LOCUS       XM_024453734            7570 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens thyroid hormone receptor beta (THRB),
            transcript variant X3, mRNA.
ACCESSION   XM_024453734
VERSION     XM_024453734.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000003.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_024453734.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7570
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
     gene            1..7570
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /note="thyroid hormone receptor beta; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 8
                     mRNAs, 3 ESTs, 432 long SRA reads, 8 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 27 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:7068"
                     /db_xref="HGNC:HGNC:11799"
                     /db_xref="MIM:190160"
     CDS             454..1839
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /codon_start=1
                     /product="thyroid hormone receptor beta isoform X1"
                     /protein_id="XP_024309502.1"
                     /db_xref="GeneID:7068"
                     /db_xref="HGNC:HGNC:11799"
                     /db_xref="MIM:190160"
                     /translation="MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSE
                     RRSTLKNEQSSPHLIQTTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLD
                     KDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQ
                     CQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEE
                     WELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKII
                     TPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEM
                     AVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERI
                     EKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTEL
                     FPPLFLEVFED"
ORIGIN      
        1 gcacatcctc gggcgggcgg ccgtgacgcg gcggggatta actttgcatg aataatatct
       61 gcgatttcct tctggttggc tgtcctgcgt gggtgccaag ttccacacat gatttaatga
      121 ataagaaggg ggcttggagg ctcatagcaa aggtccttga agagagcaag aaaaagtctt
      181 cccaggaaaa gtggacacct gagtgagtgt tacaacgaga aggggggcat cccaggcaag
      241 gcagctacca agcacaggtg tgaagctcgc cagagaggca aactccagca ttttatattt
      301 catctgcccc cagtgacttc actgtaggaa gaggaaatgc agaaaaacaa acgtcttgaa
      361 gactgaaagc ctgttattca aagaggttag cagtagactg ttggaagtaa ggagatgtca
      421 gtgaaaaaag ggatccagaa tgattactaa cctatgactc ccaacagtat gacagaaaat
      481 ggccttacag cctgggacaa accgaagcac tgtccagacc gagaacacga ctggaagcta
      541 gtaggaatgt ctgaagcctg cctacatagg aagagccatt cagagaggcg cagcacgttg
      601 aaaaatgaac agtcgtcgcc acatctcatc cagaccactt ggactagctc aatattccat
      661 ctggaccatg atgatgtgaa cgaccagagt gtctcaagtg cccagacctt ccaaacggag
      721 gagaagaaat gtaaagggta catccccagt tacttagaca aggacgagct ctgtgtagtg
      781 tgtggtgaca aagccaccgg gtatcactac cgctgtatca cgtgtgaagg ctgcaagggt
      841 ttctttagaa gaaccattca gaaaaatctc catccatcct attcctgtaa atatgaagga
      901 aaatgtgtca tagacaaagt cacgcgaaat cagtgccagg aatgtcgctt taagaaatgc
      961 atctatgttg gcatggcaac agatttggtg ctggatgaca gcaagaggct ggccaagagg
     1021 aagctgatag aggagaaccg ggagaaaaga cggcgggaag agctgcagaa gtccatcggg
     1081 cacaagccag agcccacaga cgaggaatgg gagctcatca aaactgtcac cgaagcccat
     1141 gtggcgacca acgcccaagg cagccactgg aagcaaaaac ggaaattcct gccagaagac
     1201 attggacaag caccaatagt caatgcccca gaaggtggaa aggttgactt ggaagccttc
     1261 agccatttta caaaaatcat cacaccagca attaccagag tggtggattt tgccaaaaag
     1321 ttgcctatgt tttgtgagct gccatgtgaa gaccagatca tcctcctcaa aggctgctgc
     1381 atggagatca tgtcccttcg cgctgctgtg cgctatgacc cagaaagtga gactttaacc
     1441 ttgaatgggg aaatggcagt gacacggggc cagctgaaaa atgggggtct tggggtggtg
     1501 tcagacgcca tctttgacct gggcatgtct ctgtcttctt tcaacctgga tgacactgaa
     1561 gtagccctcc ttcaggccgt cctgctgatg tcttcagatc gcccggggct tgcctgtgtt
     1621 gagagaatag aaaagtacca agatagtttc ctgctggcct ttgaacacta tatcaattac
     1681 cgaaaacacc acgtgacaca cttttggcca aaactcctga tgaaggtgac agatctgcgg
     1741 atgataggag cctgccatgc cagccgcttc ctgcacatga aggtggaatg ccccacagaa
     1801 ctcttccccc ctttgttctt ggaagtgttc gaggattaga ctgactggat tcattctcat
     1861 aattcctaca gcactactgg gtgtcatttc attccattgc ctagctcttt tttgtttgtt
     1921 tctttgtgtt gggagggatt atttgggagg gaaaagggaa gtagtccttg gcatagacat
     1981 ggatgaaatt gccccttgaa tgcgggtact tgaaactatt gcatttcgtt ctccggtcct
     2041 gtgatgtgaa tgctctgaag gttttatggt tgtggaggtg gggtggggga caatcattaa
     2101 ctcaccagca ccaagcatca ccagctccca cccgtccctg gtccaagact tgagtcagca
     2161 aaatggcgcc acaggacact aaagaagcct taaaaccaag ataatacgac cacctccacc
     2221 caatcctgat gttcgcaggg ctgaagttaa cagagcacag accaccttta gttagatgtg
     2281 gctttcagcc ttttagggaa agactcgaac aaattttcat ctattcaaga gcatgctgtt
     2341 tgcagcactc tttatggtct cctaggagca taacttggaa tgtacaggaa tatttgtgtc
     2401 ctaaaaaaat cagctgccct tccaatatca tttttataac gttatggttt aattcaagtt
     2461 atacaaaggt gtgactcaag gatgtgcagg tattgactga tggaggccaa caaggaaaat
     2521 attttttttc agtgagccca gagaaattag aaatcttcac caatgtcagt gactgcatgg
     2581 tttccaaaaa ttcacatagt attacctcac agtaggaagg cttctttccc atttaggctc
     2641 agagaacact tttacagaaa tcaaacctat ttacagggtg gcaccccttt tctgtggcat
     2701 ctgatctgtc atctcccaag ctcctgaagt tctttatcca ggttgtatct ttgctgagct
     2761 gacaacagat ttctctatgg atcaaatatt ctaatcaagg aaagatacgg tgaaacttca
     2821 gtcttcttct ggagaaatgc tgaggcgaga ttagtgcagc tacattctga gttgaaggaa
     2881 atgcagtgtt ctgagggccc ctttgtgtcc tgatggctgg aggacgcttc ctcctggtta
     2941 gatcctcaag ctccttgcct cattgacaaa tgtctcctag tccccttttt ccctctgact
     3001 ctgaggaact aaatagcttg actatctcta aacagagact ggccctgcca ctgaccctcc
     3061 tgtccctctc atagcatacc ctgacagata ctcaatagaa aacacctgca gaccatgtgc
     3121 acacttaact ttcctgccca acctgcctcc ccaacggccc atgctagaat agcttgtgcc
     3181 cagaaaacaa acagtgacac ttcatctctt cagcgtcaga aaatgggcat agaatgtacc
     3241 catgcaattg aatgtatctc attctccact ggcatagtag atataaacta ttcctttgcc
     3301 taccttttac tgccttatcc tggaaatatt ggggaaaata agccatatca gtgagattta
     3361 cctaaaaaca aaggaaggaa agtcactatg gaaaccaagt agatgctttt tgtaagtttg
     3421 gtggagcata actggcccag aagtctgggt gcctgagttc tagttcgtgc tctgtcaact
     3481 ggtagatttg taattctagg tcttggtttt cttacctggt gaataagtca tgatctctaa
     3541 aacccttcct gcccttaata ttgtctgaat ttcaagggga aaaaaaaaat ctggttcctt
     3601 taattatttt tttttaacac ttaaattcct aactttatta gacaagaagt atggcccact
     3661 taacagttaa ggaacgtaaa tttgttattg gctcgaaata ataatttgac acaatactag
     3721 tcaaccattt agaggccttg gaaaaagaag aggaacagca ctgaaaattc caagtatgat
     3781 tggaaattat ctgggagcgg ggaattaaat attcaatgca tgaaagcaat tgtactggct
     3841 tctgggaaaa aggaaacaag aacattgcta tggaacttgt tacccagaga aaggaagtga
     3901 aaagatttac aattataagc acgaaattca ttggcagatt acctgcttta tctacagaca
     3961 gattgttttg gggtttggtt ttgtctaggc agcctctggc caggctcctt aattgcttgc
     4021 tctgctaata tttcagcttc ctctcttgac tccttgagga accaaccgct ctttggaaga
     4081 caaacactta gccacctctg tgctccaggg taaccctgag aagctctgct gtctggggca
     4141 agctttcttt ccaaagggaa tgagaggaag gcaagcaggc agggtcctgc agcgtcaggc
     4201 cttctgggga aagtttcctc attttgtttg acagggtcct cagtacatca gacacccaga
     4261 tttgaatata agttcagagc ctgatctcaa gctaaatcag aatgctttgg ggactaacca
     4321 tgatcgagaa ttggccaaat agtatggcat ataaacagcc atccagccag ccgcaagtaa
     4381 aggaacgttt gatccttggc accttaaatg attgattgcc ttcaataggc aaactgctgg
     4441 tctggaaatc tcgttgaagg ctgaatactt catgcggagt aggacaagcc ttagcccacc
     4501 ttcaggttga aaggaaaggc cataggactc aaaagataat gactctgaaa ctaaactcct
     4561 tccttctgaa gctgacagag gtacttagtg catctcaaga ctccatctca taaaactcat
     4621 ttgtgaggga tttgctctag atttttctaa acattttttc atctattgtc cagacttgca
     4681 aatccagtgt ggacctgatg gagataccct tcacacctgc gctcccaccc cctcggcagg
     4741 gagacgtctc agtagaggag aacacaccca ttatgctggg atttgtattt ataaatcact
     4801 tcccttttag ggatgagcgg tgtggggcgt gtgtgcgtgt gagtgtatgc gcgtgcgtgt
     4861 gtgaccctca agtgtacttt gctcaattta gacgtgcagt atttccagaa acaatgaaaa
     4921 aagtaagatg ttttcttctt tatgattctg ctcaaaacac cacgtgccgc ctcagagctt
     4981 tttctagagc ctcggtcctc aatgacgcgc ttgacctgtt gatgcctcag cccagcgaag
     5041 cccctcacct gtgccccggg cgacagctct tcagtgtgca gtgcaggcct ggggtggact
     5101 gccaggcctt cgctctgtgc cagcaacgcc gttcttgttg ctcctccatg aacaggggta
     5161 caagccctgg cccctcctcg acactaagcc ccccacagac tcagcctcca aggaaccgct
     5221 gagcaccctt gaagcatgtc attgtcagtg ataccttttt attctatgga actctaacct
     5281 attcgtgtca tattgacctt ttgctgcatg agtcataaat tatgaaatca gtcttacagt
     5341 ttttgaaatg tagccagcat ttgtaaggct aaaccttttt catgaactga atttaagtga
     5401 ataaccaagc cacagttcct cctcaaatgg agagtgatga tcgacatttg aatctctttg
     5461 ccctttccaa cggctatggc atcaggttct aaaataagct cgtaattttt cctgttattt
     5521 taataatatg gaaatattag catagtgttt cttttgatag tgatagacta taatccatat
     5581 ttaaatttta tagagaagaa attttattgt actgtgatgt agatatttat tatccaggta
     5641 aggatttgcc cggtgtgtat tttttacaat tgagacattt tactttaatc tttaaaaaaa
     5701 atgcattaaa aacacactca aaaaaaaaaa aaaaaaaaaa aaaaaaaaac cagactgggg
     5761 gaaaaaaggt ttggccttat cacagaattt ttactgtgct gtataaatgt ttgcaaatgc
     5821 gaaaagtgtg catttatagt gtgtttccac attaattaat gccgccttca agagcaatat
     5881 tgtgcaggta aaacgctgtt tgtggctttc tgttgcacag ttaaagctga cccaccctat
     5941 gcacaagaca atcaaatata aatctgtcct cctcaggatg cagataatac tcatgtaaat
     6001 tatggagcac aatgtaagac aaaaggagac actttacata tgtattgttg atacagaaat
     6061 tatcagggca tgaatgagct gatgtgacat tatgccactt ctttcttttg gttctccctt
     6121 attaacttgg catttttaat ttgaccatag agccaaatta gttctccatg ctttcttcgt
     6181 agaaaatcct tttttttccc ataatgtttt catgccctga gaatcagaaa aatactacag
     6241 aatagaaaaa gatttacagt cattggaaga tttgtgtttt gcaaacagtg ttaagtgata
     6301 ttgctagatg gtgatatttt tttcagccta aaactctgtt gaaatctgtg atcaaaatgt
     6361 tttaaactat ccaaaaaaaa tttgtatatt tgggaaaaat ggatttttac atagcttttg
     6421 tatgcagata taaaactgta attatgaata tagtgggcgt agataaactc ataagcttaa
     6481 attctaaaaa agaaaaagct tataacagat atattttcct gtctctttct ttaaatatta
     6541 ttattttcta cataggcaaa gagttgcctg ctcttctcac ttcagctgct gccaaaagac
     6601 ggaaccacgg atgtaaggac atttatttca taaataaaca tctactagaa taagcaaatt
     6661 tacttgagaa gaaactatgg agggagagaa gaaactaagt aaaatgctga tggggggtta
     6721 cctctttgga aggggccaca aagatgaagg gaggagagag gtgaagtttt gcagctcaag
     6781 gacaacattc atcttctcat ctcaaattat tcaggaatat tactaatgga attatgttaa
     6841 catcagctgc caacatatat ctcaatctct gttgccctga acacatgtta attgagattc
     6901 tttctatgac aagtaacaaa aagctaactc aaactggctt aagcagaaag ctaattattg
     6961 actttaatat ctgggatcta gggtattgca taccaaagct tcaggcatgg ctggatctgg
     7021 gtgcacttac tcagtattct caggaagctc ctttttttgt cattcatgta gacttaacat
     7081 tcacatggcc tttcacctta cggtggcctc caatagctcc aggatgagct ttacagctcc
     7141 aaatatagtg aaaggagaat ttcttttctc caacaattct aatgaaaatt ctggcctaat
     7201 tctcactggc ccaagttcag tcatgtgccc attcctgagc caatcactgt ggtgaggaaa
     7261 acagatgcat aaccaacctt atcctcagga atcctggaac tgggtgaggg gaaagaggga
     7321 cagtcagctt catctaaact atggactgag agttgaggca agatgattcc tgaaagaaaa
     7381 ttctaagtct tgctgctata agtggaagag aatggtgggc aagcaaaagc aaccagtgcc
     7441 cacaccaaag gtaaatctaa aacaacatcc catttcagta cagcaagcgg ttctccttca
     7501 cacagaggaa gctcatctcc aagtttttat ttggccagga catgaaccaa ataaacacct
     7561 tccaaagaaa
//
