LOCUS       NM_003678               4728 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens THO complex subunit 5 (THOC5), transcript variant 4,
            mRNA.
ACCESSION   NM_003678 XM_376002
VERSION     NM_003678.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4728)
  AUTHORS   Mun,S.H., Oh,B., Lee,M.J., Bae,S., Yang,Y. and Park-Min,K.H.
  TITLE     THOC5 regulates human osteoclastogenesis
  JOURNAL   Eur J Cell Biol 101 (3), 151248 (2022)
   PUBMED   35688054
  REMARK    GeneRIF: THOC5 regulates human osteoclastogenesis.
REFERENCE   2  (bases 1 to 4728)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4728)
  AUTHORS   Alqassim,E.Y., Sharma,S., Khan,A.N.M.N.H., Emmons,T.R., Cortes
            Gomez,E., Alahmari,A., Singel,K.L., Mark,J., Davidson,B.A., Robert
            McGray,A.J., Liu,Q., Lichty,B.D., Moysich,K.B., Wang,J., Odunsi,K.,
            Segal,B.H. and Baysal,B.E.
  TITLE     RNA editing enzyme APOBEC3A promotes pro-inflammatory M1 macrophage
            polarization
  JOURNAL   Commun Biol 4 (1), 102 (2021)
   PUBMED   33483601
  REMARK    GeneRIF: RNA editing enzyme APOBEC3A promotes pro-inflammatory M1
            macrophage polarization.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4728)
  AUTHORS   Katahira,J., Senokuchi,K. and Hieda,M.
  TITLE     Human THO maintains the stability of repetitive DNA
  JOURNAL   Genes Cells 25 (5), 334-342 (2020)
   PUBMED   32065701
  REMARK    GeneRIF: Human THO maintains the stability of repetitive DNA.
REFERENCE   5  (bases 1 to 4728)
  AUTHORS   Loja-Chango,R., Salazar-Pousada,D., Escobar-Valdivieso,G.S.,
            Ramirez-Moran,C., Espinoza-Caicedo,J., Perez-Lopez,F.R.,
            Gavilanes,A.W.D. and Chedraui,P.
  TITLE     Polymorphism of the THOC5 of the transcription/export multiprotein
            complex and its correlation with the lipid and metabolic profile in
            middle-aged women
  JOURNAL   Gynecol Endocrinol 36 (3), 243-246 (2020)
   PUBMED   31402763
  REMARK    GeneRIF: Polymorphism of the THOC5 of the transcription/export
            multiprotein complex and its correlation with the lipid and
            metabolic profile in middle-aged women.
REFERENCE   6  (bases 1 to 4728)
  AUTHORS   Mancini,A., Koch,A., Whetton,A.D. and Tamura,T.
  TITLE     The M-CSF receptor substrate and interacting protein FMIP is
            governed in its subcellular localization by protein kinase
            C-mediated phosphorylation, and thereby potentiates M-CSF-mediated
            differentiation
  JOURNAL   Oncogene 23 (39), 6581-6589 (2004)
   PUBMED   15221008
REFERENCE   7  (bases 1 to 4728)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   8  (bases 1 to 4728)
  AUTHORS   Strasser,K., Masuda,S., Mason,P., Pfannstiel,J., Oppizzi,M.,
            Rodriguez-Navarro,S., Rondon,A.G., Aguilera,A., Struhl,K., Reed,R.
            and Hurt,E.
  TITLE     TREX is a conserved complex coupling transcription with messenger
            RNA export
  JOURNAL   Nature 417 (6886), 304-308 (2002)
   PUBMED   11979277
REFERENCE   9  (bases 1 to 4728)
  AUTHORS   Tamura,T., Mancini,A., Joos,H., Koch,A., Hakim,C., Dumanski,J.,
            Weidner,K.M. and Niemann,H.
  TITLE     FMIP, a novel Fms-interacting protein, affects
            granulocyte/macrophage differentiation
  JOURNAL   Oncogene 18 (47), 6488-6495 (1999)
   PUBMED   10597251
REFERENCE   10 (bases 1 to 4728)
  AUTHORS   Xie,Y.G., Han,F.Y., Peyrard,M., Ruttledge,M.H., Fransson,I.,
            DeJong,P., Collins,J., Dunham,I., Nordenskjold,M. and Dumanski,J.P.
  TITLE     Cloning of a novel, anonymous gene from a megabase-range YAC and
            cosmid contig in the neurofibromatosis type 2/meningioma region on
            human chromosome 22q12
  JOURNAL   Hum Mol Genet 2 (9), 1361-1368 (1993)
   PUBMED   8242058
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005529.7, BX404329.2, CR456542.1, BX400943.2, AB023200.1 and
            BQ184247.1.
            
            On Jun 2, 2019 this sequence version replaced NM_003678.4.
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. All four variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB023200.1, BC003615.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000490103.6/ ENSP00000420306.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC005529.7         81646-81655         c
            11-230              BX404329.2         5-224
            231-1670            CR456542.1         155-1594
            1671-2084           BX400943.2         163-576             c
            2085-2300           AB023200.1         2042-2257
            2301-2440           BQ184247.1         18-157              c
            2441-4728           AC005529.7         33777-36064         c
FEATURES             Location/Qualifiers
     source          1..4728
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.2"
     gene            1..4728
                     /gene="THOC5"
                     /gene_synonym="C22orf19; Fmip; fSAP79; PK1.3"
                     /note="THO complex subunit 5"
                     /db_xref="GeneID:8563"
                     /db_xref="HGNC:HGNC:19074"
                     /db_xref="MIM:612733"
     exon            1..87
                     /gene="THOC5"
                     /gene_synonym="C22orf19; Fmip; fSAP79; PK1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            88..194
                     /gene="THOC5"
                     /gene_synonym="C22orf19; Fmip; fSAP79; PK1.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..2150
                     /gene="THOC5"
                     /gene_synonym="C22orf19; Fmip; fSAP79; PK1.3"
                     /note="functional spliceosome-associated protein 79;
                     NF2/meningioma region protein pK1.3; placental protein
                     39.2; THO complex 5; THO complex subunit 5 homolog;
                     Fms-interacting protein; PP39.2; hTREX90"
                     /codon_start=1
                     /product="THO complex subunit 5"
                     /protein_id="NP_003669.4"
                     /db_xref="CCDS:CCDS13859.1"
                     /db_xref="GeneID:8563"
                     /db_xref="HGNC:HGNC:19074"
                     /db_xref="MIM:612733"
                     /translation="MSSESSKKRKPKVIRSDGAPAEGKRNRSDTEQEGKYYSEEAEVD
                     LRDPGRDYELYKYTCQELQRLMAEIQDLKSRGGKDVAIEIEERRIQSCVHFMTLKKLN
                     RLAHIRLKKGRDQTHEAKQKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLV
                     SLEEFYKEAPPDISKAEVTMGDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKE
                     IEVKKEYLSSLQPRLNSIMQASLPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQAT
                     AYGQACDKTLSVAIEGSVDEAKALFKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLD
                     DKRKEMLKRHPLSVMLDLKCKDDSVLHLTFYYLMNLNIMTVKAKVTTAMELITPISAG
                     DLLSPDSVLSCLYPGDHGKKTPNPANQYQFDKVGILTLSDYVLELGHPYLWVQKLGGL
                     HFPKEQPQQTVIADHSLSASHMETTMKLLKTRVQSRLALHKQFASLEHGIVPVTSDCQ
                     YLFPAKVVSRLVKWVTVAHEDYMELHFTKDIVDAGLAGDTNLYYMALIERGTAKLQAA
                     VVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRAMEGEVNVCYKELCGPWPSHQLLTN
                     QLQRLCVLLDVYLETESHDDSVEGPKEFPQEKMCLRLFRGPSRMKPFKYNHPQGFFSH
                     R"
     exon            195..338
                     /gene="THOC5"
                     /gene_synonym="C22orf19; Fmip; fSAP79; PK1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            339..452
                     /gene="THOC5"
                     /gene_synonym="C22orf19; Fmip; fSAP79; PK1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            453..550
                     /gene="THOC5"
                     /gene_synonym="C22orf19; Fmip; fSAP79; PK1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            551..697
                     /gene="THOC5"
                     /gene_synonym="C22orf19; Fmip; fSAP79; PK1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            698..812
                     /gene="THOC5"
                     /gene_synonym="C22orf19; Fmip; fSAP79; PK1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            813..945
                     /gene="THOC5"
                     /gene_synonym="C22orf19; Fmip; fSAP79; PK1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1023
                     /gene="THOC5"
                     /gene_synonym="C22orf19; Fmip; fSAP79; PK1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1064
                     /gene="THOC5"
                     /gene_synonym="C22orf19; Fmip; fSAP79; PK1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1164
                     /gene="THOC5"
                     /gene_synonym="C22orf19; Fmip; fSAP79; PK1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1273
                     /gene="THOC5"
                     /gene_synonym="C22orf19; Fmip; fSAP79; PK1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1375
                     /gene="THOC5"
                     /gene_synonym="C22orf19; Fmip; fSAP79; PK1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1472
                     /gene="THOC5"
                     /gene_synonym="C22orf19; Fmip; fSAP79; PK1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1587
                     /gene="THOC5"
                     /gene_synonym="C22orf19; Fmip; fSAP79; PK1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1691
                     /gene="THOC5"
                     /gene_synonym="C22orf19; Fmip; fSAP79; PK1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1779
                     /gene="THOC5"
                     /gene_synonym="C22orf19; Fmip; fSAP79; PK1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1895
                     /gene="THOC5"
                     /gene_synonym="C22orf19; Fmip; fSAP79; PK1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2086
                     /gene="THOC5"
                     /gene_synonym="C22orf19; Fmip; fSAP79; PK1.3"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..4728
                     /gene="THOC5"
                     /gene_synonym="C22orf19; Fmip; fSAP79; PK1.3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2260..2265
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THOC5"
                     /gene_synonym="C22orf19; Fmip; fSAP79; PK1.3"
                     /note="hexamer: ATTAAA"
     polyA_site      2278
                     /gene="THOC5"
                     /gene_synonym="C22orf19; Fmip; fSAP79; PK1.3"
                     /note="major polyA site"
     regulatory      2393..2398
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THOC5"
                     /gene_synonym="C22orf19; Fmip; fSAP79; PK1.3"
                     /note="hexamer: AATAAA"
     polyA_site      2440
                     /gene="THOC5"
                     /gene_synonym="C22orf19; Fmip; fSAP79; PK1.3"
     regulatory      2650..2655
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THOC5"
                     /gene_synonym="C22orf19; Fmip; fSAP79; PK1.3"
                     /note="hexamer: TATAAA"
     polyA_site      2676
                     /gene="THOC5"
                     /gene_synonym="C22orf19; Fmip; fSAP79; PK1.3"
     regulatory      4352..4357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THOC5"
                     /gene_synonym="C22orf19; Fmip; fSAP79; PK1.3"
                     /note="hexamer: AGTAAA"
     polyA_site      4372
                     /gene="THOC5"
                     /gene_synonym="C22orf19; Fmip; fSAP79; PK1.3"
ORIGIN      
        1 acttccggtt ctctatggtg cgcgggcaag ctttgctccg cctccggcag tggcttactc
       61 ccggtgccag gttcttggag ctgtgaggag gaacaaccat gtcatcagaa tcgagcaaaa
      121 aacggaagcc caaagtgatc cgaagcgatg gagccccagc tgaaggaaag cggaatcgat
      181 ctgacaccga gcaggaaggt aaatactaca gtgaggaggc cgaggtggat ctgcgggacc
      241 ctggcagaga ctatgagtta tacaagtaca cctgccagga gctacagagg ctgatggctg
      301 agatccaaga cctgaagagc aggggtggca aggatgtggc aatagaaata gaagaacgga
      361 ggatccagag ctgtgtgcat ttcatgactc taaagaagct taaccgatta gcccacatca
      421 ggttgaagaa aggaagagat cagacccacg aggctaagca gaaagtagat gcctatcatc
      481 tgcagctcca gaacctgttg tatgaggtga tgcacctaca gaaggagatc accaaatgtt
      541 tggagtttaa gtcaaagcat gaagaaattg atctggtcag tttagaggag ttttataagg
      601 aggctccacc agatatcagc aaggccgaag tcaccatggg agaccctcac cagcaaacac
      661 tggcacgtct ggactgggag ctggagcagc ggaaaaggct ggcagagaag taccgagagt
      721 gcctatctaa caaggagaag attctcaagg agattgaggt gaagaaggag tacctgagca
      781 gcctccagcc ccgcctcaac agcatcatgc aggcttccct tccggtgcag gagtacctgt
      841 ttatgccatt cgaccaggct cacaagcagt atgagacagc cagacacctg ccgcctcccc
      901 tctatgtcct ctttgttcag gccactgcgt atgggcaggc ctgtgataag acgttatctg
      961 tggcaatcga aggcagtgtg gatgaagcca aggctctgtt caaacctcca gaggactccc
     1021 aagatgacga gagtgactca gatgccgagg aggagcagac tacgaagcgc cggagaccca
     1081 cactgggggt tcagttggac gacaaacgca aggagatgct gaagaggcac ccactgtctg
     1141 tcatgctcga cctgaagtgc aaagatgaca gtgtgcttca cctgactttc tactacctca
     1201 tgaacctcaa catcatgaca gtaaaagcca aagtgacaac tgccatggag ctgatcaccc
     1261 ccatcagtgc aggtgacttg ctgtctcctg actcagtcct gagttgcttg tatcctgggg
     1321 atcatggaaa gaaaactccg aatccagcca atcagtatca gtttgataaa gttggcatcc
     1381 tgactttgag cgactatgta cttgagctag gtcaccccta tttgtgggtg cagaagctgg
     1441 gtggcctcca cttccccaaa gagcagcccc agcaaacagt gattgctgac cactcgctga
     1501 gcgccagcca catggagacc accatgaaac ttctgaagac cagggtgcag tcccgcctgg
     1561 ccctccacaa acagtttgca tccctagaac atggcattgt gccagttacc agtgattgcc
     1621 agtacctctt ccctgccaag gttgtctctc gcctggtgaa atgggtgaca gttgcccatg
     1681 aggattacat ggagctgcac ttcaccaaag acattgtgga tgcgggactg gctggggaca
     1741 ccaatctcta ctacatggcg ctcatcgaaa ggggcacagc caaactgcag gccgctgtgg
     1801 tgttgaaccc tggctactcc tccatcccac ctgttttcca gctctgtttg aactggaaag
     1861 gggagaaaac caacagcaac gatgacaaca ttcgggccat ggagggcgaa gtcaatgtgt
     1921 gctacaagga gctgtgtggc ccttggccca gccaccagct gttgaccaac cagctgcagc
     1981 ggctgtgtgt gctgctggat gtttacctgg agaccgagag ccatgacgac agtgtggagg
     2041 ggcccaagga atttccccag gagaagatgt gtctgcggct cttcaggggt cctagcagga
     2101 tgaagccatt taaatacaac catcctcagg gattcttcag ccatcgctga tctcccgcgc
     2161 agaccgttgt ttcccccaag gcctcaccct gagcactggg cttctgcttt ctgctctggc
     2221 ccacatgtga ctcttgatat tctccaaaga caccagccaa ttaaaaagcg tcacctgacc
     2281 agtggccttt gtctgtggtt cctggcaagg tggctttgca gtctggaagg gcaggtggga
     2341 gctgtgacac agtgtgaaaa agcatttgta gagagacttt ttctcagcag ccaataaaag
     2401 cagagtggaa aaagattcca attctgcaga gagatgctca cctcttgtct acgcacaccc
     2461 tatttgtgct ttgcggggtg aggtcctcat gatcttgtat ttattatccc aagttcctgc
     2521 tgttaagagg tggtaggaga agccaaaggc agcagagcac aaaaagcaaa actcttccct
     2581 ccccacccgc tcttcccatt agtcctgtca gggttgccga tggacaaatt gtctctgatc
     2641 gttggatgtt ataaatgtct gacagtgcag tgcaaacaga agacaaactc agttgatcct
     2701 tgaacaactc aggggttagg ggcaccaaca ccccctgccc tgcacagttg aaaaatccgt
     2761 gtataacttt tgactcccta aaaacttaac taatagcctg ctgttgacca gtagtatgct
     2821 attagtagtt acttactgct aacatagtca gtacatattt tcagtatata ttttgtatct
     2881 tatacactgt attcttacaa tacagtaaac tagagaaaag aaaatgttat aaggaaagtc
     2941 acaagggggc ctgagtgcag tggctcacgt ctgtaatccc agcactttgg gaggccaagg
     3001 cgggtggatc acttgaggtc aggagtttga gaccagcctg gccgacatgg tgaaaccctg
     3061 tctctactaa aaacatggaa attagccaag cgtggtggcg catgcctgta gtcccagtta
     3121 ctcaggaggc tgaggcagaa ttacttgaac ccatgaggca gaggttgcag taagccaaga
     3181 tcacgctcct gcgctccggc ttgggcgaga gtgagactcc gtctcaaaaa taaataaata
     3241 agaaagccat aaggaagaaa atatatatct actattaagt agaagtggat caccataaag
     3301 gtcttcacat actgtctcag ggttgaatag tctaaggaag aggaggggtt ggtcttggtg
     3361 tctcagggat ggcagaggca gaaaaagtgg gggaggtgga gggggaggca ggcaccactg
     3421 ttatttttat tgaacaaaat ctgtgcaggg actcatgact gtaatcctag tactttggaa
     3481 agctaaggcg ggaggatccc ttgaggccag gagttcaggt ccagcctggg caacgtagtg
     3541 agagaccctg tatctacaaa aaatttaaaa atcagccagg tgtggtggta tgcaccaata
     3601 gtcccagtta ctcagaaggc tgaggtgggc ggatgactgg agtccaggag ttcaaggtag
     3661 cagtgagcta ttcatcgtgc ctgtactgta ctccagcctg ggaaacaatg cgagtcccta
     3721 tctctaaaaa attttaaaaa aagaaatctg catataatag acccacagag tccaaactat
     3781 tgttcagaga tcaactgtac ttcacagaga gtaattctaa gtcttacagg atttcatgga
     3841 gatggcgaga gtggtgttgg agaatcaatc acatacagag atacaggaca gtgagaccag
     3901 gtaacatttg aggagaatat ttttttttta ttgagacagg gtcttgctct gttgtccagg
     3961 ctggagtgca gtggcacgaa cacagctcac tgccgcctca acctctcctg ggttcaagtg
     4021 atcctcctgc ctcagcctcc caagtagctg ggaccacagg tgtgtgccac catttctggc
     4081 taatttttaa attttttgta gaggcgggat cccactattt ttcccaggct ggtctcaaac
     4141 tcctgggctc aaatgatcct cccacctcgg cctcccaaag tgctaggatt ataggcatga
     4201 gccaccacac ccggcctgag tagagtcttt aaggtaatga caaaagtgcc tcaaaatata
     4261 attatttgat taagagaagt cttgggaaga taggtaacaa cctttaaaat gttcataaaa
     4321 ttacatcctt tgtaatactc ctgcaagtca aagtaaagga tggcatagac tattcttgga
     4381 cagttttgtc aaaaagtgta tcttgacccc accatcagta ctccattctt cattttaaaa
     4441 aataagatgg gctgggcaca gtggcttacg cctttaatat cagtactttg ggaggctggt
     4501 gggcggatca cctgagatca ggagttcaag accagcctgg ccaacatggt gaaaccccgt
     4561 ctctactaaa aatacaaaaa ttagctgggc atggtggtgc gcgcctgtaa tcccagccac
     4621 tcgggaggct gaggcaggag aattgcttga atccccgagg cggaggttgc actgagccga
     4681 gatggtgcca ctgcaccatc tggacaacag agcaagactc cgtcttgg
//
