LOCUS       XM_047448795            7628 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens thyroid hormone receptor beta (THRB),
            transcript variant X9, mRNA.
ACCESSION   XM_047448795
VERSION     XM_047448795.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000003.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7628
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
     gene            1..7628
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /note="thyroid hormone receptor beta; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 9
                     mRNAs, 3 ESTs, 427 long SRA reads, 8 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 5 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:7068"
                     /db_xref="HGNC:HGNC:11799"
                     /db_xref="MIM:190160"
     CDS             512..1897
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /codon_start=1
                     /product="thyroid hormone receptor beta isoform X1"
                     /protein_id="XP_047304751.1"
                     /db_xref="GeneID:7068"
                     /db_xref="HGNC:HGNC:11799"
                     /db_xref="MIM:190160"
                     /translation="MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSE
                     RRSTLKNEQSSPHLIQTTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLD
                     KDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQ
                     CQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEE
                     WELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKII
                     TPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEM
                     AVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERI
                     EKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTEL
                     FPPLFLEVFED"
ORIGIN      
        1 ctgcgccccg gatctgggag gaggtgccct ctcgtgttcg ggcaccgcgc ggcggcaggc
       61 tgggagctac ggagtggaca gtggtggaac agggtggccg ggctctgttc caatcgcagc
      121 ggctctgttc ctcaaacccc aagcccagct gttgacatgt tccttgtgaa atggagtttg
      181 gcatcctcag cgccgaaccc agtggaagtt tccatgatga ggaagttgtg tgacatgggg
      241 gttcggaaaa gatctgcgat ttccttctgg ttggctgtcc tgcgtgggtg ccaagttcca
      301 cacatgattt aatgaataag aagctcgcca gagaggcaaa ctccagcatt ttatatttca
      361 tctgccccca gtgacttcac tgtaggaaga ggaaatgcag aaaaacaaac gtcttgaaga
      421 ctgaaagcct gttattcaaa gaggttagca gtagactgtt ggaagtaagg agatgtcagt
      481 gaaaaaaggg atccagaatg attactaacc tatgactccc aacagtatga cagaaaatgg
      541 ccttacagcc tgggacaaac cgaagcactg tccagaccga gaacacgact ggaagctagt
      601 aggaatgtct gaagcctgcc tacataggaa gagccattca gagaggcgca gcacgttgaa
      661 aaatgaacag tcgtcgccac atctcatcca gaccacttgg actagctcaa tattccatct
      721 ggaccatgat gatgtgaacg accagagtgt ctcaagtgcc cagaccttcc aaacggagga
      781 gaagaaatgt aaagggtaca tccccagtta cttagacaag gacgagctct gtgtagtgtg
      841 tggtgacaaa gccaccgggt atcactaccg ctgtatcacg tgtgaaggct gcaagggttt
      901 ctttagaaga accattcaga aaaatctcca tccatcctat tcctgtaaat atgaaggaaa
      961 atgtgtcata gacaaagtca cgcgaaatca gtgccaggaa tgtcgcttta agaaatgcat
     1021 ctatgttggc atggcaacag atttggtgct ggatgacagc aagaggctgg ccaagaggaa
     1081 gctgatagag gagaaccggg agaaaagacg gcgggaagag ctgcagaagt ccatcgggca
     1141 caagccagag cccacagacg aggaatggga gctcatcaaa actgtcaccg aagcccatgt
     1201 ggcgaccaac gcccaaggca gccactggaa gcaaaaacgg aaattcctgc cagaagacat
     1261 tggacaagca ccaatagtca atgccccaga aggtggaaag gttgacttgg aagccttcag
     1321 ccattttaca aaaatcatca caccagcaat taccagagtg gtggattttg ccaaaaagtt
     1381 gcctatgttt tgtgagctgc catgtgaaga ccagatcatc ctcctcaaag gctgctgcat
     1441 ggagatcatg tcccttcgcg ctgctgtgcg ctatgaccca gaaagtgaga ctttaacctt
     1501 gaatggggaa atggcagtga cacggggcca gctgaaaaat gggggtcttg gggtggtgtc
     1561 agacgccatc tttgacctgg gcatgtctct gtcttctttc aacctggatg acactgaagt
     1621 agccctcctt caggccgtcc tgctgatgtc ttcagatcgc ccggggcttg cctgtgttga
     1681 gagaatagaa aagtaccaag atagtttcct gctggccttt gaacactata tcaattaccg
     1741 aaaacaccac gtgacacact tttggccaaa actcctgatg aaggtgacag atctgcggat
     1801 gataggagcc tgccatgcca gccgcttcct gcacatgaag gtggaatgcc ccacagaact
     1861 cttcccccct ttgttcttgg aagtgttcga ggattagact gactggattc attctcataa
     1921 ttcctacagc actactgggt gtcatttcat tccattgcct agctcttttt tgtttgtttc
     1981 tttgtgttgg gagggattat ttgggaggga aaagggaagt agtccttggc atagacatgg
     2041 atgaaattgc cccttgaatg cgggtacttg aaactattgc atttcgttct ccggtcctgt
     2101 gatgtgaatg ctctgaaggt tttatggttg tggaggtggg gtgggggaca atcattaact
     2161 caccagcacc aagcatcacc agctcccacc cgtccctggt ccaagacttg agtcagcaaa
     2221 atggcgccac aggacactaa agaagcctta aaaccaagat aatacgacca cctccaccca
     2281 atcctgatgt tcgcagggct gaagttaaca gagcacagac cacctttagt tagatgtggc
     2341 tttcagcctt ttagggaaag actcgaacaa attttcatct attcaagagc atgctgtttg
     2401 cagcactctt tatggtctcc taggagcata acttggaatg tacaggaata tttgtgtcct
     2461 aaaaaaatca gctgcccttc caatatcatt tttataacgt tatggtttaa ttcaagttat
     2521 acaaaggtgt gactcaagga tgtgcaggta ttgactgatg gaggccaaca aggaaaatat
     2581 tttttttcag tgagcccaga gaaattagaa atcttcacca atgtcagtga ctgcatggtt
     2641 tccaaaaatt cacatagtat tacctcacag taggaaggct tctttcccat ttaggctcag
     2701 agaacacttt tacagaaatc aaacctattt acagggtggc accccttttc tgtggcatct
     2761 gatctgtcat ctcccaagct cctgaagttc tttatccagg ttgtatcttt gctgagctga
     2821 caacagattt ctctatggat caaatattct aatcaaggaa agatacggtg aaacttcagt
     2881 cttcttctgg agaaatgctg aggcgagatt agtgcagcta cattctgagt tgaaggaaat
     2941 gcagtgttct gagggcccct ttgtgtcctg atggctggag gacgcttcct cctggttaga
     3001 tcctcaagct ccttgcctca ttgacaaatg tctcctagtc ccctttttcc ctctgactct
     3061 gaggaactaa atagcttgac tatctctaaa cagagactgg ccctgccact gaccctcctg
     3121 tccctctcat agcataccct gacagatact caatagaaaa cacctgcaga ccatgtgcac
     3181 acttaacttt cctgcccaac ctgcctcccc aacggcccat gctagaatag cttgtgccca
     3241 gaaaacaaac agtgacactt catctcttca gcgtcagaaa atgggcatag aatgtaccca
     3301 tgcaattgaa tgtatctcat tctccactgg catagtagat ataaactatt cctttgccta
     3361 ccttttactg ccttatcctg gaaatattgg ggaaaataag ccatatcagt gagatttacc
     3421 taaaaacaaa ggaaggaaag tcactatgga aaccaagtag atgctttttg taagtttggt
     3481 ggagcataac tggcccagaa gtctgggtgc ctgagttcta gttcgtgctc tgtcaactgg
     3541 tagatttgta attctaggtc ttggttttct tacctggtga ataagtcatg atctctaaaa
     3601 cccttcctgc ccttaatatt gtctgaattt caaggggaaa aaaaaaatct ggttccttta
     3661 attatttttt tttaacactt aaattcctaa ctttattaga caagaagtat ggcccactta
     3721 acagttaagg aacgtaaatt tgttattggc tcgaaataat aatttgacac aatactagtc
     3781 aaccatttag aggccttgga aaaagaagag gaacagcact gaaaattcca agtatgattg
     3841 gaaattatct gggagcgggg aattaaatat tcaatgcatg aaagcaattg tactggcttc
     3901 tgggaaaaag gaaacaagaa cattgctatg gaacttgtta cccagagaaa ggaagtgaaa
     3961 agatttacaa ttataagcac gaaattcatt ggcagattac ctgctttatc tacagacaga
     4021 ttgttttggg gtttggtttt gtctaggcag cctctggcca ggctccttaa ttgcttgctc
     4081 tgctaatatt tcagcttcct ctcttgactc cttgaggaac caaccgctct ttggaagaca
     4141 aacacttagc cacctctgtg ctccagggta accctgagaa gctctgctgt ctggggcaag
     4201 ctttctttcc aaagggaatg agaggaaggc aagcaggcag ggtcctgcag cgtcaggcct
     4261 tctggggaaa gtttcctcat tttgtttgac agggtcctca gtacatcaga cacccagatt
     4321 tgaatataag ttcagagcct gatctcaagc taaatcagaa tgctttgggg actaaccatg
     4381 atcgagaatt ggccaaatag tatggcatat aaacagccat ccagccagcc gcaagtaaag
     4441 gaacgtttga tccttggcac cttaaatgat tgattgcctt caataggcaa actgctggtc
     4501 tggaaatctc gttgaaggct gaatacttca tgcggagtag gacaagcctt agcccacctt
     4561 caggttgaaa ggaaaggcca taggactcaa aagataatga ctctgaaact aaactccttc
     4621 cttctgaagc tgacagaggt acttagtgca tctcaagact ccatctcata aaactcattt
     4681 gtgagggatt tgctctagat ttttctaaac attttttcat ctattgtcca gacttgcaaa
     4741 tccagtgtgg acctgatgga gatacccttc acacctgcgc tcccaccccc tcggcaggga
     4801 gacgtctcag tagaggagaa cacacccatt atgctgggat ttgtatttat aaatcacttc
     4861 ccttttaggg atgagcggtg tggggcgtgt gtgcgtgtga gtgtatgcgc gtgcgtgtgt
     4921 gaccctcaag tgtactttgc tcaatttaga cgtgcagtat ttccagaaac aatgaaaaaa
     4981 gtaagatgtt ttcttcttta tgattctgct caaaacacca cgtgccgcct cagagctttt
     5041 tctagagcct cggtcctcaa tgacgcgctt gacctgttga tgcctcagcc cagcgaagcc
     5101 cctcacctgt gccccgggcg acagctcttc agtgtgcagt gcaggcctgg ggtggactgc
     5161 caggccttcg ctctgtgcca gcaacgccgt tcttgttgct cctccatgaa caggggtaca
     5221 agccctggcc cctcctcgac actaagcccc ccacagactc agcctccaag gaaccgctga
     5281 gcacccttga agcatgtcat tgtcagtgat acctttttat tctatggaac tctaacctat
     5341 tcgtgtcata ttgacctttt gctgcatgag tcataaatta tgaaatcagt cttacagttt
     5401 ttgaaatgta gccagcattt gtaaggctaa acctttttca tgaactgaat ttaagtgaat
     5461 aaccaagcca cagttcctcc tcaaatggag agtgatgatc gacatttgaa tctctttgcc
     5521 ctttccaacg gctatggcat caggttctaa aataagctcg taatttttcc tgttatttta
     5581 ataatatgga aatattagca tagtgtttct tttgatagtg atagactata atccatattt
     5641 aaattttata gagaagaaat tttattgtac tgtgatgtag atatttatta tccaggtaag
     5701 gatttgcccg gtgtgtattt tttacaattg agacatttta ctttaatctt taaaaaaaat
     5761 gcattaaaaa cacactcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaacca gactggggga
     5821 aaaaaggttt ggccttatca cagaattttt actgtgctgt ataaatgttt gcaaatgcga
     5881 aaagtgtgca tttatagtgt gtttccacat taattaatgc cgccttcaag agcaatattg
     5941 tgcaggtaaa acgctgtttg tggctttctg ttgcacagtt aaagctgacc caccctatgc
     6001 acaagacaat caaatataaa tctgtcctcc tcaggatgca gataatactc atgtaaatta
     6061 tggagcacaa tgtaagacaa aaggagacac tttacatatg tattgttgat acagaaatta
     6121 tcagggcatg aatgagctga tgtgacatta tgccacttct ttcttttggt tctcccttat
     6181 taacttggca tttttaattt gaccatagag ccaaattagt tctccatgct ttcttcgtag
     6241 aaaatccttt tttttcccat aatgttttca tgccctgaga atcagaaaaa tactacagaa
     6301 tagaaaaaga tttacagtca ttggaagatt tgtgttttgc aaacagtgtt aagtgatatt
     6361 gctagatggt gatatttttt tcagcctaaa actctgttga aatctgtgat caaaatgttt
     6421 taaactatcc aaaaaaaatt tgtatatttg ggaaaaatgg atttttacat agcttttgta
     6481 tgcagatata aaactgtaat tatgaatata gtgggcgtag ataaactcat aagcttaaat
     6541 tctaaaaaag aaaaagctta taacagatat attttcctgt ctctttcttt aaatattatt
     6601 attttctaca taggcaaaga gttgcctgct cttctcactt cagctgctgc caaaagacgg
     6661 aaccacggat gtaaggacat ttatttcata aataaacatc tactagaata agcaaattta
     6721 cttgagaaga aactatggag ggagagaaga aactaagtaa aatgctgatg gggggttacc
     6781 tctttggaag gggccacaaa gatgaaggga ggagagaggt gaagttttgc agctcaagga
     6841 caacattcat cttctcatct caaattattc aggaatatta ctaatggaat tatgttaaca
     6901 tcagctgcca acatatatct caatctctgt tgccctgaac acatgttaat tgagattctt
     6961 tctatgacaa gtaacaaaaa gctaactcaa actggcttaa gcagaaagct aattattgac
     7021 tttaatatct gggatctagg gtattgcata ccaaagcttc aggcatggct ggatctgggt
     7081 gcacttactc agtattctca ggaagctcct ttttttgtca ttcatgtaga cttaacattc
     7141 acatggcctt tcaccttacg gtggcctcca atagctccag gatgagcttt acagctccaa
     7201 atatagtgaa aggagaattt cttttctcca acaattctaa tgaaaattct ggcctaattc
     7261 tcactggccc aagttcagtc atgtgcccat tcctgagcca atcactgtgg tgaggaaaac
     7321 agatgcataa ccaaccttat cctcaggaat cctggaactg ggtgagggga aagagggaca
     7381 gtcagcttca tctaaactat ggactgagag ttgaggcaag atgattcctg aaagaaaatt
     7441 ctaagtcttg ctgctataag tggaagagaa tggtgggcaa gcaaaagcaa ccagtgccca
     7501 caccaaaggt aaatctaaaa caacatccca tttcagtaca gcaagcggtt ctccttcaca
     7561 cagaggaagc tcatctccaa gtttttattt ggccaggaca tgaaccaaat aaacaccttc
     7621 caaagaaa
//
