tgtgaattca aaaatacatg atatttttaa
     4801 aggatggtct cttcaaccac ttgatccaga tggccgagta aaaatttggg tttatggcgt
     4861 ttcaggtggc gcttttctca tcatgatttt cctaatattt acttcctacc ttgtttgcaa
     4921 gaagccaaaa ccacatcaaa gcacacctcc ccaacagaag cctctgacct tagcctacga
     4981 tggagactta gacatgtaat ctgaaaaaga aatccaaatg tagacatcaa ctgccttaac
     5041 cgctttctct tttgtagctc tcagacttct cagttttttg aggaatctca agatgtgata
     5101 tattgggcag aatacaaata ttgcaaaagt aatattgcct caacttcatt tggacatgga
     5161 gtcaaggatt attaggtctg ccattttgtt ttcaagttgt ttgtgggtgt gttttatttt
     5221 tttggttttc ccaagggacc tgaaaaccct tctcttcctg tttggaactg ggaggaagaa
     5281 aacatgatgg aattcccaca gacttgagta aacttgatct tcagcagcat aatgacaatc
     5341 cagaggaaaa tacagtcaag gcatttactc taaatgacga gtctgacact gcattgttac
     5401 gcactatatt agtgcaaagt ctttattctt cccatacttc aacactgagt tttctagagt
     5461 ttactttggt ttaaagactt tcaaattgga ttgcctattt ttcatgaaca cagagagaat
     5521 ggattaccat ttcagaaatt ctctgagttt ttaaccttta aatattgtat tttgttttgt
     5581 agccagggga tgatggcgct tcatgggttg cagctactga aaatagcagc gtgtgtgtaa
     5641 ttgctggact agatgaaagc taggtcattt ctgaagggaa tgtgtactga atgttagagt
     5701 gtacaaatga aatatgtggt taaattggag aatgaggtag attatttgat tactaaaact
     5761 gtattttaac aaaaacttat ccatgtagat atagcattaa ccacacacag ttgtaattca
     5821 gtttaatgat gacaaactct gcttttgtaa tttcaatttt cttatctgaa tatttataaa
     5881 ttcttctttc aaatttaatt atctgacctc atttaatata catcaaacac cgatcctgtt
     5941 tgtacaaagt cttgctttta taaggtttca ataatatcta aaacaacaca ttaaaaagct
     6001 gagaccattt tatgaagata attgtttgta atcataggtg ttgaaagtaa aaaggtgcca
     6061 tcttgtggta ttgacttgta tttataacaa ataaactgct caagagactg ca
//
