LOCUS       NM_001354711            7287 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens thyroid hormone receptor beta (THRB), transcript
            variant 8, mRNA.
ACCESSION   NM_001354711 XM_005265423
VERSION     NM_001354711.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7287)
  AUTHORS   Salas-Lucia,F., Stan,M.N., James,H., Rajwani,A., Liao,X.H.,
            Dumitrescu,A.M. and Refetoff,S.
  TITLE     Effect of the Fetal THRB Genotype on the Placenta
  JOURNAL   J Clin Endocrinol Metab 108 (10), e944-e948 (2023)
   PUBMED   37149816
  REMARK    GeneRIF: Effect of the Fetal THRB Genotype on the Placenta.
REFERENCE   2  (bases 1 to 7287)
  AUTHORS   Copur,S., Yavuz,F. and Kanbay,M.
  TITLE     Thyroid hormone Beta receptor agonists for treatment of kidney
            disease: A promising agent?
  JOURNAL   Eur J Clin Invest 53 (5), e13939 (2023)
   PUBMED   36537819
  REMARK    GeneRIF: Thyroid hormone Beta receptor agonists for treatment of
            kidney disease: A promising agent?
            Review article
REFERENCE   3  (bases 1 to 7287)
  AUTHORS   Ng,L., Liu,H., Liu,Y. and Forrest,D.
  TITLE     Biphasic expression of thyroid hormone receptor TRbeta1 in
            mammalian retina and anterior ocular tissues
  JOURNAL   Front Endocrinol (Lausanne) 14, 1174600 (2023)
   PUBMED   37033230
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7287)
  AUTHORS   Lai,H.P. and Chen,M.H.
  TITLE     Atrial Fibrillation with Heart Failure in a Case with Resistance to
            Thyroid Hormone Due to a Rare Thyroid Hormone Receptor beta Gene
            Mutation
  JOURNAL   Int J Mol Sci 23 (23), 15241 (2022)
   PUBMED   36499571
  REMARK    GeneRIF: Atrial Fibrillation with Heart Failure in a Case with
            Resistance to Thyroid Hormone Due to a Rare Thyroid Hormone
            Receptor beta Gene Mutation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7287)
  AUTHORS   Cui,B., Xiao,X., Wang,J., Wang,H., Wu,C., Yan,Y., Zheng,J.,
            Wang,J., Zong,Y., Zhang,Y., Hui,R., Gerdes,A.M. and Wang,Y.
  TITLE     Low THRB (thyroid hormone receptor beta) Promoter Methylation
            Levels in Peripheral Blood Leukocytes Induced By Systematic
            Inflammation Are Involved in Low Thyroid Hormone Function in
            Metabolic Syndrome
  JOURNAL   Hypertension 78 (4), 1005-1015 (2021)
   PUBMED   34397273
  REMARK    GeneRIF: Low THRB (thyroid hormone receptor beta) Promoter
            Methylation Levels in Peripheral Blood Leukocytes Induced By
            Systematic Inflammation Are Involved in Low Thyroid Hormone
            Function in Metabolic Syndrome.
REFERENCE   6  (bases 1 to 7287)
  AUTHORS   Falcone,M., Miyamoto,T., Fierro-Renoy,F., Macchia,E. and
            DeGroot,L.J.
  TITLE     Antipeptide polyclonal antibodies specifically recognize each human
            thyroid hormone receptor isoform
  JOURNAL   Endocrinology 131 (5), 2419-2429 (1992)
   PUBMED   1425440
REFERENCE   7  (bases 1 to 7287)
  AUTHORS   Behr,M. and Loos,U.
  TITLE     A point mutation (Ala229 to Thr) in the hinge domain of the c-erbA
            beta thyroid hormone receptor gene in a family with generalized
            thyroid hormone resistance
  JOURNAL   Mol Endocrinol 6 (7), 1119-1126 (1992)
   PUBMED   1324420
REFERENCE   8  (bases 1 to 7287)
  AUTHORS   Cugini,C.D. Jr., Leidy,J.W. Jr., Chertow,B.S., Berard,J.,
            Bradley,W.E., Menke,J.B., Hao,E.H. and Usala,S.J.
  TITLE     An arginine to histidine mutation in codon 315 of the c-erbA beta
            thyroid hormone receptor in a kindred with generalized resistance
            to thyroid hormones results in a receptor with significant
            3,5,3'-triiodothyronine binding activity
  JOURNAL   J Clin Endocrinol Metab 74 (5), 1164-1170 (1992)
   PUBMED   1314846
REFERENCE   9  (bases 1 to 7287)
  AUTHORS   Schmidt,E.D., Schmidt,E.D., van der Gaag,R., Ganpat,R.,
            Broersma,L., de Boer,P.A., Moorman,A.F., Lamers,W.H.,
            Wiersinga,W.M. and Koornneef,L.
  TITLE     Distribution of the nuclear thyroid-hormone receptor in extraocular
            and skeletal muscles
  JOURNAL   J Endocrinol 133 (1), 67-74 (1992)
   PUBMED   1517709
REFERENCE   10 (bases 1 to 7287)
  AUTHORS   Adams,M., Nagaya,T., Tone,Y., Jameson,J.L. and Chatterjee,V.K.
  TITLE     Functional properties of a novel mutant thyroid hormone receptor in
            a family with generalized thyroid hormone resistance syndrome
  JOURNAL   Clin Endocrinol (Oxf) 36 (3), 281-289 (1992)
   PUBMED   1563081
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC012087.10, AC099054.2,
            AC093927.3 and AC098971.2.
            
            On Jun 3, 2019 this sequence version replaced NM_001354711.1.
            
            Summary: The protein encoded by this gene is a nuclear hormone
            receptor for triiodothyronine. It is one of the several receptors
            for thyroid hormone, and has been shown to mediate the biological
            activities of thyroid hormone. Knockout studies in mice suggest
            that the different receptors, while having certain extent of
            redundancy, may mediate different functions of thyroid hormone.
            Mutations in this gene are known to be a cause of generalized
            thyroid hormone resistance (GTHR), a syndrome characterized by
            goiter and high levels of circulating thyroid hormone (T3-T4), with
            normal or slightly elevated thyroid stimulating hormone (TSH).
            Several alternatively spliced transcript variants encoding the same
            protein have been observed for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (8) differs in the 5' UTR compared
            to variant 1. Variants 1-10 all encode the same isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.240981.1,
                                           SRR1660807.3963.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AC012087.10        124144-124199
            57-128              AC099054.2         46606-46677
            129-192             AC093927.3         70721-70784
            193-453             AC093927.3         109388-109648
            454-554             AC093927.3         147232-147332
            555-702             AC098971.2         171345-171492       c
            703-908             AC098971.2         168171-168376       c
            909-1055            AC098971.2         157986-158132       c
            1056-1314           AC098971.2         152169-152427       c
            1315-7287           AC098971.2         141823-147795       c
FEATURES             Location/Qualifiers
     source          1..7287
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p24.2"
     gene            1..7287
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /note="thyroid hormone receptor beta"
                     /db_xref="GeneID:7068"
                     /db_xref="HGNC:HGNC:11799"
                     /db_xref="MIM:190160"
     exon            1..56
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            57..128
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            129..192
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1556
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /note="isoform a is encoded by transcript variant 8;
                     oncogene ERBA2; nuclear receptor subfamily 1 group A
                     member 2; thyroid hormone receptor, beta (erythroblastic
                     leukemia viral (v-erb-a) oncogene homolog 2, avian)"
                     /codon_start=1
                     /product="thyroid hormone receptor beta isoform a"
                     /protein_id="NP_001341640.1"
                     /db_xref="CCDS:CCDS2641.1"
                     /db_xref="GeneID:7068"
                     /db_xref="HGNC:HGNC:11799"
                     /db_xref="MIM:190160"
                     /translation="MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSE
                     RRSTLKNEQSSPHLIQTTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLD
                     KDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQ
                     CQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEE
                     WELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKII
                     TPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEM
                     AVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERI
                     EKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTEL
                     FPPLFLEVFED"
     exon            193..453
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            454..554
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            555..702
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            703..908
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1055
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1314
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..7287
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6207..6212
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /note="hexamer: AAGAAA"
     polyA_site      6226
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /note="major polyA site"
     regulatory      6350..6355
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /note="hexamer: AATAAA"
     polyA_site      6375
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
     regulatory      7267..7272
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /note="hexamer: AATAAA"
     polyA_site      7287
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
ORIGIN      
        1 gcacatcctc gggcgggcgg ccgtgacgcg gcggggatta actttgcatg aataatatct
       61 gcgatttcct tctggttggc tgtcctgcgt gggtgccaag ttccacacat gatttaatga
      121 ataagaagga gatgtcagtg aaaaaaggga tccagaatga ttactaacct atgactccca
      181 acagtatgac agaaaatggc cttacagcct gggacaaacc gaagcactgt ccagaccgag
      241 aacacgactg gaagctagta ggaatgtctg aagcctgcct acataggaag agccattcag
      301 agaggcgcag cacgttgaaa aatgaacagt cgtcgccaca tctcatccag accacttgga
      361 ctagctcaat attccatctg gaccatgatg atgtgaacga ccagagtgtc tcaagtgccc
      421 agaccttcca aacggaggag aagaaatgta aagggtacat ccccagttac ttagacaagg
      481 acgagctctg tgtagtgtgt ggtgacaaag ccaccgggta tcactaccgc tgtatcacgt
      541 gtgaaggctg caagggtttc tttagaagaa ccattcagaa aaatctccat ccatcctatt
      601 cctgtaaata tgaaggaaaa tgtgtcatag acaaagtcac gcgaaatcag tgccaggaat
      661 gtcgctttaa gaaatgcatc tatgttggca tggcaacaga tttggtgctg gatgacagca
      721 agaggctggc caagaggaag ctgatagagg agaaccggga gaaaagacgg cgggaagagc
      781 tgcagaagtc catcgggcac aagccagagc ccacagacga ggaatgggag ctcatcaaaa
      841 ctgtcaccga agcccatgtg gcgaccaacg cccaaggcag ccactggaag caaaaacgga
      901 aattcctgcc agaagacatt ggacaagcac caatagtcaa tgccccagaa ggtggaaagg
      961 ttgacttgga agccttcagc cattttacaa aaatcatcac accagcaatt accagagtgg
     1021 tggattttgc caaaaagttg cctatgtttt gtgagctgcc atgtgaagac cagatcatcc
     1081 tcctcaaagg ctgctgcatg gagatcatgt cccttcgcgc tgctgtgcgc tatgacccag
     1141 aaagtgagac tttaaccttg aatggggaaa tggcagtgac acggggccag ctgaaaaatg
     1201 ggggtcttgg ggtggtgtca gacgccatct ttgacctggg catgtctctg tcttctttca
     1261 acctggatga cactgaagta gccctccttc aggccgtcct gctgatgtct tcagatcgcc
     1321 cggggcttgc ctgtgttgag agaatagaaa agtaccaaga tagtttcctg ctggcctttg
     1381 aacactatat caattaccga aaacaccacg tgacacactt ttggccaaaa ctcctgatga
     1441 aggtgacaga tctgcggatg ataggagcct gccatgccag ccgcttcctg cacatgaagg
     1501 tggaatgccc cacagaactc ttcccccctt tgttcttgga agtgttcgag gattagactg
     1561 actggattca ttctcataat tcctacagca ctactgggtg tcatttcatt ccattgccta
     1621 gctctttttt gtttgtttct ttgtgttggg agggattatt tgggagggaa aagggaagta
     1681 gtccttggca tagacatgga tgaaattgcc ccttgaatgc gggtacttga aactattgca
     1741 tttcgttctc cggtcctgtg atgtgaatgc tctgaaggtt ttatggttgt ggaggtgggg
     1801 tgggggacaa tcattaactc accagcacca agcatcacca gctcccaccc gtccctggtc
     1861 caagacttga gtcagcaaaa tggcgccaca ggacactaaa gaagccttaa aaccaagata
     1921 atacgaccac ctccacccaa tcctgatgtt cgcagggctg aagttaacag agcacagacc
     1981 acctttagtt agatgtggct ttcagccttt tagggaaaga ctcgaacaaa ttttcatcta
     2041 ttcaagagca tgctgtttgc agcactcttt atggtctcct aggagcataa cttggaatgt
     2101 acaggaatat ttgtgtccta aaaaaatcag ctgcccttcc aatatcattt ttataacgtt
     2161 atggtttaat tcaagttata caaaggtgtg actcaaggat gtgcaggtat tgactgatgg
     2221 aggccaacaa ggaaaatatt ttttttcagt gagcccagag aaattagaaa tcttcaccaa
     2281 tgtcagtgac tgcatggttt ccaaaaattc acatagtatt acctcacagt aggaaggctt
     2341 ctttcccatt taggctcaga gaacactttt acagaaatca aacctattta cagggtggca
     2401 ccccttttct gtggcatctg atctgtcatc tcccaagctc ctgaagttct ttatccaggt
     2461 tgtatctttg ctgagctgac aacagatttc tctatggatc aaatattcta atcaaggaaa
     2521 gatacggtga aacttcagtc ttcttctgga gaaatgctga ggcgagatta gtgcagctac
     2581 attctgagtt gaaggaaatg cagtgttctg agggcccctt tgtgtcctga tggctggagg
     2641 acgcttcctc ctggttagat cctcaagctc cttgcctcat tgacaaatgt ctcctagtcc
     2701 cctttttccc tctgactctg aggaactaaa tagcttgact atctctaaac agagactggc
     2761 cctgccactg accctcctgt ccctctcata gcataccctg acagatactc aatagaaaac
     2821 acctgcagac catgtgcaca cttaactttc ctgcccaacc tgcctcccca acggcccatg
     2881 ctagaatagc ttgtgcccag aaaacaaaca gtgacacttc atctcttcag cgtcagaaaa
     2941 tgggcataga atgtacccat gcaattgaat gtatctcatt ctccactggc atagtagata
     3001 taaactattc ctttgcctac cttttactgc cttatcctgg aaatattggg gaaaataagc
     3061 catatcagtg agatttacct aaaaacaaag gaaggaaagt cactatggaa accaagtaga
     3121 tgctttttgt aagtttggtg gagcataact ggcccagaag tctgggtgcc tgagttctag
     3181 ttcgtgctct gtcaactggt agatttgtaa ttctaggtct tggttttctt acctggtgaa
     3241 taagtcatga tctctaaaac ccttcctgcc cttaatattg tctgaatttc aaggggaaaa
     3301 aaaaaatctg gttcctttaa ttattttttt ttaacactta aattcctaac tttattagac
     3361 aagaagtatg gcccacttaa cagttaagga acgtaaattt gttattggct cgaaataata
     3421 atttgacaca atactagtca accatttaga ggccttggaa aaagaagagg aacagcactg
     3481 aaaattccaa gtatgattgg aaattatctg ggagcgggga attaaatatt caatgcatga
     3541 aagcaattgt actggcttct gggaaaaagg aaacaagaac attgctatgg aacttgttac
     3601 ccagagaaag gaagtgaaaa gatttacaat tataagcacg aaattcattg gcagattacc
     3661 tgctttatct acagacagat tgttttgggg tttggttttg tctaggcagc ctctggccag
     3721 gctccttaat tgcttgctct gctaatattt cagcttcctc tcttgactcc ttgaggaacc
     3781 aaccgctctt tggaagacaa acacttagcc acctctgtgc tccagggtaa ccctgagaag
     3841 ctctgctgtc tggggcaagc tttctttcca aagggaatga gaggaaggca agcaggcagg
     3901 gtcctgcagc gtcaggcctt ctggggaaag tttcctcatt ttgtttgaca gggtcctcag
     3961 tacatcagac acccagattt gaatataagt tcagagcctg atctcaagct aaatcagaat
     4021 gctttgggga ctaaccatga tcgagaattg gccaaatagt atggcatata aacagccatc
     4081 cagccagccg caagtaaagg aacgtttgat ccttggcacc ttaaatgatt gattgccttc
     4141 aataggcaaa ctgctggtct ggaaatctcg ttgaaggctg aatacttcat gcggagtagg
     4201 acaagcctta gcccaccttc aggttgaaag gaaaggccat aggactcaaa agataatgac
     4261 tctgaaacta aactccttcc ttctgaagct gacagaggta cttagtgcat ctcaagactc
     4321 catctcataa aactcatttg tgagggattt gctctagatt tttctaaaca ttttttcatc
     4381 tattgtccag acttgcaaat ccagtgtgga cctgatggag atacccttca cacctgcgct
     4441 cccaccccct cggcagggag acgtctcagt agaggagaac acacccatta tgctgggatt
     4501 tgtatttata aatcacttcc cttttaggga tgagcggtgt ggggcgtgtg tgcgtgtgag
     4561 tgtatgcgcg tgcgtgtgtg accctcaagt gtactttgct caatttagac gtgcagtatt
     4621 tccagaaaca atgaaaaaag taagatgttt tcttctttat gattctgctc aaaacaccac
     4681 gtgccgcctc agagcttttt ctagagcctc ggtcctcaat gacgcgcttg acctgttgat
     4741 gcctcagccc agcgaagccc ctcacctgtg ccccgggcga cagctcttca gtgtgcagtg
     4801 caggcctggg gtggactgcc aggccttcgc tctgtgccag caacgccgtt cttgttgctc
     4861 ctccatgaac aggggtacaa gccctggccc ctcctcgaca ctaagccccc cacagactca
     4921 gcctccaagg aaccgctgag cacccttgaa gcatgtcatt gtcagtgata cctttttatt
     4981 ctatggaact ctaacctatt cgtgtcatat tgaccttttg ctgcatgagt cataaattat
     5041 gaaatcagtc ttacagtttt tgaaatgtag ccagcatttg taaggctaaa cctttttcat
     5101 gaactgaatt taagtgaata accaagccac agttcctcct caaatggaga gtgatgatcg
     5161 acatttgaat ctctttgccc tttccaacgg ctatggcatc aggttctaaa ataagctcgt
     5221 aatttttcct gttattttaa taatatggaa atattagcat agtgtttctt ttgatagtga
     5281 tagactataa tccatattta aattttatag agaagaaatt ttattgtact gtgatgtaga
     5341 tatttattat ccaggtaagg atttgcccgg tgtgtatttt ttacaattga gacattttac
     5401 tttaatcttt aaaaaaaatg cattaaaaac acactcaaaa aaaaaaaaaa aaaaaaaaaa
     5461 aaaaaaccag actgggggaa aaaaggtttg gccttatcac agaattttta ctgtgctgta
     5521 taaatgtttg caaatgcgaa aagtgtgcat ttatagtgtg tttccacatt aattaatgcc
     5581 gccttcaaga gcaatattgt gcaggtaaaa cgctgtttgt ggctttctgt tgcacagtta
     5641 aagctgaccc accctatgca caagacaatc aaatataaat ctgtcctcct caggatgcag
     5701 ataatactca tgtaaattat ggagcacaat gtaagacaaa aggagacact ttacatatgt
     5761 attgttgata cagaaattat cagggcatga atgagctgat gtgacattat gccacttctt
     5821 tcttttggtt ctcccttatt aacttggcat ttttaatttg accatagagc caaattagtt
     5881 ctccatgctt tcttcgtaga aaatcctttt ttttcccata atgttttcat gccctgagaa
     5941 tcagaaaaat actacagaat agaaaaagat ttacagtcat tggaagattt gtgttttgca
     6001 aacagtgtta agtgatattg ctagatggtg atattttttt cagcctaaaa ctctgttgaa
     6061 atctgtgatc aaaatgtttt aaactatcca aaaaaaattt gtatatttgg gaaaaatgga
     6121 tttttacata gcttttgtat gcagatataa aactgtaatt atgaatatag tgggcgtaga
     6181 taaactcata agcttaaatt ctaaaaaaga aaaagcttat aacagatata ttttcctgtc
     6241 tctttcttta aatattatta ttttctacat aggcaaagag ttgcctgctc ttctcacttc
     6301 agctgctgcc aaaagacgga accacggatg taaggacatt tatttcataa ataaacatct
     6361 actagaataa gcaaatttac ttgagaagaa actatggagg gagagaagaa actaagtaaa
     6421 atgctgatgg ggggttacct ctttggaagg ggccacaaag atgaagggag gagagaggtg
     6481 aagttttgca gctcaaggac aacattcatc ttctcatctc aaattattca ggaatattac
     6541 taatggaatt atgttaacat cagctgccaa catatatctc aatctctgtt gccctgaaca
     6601 catgttaatt gagattcttt ctatgacaag taacaaaaag ctaactcaaa ctggcttaag
     6661 cagaaagcta attattgact ttaatatctg ggatctaggg tattgcatac caaagcttca
     6721 ggcatggctg gatctgggtg cacttactca gtattctcag gaagctcctt tttttgtcat
     6781 tcatgtagac ttaacattca catggccttt caccttacgg tggcctccaa tagctccagg
     6841 atgagcttta cagctccaaa tatagtgaaa ggagaatttc ttttctccaa caattctaat
     6901 gaaaattctg gcctaattct cactggccca agttcagtca tgtgcccatt cctgagccaa
     6961 tcactgtggt gaggaaaaca gatgcataac caaccttatc ctcaggaatc ctggaactgg
     7021 gtgaggggaa agagggacag tcagcttcat ctaaactatg gactgagagt tgaggcaaga
     7081 tgattcctga aagaaaattc taagtcttgc tgctataagt ggaagagaat ggtgggcaag
     7141 caaaagcaac cagtgcccac accaaaggta aatctaaaac aacatcccat ttcagtacag
     7201 caagcggttc tccttcacac agaggaagct catctccaag tttttatttg gccaggacat
     7261 gaaccaaata aacaccttcc aaagaaa
//
