LOCUS       NM_001374826            7532 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens thyroid hormone receptor beta (THRB), transcript
            variant 17, mRNA.
ACCESSION   NM_001374826
VERSION     NM_001374826.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7532)
  AUTHORS   Salas-Lucia,F., Stan,M.N., James,H., Rajwani,A., Liao,X.H.,
            Dumitrescu,A.M. and Refetoff,S.
  TITLE     Effect of the Fetal THRB Genotype on the Placenta
  JOURNAL   J Clin Endocrinol Metab 108 (10), e944-e948 (2023)
   PUBMED   37149816
  REMARK    GeneRIF: Effect of the Fetal THRB Genotype on the Placenta.
REFERENCE   2  (bases 1 to 7532)
  AUTHORS   Copur,S., Yavuz,F. and Kanbay,M.
  TITLE     Thyroid hormone Beta receptor agonists for treatment of kidney
            disease: A promising agent?
  JOURNAL   Eur J Clin Invest 53 (5), e13939 (2023)
   PUBMED   36537819
  REMARK    GeneRIF: Thyroid hormone Beta receptor agonists for treatment of
            kidney disease: A promising agent?
            Review article
REFERENCE   3  (bases 1 to 7532)
  AUTHORS   Ng,L., Liu,H., Liu,Y. and Forrest,D.
  TITLE     Biphasic expression of thyroid hormone receptor TRbeta1 in
            mammalian retina and anterior ocular tissues
  JOURNAL   Front Endocrinol (Lausanne) 14, 1174600 (2023)
   PUBMED   37033230
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7532)
  AUTHORS   Lai,H.P. and Chen,M.H.
  TITLE     Atrial Fibrillation with Heart Failure in a Case with Resistance to
            Thyroid Hormone Due to a Rare Thyroid Hormone Receptor beta Gene
            Mutation
  JOURNAL   Int J Mol Sci 23 (23), 15241 (2022)
   PUBMED   36499571
  REMARK    GeneRIF: Atrial Fibrillation with Heart Failure in a Case with
            Resistance to Thyroid Hormone Due to a Rare Thyroid Hormone
            Receptor beta Gene Mutation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7532)
  AUTHORS   Cui,B., Xiao,X., Wang,J., Wang,H., Wu,C., Yan,Y., Zheng,J.,
            Wang,J., Zong,Y., Zhang,Y., Hui,R., Gerdes,A.M. and Wang,Y.
  TITLE     Low THRB (thyroid hormone receptor beta) Promoter Methylation
            Levels in Peripheral Blood Leukocytes Induced By Systematic
            Inflammation Are Involved in Low Thyroid Hormone Function in
            Metabolic Syndrome
  JOURNAL   Hypertension 78 (4), 1005-1015 (2021)
   PUBMED   34397273
  REMARK    GeneRIF: Low THRB (thyroid hormone receptor beta) Promoter
            Methylation Levels in Peripheral Blood Leukocytes Induced By
            Systematic Inflammation Are Involved in Low Thyroid Hormone
            Function in Metabolic Syndrome.
REFERENCE   6  (bases 1 to 7532)
  AUTHORS   Falcone,M., Miyamoto,T., Fierro-Renoy,F., Macchia,E. and
            DeGroot,L.J.
  TITLE     Antipeptide polyclonal antibodies specifically recognize each human
            thyroid hormone receptor isoform
  JOURNAL   Endocrinology 131 (5), 2419-2429 (1992)
   PUBMED   1425440
REFERENCE   7  (bases 1 to 7532)
  AUTHORS   Behr,M. and Loos,U.
  TITLE     A point mutation (Ala229 to Thr) in the hinge domain of the c-erbA
            beta thyroid hormone receptor gene in a family with generalized
            thyroid hormone resistance
  JOURNAL   Mol Endocrinol 6 (7), 1119-1126 (1992)
   PUBMED   1324420
REFERENCE   8  (bases 1 to 7532)
  AUTHORS   Cugini,C.D. Jr., Leidy,J.W. Jr., Chertow,B.S., Berard,J.,
            Bradley,W.E., Menke,J.B., Hao,E.H. and Usala,S.J.
  TITLE     An arginine to histidine mutation in codon 315 of the c-erbA beta
            thyroid hormone receptor in a kindred with generalized resistance
            to thyroid hormones results in a receptor with significant
            3,5,3'-triiodothyronine binding activity
  JOURNAL   J Clin Endocrinol Metab 74 (5), 1164-1170 (1992)
   PUBMED   1314846
REFERENCE   9  (bases 1 to 7532)
  AUTHORS   Schmidt,E.D., Schmidt,E.D., van der Gaag,R., Ganpat,R.,
            Broersma,L., de Boer,P.A., Moorman,A.F., Lamers,W.H.,
            Wiersinga,W.M. and Koornneef,L.
  TITLE     Distribution of the nuclear thyroid-hormone receptor in extraocular
            and skeletal muscles
  JOURNAL   J Endocrinol 133 (1), 67-74 (1992)
   PUBMED   1517709
REFERENCE   10 (bases 1 to 7532)
  AUTHORS   Adams,M., Nagaya,T., Tone,Y., Jameson,J.L. and Chatterjee,V.K.
  TITLE     Functional properties of a novel mutant thyroid hormone receptor in
            a family with generalized thyroid hormone resistance syndrome
  JOURNAL   Clin Endocrinol (Oxf) 36 (3), 281-289 (1992)
   PUBMED   1563081
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC012087.10, AC099054.2,
            AC093927.3 and AC098971.2.
            
            Summary: The protein encoded by this gene is a nuclear hormone
            receptor for triiodothyronine. It is one of the several receptors
            for thyroid hormone, and has been shown to mediate the biological
            activities of thyroid hormone. Knockout studies in mice suggest
            that the different receptors, while having certain extent of
            redundancy, may mediate different functions of thyroid hormone.
            Mutations in this gene are known to be a cause of generalized
            thyroid hormone resistance (GTHR), a syndrome characterized by
            goiter and high levels of circulating thyroid hormone (T3-T4), with
            normal or slightly elevated thyroid stimulating hormone (TSH).
            Several alternatively spliced transcript variants encoding the same
            protein have been observed for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (17), as well as variants 1-10 and
            13-16, encodes isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.2791512.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               AC012087.10        124144-124307
            165-236             AC099054.2         46606-46677
            237-373             AC099054.2         65483-65619
            374-437             AC093927.3         70721-70784
            438-698             AC093927.3         109388-109648
            699-799             AC093927.3         147232-147332
            800-947             AC098971.2         171345-171492       c
            948-1153            AC098971.2         168171-168376       c
            1154-1300           AC098971.2         157986-158132       c
            1301-1559           AC098971.2         152169-152427       c
            1560-7532           AC098971.2         141823-147795       c
FEATURES             Location/Qualifiers
     source          1..7532
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p24.2"
     gene            1..7532
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /note="thyroid hormone receptor beta"
                     /db_xref="GeneID:7068"
                     /db_xref="HGNC:HGNC:11799"
                     /db_xref="MIM:190160"
     exon            1..164
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            165..236
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            237..373
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            374..437
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /inference="alignment:Splign:2.1.0"
     CDS             416..1801
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /note="isoform a is encoded by transcript variant 17;
                     oncogene ERBA2; nuclear receptor subfamily 1 group A
                     member 2; thyroid hormone receptor, beta (erythroblastic
                     leukemia viral (v-erb-a) oncogene homolog 2, avian)"
                     /codon_start=1
                     /product="thyroid hormone receptor beta isoform a"
                     /protein_id="NP_001361755.1"
                     /db_xref="CCDS:CCDS2641.1"
                     /db_xref="GeneID:7068"
                     /db_xref="HGNC:HGNC:11799"
                     /db_xref="MIM:190160"
                     /translation="MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSE
                     RRSTLKNEQSSPHLIQTTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLD
                     KDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQ
                     CQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEE
                     WELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKII
                     TPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEM
                     AVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERI
                     EKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTEL
                     FPPLFLEVFED"
     exon            438..698
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            699..799
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            800..947
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1153
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1300
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1559
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..7532
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6452..6457
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /note="hexamer: AAGAAA"
     polyA_site      6471
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /note="major polyA site"
     regulatory      6595..6600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /note="hexamer: AATAAA"
     polyA_site      6620
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
     regulatory      7512..7517
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /note="hexamer: AATAAA"
     polyA_site      7532
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
ORIGIN      
        1 gcacatcctc gggcgggcgg ccgtgacgcg gcggggatta actttgcatg aataatgtga
       61 gtgcgcttgg aaaagagacc tcctgctccg cgggctcggg gcaagagccc gcaggctacc
      121 ttccccgggc aggggcgctc aacccaaccg gctccagggc actgatctgc gatttccttc
      181 tggttggctg tcctgcgtgg gtgccaagtt ccacacatga tttaatgaat aagaaggggg
      241 cttggaggct catagcaaag gtccttgaag agagcaagaa aaagtcttcc caggaaaagt
      301 ggacacctga gtgagtgtta caacgagaag gggggcatcc caggcaaggc agctaccaag
      361 cacaggtgtg aaggagatgt cagtgaaaaa agggatccag aatgattact aacctatgac
      421 tcccaacagt atgacagaaa atggccttac agcctgggac aaaccgaagc actgtccaga
      481 ccgagaacac gactggaagc tagtaggaat gtctgaagcc tgcctacata ggaagagcca
      541 ttcagagagg cgcagcacgt tgaaaaatga acagtcgtcg ccacatctca tccagaccac
      601 ttggactagc tcaatattcc atctggacca tgatgatgtg aacgaccaga gtgtctcaag
      661 tgcccagacc ttccaaacgg aggagaagaa atgtaaaggg tacatcccca gttacttaga
      721 caaggacgag ctctgtgtag tgtgtggtga caaagccacc gggtatcact accgctgtat
      781 cacgtgtgaa ggctgcaagg gtttctttag aagaaccatt cagaaaaatc tccatccatc
      841 ctattcctgt aaatatgaag gaaaatgtgt catagacaaa gtcacgcgaa atcagtgcca
      901 ggaatgtcgc tttaagaaat gcatctatgt tggcatggca acagatttgg tgctggatga
      961 cagcaagagg ctggccaaga ggaagctgat agaggagaac cgggagaaaa gacggcggga
     1021 agagctgcag aagtccatcg ggcacaagcc agagcccaca gacgaggaat gggagctcat
     1081 caaaactgtc accgaagccc atgtggcgac caacgcccaa ggcagccact ggaagcaaaa
     1141 acggaaattc ctgccagaag acattggaca agcaccaata gtcaatgccc cagaaggtgg
     1201 aaaggttgac ttggaagcct tcagccattt tacaaaaatc atcacaccag caattaccag
     1261 agtggtggat tttgccaaaa agttgcctat gttttgtgag ctgccatgtg aagaccagat
     1321 catcctcctc aaaggctgct gcatggagat catgtccctt cgcgctgctg tgcgctatga
     1381 cccagaaagt gagactttaa ccttgaatgg ggaaatggca gtgacacggg gccagctgaa
     1441 aaatgggggt cttggggtgg tgtcagacgc catctttgac ctgggcatgt ctctgtcttc
     1501 tttcaacctg gatgacactg aagtagccct ccttcaggcc gtcctgctga tgtcttcaga
     1561 tcgcccgggg cttgcctgtg ttgagagaat agaaaagtac caagatagtt tcctgctggc
     1621 ctttgaacac tatatcaatt accgaaaaca ccacgtgaca cacttttggc caaaactcct
     1681 gatgaaggtg acagatctgc ggatgatagg agcctgccat gccagccgct tcctgcacat
     1741 gaaggtggaa tgccccacag aactcttccc ccctttgttc ttggaagtgt tcgaggatta
     1801 gactgactgg attcattctc ataattccta cagcactact gggtgtcatt tcattccatt
     1861 gcctagctct tttttgtttg tttctttgtg ttgggaggga ttatttggga gggaaaaggg
     1921 aagtagtcct tggcatagac atggatgaaa ttgccccttg aatgcgggta cttgaaacta
     1981 ttgcatttcg ttctccggtc ctgtgatgtg aatgctctga aggttttatg gttgtggagg
     2041 tggggtgggg gacaatcatt aactcaccag caccaagcat caccagctcc cacccgtccc
     2101 tggtccaaga cttgagtcag caaaatggcg ccacaggaca ctaaagaagc cttaaaacca
     2161 agataatacg accacctcca cccaatcctg atgttcgcag ggctgaagtt aacagagcac
     2221 agaccacctt tagttagatg tggctttcag ccttttaggg aaagactcga acaaattttc
     2281 atctattcaa gagcatgctg tttgcagcac tctttatggt ctcctaggag cataacttgg
     2341 aatgtacagg aatatttgtg tcctaaaaaa atcagctgcc cttccaatat catttttata
     2401 acgttatggt ttaattcaag ttatacaaag gtgtgactca aggatgtgca ggtattgact
     2461 gatggaggcc aacaaggaaa atattttttt tcagtgagcc cagagaaatt agaaatcttc
     2521 accaatgtca gtgactgcat ggtttccaaa aattcacata gtattacctc acagtaggaa
     2581 ggcttctttc ccatttaggc tcagagaaca cttttacaga aatcaaacct atttacaggg
     2641 tggcacccct tttctgtggc atctgatctg tcatctccca agctcctgaa gttctttatc
     2701 caggttgtat ctttgctgag ctgacaacag atttctctat ggatcaaata ttctaatcaa
     2761 ggaaagatac ggtgaaactt cagtcttctt ctggagaaat gctgaggcga gattagtgca
     2821 gctacattct gagttgaagg aaatgcagtg ttctgagggc ccctttgtgt cctgatggct
     2881 ggaggacgct tcctcctggt tagatcctca agctccttgc ctcattgaca aatgtctcct
     2941 agtccccttt ttccctctga ctctgaggaa ctaaatagct tgactatctc taaacagaga
     3001 ctggccctgc cactgaccct cctgtccctc tcatagcata ccctgacaga tactcaatag
     3061 aaaacacctg cagaccatgt gcacacttaa ctttcctgcc caacctgcct ccccaacggc
     3121 ccatgctaga atagcttgtg cccagaaaac aaacagtgac acttcatctc ttcagcgtca
     3181 gaaaatgggc atagaatgta cccatgcaat tgaatgtatc tcattctcca ctggcatagt
     3241 agatataaac tattcctttg cctacctttt actgccttat cctggaaata ttggggaaaa
     3301 taagccatat cagtgagatt tacctaaaaa caaaggaagg aaagtcacta tggaaaccaa
     3361 gtagatgctt tttgtaagtt tggtggagca taactggccc agaagtctgg gtgcctgagt
     3421 tctagttcgt gctctgtcaa ctggtagatt tgtaattcta ggtcttggtt ttcttacctg
     3481 gtgaataagt catgatctct aaaacccttc ctgcccttaa tattgtctga atttcaaggg
     3541 gaaaaaaaaa atctggttcc tttaattatt tttttttaac acttaaattc ctaactttat
     3601 tagacaagaa gtatggccca cttaacagtt aaggaacgta aatttgttat tggctcgaaa
     3661 taataatttg acacaatact agtcaaccat ttagaggcct tggaaaaaga agaggaacag
     3721 cactgaaaat tccaagtatg attggaaatt atctgggagc ggggaattaa atattcaatg
     3781 catgaaagca attgtactgg cttctgggaa aaaggaaaca agaacattgc tatggaactt
     3841 gttacccaga gaaaggaagt gaaaagattt acaattataa gcacgaaatt cattggcaga
     3901 ttacctgctt tatctacaga cagattgttt tggggtttgg ttttgtctag gcagcctctg
     3961 gccaggctcc ttaattgctt gctctgctaa tatttcagct tcctctcttg actccttgag
     4021 gaaccaaccg ctctttggaa gacaaacact tagccacctc tgtgctccag ggtaaccctg
     4081 agaagctctg ctgtctgggg caagctttct ttccaaaggg aatgagagga aggcaagcag
     4141 gcagggtcct gcagcgtcag gccttctggg gaaagtttcc tcattttgtt tgacagggtc
     4201 ctcagtacat cagacaccca gatttgaata taagttcaga gcctgatctc aagctaaatc
     4261 agaatgcttt ggggactaac catgatcgag aattggccaa atagtatggc atataaacag
     4321 ccatccagcc agccgcaagt aaaggaacgt ttgatccttg gcaccttaaa tgattgattg
     4381 ccttcaatag gcaaactgct ggtctggaaa tctcgttgaa ggctgaatac ttcatgcgga
     4441 gtaggacaag ccttagccca ccttcaggtt gaaaggaaag gccataggac tcaaaagata
     4501 atgactctga aactaaactc cttccttctg aagctgacag aggtacttag tgcatctcaa
     4561 gactccatct cataaaactc atttgtgagg gatttgctct agatttttct aaacattttt
     4621 tcatctattg tccagacttg caaatccagt gtggacctga tggagatacc cttcacacct
     4681 gcgctcccac cccctcggca gggagacgtc tcagtagagg agaacacacc cattatgctg
     4741 ggatttgtat ttataaatca cttccctttt agggatgagc ggtgtggggc gtgtgtgcgt
     4801 gtgagtgtat gcgcgtgcgt gtgtgaccct caagtgtact ttgctcaatt tagacgtgca
     4861 gtatttccag aaacaatgaa aaaagtaaga tgttttcttc tttatgattc tgctcaaaac
     4921 accacgtgcc gcctcagagc tttttctaga gcctcggtcc tcaatgacgc gcttgacctg
     4981 ttgatgcctc agcccagcga agcccctcac ctgtgccccg ggcgacagct cttcagtgtg
     5041 cagtgcaggc ctggggtgga ctgccaggcc ttcgctctgt gccagcaacg ccgttcttgt
     5101 tgctcctcca tgaacagggg tacaagccct ggcccctcct cgacactaag ccccccacag
     5161 actcagcctc caaggaaccg ctgagcaccc ttgaagcatg tcattgtcag tgataccttt
     5221 ttattctatg gaactctaac ctattcgtgt catattgacc ttttgctgca tgagtcataa
     5281 attatgaaat cagtcttaca gtttttgaaa tgtagccagc atttgtaagg ctaaaccttt
     5341 ttcatgaact gaatttaagt gaataaccaa gccacagttc ctcctcaaat ggagagtgat
     5401 gatcgacatt tgaatctctt tgccctttcc aacggctatg gcatcaggtt ctaaaataag
     5461 ctcgtaattt ttcctgttat tttaataata tggaaatatt agcatagtgt ttcttttgat
     5521 agtgatagac tataatccat atttaaattt tatagagaag aaattttatt gtactgtgat
     5581 gtagatattt attatccagg taaggatttg cccggtgtgt attttttaca attgagacat
     5641 tttactttaa tctttaaaaa aaatgcatta aaaacacact caaaaaaaaa aaaaaaaaaa
     5701 aaaaaaaaaa accagactgg gggaaaaaag gtttggcctt atcacagaat ttttactgtg
     5761 ctgtataaat gtttgcaaat gcgaaaagtg tgcatttata gtgtgtttcc acattaatta
     5821 atgccgcctt caagagcaat attgtgcagg taaaacgctg tttgtggctt tctgttgcac
     5881 agttaaagct gacccaccct atgcacaaga caatcaaata taaatctgtc ctcctcagga
     5941 tgcagataat actcatgtaa attatggagc acaatgtaag acaaaaggag acactttaca
     6001 tatgtattgt tgatacagaa attatcaggg catgaatgag ctgatgtgac attatgccac
     6061 ttctttcttt tggttctccc ttattaactt ggcattttta atttgaccat agagccaaat
     6121 tagttctcca tgctttcttc gtagaaaatc cttttttttc ccataatgtt ttcatgccct
     6181 gagaatcaga aaaatactac agaatagaaa aagatttaca gtcattggaa gatttgtgtt
     6241 ttgcaaacag tgttaagtga tattgctaga tggtgatatt tttttcagcc taaaactctg
     6301 ttgaaatctg tgatcaaaat gttttaaact atccaaaaaa aatttgtata tttgggaaaa
     6361 atggattttt acatagcttt tgtatgcaga tataaaactg taattatgaa tatagtgggc
     6421 gtagataaac tcataagctt aaattctaaa aaagaaaaag cttataacag atatattttc
     6481 ctgtctcttt ctttaaatat tattattttc tacataggca aagagttgcc tgctcttctc
     6541 acttcagctg ctgccaaaag acggaaccac ggatgtaagg acatttattt cataaataaa
     6601 catctactag aataagcaaa tttacttgag aagaaactat ggagggagag aagaaactaa
     6661 gtaaaatgct gatggggggt tacctctttg gaaggggcca caaagatgaa gggaggagag
     6721 aggtgaagtt ttgcagctca aggacaacat tcatcttctc atctcaaatt attcaggaat
     6781 attactaatg gaattatgtt aacatcagct gccaacatat atctcaatct ctgttgccct
     6841 gaacacatgt taattgagat tctttctatg acaagtaaca aaaagctaac tcaaactggc
     6901 ttaagcagaa agctaattat tgactttaat atctgggatc tagggtattg cataccaaag
     6961 cttcaggcat ggctggatct gggtgcactt actcagtatt ctcaggaagc tccttttttt
     7021 gtcattcatg tagacttaac attcacatgg cctttcacct tacggtggcc tccaatagct
     7081 ccaggatgag ctttacagct ccaaatatag tgaaaggaga atttcttttc tccaacaatt
     7141 ctaatgaaaa ttctggccta attctcactg gcccaagttc agtcatgtgc ccattcctga
     7201 gccaatcact gtggtgagga aaacagatgc ataaccaacc ttatcctcag gaatcctgga
     7261 actgggtgag gggaaagagg gacagtcagc ttcatctaaa ctatggactg agagttgagg
     7321 caagatgatt cctgaaagaa aattctaagt cttgctgcta taagtggaag agaatggtgg
     7381 gcaagcaaaa gcaaccagtg cccacaccaa aggtaaatct aaaacaacat cccatttcag
     7441 tacagcaagc ggttctcctt cacacagagg aagctcatct ccaagttttt atttggccag
     7501 gacatgaacc aaataaacac cttccaaaga aa
//
