LOCUS       NM_001354709            7344 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens thyroid hormone receptor beta (THRB), transcript
            variant 6, mRNA.
ACCESSION   NM_001354709 XM_011534051
VERSION     NM_001354709.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7344)
  AUTHORS   Salas-Lucia,F., Stan,M.N., James,H., Rajwani,A., Liao,X.H.,
            Dumitrescu,A.M. and Refetoff,S.
  TITLE     Effect of the Fetal THRB Genotype on the Placenta
  JOURNAL   J Clin Endocrinol Metab 108 (10), e944-e948 (2023)
   PUBMED   37149816
  REMARK    GeneRIF: Effect of the Fetal THRB Genotype on the Placenta.
REFERENCE   2  (bases 1 to 7344)
  AUTHORS   Copur,S., Yavuz,F. and Kanbay,M.
  TITLE     Thyroid hormone Beta receptor agonists for treatment of kidney
            disease: A promising agent?
  JOURNAL   Eur J Clin Invest 53 (5), e13939 (2023)
   PUBMED   36537819
  REMARK    GeneRIF: Thyroid hormone Beta receptor agonists for treatment of
            kidney disease: A promising agent?
            Review article
REFERENCE   3  (bases 1 to 7344)
  AUTHORS   Ng,L., Liu,H., Liu,Y. and Forrest,D.
  TITLE     Biphasic expression of thyroid hormone receptor TRbeta1 in
            mammalian retina and anterior ocular tissues
  JOURNAL   Front Endocrinol (Lausanne) 14, 1174600 (2023)
   PUBMED   37033230
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7344)
  AUTHORS   Lai,H.P. and Chen,M.H.
  TITLE     Atrial Fibrillation with Heart Failure in a Case with Resistance to
            Thyroid Hormone Due to a Rare Thyroid Hormone Receptor beta Gene
            Mutation
  JOURNAL   Int J Mol Sci 23 (23), 15241 (2022)
   PUBMED   36499571
  REMARK    GeneRIF: Atrial Fibrillation with Heart Failure in a Case with
            Resistance to Thyroid Hormone Due to a Rare Thyroid Hormone
            Receptor beta Gene Mutation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7344)
  AUTHORS   Cui,B., Xiao,X., Wang,J., Wang,H., Wu,C., Yan,Y., Zheng,J.,
            Wang,J., Zong,Y., Zhang,Y., Hui,R., Gerdes,A.M. and Wang,Y.
  TITLE     Low THRB (thyroid hormone receptor beta) Promoter Methylation
            Levels in Peripheral Blood Leukocytes Induced By Systematic
            Inflammation Are Involved in Low Thyroid Hormone Function in
            Metabolic Syndrome
  JOURNAL   Hypertension 78 (4), 1005-1015 (2021)
   PUBMED   34397273
  REMARK    GeneRIF: Low THRB (thyroid hormone receptor beta) Promoter
            Methylation Levels in Peripheral Blood Leukocytes Induced By
            Systematic Inflammation Are Involved in Low Thyroid Hormone
            Function in Metabolic Syndrome.
REFERENCE   6  (bases 1 to 7344)
  AUTHORS   Falcone,M., Miyamoto,T., Fierro-Renoy,F., Macchia,E. and
            DeGroot,L.J.
  TITLE     Antipeptide polyclonal antibodies specifically recognize each human
            thyroid hormone receptor isoform
  JOURNAL   Endocrinology 131 (5), 2419-2429 (1992)
   PUBMED   1425440
REFERENCE   7  (bases 1 to 7344)
  AUTHORS   Behr,M. and Loos,U.
  TITLE     A point mutation (Ala229 to Thr) in the hinge domain of the c-erbA
            beta thyroid hormone receptor gene in a family with generalized
            thyroid hormone resistance
  JOURNAL   Mol Endocrinol 6 (7), 1119-1126 (1992)
   PUBMED   1324420
REFERENCE   8  (bases 1 to 7344)
  AUTHORS   Cugini,C.D. Jr., Leidy,J.W. Jr., Chertow,B.S., Berard,J.,
            Bradley,W.E., Menke,J.B., Hao,E.H. and Usala,S.J.
  TITLE     An arginine to histidine mutation in codon 315 of the c-erbA beta
            thyroid hormone receptor in a kindred with generalized resistance
            to thyroid hormones results in a receptor with significant
            3,5,3'-triiodothyronine binding activity
  JOURNAL   J Clin Endocrinol Metab 74 (5), 1164-1170 (1992)
   PUBMED   1314846
REFERENCE   9  (bases 1 to 7344)
  AUTHORS   Schmidt,E.D., Schmidt,E.D., van der Gaag,R., Ganpat,R.,
            Broersma,L., de Boer,P.A., Moorman,A.F., Lamers,W.H.,
            Wiersinga,W.M. and Koornneef,L.
  TITLE     Distribution of the nuclear thyroid-hormone receptor in extraocular
            and skeletal muscles
  JOURNAL   J Endocrinol 133 (1), 67-74 (1992)
   PUBMED   1517709
REFERENCE   10 (bases 1 to 7344)
  AUTHORS   Adams,M., Nagaya,T., Tone,Y., Jameson,J.L. and Chatterjee,V.K.
  TITLE     Functional properties of a novel mutant thyroid hormone receptor in
            a family with generalized thyroid hormone resistance syndrome
  JOURNAL   Clin Endocrinol (Oxf) 36 (3), 281-289 (1992)
   PUBMED   1563081
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC012087.10, AC099054.2,
            AC093927.3 and AC098971.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001354709.1.
            
            Summary: The protein encoded by this gene is a nuclear hormone
            receptor for triiodothyronine. It is one of the several receptors
            for thyroid hormone, and has been shown to mediate the biological
            activities of thyroid hormone. Knockout studies in mice suggest
            that the different receptors, while having certain extent of
            redundancy, may mediate different functions of thyroid hormone.
            Mutations in this gene are known to be a cause of generalized
            thyroid hormone resistance (GTHR), a syndrome characterized by
            goiter and high levels of circulating thyroid hormone (T3-T4), with
            normal or slightly elevated thyroid stimulating hormone (TSH).
            Several alternatively spliced transcript variants encoding the same
            protein have been observed for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (6) differs in the 5' UTR compared
            to variant 1. Variants 1-10 all encode the same isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.172304.1,
                                           SRR9304715.603812.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AC012087.10        124144-124199
            57-113              AC099054.2         35363-35419
            114-185             AC099054.2         46606-46677
            186-249             AC093927.3         70721-70784
            250-510             AC093927.3         109388-109648
            511-611             AC093927.3         147232-147332
            612-759             AC098971.2         171345-171492       c
            760-965             AC098971.2         168171-168376       c
            966-1112            AC098971.2         157986-158132       c
            1113-1371           AC098971.2         152169-152427       c
            1372-7344           AC098971.2         141823-147795       c
FEATURES             Location/Qualifiers
     source          1..7344
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p24.2"
     gene            1..7344
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /note="thyroid hormone receptor beta"
                     /db_xref="GeneID:7068"
                     /db_xref="HGNC:HGNC:11799"
                     /db_xref="MIM:190160"
     exon            1..56
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            57..113
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            114..185
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            186..249
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..1613
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /note="isoform a is encoded by transcript variant 6;
                     oncogene ERBA2; nuclear receptor subfamily 1 group A
                     member 2; thyroid hormone receptor, beta (erythroblastic
                     leukemia viral (v-erb-a) oncogene homolog 2, avian)"
                     /codon_start=1
                     /product="thyroid hormone receptor beta isoform a"
                     /protein_id="NP_001341638.1"
                     /db_xref="CCDS:CCDS2641.1"
                     /db_xref="GeneID:7068"
                     /db_xref="HGNC:HGNC:11799"
                     /db_xref="MIM:190160"
                     /translation="MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSE
                     RRSTLKNEQSSPHLIQTTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLD
                     KDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQ
                     CQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEE
                     WELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKII
                     TPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEM
                     AVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERI
                     EKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTEL
                     FPPLFLEVFED"
     exon            250..510
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            511..611
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            612..759
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            760..965
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1112
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1371
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..7344
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6264..6269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /note="hexamer: AAGAAA"
     polyA_site      6283
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /note="major polyA site"
     regulatory      6407..6412
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /note="hexamer: AATAAA"
     polyA_site      6432
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
     regulatory      7324..7329
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
                     /note="hexamer: AATAAA"
     polyA_site      7344
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2;
                     TRb; TRbeta; TRbeta1"
ORIGIN      
        1 gcacatcctc gggcgggcgg ccgtgacgcg gcggggatta actttgcatg aataatgtcc
       61 tagaaaggaa agcacagcac atcgtgcaga aggccgcatg ggaaaagggc cagatctgcg
      121 atttccttct ggttggctgt cctgcgtggg tgccaagttc cacacatgat ttaatgaata
      181 agaaggagat gtcagtgaaa aaagggatcc agaatgatta ctaacctatg actcccaaca
      241 gtatgacaga aaatggcctt acagcctggg acaaaccgaa gcactgtcca gaccgagaac
      301 acgactggaa gctagtagga atgtctgaag cctgcctaca taggaagagc cattcagaga
      361 ggcgcagcac gttgaaaaat gaacagtcgt cgccacatct catccagacc acttggacta
      421 gctcaatatt ccatctggac catgatgatg tgaacgacca gagtgtctca agtgcccaga
      481 ccttccaaac ggaggagaag aaatgtaaag ggtacatccc cagttactta gacaaggacg
      541 agctctgtgt agtgtgtggt gacaaagcca ccgggtatca ctaccgctgt atcacgtgtg
      601 aaggctgcaa gggtttcttt agaagaacca ttcagaaaaa tctccatcca tcctattcct
      661 gtaaatatga aggaaaatgt gtcatagaca aagtcacgcg aaatcagtgc caggaatgtc
      721 gctttaagaa atgcatctat gttggcatgg caacagattt ggtgctggat gacagcaaga
      781 ggctggccaa gaggaagctg atagaggaga accgggagaa aagacggcgg gaagagctgc
      841 agaagtccat cgggcacaag ccagagccca cagacgagga atgggagctc atcaaaactg
      901 tcaccgaagc ccatgtggcg accaacgccc aaggcagcca ctggaagcaa aaacggaaat
      961 tcctgccaga agacattgga caagcaccaa tagtcaatgc cccagaaggt ggaaaggttg
     1021 acttggaagc cttcagccat tttacaaaaa tcatcacacc agcaattacc agagtggtgg
     1081 attttgccaa aaagttgcct atgttttgtg agctgccatg tgaagaccag atcatcctcc
     1141 tcaaaggctg ctgcatggag atcatgtccc ttcgcgctgc tgtgcgctat gacccagaaa
     1201 gtgagacttt aaccttgaat ggggaaatgg cagtgacacg gggccagctg aaaaatgggg
     1261 gtcttggggt ggtgtcagac gccatctttg acctgggcat gtctctgtct tctttcaacc
     1321 tggatgacac tgaagtagcc ctccttcagg ccgtcctgct gatgtcttca gatcgcccgg
     1381 ggcttgcctg tgttgagaga atagaaaagt accaagatag tttcctgctg gcctttgaac
     1441 actatatcaa ttaccgaaaa caccacgtga cacacttttg gccaaaactc ctgatgaagg
     1501 tgacagatct gcggatgata ggagcctgcc atgccagccg cttcctgcac atgaaggtgg
     1561 aatgccccac agaactcttc ccccctttgt tcttggaagt gttcgaggat tagactgact
     1621 ggattcattc tcataattcc tacagcacta ctgggtgtca tttcattcca ttgcctagct
     1681 cttttttgtt tgtttctttg tgttgggagg gattatttgg gagggaaaag ggaagtagtc
     1741 cttggcatag acatggatga aattgcccct tgaatgcggg tacttgaaac tattgcattt
     1801 cgttctccgg tcctgtgatg tgaatgctct gaaggtttta tggttgtgga ggtggggtgg
     1861 gggacaatca ttaactcacc agcaccaagc atcaccagct cccacccgtc cctggtccaa
     1921 gacttgagtc agcaaaatgg cgccacagga cactaaagaa gccttaaaac caagataata
     1981 cgaccacctc cacccaatcc tgatgttcgc agggctgaag ttaacagagc acagaccacc
     2041 tttagttaga tgtggctttc agccttttag ggaaagactc gaacaaattt tcatctattc
     2101 aagagcatgc tgtttgcagc actctttatg gtctcctagg agcataactt ggaatgtaca
     2161 ggaatatttg tgtcctaaaa aaatcagctg cccttccaat atcattttta taacgttatg
     2221 gtttaattca agttatacaa aggtgtgact caaggatgtg caggtattga ctgatggagg
     2281 ccaacaagga aaatattttt tttcagtgag cccagagaaa ttagaaatct tcaccaatgt
     2341 cagtgactgc atggtttcca aaaattcaca tagtattacc tcacagtagg aaggcttctt
     2401 tcccatttag gctcagagaa cacttttaca gaaatcaaac ctatttacag ggtggcaccc
     2461 cttttctgtg gcatctgatc tgtcatctcc caagctcctg aagttcttta tccaggttgt
     2521 atctttgctg agctgacaac agatttctct atggatcaaa tattctaatc aaggaaagat
     2581 acggtgaaac ttcagtcttc ttctggagaa atgctgaggc gagattagtg cagctacatt
     2641 ctgagttgaa ggaaatgcag tgttctgagg gcccctttgt gtcctgatgg ctggaggacg
     2701 cttcctcctg gttagatcct caagctcctt gcctcattga caaatgtctc ctagtcccct
     2761 ttttccctct gactctgagg aactaaatag cttgactatc tctaaacaga gactggccct
     2821 gccactgacc ctcctgtccc tctcatagca taccctgaca gatactcaat agaaaacacc
     2881 tgcagaccat gtgcacactt aactttcctg cccaacctgc ctccccaacg gcccatgcta
     2941 gaatagcttg tgcccagaaa acaaacagtg acacttcatc tcttcagcgt cagaaaatgg
     3001 gcatagaatg tacccatgca attgaatgta tctcattctc cactggcata gtagatataa
     3061 actattcctt tgcctacctt ttactgcctt atcctggaaa tattggggaa aataagccat
     3121 atcagtgaga tttacctaaa aacaaaggaa ggaaagtcac tatggaaacc aagtagatgc
     3181 tttttgtaag tttggtggag cataactggc ccagaagtct gggtgcctga gttctagttc
     3241 gtgctctgtc aactggtaga tttgtaattc taggtcttgg ttttcttacc tggtgaataa
     3301 gtcatgatct ctaaaaccct tcctgccctt aatattgtct gaatttcaag gggaaaaaaa
     3361 aaatctggtt cctttaatta ttttttttta acacttaaat tcctaacttt attagacaag
     3421 aagtatggcc cacttaacag ttaaggaacg taaatttgtt attggctcga aataataatt
     3481 tgacacaata ctagtcaacc atttagaggc cttggaaaaa gaagaggaac agcactgaaa
     3541 attccaagta tgattggaaa ttatctggga gcggggaatt aaatattcaa tgcatgaaag
     3601 caattgtact ggcttctggg aaaaaggaaa caagaacatt gctatggaac ttgttaccca
     3661 gagaaaggaa gtgaaaagat ttacaattat aagcacgaaa ttcattggca gattacctgc
     3721 tttatctaca gacagattgt tttggggttt ggttttgtct aggcagcctc tggccaggct
     3781 ccttaattgc ttgctctgct aatatttcag cttcctctct tgactccttg aggaaccaac
     3841 cgctctttgg aagacaaaca cttagccacc tctgtgctcc agggtaaccc tgagaagctc
     3901 tgctgtctgg ggcaagcttt ctttccaaag ggaatgagag gaaggcaagc aggcagggtc
     3961 ctgcagcgtc aggccttctg gggaaagttt cctcattttg tttgacaggg tcctcagtac
     4021 atcagacacc cagatttgaa tataagttca gagcctgatc tcaagctaaa tcagaatgct
     4081 ttggggacta accatgatcg agaattggcc aaatagtatg gcatataaac agccatccag
     4141 ccagccgcaa gtaaaggaac gtttgatcct tggcacctta aatgattgat tgccttcaat
     4201 aggcaaactg ctggtctgga aatctcgttg aaggctgaat acttcatgcg gagtaggaca
     4261 agccttagcc caccttcagg ttgaaaggaa aggccatagg actcaaaaga taatgactct
     4321 gaaactaaac tccttccttc tgaagctgac agaggtactt agtgcatctc aagactccat
     4381 ctcataaaac tcatttgtga gggatttgct ctagattttt ctaaacattt tttcatctat
     4441 tgtccagact tgcaaatcca gtgtggacct gatggagata cccttcacac ctgcgctccc
     4501 accccctcgg cagggagacg tctcagtaga ggagaacaca cccattatgc tgggatttgt
     4561 atttataaat cacttccctt ttagggatga gcggtgtggg gcgtgtgtgc gtgtgagtgt
     4621 atgcgcgtgc gtgtgtgacc ctcaagtgta ctttgctcaa tttagacgtg cagtatttcc
     4681 agaaacaatg aaaaaagtaa gatgttttct tctttatgat tctgctcaaa acaccacgtg
     4741 ccgcctcaga gctttttcta gagcctcggt cctcaatgac gcgcttgacc tgttgatgcc
     4801 tcagcccagc gaagcccctc acctgtgccc cgggcgacag ctcttcagtg tgcagtgcag
     4861 gcctggggtg gactgccagg ccttcgctct gtgccagcaa cgccgttctt gttgctcctc
     4921 catgaacagg ggtacaagcc ctggcccctc ctcgacacta agccccccac agactcagcc
     4981 tccaaggaac cgctgagcac ccttgaagca tgtcattgtc agtgatacct ttttattcta
     5041 tggaactcta acctattcgt gtcatattga ccttttgctg catgagtcat aaattatgaa
     5101 atcagtctta cagtttttga aatgtagcca gcatttgtaa ggctaaacct ttttcatgaa
     5161 ctgaatttaa gtgaataacc aagccacagt tcctcctcaa atggagagtg atgatcgaca
     5221 tttgaatctc tttgcccttt ccaacggcta tggcatcagg ttctaaaata agctcgtaat
     5281 ttttcctgtt attttaataa tatggaaata ttagcatagt gtttcttttg atagtgatag
     5341 actataatcc atatttaaat tttatagaga agaaatttta ttgtactgtg atgtagatat
     5401 ttattatcca ggtaaggatt tgcccggtgt gtatttttta caattgagac attttacttt
     5461 aatctttaaa aaaaatgcat taaaaacaca ctcaaaaaaa aaaaaaaaaa aaaaaaaaaa
     5521 aaaccagact gggggaaaaa aggtttggcc ttatcacaga atttttactg tgctgtataa
     5581 atgtttgcaa atgcgaaaag tgtgcattta tagtgtgttt ccacattaat taatgccgcc
     5641 ttcaagagca atattgtgca ggtaaaacgc tgtttgtggc tttctgttgc acagttaaag
     5701 ctgacccacc ctatgcacaa gacaatcaaa tataaatctg tcctcctcag gatgcagata
     5761 atactcatgt aaattatgga gcacaatgta agacaaaagg agacacttta catatgtatt
     5821 gttgatacag aaattatcag ggcatgaatg agctgatgtg acattatgcc acttctttct
     5881 tttggttctc ccttattaac ttggcatttt taatttgacc atagagccaa attagttctc
     5941 catgctttct tcgtagaaaa tccttttttt tcccataatg ttttcatgcc ctgagaatca
     6001 gaaaaatact acagaataga aaaagattta cagtcattgg aagatttgtg ttttgcaaac
     6061 agtgttaagt gatattgcta gatggtgata tttttttcag cctaaaactc tgttgaaatc
     6121 tgtgatcaaa atgttttaaa ctatccaaaa aaaatttgta tatttgggaa aaatggattt
     6181 ttacatagct tttgtatgca gatataaaac tgtaattatg aatatagtgg gcgtagataa
     6241 actcataagc ttaaattcta aaaaagaaaa agcttataac agatatattt tcctgtctct
     6301 ttctttaaat attattattt tctacatagg caaagagttg cctgctcttc tcacttcagc
     6361 tgctgccaaa agacggaacc acggatgtaa ggacatttat ttcataaata aacatctact
     6421 agaataagca aatttacttg agaagaaact atggagggag agaagaaact aagtaaaatg
     6481 ctgatggggg gttacctctt tggaaggggc cacaaagatg aagggaggag agaggtgaag
     6541 ttttgcagct caaggacaac attcatcttc tcatctcaaa ttattcagga atattactaa
     6601 tggaattatg ttaacatcag ctgccaacat atatctcaat ctctgttgcc ctgaacacat
     6661 gttaattgag attctttcta tgacaagtaa caaaaagcta actcaaactg gcttaagcag
     6721 aaagctaatt attgacttta atatctggga tctagggtat tgcataccaa agcttcaggc
     6781 atggctggat ctgggtgcac ttactcagta ttctcaggaa gctccttttt ttgtcattca
     6841 tgtagactta acattcacat ggcctttcac cttacggtgg cctccaatag ctccaggatg
     6901 agctttacag ctccaaatat agtgaaagga gaatttcttt tctccaacaa ttctaatgaa
     6961 aattctggcc taattctcac tggcccaagt tcagtcatgt gcccattcct gagccaatca
     7021 ctgtggtgag gaaaacagat gcataaccaa ccttatcctc aggaatcctg gaactgggtg
     7081 aggggaaaga gggacagtca gcttcatcta aactatggac tgagagttga ggcaagatga
     7141 ttcctgaaag aaaattctaa gtcttgctgc tataagtgga agagaatggt gggcaagcaa
     7201 aagcaaccag tgcccacacc aaaggtaaat ctaaaacaac atcccatttc agtacagcaa
     7261 gcggttctcc ttcacacaga ggaagctcat ctccaagttt ttatttggcc aggacatgaa
     7321 ccaaataaac accttccaaa gaaa
//
