LOCUS       XM_047448802            7493 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens thyroid hormone receptor beta (THRB),
            transcript variant X16, mRNA.
ACCESSION   XM_047448802
VERSION     XM_047448802.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000003.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7493
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
     gene            1..7493
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /note="thyroid hormone receptor beta; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 8
                     mRNAs, 3 ESTs, 428 long SRA reads, 8 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 21 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:7068"
                     /db_xref="HGNC:HGNC:11799"
                     /db_xref="MIM:190160"
     CDS             377..1762
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /codon_start=1
                     /product="thyroid hormone receptor beta isoform X1"
                     /protein_id="XP_047304758.1"
                     /db_xref="GeneID:7068"
                     /db_xref="HGNC:HGNC:11799"
                     /db_xref="MIM:190160"
                     /translation="MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSE
                     RRSTLKNEQSSPHLIQTTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLD
                     KDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQ
                     CQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEE
                     WELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKII
                     TPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEM
                     AVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERI
                     EKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTEL
                     FPPLFLEVFED"
ORIGIN      
        1 gcacatcctc gggcgggcgg ccgtgacgcg gcggggatta actttgcatg aataatgtga
       61 gtgcgcttgg aaaagagacc tcctgctccg cgggctcggg gcaagagccc gcaggctacc
      121 ttccccgggc aggggcgctc aacccaaccg gctccagggc actgatctgc gatttccttc
      181 tggttggctg tcctgcgtgg gtgccaagtt ccacacatga tttaatgaat aagaagtgac
      241 ttcactgtag gaagaggaaa tgcagaaaaa caaacgtctt gaagactgaa agcctgttat
      301 tcaaagaggt tagcagtaga ctgttggaag taaggagatg tcagtgaaaa aagggatcca
      361 gaatgattac taacctatga ctcccaacag tatgacagaa aatggcctta cagcctggga
      421 caaaccgaag cactgtccag accgagaaca cgactggaag ctagtaggaa tgtctgaagc
      481 ctgcctacat aggaagagcc attcagagag gcgcagcacg ttgaaaaatg aacagtcgtc
      541 gccacatctc atccagacca cttggactag ctcaatattc catctggacc atgatgatgt
      601 gaacgaccag agtgtctcaa gtgcccagac cttccaaacg gaggagaaga aatgtaaagg
      661 gtacatcccc agttacttag acaaggacga gctctgtgta gtgtgtggtg acaaagccac
      721 cgggtatcac taccgctgta tcacgtgtga aggctgcaag ggtttcttta gaagaaccat
      781 tcagaaaaat ctccatccat cctattcctg taaatatgaa ggaaaatgtg tcatagacaa
      841 agtcacgcga aatcagtgcc aggaatgtcg ctttaagaaa tgcatctatg ttggcatggc
      901 aacagatttg gtgctggatg acagcaagag gctggccaag aggaagctga tagaggagaa
      961 ccgggagaaa agacggcggg aagagctgca gaagtccatc gggcacaagc cagagcccac
     1021 agacgaggaa tgggagctca tcaaaactgt caccgaagcc catgtggcga ccaacgccca
     1081 aggcagccac tggaagcaaa aacggaaatt cctgccagaa gacattggac aagcaccaat
     1141 agtcaatgcc ccagaaggtg gaaaggttga cttggaagcc ttcagccatt ttacaaaaat
     1201 catcacacca gcaattacca gagtggtgga ttttgccaaa aagttgccta tgttttgtga
     1261 gctgccatgt gaagaccaga tcatcctcct caaaggctgc tgcatggaga tcatgtccct
     1321 tcgcgctgct gtgcgctatg acccagaaag tgagacttta accttgaatg gggaaatggc
     1381 agtgacacgg ggccagctga aaaatggggg tcttggggtg gtgtcagacg ccatctttga
     1441 cctgggcatg tctctgtctt ctttcaacct ggatgacact gaagtagccc tccttcaggc
     1501 cgtcctgctg atgtcttcag atcgcccggg gcttgcctgt gttgagagaa tagaaaagta
     1561 ccaagatagt ttcctgctgg cctttgaaca ctatatcaat taccgaaaac accacgtgac
     1621 acacttttgg ccaaaactcc tgatgaaggt gacagatctg cggatgatag gagcctgcca
     1681 tgccagccgc ttcctgcaca tgaaggtgga atgccccaca gaactcttcc cccctttgtt
     1741 cttggaagtg ttcgaggatt agactgactg gattcattct cataattcct acagcactac
     1801 tgggtgtcat ttcattccat tgcctagctc ttttttgttt gtttctttgt gttgggaggg
     1861 attatttggg agggaaaagg gaagtagtcc ttggcataga catggatgaa attgcccctt
     1921 gaatgcgggt acttgaaact attgcatttc gttctccggt cctgtgatgt gaatgctctg
     1981 aaggttttat ggttgtggag gtggggtggg ggacaatcat taactcacca gcaccaagca
     2041 tcaccagctc ccacccgtcc ctggtccaag acttgagtca gcaaaatggc gccacaggac
     2101 actaaagaag ccttaaaacc aagataatac gaccacctcc acccaatcct gatgttcgca
     2161 gggctgaagt taacagagca cagaccacct ttagttagat gtggctttca gccttttagg
     2221 gaaagactcg aacaaatttt catctattca agagcatgct gtttgcagca ctctttatgg
     2281 tctcctagga gcataacttg gaatgtacag gaatatttgt gtcctaaaaa aatcagctgc
     2341 ccttccaata tcatttttat aacgttatgg tttaattcaa gttatacaaa ggtgtgactc
     2401 aaggatgtgc aggtattgac tgatggaggc caacaaggaa aatatttttt ttcagtgagc
     2461 ccagagaaat tagaaatctt caccaatgtc agtgactgca tggtttccaa aaattcacat
     2521 agtattacct cacagtagga aggcttcttt cccatttagg ctcagagaac acttttacag
     2581 aaatcaaacc tatttacagg gtggcacccc ttttctgtgg catctgatct gtcatctccc
     2641 aagctcctga agttctttat ccaggttgta tctttgctga gctgacaaca gatttctcta
     2701 tggatcaaat attctaatca aggaaagata cggtgaaact tcagtcttct tctggagaaa
     2761 tgctgaggcg agattagtgc agctacattc tgagttgaag gaaatgcagt gttctgaggg
     2821 cccctttgtg tcctgatggc tggaggacgc ttcctcctgg ttagatcctc aagctccttg
     2881 cctcattgac aaatgtctcc tagtcccctt tttccctctg actctgagga actaaatagc
     2941 ttgactatct ctaaacagag actggccctg ccactgaccc tcctgtccct ctcatagcat
     3001 accctgacag atactcaata gaaaacacct gcagaccatg tgcacactta actttcctgc
     3061 ccaacctgcc tccccaacgg cccatgctag aatagcttgt gcccagaaaa caaacagtga
     3121 cacttcatct cttcagcgtc agaaaatggg catagaatgt acccatgcaa ttgaatgtat
     3181 ctcattctcc actggcatag tagatataaa ctattccttt gcctaccttt tactgcctta
     3241 tcctggaaat attggggaaa ataagccata tcagtgagat ttacctaaaa acaaaggaag
     3301 gaaagtcact atggaaacca agtagatgct ttttgtaagt ttggtggagc ataactggcc
     3361 cagaagtctg ggtgcctgag ttctagttcg tgctctgtca actggtagat ttgtaattct
     3421 aggtcttggt tttcttacct ggtgaataag tcatgatctc taaaaccctt cctgccctta
     3481 atattgtctg aatttcaagg ggaaaaaaaa aatctggttc ctttaattat ttttttttaa
     3541 cacttaaatt cctaacttta ttagacaaga agtatggccc acttaacagt taaggaacgt
     3601 aaatttgtta ttggctcgaa ataataattt gacacaatac tagtcaacca tttagaggcc
     3661 ttggaaaaag aagaggaaca gcactgaaaa ttccaagtat gattggaaat tatctgggag
     3721 cggggaatta aatattcaat gcatgaaagc aattgtactg gcttctggga aaaaggaaac
     3781 aagaacattg ctatggaact tgttacccag agaaaggaag tgaaaagatt tacaattata
     3841 agcacgaaat tcattggcag attacctgct ttatctacag acagattgtt ttggggtttg
     3901 gttttgtcta ggcagcctct ggccaggctc cttaattgct tgctctgcta atatttcagc
     3961 ttcctctctt gactccttga ggaaccaacc gctctttgga agacaaacac ttagccacct
     4021 ctgtgctcca gggtaaccct gagaagctct gctgtctggg gcaagctttc tttccaaagg
     4081 gaatgagagg aaggcaagca ggcagggtcc tgcagcgtca ggccttctgg ggaaagtttc
     4141 ctcattttgt ttgacagggt cctcagtaca tcagacaccc agatttgaat ataagttcag
     4201 agcctgatct caagctaaat cagaatgctt tggggactaa ccatgatcga gaattggcca
     4261 aatagtatgg catataaaca gccatccagc cagccgcaag taaaggaacg tttgatcctt
     4321 ggcaccttaa atgattgatt gccttcaata ggcaaactgc tggtctggaa atctcgttga
     4381 aggctgaata cttcatgcgg agtaggacaa gccttagccc accttcaggt tgaaaggaaa
     4441 ggccatagga ctcaaaagat aatgactctg aaactaaact ccttccttct gaagctgaca
     4501 gaggtactta gtgcatctca agactccatc tcataaaact catttgtgag ggatttgctc
     4561 tagatttttc taaacatttt ttcatctatt gtccagactt gcaaatccag tgtggacctg
     4621 atggagatac ccttcacacc tgcgctccca ccccctcggc agggagacgt ctcagtagag
     4681 gagaacacac ccattatgct gggatttgta tttataaatc acttcccttt tagggatgag
     4741 cggtgtgggg cgtgtgtgcg tgtgagtgta tgcgcgtgcg tgtgtgaccc tcaagtgtac
     4801 tttgctcaat ttagacgtgc agtatttcca gaaacaatga aaaaagtaag atgttttctt
     4861 ctttatgatt ctgctcaaaa caccacgtgc cgcctcagag ctttttctag agcctcggtc
     4921 ctcaatgacg cgcttgacct gttgatgcct cagcccagcg aagcccctca cctgtgcccc
     4981 gggcgacagc tcttcagtgt gcagtgcagg cctggggtgg actgccaggc cttcgctctg
     5041 tgccagcaac gccgttcttg ttgctcctcc atgaacaggg gtacaagccc tggcccctcc
     5101 tcgacactaa gccccccaca gactcagcct ccaaggaacc gctgagcacc cttgaagcat
     5161 gtcattgtca gtgatacctt tttattctat ggaactctaa cctattcgtg tcatattgac
     5221 cttttgctgc atgagtcata aattatgaaa tcagtcttac agtttttgaa atgtagccag
     5281 catttgtaag gctaaacctt tttcatgaac tgaatttaag tgaataacca agccacagtt
     5341 cctcctcaaa tggagagtga tgatcgacat ttgaatctct ttgccctttc caacggctat
     5401 ggcatcaggt tctaaaataa gctcgtaatt tttcctgtta ttttaataat atggaaatat
     5461 tagcatagtg tttcttttga tagtgataga ctataatcca tatttaaatt ttatagagaa
     5521 gaaattttat tgtactgtga tgtagatatt tattatccag gtaaggattt gcccggtgtg
     5581 tattttttac aattgagaca ttttacttta atctttaaaa aaaatgcatt aaaaacacac
     5641 tcaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaccagactg ggggaaaaaa ggtttggcct
     5701 tatcacagaa tttttactgt gctgtataaa tgtttgcaaa tgcgaaaagt gtgcatttat
     5761 agtgtgtttc cacattaatt aatgccgcct tcaagagcaa tattgtgcag gtaaaacgct
     5821 gtttgtggct ttctgttgca cagttaaagc tgacccaccc tatgcacaag acaatcaaat
     5881 ataaatctgt cctcctcagg atgcagataa tactcatgta aattatggag cacaatgtaa
     5941 gacaaaagga gacactttac atatgtattg ttgatacaga aattatcagg gcatgaatga
     6001 gctgatgtga cattatgcca cttctttctt ttggttctcc cttattaact tggcattttt
     6061 aatttgacca tagagccaaa ttagttctcc atgctttctt cgtagaaaat cctttttttt
     6121 cccataatgt tttcatgccc tgagaatcag aaaaatacta cagaatagaa aaagatttac
     6181 agtcattgga agatttgtgt tttgcaaaca gtgttaagtg atattgctag atggtgatat
     6241 ttttttcagc ctaaaactct gttgaaatct gtgatcaaaa tgttttaaac tatccaaaaa
     6301 aaatttgtat atttgggaaa aatggatttt tacatagctt ttgtatgcag atataaaact
     6361 gtaattatga atatagtggg cgtagataaa ctcataagct taaattctaa aaaagaaaaa
     6421 gcttataaca gatatatttt cctgtctctt tctttaaata ttattatttt ctacataggc
     6481 aaagagttgc ctgctcttct cacttcagct gctgccaaaa gacggaacca cggatgtaag
     6541 gacatttatt tcataaataa acatctacta gaataagcaa atttacttga gaagaaacta
     6601 tggagggaga gaagaaacta agtaaaatgc tgatgggggg ttacctcttt ggaaggggcc
     6661 acaaagatga agggaggaga gaggtgaagt tttgcagctc aaggacaaca ttcatcttct
     6721 catctcaaat tattcaggaa tattactaat ggaattatgt taacatcagc tgccaacata
     6781 tatctcaatc tctgttgccc tgaacacatg ttaattgaga ttctttctat gacaagtaac
     6841 aaaaagctaa ctcaaactgg cttaagcaga aagctaatta ttgactttaa tatctgggat
     6901 ctagggtatt gcataccaaa gcttcaggca tggctggatc tgggtgcact tactcagtat
     6961 tctcaggaag ctcctttttt tgtcattcat gtagacttaa cattcacatg gcctttcacc
     7021 ttacggtggc ctccaatagc tccaggatga gctttacagc tccaaatata gtgaaaggag
     7081 aatttctttt ctccaacaat tctaatgaaa attctggcct aattctcact ggcccaagtt
     7141 cagtcatgtg cccattcctg agccaatcac tgtggtgagg aaaacagatg cataaccaac
     7201 cttatcctca ggaatcctgg aactgggtga ggggaaagag ggacagtcag cttcatctaa
     7261 actatggact gagagttgag gcaagatgat tcctgaaaga aaattctaag tcttgctgct
     7321 ataagtggaa gagaatggtg ggcaagcaaa agcaaccagt gcccacacca aaggtaaatc
     7381 taaaacaaca tcccatttca gtacagcaag cggttctcct tcacacagag gaagctcatc
     7441 tccaagtttt tatttggcca ggacatgaac caaataaaca ccttccaaag aaa
//
