LOCUS       NM_025075                892 bp    mRNA    linear   PRI 06-OCT-2024
DEFINITION  Homo sapiens THO complex subunit 7 (THOC7), transcript variant 1,
            mRNA.
ACCESSION   NM_025075
VERSION     NM_025075.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 892)
  AUTHORS   Katahira,J., Senokuchi,K. and Hieda,M.
  TITLE     Human THO maintains the stability of repetitive DNA
  JOURNAL   Genes Cells 25 (5), 334-342 (2020)
   PUBMED   32065701
  REMARK    GeneRIF: Human THO maintains the stability of repetitive DNA.
REFERENCE   2  (bases 1 to 892)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 892)
  AUTHORS   He,T.S., Xie,T., Li,J., Yang,Y.X., Li,C., Wang,W., Cao,L., Rao,H.,
            Ju,C. and Xu,L.G.
  TITLE     THO Complex Subunit 7 Homolog Negatively Regulates Cellular
            Antiviral Response against RNA Viruses by Targeting TBK1
  JOURNAL   Viruses 11 (2), 158 (2019)
   PUBMED   30769920
  REMARK    GeneRIF: THOC7 negatively regulates type I IFN production by
            promoting TBK1 proteasomal degradation in Sendai virus infection
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 892)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   5  (bases 1 to 892)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   6  (bases 1 to 892)
  AUTHORS   Masuda,S., Das,R., Cheng,H., Hurt,E., Dorman,N. and Reed,R.
  TITLE     Recruitment of the human TREX complex to mRNA during splicing
  JOURNAL   Genes Dev 19 (13), 1512-1517 (2005)
   PUBMED   15998806
REFERENCE   7  (bases 1 to 892)
  AUTHORS   Guo,S., Hakimi,M.A., Baillat,D., Chen,X., Farber,M.J.,
            Klein-Szanto,A.J., Cooch,N.S., Godwin,A.K. and Shiekhattar,R.
  TITLE     Linking transcriptional elongation and messenger RNA export to
            metastatic breast cancers
  JOURNAL   Cancer Res 65 (8), 3011-3016 (2005)
   PUBMED   15833825
REFERENCE   8  (bases 1 to 892)
  AUTHORS   Tascou,S., Kang,T.W., Trappe,R., Engel,W. and Burfeind,P.
  TITLE     Identification and characterization of NIF3L1 BP1, a novel
            cytoplasmic interaction partner of the NIF3L1 protein
  JOURNAL   Biochem Biophys Res Commun 309 (2), 440-448 (2003)
   PUBMED   12951069
REFERENCE   9  (bases 1 to 892)
  AUTHORS   Sato,S., Tomomori-Sato,C., Banks,C.A., Sorokina,I., Parmely,T.J.,
            Kong,S.E., Jin,J., Cai,Y., Lane,W.S., Brower,C.S., Conaway,R.C. and
            Conaway,J.W.
  TITLE     Identification of mammalian Mediator subunits with similarities to
            yeast Mediator subunits Srb5, Srb6, Med11, and Rox3
  JOURNAL   J Biol Chem 278 (17), 15123-15127 (2003)
   PUBMED   12584197
REFERENCE   10 (bases 1 to 892)
  AUTHORS   Kleiderlein,J.J., Nisson,P.E., Jessee,J., Li,W.B., Becker,K.G.,
            Derby,M.L., Ross,C.A. and Margolis,R.L.
  TITLE     CCG repeats in cDNAs from human brain
  JOURNAL   Hum Genet 103 (6), 666-673 (1998)
   PUBMED   9921901
  REMARK    Erratum:[Hum Genet 1999 Jan;104(1):113]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK225110.1.
            
            On Nov 22, 2018 this sequence version replaced NM_025075.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK027098.1, AK225110.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295899.10/ ENSP00000295899.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-892               AK225110.1         7-898
FEATURES             Location/Qualifiers
     source          1..892
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.1"
     gene            1..892
                     /gene="THOC7"
                     /gene_synonym="fSAP24; hTREX30; NIF3L1BP1"
                     /note="THO complex subunit 7"
                     /db_xref="GeneID:80145"
                     /db_xref="HGNC:HGNC:29874"
                     /db_xref="MIM:611965"
     exon            1..34
                     /gene="THOC7"
                     /gene_synonym="fSAP24; hTREX30; NIF3L1BP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..630
                     /gene="THOC7"
                     /gene_synonym="fSAP24; hTREX30; NIF3L1BP1"
                     /note="isoform 1 is encoded by transcript variant 1; Ngg1
                     interacting factor 3 like 1 binding protein 1; functional
                     spliceosome-associated protein 24; THO complex subunit 7
                     homolog; NIF3L1-binding protein 1; THO complex 7 homolog;
                     ngg1-interacting factor 3-like protein 1-binding protein
                     1"
                     /codon_start=1
                     /product="THO complex subunit 7 isoform 1"
                     /protein_id="NP_079351.2"
                     /db_xref="CCDS:CCDS2900.1"
                     /db_xref="GeneID:80145"
                     /db_xref="HGNC:HGNC:29874"
                     /db_xref="MIM:611965"
                     /translation="MGAVTDDEVIRKRLLIDGDGAGDDRRINLLVKSFIKWCNSGSQE
                     EGYSQYQRMLSTLSQCEFSMGKTLLVYDMNLREMENYEKIYKEIECSIAGAHEKIAEC
                     KKQILQAKRIRKNRQEYDALAKVIQHHPDRHETLKELEALGKELEHLSHIKESVEDKL
                     ELRRKQFHVLLSTIHELQQTLENDEKLSEVEEAQEASMETDPKP"
     exon            35..152
                     /gene="THOC7"
                     /gene_synonym="fSAP24; hTREX30; NIF3L1BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            153..280
                     /gene="THOC7"
                     /gene_synonym="fSAP24; hTREX30; NIF3L1BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            281..367
                     /gene="THOC7"
                     /gene_synonym="fSAP24; hTREX30; NIF3L1BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            368..425
                     /gene="THOC7"
                     /gene_synonym="fSAP24; hTREX30; NIF3L1BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            426..492
                     /gene="THOC7"
                     /gene_synonym="fSAP24; hTREX30; NIF3L1BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            493..562
                     /gene="THOC7"
                     /gene_synonym="fSAP24; hTREX30; NIF3L1BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            563..892
                     /gene="THOC7"
                     /gene_synonym="fSAP24; hTREX30; NIF3L1BP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      871..876
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THOC7"
                     /gene_synonym="fSAP24; hTREX30; NIF3L1BP1"
                     /note="hexamer: AATAAA"
     polyA_site      892
                     /gene="THOC7"
                     /gene_synonym="fSAP24; hTREX30; NIF3L1BP1"
                     /note="major polyA site"
ORIGIN      
        1 gccgccgcgc acgccatggg agccgtgact gacgacgaag ttatacggaa gcgtctcctc
       61 attgatggag atggtgctgg agatgatcgg agaattaatc tgctagtgaa gagtttcatt
      121 aaatggtgca actctgggtc ccaggaagag ggatatagcc agtaccaacg tatgctgagc
      181 acgctgtctc aatgtgaatt ttcaatgggc aaaactttac tagtatatga tatgaatctc
      241 agagaaatgg aaaattatga aaaaatttac aaggaaatag aatgtagcat agctggagca
      301 catgaaaaaa ttgctgagtg caaaaagcaa attcttcaag caaaacgaat acgaaaaaat
      361 cgccaagaat atgatgcttt ggcaaaagtg attcagcacc atccagacag gcatgagaca
      421 ttaaaggaac tagaggctct gggaaaagaa ttagagcatc tttcacacat taaagaaagt
      481 gttgaagata agctggaatt gagacggaaa cagtttcatg ttcttcttag taccatccat
      541 gaacttcagc aaacattgga aaatgatgaa aaactctcag aggtagaaga agctcaggaa
      601 gcaagcatgg aaacagatcc taagccatag acaggctaat tgcccaccac tcccaggaat
      661 attgaaatag ctacatgacc ataatgtgtt taaaatgtgg tatgctcttg agatatttaa
      721 agttttggca gtaaaatact ctgtttttaa gtatgaatgt atttcattca tatttcctct
      781 cacaaaggaa aatgacttca gtatagattt gtttttatta aaatgcattt tttattctta
      841 agtggtagga agcaacatcc aaaaatgctt aataaaatgc ttttaagctg ca
//
