LOCUS       NM_005119               4405 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens thyroid hormone receptor associated protein 3
            (THRAP3), transcript variant 1, mRNA.
ACCESSION   NM_005119
VERSION     NM_005119.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4405)
  AUTHORS   Jang,H.J., Lee,Y.H., Dao,T., Jo,Y., Khim,K.W., Eom,H.J., Lee,J.E.,
            Song,Y.J., Choi,S.S., Park,K., Ji,H., Chae,Y.C., Myung,K., Kim,H.,
            Ryu,D., Park,N.H., Park,S.H. and Choi,J.H.
  TITLE     Thrap3 promotes nonalcoholic fatty liver disease by suppressing
            AMPK-mediated autophagy
  JOURNAL   Exp Mol Med 55 (8), 1720-1733 (2023)
   PUBMED   37524868
  REMARK    GeneRIF: Thrap3 promotes nonalcoholic fatty liver disease by
            suppressing AMPK-mediated autophagy.
REFERENCE   2  (bases 1 to 4405)
  AUTHORS   Zhou,L., Li,H., Sun,S., Zhang,T., Yu,Y., Xu,L. and Wang,M.
  TITLE     Thrap3 promotes osteogenesis by inhibiting the degradation of Runx2
  JOURNAL   FASEB J 36 (4), e22231 (2022)
   PUBMED   35230719
  REMARK    GeneRIF: Thrap3 promotes osteogenesis by inhibiting the degradation
            of Runx2.
REFERENCE   3  (bases 1 to 4405)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 4405)
  AUTHORS   Kang,H.J., Eom,H.J., Kim,H., Myung,K., Kwon,H.M. and Choi,J.H.
  TITLE     Thrap3 promotes R-loop resolution via interaction with methylated
            DDX5
  JOURNAL   Exp Mol Med 53 (10), 1602-1611 (2021)
   PUBMED   34697388
  REMARK    GeneRIF: Thrap3 promotes R-loop resolution via interaction with
            methylated DDX5.
REFERENCE   5  (bases 1 to 4405)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   6  (bases 1 to 4405)
  AUTHORS   Jia,L., Young,M.F., Powell,J., Yang,L., Ho,N.C., Hotchkiss,R.,
            Robey,P.G. and Francomano,C.A.
  TITLE     Gene expression profile of human bone marrow stromal cells:
            high-throughput expressed sequence tag sequencing analysis
  JOURNAL   Genomics 79 (1), 7-17 (2002)
   PUBMED   11827452
REFERENCE   7  (bases 1 to 4405)
  AUTHORS   Naar,A.M., Beaurang,P.A., Zhou,S., Abraham,S., Solomon,W. and
            Tjian,R.
  TITLE     Composite co-activator ARC mediates chromatin-directed
            transcriptional activation
  JOURNAL   Nature 398 (6730), 828-832 (1999)
   PUBMED   10235267
REFERENCE   8  (bases 1 to 4405)
  AUTHORS   Rachez,C., Lemon,B.D., Suldan,Z., Bromleigh,V., Gamble,M.,
            Naar,A.M., Erdjument-Bromage,H., Tempst,P. and Freedman,L.P.
  TITLE     Ligand-dependent transcription activation by nuclear receptors
            requires the DRIP complex
  JOURNAL   Nature 398 (6730), 824-828 (1999)
   PUBMED   10235266
REFERENCE   9  (bases 1 to 4405)
  AUTHORS   Ito,M., Yuan,C.X., Malik,S., Gu,W., Fondell,J.D., Yamamura,S.,
            Fu,Z.Y., Zhang,X., Qin,J. and Roeder,R.G.
  TITLE     Identity between TRAP and SMCC complexes indicates novel pathways
            for the function of nuclear receptors and diverse mammalian
            activators
  JOURNAL   Mol Cell 3 (3), 361-370 (1999)
   PUBMED   10198638
REFERENCE   10 (bases 1 to 4405)
  AUTHORS   Fondell,J.D., Ge,H. and Roeder,R.G.
  TITLE     Ligand induction of a transcriptionally active thyroid hormone
            receptor coactivator complex
  JOURNAL   Proc Natl Acad Sci U S A 93 (16), 8329-8333 (1996)
   PUBMED   8710870
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG572651.1, BC112350.1, AK025735.1 and AI754117.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005119.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.40628.1,
                                           SRR1660805.238292.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354618.10/ ENSP00000346634.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                BG572651.1         29-91
            64-3064             BC112350.1         185-3185
            3065-4045           AK025735.1         829-1809
            4046-4405           AI754117.1         16-375              c
FEATURES             Location/Qualifiers
     source          1..4405
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.3"
     gene            1..4405
                     /gene="THRAP3"
                     /gene_synonym="BCLAF2; TRAP150"
                     /note="thyroid hormone receptor associated protein 3"
                     /db_xref="GeneID:9967"
                     /db_xref="HGNC:HGNC:22964"
                     /db_xref="MIM:603809"
     exon            1..63
                     /gene="THRAP3"
                     /gene_synonym="BCLAF2; TRAP150"
                     /inference="alignment:Splign:2.1.0"
     exon            64..166
                     /gene="THRAP3"
                     /gene_synonym="BCLAF2; TRAP150"
                     /inference="alignment:Splign:2.1.0"
     exon            167..334
                     /gene="THRAP3"
                     /gene_synonym="BCLAF2; TRAP150"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..3065
                     /gene="THRAP3"
                     /gene_synonym="BCLAF2; TRAP150"
                     /note="isoform 1 is encoded by transcript variant 1;
                     thyroid hormone receptor-associated protein, 150 kDa
                     subunit; thyroid hormone receptor-associated protein
                     complex 150 kDa component; TR-associated protein, 150-kDa;
                     BCLAF1 and THRAP3 family member 2"
                     /codon_start=1
                     /product="thyroid hormone receptor-associated protein 3
                     isoform 1"
                     /protein_id="NP_005110.2"
                     /db_xref="CCDS:CCDS405.1"
                     /db_xref="GeneID:9967"
                     /db_xref="HGNC:HGNC:22964"
                     /db_xref="MIM:603809"
                     /translation="MSKTNKSKSGSRSSRSRSASRSRSRSFSKSRSRSRSLSRSRKRR
                     LSSRSRSRSYSPAHNRERNHPRVYQNRDFRGHNRGYRRPYYFRGRNRGFYPWGQYNRG
                     GYGNYRSNWQNYRQAYSPRRGRSRSRSPKRRSPSPRSRSHSRNSDKSSSDRSRRSSSS
                     RSSSNHSRVESSKRKSAKEKKSSSKDSRPSQAAGDNQGDEAKEQTFSGGTSQDTKASE
                     SSKPWPDATYGTGSASRASAVSELSPRERSPALKSPLQSVVVRRRSPRPSPVPKPSPP
                     LSSTSQMGSTLPSGAGYQSGTHQGQFDHGSGSLSPSKKSPVGKSPPSTGSTYGSSQKE
                     ESAASGGAAYTKRYLEEQKTENGKDKEQKQTNTDKEKIKEKGSFSDTGLGDGKMKSDS
                     FAPKTDSEKPFRGSQSPKRYKLRDDFEKKMADFHKEEMDDQDKDKAKGRKESEFDDEP
                     KFMSKVIGANKNQEEEKSGKWEGLVYAPPGKEKQRKTEELEEESFPERSKKEDRGKRS
                     EGGHRGFVPEKNFRVTAYKAVQEKSSSPPPRKTSESRDKLGAKGDFPTGKSSFSITRE
                     AQVNVRMDSFDEDLARPSGLLAQERKLCRDLVHSNKKEQEFRSIFQHIQSAQSQRSPS
                     ELFAQHIVTIVHHVKEHHFGSSGMTLHERFTKYLKRGTEQEAAKNKKSPEIHRRIDIS
                     PSTFRKHGLAHDEMKSPREPGYKAEGKYKDDPVDLRLDIERRKKHKERDLKRGKSRES
                     VDSRDSSHSRERSAEKTEKTHKGSKKQKKHRRARDRSRSSSSSSQSSHSYKAEEYTEE
                     TEEREESTTGFDKSRLGTKDFVGPSERGGGRARGTFQFRARGRGWGRGNYSGNNNNNS
                     NNDFQKRNREEEWDPEYTPKSKKYYLHDDREGEGSDKWVSRGRGRGAFPRGRGRFMFR
                     KSSTSPKWAHDKFSGEEGEIEDDESGTENREEKDNIQPTTE"
     exon            335..1237
                     /gene="THRAP3"
                     /gene_synonym="BCLAF2; TRAP150"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1942
                     /gene="THRAP3"
                     /gene_synonym="BCLAF2; TRAP150"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2115
                     /gene="THRAP3"
                     /gene_synonym="BCLAF2; TRAP150"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2227
                     /gene="THRAP3"
                     /gene_synonym="BCLAF2; TRAP150"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2312
                     /gene="THRAP3"
                     /gene_synonym="BCLAF2; TRAP150"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..2500
                     /gene="THRAP3"
                     /gene_synonym="BCLAF2; TRAP150"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2699
                     /gene="THRAP3"
                     /gene_synonym="BCLAF2; TRAP150"
                     /inference="alignment:Splign:2.1.0"
     exon            2700..2843
                     /gene="THRAP3"
                     /gene_synonym="BCLAF2; TRAP150"
                     /inference="alignment:Splign:2.1.0"
     exon            2844..4405
                     /gene="THRAP3"
                     /gene_synonym="BCLAF2; TRAP150"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4377..4382
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THRAP3"
                     /gene_synonym="BCLAF2; TRAP150"
                     /note="hexamer: AATAAA"
     regulatory      4386..4391
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THRAP3"
                     /gene_synonym="BCLAF2; TRAP150"
                     /note="hexamer: AATGAA"
     polyA_site      4397
                     /gene="THRAP3"
                     /gene_synonym="BCLAF2; TRAP150"
                     /note="major polyA site"
     polyA_site      4405
                     /gene="THRAP3"
                     /gene_synonym="BCLAF2; TRAP150"
                     /note="major polyA site"
ORIGIN      
        1 gggcgaggtt cgggctggtt gttccgttgc gagctgcagc tgcgatctct gtggtaggcc
       61 cagaagtgta tgctgacttg taaagtgaag aagccagtgg tgctgcgggt gttcttttgg
      121 ggtagtgtct gggatccagt acgagttgaa tcattgttca aataaggtgt aattgaaaag
      181 tgatcctctc ttcagagatg tcaaaaacaa acaaatccaa gtctggatct cgctcttctc
      241 gctcaagatc tgcatcaaga tctcgttctc gttcattttc gaagtctcgg tcccgaagcc
      301 gatctctctc tcgttcaagg aagcgcaggc tgagttctag gtctcgttcc agatcatatt
      361 ctccagctca taacagagaa agaaaccacc caagagtata tcagaatcgg gatttccgag
      421 gtcacaacag aggctataga aggccctatt atttccgtgg gcgtaacaga ggcttttatc
      481 catggggcca atataaccga ggaggctatg gaaactaccg ctcaaattgg cagaattacc
      541 ggcaagcata cagtcctcgt cgaggccgtt caagatcccg gtccccaaag agaaggtccc
      601 cttcaccaag gtccaggagc cattctagaa actctgataa gtcgtcttct gaccggtcaa
      661 ggcgctcctc atcctcccgt tcttcctcca accatagccg agttgaatct tctaagcgca
      721 agtctgcaaa ggagaaaaag tcctcttcta aggatagccg gccatctcag gctgccgggg
      781 ataaccaggg agatgaggcc aaggagcaga cattctctgg aggcacctct caagatacaa
      841 aagcatctga gagctcgaag ccatggccag atgccaccta cggcactggt tctgcatcac
      901 gggcctcagc agtttctgag ctgagtcctc gggagcgaag cccagctctc aaaagccccc
      961 tccagtctgt ggtggtgagg cggcggtcac cccgtcctag ccccgtgcca aaacctagtc
     1021 ctccactttc cagcacatcc cagatgggct caactctgcc gagtggtgcc gggtatcagt
     1081 ctgggacaca ccaaggtcag ttcgaccatg gttctgggtc cctgagtcca tccaaaaaga
     1141 gccctgtggg taagagtcca ccatccactg gctccacata tggctcatct cagaaggagg
     1201 agagtgctgc ttcaggagga gcagcctata caaagaggta tctagaagag cagaagacag
     1261 agaatggaaa agataaggaa cagaaacaaa caaataccga taaagaaaaa ataaaagaga
     1321 aagggagctt ctctgacaca ggcttgggtg atggaaaaat gaaatctgat tcttttgctc
     1381 ccaaaactga ttctgagaag ccttttcggg gcagtcagtc tcccaaaagg tataagctcc
     1441 gagatgactt tgagaagaag atggctgact tccacaagga ggagatggat gatcaagata
     1501 aggacaaagc taagggaaga aaggaatctg agtttgatga tgaacccaaa tttatgtcta
     1561 aagtcatagg tgcaaacaaa aaccaggagg aggagaagtc aggcaaatgg gagggcctgg
     1621 tatatgcacc tccagggaag gaaaagcaga gaaaaacaga ggagctggag gaggagtctt
     1681 tcccagagag atccaaaaag gaagatcggg gcaagagaag cgaaggtggg cacaggggct
     1741 ttgtgcctga gaagaatttc cgagtgactg cttataaagc agtccaggag aaaagctcat
     1801 cacctccccc aagaaagacc tctgagagcc gagacaagct gggagcgaaa ggagattttc
     1861 ccacaggaaa gtcttccttt tccattactc gagaggcaca ggtcaatgtc cggatggact
     1921 cttttgatga ggacctcgca cgacccagtg gcttattggc tcaggaacgc aagctttgcc
     1981 gagatctagt ccatagcaac aaaaaggaac aggagtttcg ttccattttc cagcacatac
     2041 aatcagctca gtctcagcgt agcccctcag aactgtttgc ccaacatata gtgaccattg
     2101 ttcaccatgt taaagagcat cactttgggt cctcaggaat gacattacat gaacgcttta
     2161 ctaaatacct aaagagagga actgagcagg aggcagccaa aaacaagaaa agcccagaga
     2221 tacacaggag aatagacatt tcccccagta cattcagaaa acatggtttg gctcatgatg
     2281 aaatgaaaag tccccgggaa cctggctaca aggctgaggg aaaatacaaa gatgatcctg
     2341 ttgatctccg ccttgatatt gaacgtcgta aaaaacataa ggagagagat cttaaacgag
     2401 gtaaatcgag agaatcagtg gattcccgag actccagtca ctcaagggaa aggtcagctg
     2461 aaaaaacaga gaaaactcat aaaggatcaa agaaacagaa gaagcatcgg agagcaagag
     2521 acaggtccag atcctcctcc tcttcctccc agtcatctca ctcctacaaa gcagaagagt
     2581 acactgaaga gacagaggaa agagaggaga gcaccacggg ctttgacaaa tcaagactgg
     2641 ggaccaaaga ctttgtgggt ccaagtgaaa gaggaggtgg cagagctcga ggaacctttc
     2701 agtttcgagc cagaggaaga ggctggggca gaggcaacta ctctgggaac aataacaaca
     2761 acagcaacaa cgattttcaa aaaagaaacc gggaagagga gtgggaccca gagtacacac
     2821 ccaaaagcaa gaagtattac ttgcatgatg accgtgaagg cgaaggcagt gacaagtggg
     2881 tgagccgggg ccggggccga ggagcctttc ctcggggtcg gggccggttc atgttccgga
     2941 aatcaagtac cagccccaag tgggcccatg acaagttcag tggggaggaa ggggagattg
     3001 aagacgacga gagtgggaca gagaaccgag aagagaagga caatatacag cccacaaccg
     3061 agtaggggcc acccttgacg ggattcctgc ccaggggaga gaggcgctgg gaagatggct
     3121 ggtgaggagc ttaacagagg aacctcaaga agattctgaa aatcctaccc ccacccccca
     3181 ccagccgcac agattgtact accgcgagag gcatccctgg cgctgtctcc cactggacag
     3241 aggaggctgg ccatggggcc caggggtcag gcccagcttt tgagcagaat acaacgcatt
     3301 gggctttagc tgtttttctc atttgttggt gtgtggggtg ggggcagggg tagggcggga
     3361 gagcgatgct tggatttttg tttcctatta gaaaccaaca gttttgttct aatttcattt
     3421 catttggagc taagatgact aatttgatga ttttcgatct cttttcccct gtcctgattt
     3481 taaaagcccc ctcctttttt tttttttttt tcttttttta ggcatatgta gtaatattag
     3541 aaacatttaa tttgggaaac tttgattctt gaaagagaaa acaaaagcat gtgaataaac
     3601 tttgaagtgt tcacctcagt ttgggaccaa actgcttgga tctttgtaaa aaccggtttt
     3661 gtatgtcaag gaggagttta aggcctttcc gaccaccttg tgttcccctt ttctgcgcag
     3721 ccatgtatca cgtggagttg ctccttacca cacctcacgt gcccctgagc cctatttcct
     3781 gatttcttct gggctggact tccccgttct ccaccagcag ctccagtatc ccaaactttc
     3841 tagtcctgct gatcctccca gcaacggggt ggaaactgga gggcagtgtc tggtctgttt
     3901 tctaagaaac ttatgaattc tattatcttt acaaatatga gaaaattttt tcaatatttt
     3961 ttattaatct ttttataaaa tgaaaagaaa ctcctatgat cgattaagga aggtggttat
     4021 ggctgggtgg ttcaggggtt tttttgggtt tctttttttt tttctttgtc tttttaacct
     4081 taagctgttt aagttgaagc attctcagat gtttgggggg aaacatcctc ttaaaatggg
     4141 tccttgtgct tgccttctgg ggaggcggtc ctgagcaggt gaatcataag gcatttatgc
     4201 atatgttata tgcggactgc acccacctct cccccccagc ctttgcctct tgcgttgttg
     4261 tgctgctttc cccttacttt gctacatttc tatagttaag ttggttttac ttgaatgatt
     4321 catgtttagg gggaaaatga aaatctccct taaaatttgt ttcaactcct cctgcaaata
     4381 aaataaatga agtggcagat gtaaa
//
