LOCUS       NM_003251               1174 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens thyroid hormone responsive (THRSP), mRNA.
ACCESSION   NM_003251
VERSION     NM_003251.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1174)
  AUTHORS   Ahonen,M.A., Horing,M., Nguyen,V.D., Qadri,S., Taskinen,J.H.,
            Nagaraj,M., Wabitsch,M., Fischer-Posovszky,P., Zhou,Y.,
            Liebisch,G., Haridas,P.A.N., Yki-Jarvinen,H. and Olkkonen,V.M.
  TITLE     Insulin-inducible THRSP maintains mitochondrial function and
            regulates sphingolipid metabolism in human adipocytes
  JOURNAL   Mol Med 28 (1), 68 (2022)
   PUBMED   35715726
  REMARK    GeneRIF: Insulin-inducible THRSP maintains mitochondrial function
            and regulates sphingolipid metabolism in human adipocytes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1174)
  AUTHORS   Ding,Y., Liu,X., Yuan,Y., Sheng,Y., Li,D., Ojha,S.C., Sun,C. and
            Deng,C.
  TITLE     THRSP identified as a potential hepatocellular carcinoma marker by
            integrated bioinformatics analysis and experimental validation
  JOURNAL   Aging (Albany NY) 14 (4), 1743-1766 (2022)
   PUBMED   35196258
  REMARK    GeneRIF: THRSP identified as a potential hepatocellular carcinoma
            marker by integrated bioinformatics analysis and experimental
            validation.
REFERENCE   3  (bases 1 to 1174)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1174)
  AUTHORS   Zeng,N., Huang,R., Li,N., Jiang,H., Li,R., Wang,F., Chen,W., Xia,M.
            and Wang,Q.
  TITLE     MiR-451a attenuates free fatty acids-mediated hepatocyte steatosis
            by targeting the thyroid hormone responsive spot 14 gene
  JOURNAL   Mol Cell Endocrinol 474, 260-271 (2018)
   PUBMED   29604329
  REMARK    GeneRIF: miR-451a might participate in the free fatty acid-induced
            hepatic steatosis by regulating the expression of the THRSP gene.
REFERENCE   5  (bases 1 to 1174)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1174)
  AUTHORS   Cunningham,B.A., Maloney,M. and Kinlaw,W.B.
  TITLE     Spot 14 protein-protein interactions: evidence for both homo- and
            heterodimer formation in vivo
  JOURNAL   Endocrinology 138 (12), 5184-5188 (1997)
   PUBMED   9389499
REFERENCE   7  (bases 1 to 1174)
  AUTHORS   Grillasca,J.P., Gastaldi,M., Khiri,H., Dace,A., Peyrol,N.,
            Reynier,P., Torresani,J. and Planells,R.
  TITLE     Cloning and initial characterization of human and mouse Spot 14
            genes
  JOURNAL   FEBS Lett 401 (1), 38-42 (1997)
   PUBMED   9003802
REFERENCE   8  (bases 1 to 1174)
  AUTHORS   Ota,Y., Mariash,A., Wagner,J.L. and Mariash,C.N.
  TITLE     Cloning, expression and regulation of the human S14 gene
  JOURNAL   Mol Cell Endocrinol 126 (1), 75-81 (1997)
   PUBMED   9027365
REFERENCE   9  (bases 1 to 1174)
  AUTHORS   Moncur,J.T., Park,J.P., Maloney,M., Mohandas,T.K. and Kinlaw,W.B.
  TITLE     Assignment of the 'spot 14' gene (THRSP) to human chromosome band
            11q13.5 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 78 (2), 131-132 (1997)
   PUBMED   9371405
REFERENCE   10 (bases 1 to 1174)
  AUTHORS   Taviaux,S., Planells,R., Gastaldi,M., Torresani,J. and
            Grillasca,J.P.
  TITLE     Assignment of thyroid hormone responsive SPOT 14 homolog (THRSP) to
            human chromosome 11 bands q13.5-->q14.1 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 76 (3-4), 219-220 (1997)
   PUBMED   9186528
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP317892.1, BC031989.1,
            AI480357.1 and AI749106.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003251.3.
            
            Summary: The protein encoded by this gene is similar to the gene
            product of S14, a rat gene whose expression is limited to liver and
            adipose tissue and is controlled by nutritional and hormonal
            factors. This gene has been shown to be expressed in liver and
            adipocytes, particularly in lipomatous modules. It is also found to
            be expressed in lipogenic breast cancers, which suggests a role in
            controlling tumor lipid metabolism. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.89389.1,
                                           SRR3476690.758620.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000281030.2/ ENSP00000281030.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BP317892.1         1-17
            18-910              BC031989.1         1-893
            911-1173            AI480357.1         1-263               c
            1174-1174           AI749106.1         9-9                 c
FEATURES             Location/Qualifiers
     source          1..1174
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q14.1"
     gene            1..1174
                     /gene="THRSP"
                     /gene_synonym="Lpgp; LPGP1; S14; SPOT14; THRP"
                     /note="thyroid hormone responsive"
                     /db_xref="GeneID:7069"
                     /db_xref="HGNC:HGNC:11800"
                     /db_xref="MIM:601926"
     exon            1..481
                     /gene="THRSP"
                     /gene_synonym="Lpgp; LPGP1; S14; SPOT14; THRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..462
                     /gene="THRSP"
                     /gene_synonym="Lpgp; LPGP1; S14; SPOT14; THRP"
                     /note="lipogenic protein 1; thyroid hormone responsive
                     (SPOT14 homolog, rat); spot 14 protein"
                     /codon_start=1
                     /product="thyroid hormone-inducible hepatic protein"
                     /protein_id="NP_003242.1"
                     /db_xref="CCDS:CCDS8256.1"
                     /db_xref="GeneID:7069"
                     /db_xref="HGNC:HGNC:11800"
                     /db_xref="MIM:601926"
                     /translation="MQVLTKRYPKNCLLTVMDRYAAEVHNMEQVVMIPSLLRDVQLSG
                     PGGQAQAEAPDLYTYFTMLKAICVDVDHGLLPREEWQAKVAGSEENGTAETEEVEDES
                     ASGELDLEAQFHLHFSSLHHILMHLTEKAQEVTRKYQEMTGQVW"
     exon            482..1174
                     /gene="THRSP"
                     /gene_synonym="Lpgp; LPGP1; S14; SPOT14; THRP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1152..1157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THRSP"
                     /gene_synonym="Lpgp; LPGP1; S14; SPOT14; THRP"
                     /note="hexamer: AATAAA"
     polyA_site      1174
                     /gene="THRSP"
                     /gene_synonym="Lpgp; LPGP1; S14; SPOT14; THRP"
                     /note="major polyA site"
ORIGIN      
        1 attgtgtcag aggaagcaac catgcaggtg ctaaccaagc gttaccccaa gaactgcctg
       61 ctgaccgtca tggaccggta tgcagccgag gtgcacaaca tggagcaggt ggtgatgatc
      121 cccagccttc tgcgggacgt gcagctgagt gggcctgggg gccaggccca ggctgaggcc
      181 cctgatctct acacctactt caccatgctc aaggccatct gtgtggatgt ggaccatggg
      241 ctgctgccgc gggaggagtg gcaggccaag gtggcaggca gcgaagagaa tggaaccgca
      301 gagacagagg aagtcgagga cgagagtgcc tcaggagagc tggacctgga agcccagttc
      361 cacctgcact tctccagcct ccatcacatc ctcatgcacc tcaccgagaa agcccaggag
      421 gtgacaagga aataccagga aatgacggga caagtttggt agaccttgga cactagggaa
      481 gatcccttca catgatagaa gacagactct ttgatgaggt cggcggagca gttcactagc
      541 caatgatgag agcagaaagg cctagacctg cagccagaag tgaaggcggc tcagttctcc
      601 gggatgcttc tctacctcct gagcaccaat tcctggattc cagtcactgg ctcaccttta
      661 gaatgtctgt tgctattcac tgctcccctc gctcctctta acagcttggg gaggtgacca
      721 gtggttcagg agggactaga caattacctg tccagtgtgg tatggtagga agagtgtagg
      781 tgttggcacg tgaccaaaat tcacatccct cctcatggca gtcattcagt atgtgtactt
      841 gtacaagtta tttaacccat tggagcctaa attccctcat ctataaaatg gggataatat
      901 tatctacctc acaagcttat gaaaactaaa catgatgaat caaaagcact tggcatgtga
      961 gggctattaa aatagcctga tttttttttt ctccccctct ccccaatgta tttgctctgg
     1021 cccttgcttt ttaccctcca gagctaagag gtagcagagt ctcttgggat gagtgattca
     1081 ccctcttact tggcgaccac tgatgagatc aacaacaggt gaactataaa cctattattt
     1141 attgcagaac taataaaaaa tccaaagcct tgta
//
