LOCUS       NM_199334               5204 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens thyroid hormone receptor alpha (THRA), transcript
            variant 1, mRNA.
ACCESSION   NM_199334
VERSION     NM_199334.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5204)
  AUTHORS   Graceffo,E., Opitz,R., Megges,M., Krude,H. and Schuelke,M.
  TITLE     RNA Sequencing Reveals a Strong Predominance of THRA Splicing
            Isoform 2 in the Developing and Adult Human Brain
  JOURNAL   Int J Mol Sci 25 (18), 9883 (2024)
   PUBMED   39337374
  REMARK    GeneRIF: RNA Sequencing Reveals a Strong Predominance of THRA
            Splicing Isoform 2 in the Developing and Adult Human Brain.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5204)
  AUTHORS   Graffunder,A.S., Bresser,A.A.J., Fernandez Vallone,V., Megges,M.,
            Stachelscheid,H., Kuhnen,P. and Opitz,R.
  TITLE     Spatiotemporal expression of thyroid hormone transporter MCT8 and
            THRA mRNA in human cerebral organoids recapitulating first
            trimester cortex development
  JOURNAL   Sci Rep 14 (1), 9355 (2024)
   PUBMED   38654093
  REMARK    GeneRIF: Spatiotemporal expression of thyroid hormone transporter
            MCT8 and THRA mRNA in human cerebral organoids recapitulating first
            trimester cortex development.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5204)
  AUTHORS   Hwang,E., Doolittle,W.K.L., Zhu,Y.J., Zhu,X., Zhao,L., Yu,Y. and
            Cheng,S.Y.
  TITLE     Thyroid hormone receptor alpha1: a novel regulator of thyroid
            cancer cell differentiation
  JOURNAL   Oncogene 42 (41), 3075-3086 (2023)
   PUBMED   37634007
  REMARK    GeneRIF: Thyroid hormone receptor alpha1: a novel regulator of
            thyroid cancer cell differentiation.
REFERENCE   4  (bases 1 to 5204)
  AUTHORS   Giolito,M.V., La Rosa,T., Farhat,D., Bodoirat,S., Guardia,G.D.A.,
            Domon-Dell,C., Galante,P.A.F., Freund,J.N. and Plateroti,M.
  TITLE     Regulation of the THRA gene, encoding the thyroid hormone nuclear
            receptor TRalpha1, in intestinal lesions
  JOURNAL   Mol Oncol 16 (22), 3975-3993 (2022)
   PUBMED   36217307
  REMARK    GeneRIF: Regulation of the THRA gene, encoding the thyroid hormone
            nuclear receptor TRalpha1, in intestinal lesions.
REFERENCE   5  (bases 1 to 5204)
  AUTHORS   Sandsveden,M., Borgquist,S., Rosendahl,A.H. and Manjer,J.
  TITLE     Low thyroid hormone receptor alpha-2 (THRalpha-2) tumor expression
            is associated with unfavorable tumor characteristics and high
            breast cancer mortality
  JOURNAL   Breast Cancer Res 23 (1), 117 (2021)
   PUBMED   34930399
  REMARK    GeneRIF: Low thyroid hormone receptor alpha-2 (THRalpha-2) tumor
            expression is associated with unfavorable tumor characteristics and
            high breast cancer mortality.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5204)
  AUTHORS   Sakurai,A., Bell,G.I. and DeGroot,L.J.
  TITLE     Dinucleotide repeat polymorphism in the human thyroid hormone
            receptor alpha gene (THRA1) on chromosome 17
  JOURNAL   Hum Mol Genet 1 (7), 553 (1992)
   PUBMED   1307263
REFERENCE   7  (bases 1 to 5204)
  AUTHORS   Berrodin,T.J., Marks,M.S., Ozato,K., Linney,E. and Lazar,M.A.
  TITLE     Heterodimerization among thyroid hormone receptor, retinoic acid
            receptor, retinoid X receptor, chicken ovalbumin upstream promoter
            transcription factor, and an endogenous liver protein
  JOURNAL   Mol Endocrinol 6 (9), 1468-1478 (1992)
   PUBMED   1331778
REFERENCE   8  (bases 1 to 5204)
  AUTHORS   Schmidt,E.D., Schmidt,E.D., van der Gaag,R., Ganpat,R.,
            Broersma,L., de Boer,P.A., Moorman,A.F., Lamers,W.H.,
            Wiersinga,W.M. and Koornneef,L.
  TITLE     Distribution of the nuclear thyroid-hormone receptor in extraocular
            and skeletal muscles
  JOURNAL   J Endocrinol 133 (1), 67-74 (1992)
   PUBMED   1517709
REFERENCE   9  (bases 1 to 5204)
  AUTHORS   Yen,P.M., Sunday,M.E., Darling,D.S. and Chin,W.W.
  TITLE     Isoform-specific thyroid hormone receptor antibodies detect
            multiple thyroid hormone receptors in rat and human pituitaries
  JOURNAL   Endocrinology 130 (3), 1539-1546 (1992)
   PUBMED   1537303
REFERENCE   10 (bases 1 to 5204)
  AUTHORS   Zhang,X.K., Hoffmann,B., Tran,P.B., Graupner,G. and Pfahl,M.
  TITLE     Retinoid X receptor is an auxiliary protein for thyroid hormone and
            retinoic acid receptors
  JOURNAL   Nature 355 (6359), 441-446 (1992)
   PUBMED   1310350
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC035137.1, AC068669.21 and
            X55005.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 28, 2019 this sequence version replaced NM_199334.4.
            
            Summary: The protein encoded by this gene is a nuclear hormone
            receptor for triiodothyronine. It is one of the several receptors
            for thyroid hormone, and has been shown to mediate the biological
            activities of thyroid hormone. Knockout studies in mice suggest
            that the different receptors, while having certain extent of
            redundancy, may mediate different functions of thyroid hormone.
            Alternatively spliced transcript variants encoding distinct
            isoforms have been reported. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) has a different 3' end exon
            compared to variant 2. The resulting isoform (1) is shorter and has
            a distinct C-terminus compared to isoform 2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853558.10390.1,
                                           SRR14038192.791925.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000450525.7/ ENSP00000395641.3
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1535              BC035137.1         160-1694
            1536-2160           AC068669.21        34305-34929
            2161-2239           X55005.1           2199-2277
            2240-5204           AC068669.21        35009-37973
FEATURES             Location/Qualifiers
     source          1..5204
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.1"
     gene            1..5204
                     /gene="THRA"
                     /gene_synonym="AR7; c-erbA; c-ERBA-1; CHNG6; EAR7;
                     ERB-T-1; ERBA; ERBA1; NR1A1; THRA1; THRA2; THRalpha;
                     THRalpha1; THRalpha2; TRalpha; TRalpha1; TRalpha2"
                     /note="thyroid hormone receptor alpha"
                     /db_xref="GeneID:7067"
                     /db_xref="HGNC:HGNC:11796"
                     /db_xref="MIM:190120"
     exon            1..128
                     /gene="THRA"
                     /gene_synonym="AR7; c-erbA; c-ERBA-1; CHNG6; EAR7;
                     ERB-T-1; ERBA; ERBA1; NR1A1; THRA1; THRA2; THRalpha;
                     THRalpha1; THRalpha2; TRalpha; TRalpha1; TRalpha2"
                     /inference="alignment:Splign:2.1.0"
     exon            129..478
                     /gene="THRA"
                     /gene_synonym="AR7; c-erbA; c-ERBA-1; CHNG6; EAR7;
                     ERB-T-1; ERBA; ERBA1; NR1A1; THRA1; THRA2; THRalpha;
                     THRalpha1; THRalpha2; TRalpha; TRalpha1; TRalpha2"
                     /inference="alignment:Splign:2.1.0"
     CDS             426..1658
                     /gene="THRA"
                     /gene_synonym="AR7; c-erbA; c-ERBA-1; CHNG6; EAR7;
                     ERB-T-1; ERBA; ERBA1; NR1A1; THRA1; THRA2; THRalpha;
                     THRalpha1; THRalpha2; TRalpha; TRalpha1; TRalpha2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     thyroid hormone receptor, alpha (erythroblastic leukemia
                     viral (v-erb-a) oncogene homolog, avian); ERBA-related 7;
                     triiodothyronine receptor; thyroid hormone receptor alpha
                     1; EAR-7; c-erbA protooncogene; c-erbA-alpha;
                     V-erbA-related protein 7; nuclear receptor subfamily 1
                     group A member 1"
                     /codon_start=1
                     /product="thyroid hormone receptor alpha isoform 1"
                     /protein_id="NP_955366.1"
                     /db_xref="CCDS:CCDS42316.1"
                     /db_xref="GeneID:7067"
                     /db_xref="HGNC:HGNC:11796"
                     /db_xref="MIM:190120"
                     /translation="MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIP
                     SYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKI
                     TRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEP
                     TPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEF
                     TKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTL
                     SGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLC
                     VDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKVTDLRMIGACHASRFLHMKVEC
                     PTELFPPLFLEVFEDQEV"
     exon            479..546
                     /gene="THRA"
                     /gene_synonym="AR7; c-erbA; c-ERBA-1; CHNG6; EAR7;
                     ERB-T-1; ERBA; ERBA1; NR1A1; THRA1; THRA2; THRalpha;
                     THRalpha1; THRalpha2; TRalpha; TRalpha1; TRalpha2"
                     /inference="alignment:Splign:2.1.0"
     exon            547..647
                     /gene="THRA"
                     /gene_synonym="AR7; c-erbA; c-ERBA-1; CHNG6; EAR7;
                     ERB-T-1; ERBA; ERBA1; NR1A1; THRA1; THRA2; THRalpha;
                     THRalpha1; THRalpha2; TRalpha; TRalpha1; TRalpha2"
                     /inference="alignment:Splign:2.1.0"
     exon            648..795
                     /gene="THRA"
                     /gene_synonym="AR7; c-erbA; c-ERBA-1; CHNG6; EAR7;
                     ERB-T-1; ERBA; ERBA1; NR1A1; THRA1; THRA2; THRalpha;
                     THRalpha1; THRalpha2; TRalpha; TRalpha1; TRalpha2"
                     /inference="alignment:Splign:2.1.0"
     exon            796..1001
                     /gene="THRA"
                     /gene_synonym="AR7; c-erbA; c-ERBA-1; CHNG6; EAR7;
                     ERB-T-1; ERBA; ERBA1; NR1A1; THRA1; THRA2; THRalpha;
                     THRalpha1; THRalpha2; TRalpha; TRalpha1; TRalpha2"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1148
                     /gene="THRA"
                     /gene_synonym="AR7; c-erbA; c-ERBA-1; CHNG6; EAR7;
                     ERB-T-1; ERBA; ERBA1; NR1A1; THRA1; THRA2; THRalpha;
                     THRalpha1; THRalpha2; TRalpha; TRalpha1; TRalpha2"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1407
                     /gene="THRA"
                     /gene_synonym="AR7; c-erbA; c-ERBA-1; CHNG6; EAR7;
                     ERB-T-1; ERBA; ERBA1; NR1A1; THRA1; THRA2; THRalpha;
                     THRalpha1; THRalpha2; TRalpha; TRalpha1; TRalpha2"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..5204
                     /gene="THRA"
                     /gene_synonym="AR7; c-erbA; c-ERBA-1; CHNG6; EAR7;
                     ERB-T-1; ERBA; ERBA1; NR1A1; THRA1; THRA2; THRalpha;
                     THRalpha1; THRalpha2; TRalpha; TRalpha1; TRalpha2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4753..4758
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THRA"
                     /gene_synonym="AR7; c-erbA; c-ERBA-1; CHNG6; EAR7;
                     ERB-T-1; ERBA; ERBA1; NR1A1; THRA1; THRA2; THRalpha;
                     THRalpha1; THRalpha2; TRalpha; TRalpha1; TRalpha2"
                     /note="hexamer: AAGAAA"
     polyA_site      4774
                     /gene="THRA"
                     /gene_synonym="AR7; c-erbA; c-ERBA-1; CHNG6; EAR7;
                     ERB-T-1; ERBA; ERBA1; NR1A1; THRA1; THRA2; THRalpha;
                     THRalpha1; THRalpha2; TRalpha; TRalpha1; TRalpha2"
     regulatory      4808..4813
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THRA"
                     /gene_synonym="AR7; c-erbA; c-ERBA-1; CHNG6; EAR7;
                     ERB-T-1; ERBA; ERBA1; NR1A1; THRA1; THRA2; THRalpha;
                     THRalpha1; THRalpha2; TRalpha; TRalpha1; TRalpha2"
                     /note="hexamer: AATAAA"
     regulatory      4812..4817
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THRA"
                     /gene_synonym="AR7; c-erbA; c-ERBA-1; CHNG6; EAR7;
                     ERB-T-1; ERBA; ERBA1; NR1A1; THRA1; THRA2; THRalpha;
                     THRalpha1; THRalpha2; TRalpha; TRalpha1; TRalpha2"
                     /note="hexamer: AATATA"
     polyA_site      4826
                     /gene="THRA"
                     /gene_synonym="AR7; c-erbA; c-ERBA-1; CHNG6; EAR7;
                     ERB-T-1; ERBA; ERBA1; NR1A1; THRA1; THRA2; THRalpha;
                     THRalpha1; THRalpha2; TRalpha; TRalpha1; TRalpha2"
     polyA_site      4829
                     /gene="THRA"
                     /gene_synonym="AR7; c-erbA; c-ERBA-1; CHNG6; EAR7;
                     ERB-T-1; ERBA; ERBA1; NR1A1; THRA1; THRA2; THRalpha;
                     THRalpha1; THRalpha2; TRalpha; TRalpha1; TRalpha2"
                     /note="major polyA site"
     regulatory      5178..5183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THRA"
                     /gene_synonym="AR7; c-erbA; c-ERBA-1; CHNG6; EAR7;
                     ERB-T-1; ERBA; ERBA1; NR1A1; THRA1; THRA2; THRalpha;
                     THRalpha1; THRalpha2; TRalpha; TRalpha1; TRalpha2"
                     /note="hexamer: TATAAA"
     polyA_site      5204
                     /gene="THRA"
                     /gene_synonym="AR7; c-erbA; c-ERBA-1; CHNG6; EAR7;
                     ERB-T-1; ERBA; ERBA1; NR1A1; THRA1; THRA2; THRalpha;
                     THRalpha1; THRalpha2; TRalpha; TRalpha1; TRalpha2"
ORIGIN      
        1 actcgcactc acacccgggc gcaggaggcg ggcggcccgg gccccaccgg ccccccatgg
       61 acgcccccag cacggggcgc tgagaccccc gcgtcgctgc ccagcccggt ccggcgcgcc
      121 acgccgaggg atctctggac aggacaagac tccgaagcta ctcccccagc acacagcccg
      181 ggacccacaa acccagcttg cccccagccc tcccacctgc cactccctgg cccctcccac
      241 cgcccgcccc ccttggggcg cagggcatgg tgtgaaaggc caagtgctga ggcgggtatc
      301 atgggtgctg tgccctaggg cctgggtggc agggggtggg tggcctgtgg gtgtgccggg
      361 ggggccagtg tgcccacccc agtctcttgg cgtgctggag ggcatcctgg atggaattga
      421 agtgaatgga acagaagcca agcaaggtgg agtgtgggtc agacccagag gagaacagtg
      481 ccaggtcacc agatggaaag cgaaaaagaa agaacggcca atgttccctg aaaaccagca
      541 tgtcagggta tatccctagt tacctggaca aagacgagca gtgtgtcgtg tgtggggaca
      601 aggcaactgg ttatcactac cgctgtatca cttgtgaggg ctgcaagggc ttctttcgcc
      661 gcacaatcca gaagaacctc catcccacct attcctgcaa atatgacagc tgctgtgtca
      721 ttgacaagat cacccgcaat cagtgccagc tgtgccgctt caagaagtgc atcgccgtgg
      781 gcatggccat ggacttggtt ctagatgact cgaagcgggt ggccaagcgt aagctgattg
      841 agcagaaccg ggagcggcgg cggaaggagg agatgatccg atcactgcag cagcgaccag
      901 agcccactcc tgaagagtgg gatctgatcc acattgccac agaggcccat cgcagcacca
      961 atgcccaggg cagccattgg aaacagaggc ggaaattcct gcccgatgac attggccagt
     1021 cacccattgt ctccatgccg gacggagaca aggtggacct ggaagccttc agcgagttta
     1081 ccaagatcat caccccggcc atcacccgtg tggtggactt tgccaaaaaa ctgcccatgt
     1141 tctccgagct gccttgcgaa gaccagatca tcctcctgaa ggggtgctgc atggagatca
     1201 tgtccctgcg ggcggctgtc cgctacgacc ctgagagcga caccctgacg ctgagtgggg
     1261 agatggctgt caagcgggag cagctcaaga atggcggcct gggcgtagtc tccgacgcca
     1321 tctttgaact gggcaagtca ctctctgcct ttaacctgga tgacacggaa gtggctctgc
     1381 tgcaggctgt gctgctaatg tcaacagacc gctcgggcct gctgtgtgtg gacaagatcg
     1441 agaagagtca ggaggcgtac ctgctggcgt tcgagcacta cgtcaaccac cgcaaacaca
     1501 acattccgca cttctggccc aagctgctga tgaaggtgac tgacctccgc atgatcgggg
     1561 cctgccacgc cagccgcttc ctccacatga aagtcgagtg ccccaccgaa ctcttccccc
     1621 cactcttcct cgaggtcttt gaggatcagg aagtctaaag cctcaggcgg ccagagggtg
     1681 tgcggagctg gtggggagga gcctggagag aaggggcaga gctgggggct gagggagacc
     1741 cccccacacc ccttctctcc ttcctctcgt ccttggatag attcagctcc cacacacaca
     1801 cccgcactgc ccaggtccct cctcagacct ccagccctgg gacagggcaa acaactgaac
     1861 ttgctatgga aaggacagtg tgggaggctg ggggagctgt gtcctgcagt tcccaggacc
     1921 ccatcctctc agaaggtagg ggaagggcgg gaggattgag aagggacaag ccaccttgac
     1981 cgtaggggaa ggaggaatgt gggctggggg aagatgccct caactcaccc cctacacaca
     2041 catgagagag agcccccacc cagttccttg gcctaggtct cccctccagg ctgagggcct
     2101 ctctacttcc ccagatgcct gggtgcaaag aacggcttgg cttggctcct cctctggagg
     2161 ttaaaattta tagtcattct aactgcactt tggaaaccaa gcaaggggag aagacaaatg
     2221 aagaaaaact agacagagag aaaaatacaa aaaagagaga gcgagcgata gagagagatg
     2281 atattaagtt attaactgag gctgaccaga ggggaggacc ccccctttac caccccatgc
     2341 actttgcgag ctgccccttc ttcccccaca tcagagagaa atgcccccac accagagccc
     2401 caagggtagg gctgccgatc agagctgtga gttaacacaa cagggtcctg gccacccccc
     2461 ttgccatacc ccgccctctg tgcccctttg gcacccccca accctagtat gtcctctgct
     2521 ttctgccact cgtgcccgct gagttccatc tacctctcat gctggatgcc agctggcccc
     2581 tcaccagcct gccctgctgc ccacacagct cccctttaag tgcccagccc taggggcctc
     2641 tccccatcca cctcctcctt ccacaccttg gcacccaccc aggaaaaaac tgtggctcca
     2701 actcctaccc tccttatatc ctgcagtatt agctagaaac cggatgctgc tgcattggtt
     2761 gggtcggggg taggagggct gtgcgtgagc gtctcccaga accctccacc cctttagcac
     2821 tctgtttccc tgtttcccat ctgtcttctg ggctctctct aacctctgcc ctcctcccca
     2881 gctcctactc actgcactaa ctctgggcgg gcaggtacca gaatgggggt gtttagataa
     2941 gtgacactta gttggggccc caggggaggg gtggtcggtg ctcctttttc tttaaagctc
     3001 ttttggccag ctgcccctct gccccgggac cccttcccct cttcttttct ctaattcagg
     3061 gactttggct tgagcccctc tcgccctcct ggtgagggtg ctctgttggt ctgcacttgg
     3121 gtgagctgtc ctcctccccc tccctgtggc tgccgcccac tcctcagggg agagagggag
     3181 agaggaggtg gtcctcccat gggagcagga ggtggggtgg gacagagcag accagagggt
     3241 gctgggctca gggctgcatg tcggcaggga tggatgggtg gacacagatg cccccggaag
     3301 ccatggggat tggggcaggg ggtgggggga ggggtgccag ggcttcctgc gctttgcact
     3361 attggggcaa aaatgtctta agcagtgggg aacctgccac cccaccctga ccctcagcct
     3421 gccacagccc cctacacaca cacacacaca cacacacaca cacacacaca cacggacatg
     3481 cacacacgga catgggaagg caatgctatg ctgcccgtca gggcactgtc cttccccaat
     3541 cgttcaggtg ttccaacagg ggtggagggc ctggaggagc acccgctgtc acctgtgcat
     3601 gtgcctgtcc caccctgctg gggcctcggg ctgcccgcgc tgtctttgtc tctatcctct
     3661 ctctctctcc tggagtactg aatcctgtat tactccagtc ccatgggtag gccctcttgt
     3721 accttcctac cacgcctggg ggcccagtgg aattcctgac ctgtctgctg tcttccccat
     3781 ccctccatcc ccaccccaac ccctccatcc ccattctcag ccatggacac ggcagagaaa
     3841 aggccttgaa gagccttagc ctcttatagg cacttgggac tcccccaccc tccccaatca
     3901 tatgagctgt gatcccatcc tccccggacc cctcccttcc ccctcggtga tgtggggtgt
     3961 atgtgtgcgt tcctctgcgt gaatgtgtga gtgagtacac atggtagggg aggagccagg
     4021 gcgactcagg agtgccacgc acctgctcta gagcggcagc tgtcccagtc cctgctgtgg
     4081 aagtggggga cagggccctc tcctgggggc cattggtgct aatgaggggg atggccttga
     4141 tgtgggtgct cagcatgcct cccccagtat tggcccgggg cactagggca ggcagggtgg
     4201 agcagcaggt gcagtatcgg tgggaggacg ggttgctggg aataggacga gggggccagg
     4261 ccaggacaag gggttgccag agccatgacc actaccccgc ccccaccacc cgcctctcca
     4321 tctcagtatt gcccctccca tcactcataa cacacatacc tcatccagcc tcctccctgc
     4381 tcagacttgg ggagggtggg ggaggagccc ctaccccttc tcctggtggc gggtctgcag
     4441 ggctgggaga gggcagggcg ttgtgagaga gagaccgtcc ataaggagga cagtaactcc
     4501 tgccctggga actcctgggc gggggggagg gggacactgc ccagaggcgc tactgaatgt
     4561 atgagaagct ggtgctgggc tggggggagg ggggttgtgg ccagaaacag ggaaggaggt
     4621 aggtctcttc cccagggagg ggtgggaccg gcaggggtga cttgaggggc tcctactcct
     4681 gccccacgtt gacaatcagt atgtctgtta tgtgcgattt ttcaccccgt tgtgttttgg
     4741 gtcaggattt taaagaaaga tatttttatg gtaattgttg ctcgtctatt ttactatata
     4801 tttatgtaat aaatatatga tgaaaataac ccccttgggc acccccctta gacttgtgtg
     4861 ctgtttccct atatcctccc atctgctggc agagtaccca ccccacaaac tgaccagatg
     4921 gagaggtggc cccccccagc cttggcagta tttccacccc accccccaaa cgagcacaca
     4981 ccacagaagc cagctcagct gtgaactatt ggatttgaga caggaacaga acaaatcaga
     5041 gggccagggg agggttgtgg gggagacaga gtggtttaaa taggggagga ggggaagttc
     5101 ggtgatgggg gagggaggca ggtatttaca agaaggctca gggggccaga ggctcatctt
     5161 ggaatatttt ataacaatat aaataagatt ctggtttgct tttc
//
