LOCUS       NM_005131               2108 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens THO complex subunit 1 (THOC1), mRNA.
ACCESSION   NM_005131
VERSION     NM_005131.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2108)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2108)
  AUTHORS   Zhang,L., Gao,Y., Zhang,R., Sun,F., Cheng,C., Qian,F., Duan,X.,
            Wei,G., Sun,C., Pang,X., Chen,P., Chai,R., Yang,T., Wu,H. and
            Liu,D.
  TITLE     THOC1 deficiency leads to late-onset nonsyndromic hearing loss
            through p53-mediated hair cell apoptosis
  JOURNAL   PLoS Genet 16 (8), e1008953 (2020)
   PUBMED   32776944
  REMARK    GeneRIF: THOC1 deficiency leads to late-onset nonsyndromic hearing
            loss through p53-mediated hair cell apoptosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2108)
  AUTHORS   Cai,S., Bai,Y., Wang,H., Zhao,Z., Ding,X., Zhang,H., Zhang,X.,
            Liu,Y., Jia,Y., Li,Y., Chen,S., Zhou,H., Liu,H., Yang,C. and Sun,T.
  TITLE     Knockdown of THOC1 reduces the proliferation of hepatocellular
            carcinoma and increases the sensitivity to cisplatin
  JOURNAL   J Exp Clin Cancer Res 39 (1), 135 (2020)
   PUBMED   32669125
  REMARK    GeneRIF: Knockdown of THOC1 reduces the proliferation of
            hepatocellular carcinoma and increases the sensitivity to
            cisplatin.
            Erratum:[J Exp Clin Cancer Res. 2024 Oct 14;43(1):285. doi:
            10.1186/s13046-024-03208-3.. PMID: 39396979]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2108)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2108)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2108)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   7  (bases 1 to 2108)
  AUTHORS   Dennehey,B.K., Gutches,D.G., McConkey,E.H. and Krauter,K.S.
  TITLE     Inversion, duplication, and changes in gene context are associated
            with human chromosome 18 evolution
  JOURNAL   Genomics 83 (3), 493-501 (2004)
   PUBMED   14962675
REFERENCE   8  (bases 1 to 2108)
  AUTHORS   Strasser,K., Masuda,S., Mason,P., Pfannstiel,J., Oppizzi,M.,
            Rodriguez-Navarro,S., Rondon,A.G., Aguilera,A., Struhl,K., Reed,R.
            and Hurt,E.
  TITLE     TREX is a conserved complex coupling transcription with messenger
            RNA export
  JOURNAL   Nature 417 (6886), 304-308 (2002)
   PUBMED   11979277
REFERENCE   9  (bases 1 to 2108)
  AUTHORS   Doostzadeh-Cizeron,J., Evans,R., Yin,S. and Goodrich,D.W.
  TITLE     Apoptosis induced by the nuclear death domain protein p84N5 is
            inhibited by association with Rb protein
  JOURNAL   Mol Biol Cell 10 (10), 3251-3261 (1999)
   PUBMED   10512864
REFERENCE   10 (bases 1 to 2108)
  AUTHORS   Durfee,T., Mancini,M.A., Jones,D., Elledge,S.J. and Lee,W.H.
  TITLE     The amino-terminal region of the retinoblastoma gene product binds
            a novel nuclear matrix protein that co-localizes to centers for RNA
            processing
  JOURNAL   J Cell Biol 127 (3), 609-622 (1994)
   PUBMED   7525595
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA902294.1, BC010381.1, AP000845.4 and AK225709.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005131.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.172.1,
                                           SRR3476690.838896.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261600.11/ ENSP00000261600.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-492               DA902294.1         13-504
            493-684             BC010381.1         496-687
            685-685             AP000845.4         102272-102272       c
            686-2015            BC010381.1         689-2018
            2016-2108           AK225709.1         1992-2084
FEATURES             Location/Qualifiers
     source          1..2108
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.32"
     gene            1..2108
                     /gene="THOC1"
                     /gene_synonym="DFNA86; HPR1; P84; P84N5"
                     /note="THO complex subunit 1"
                     /db_xref="GeneID:9984"
                     /db_xref="HGNC:HGNC:19070"
                     /db_xref="MIM:606930"
     exon            1..82
                     /gene="THOC1"
                     /gene_synonym="DFNA86; HPR1; P84; P84N5"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..2002
                     /gene="THOC1"
                     /gene_synonym="DFNA86; HPR1; P84; P84N5"
                     /note="nuclear matrix protein p84; tho1; hTREX84; THO
                     complex 1"
                     /codon_start=1
                     /product="THO complex subunit 1"
                     /protein_id="NP_005122.2"
                     /db_xref="CCDS:CCDS45820.1"
                     /db_xref="GeneID:9984"
                     /db_xref="HGNC:HGNC:19070"
                     /db_xref="MIM:606930"
                     /translation="MSPTPPLFSLPEARTRFTKSTREALNNKNIKPLLSTFSQVPGSE
                     NEKKCTLDQAFRGILEEEIINHSSCENVLAIISLAIGGVTEGICTASTPFVLLGDVLD
                     CLPLDQCDTIFTFVEKNVATWKSNTFYSAGKNYLLRMCNDLLRRLSKSQNTVFCGRIQ
                     LFLARLFPLSEKSGLNLQSQFNLENVTVFNTNEQESTLGQKHTEDREEGMDVEEGEMG
                     DEEAPTTCSIPIDYNLYRKFWSLQDYFRNPVQCYEKISWKTFLKYSEEVLAVFKSYKL
                     DDTQASRKKMEELKTGGEHVYFAKFLTSEKLMDLQLSDSNFRRHILLQYLILFQYLKG
                     QVKFKSSNYVLTDEQSLWIEDTTKSVYQLLSENPPDGERFSKMVEHILNTEENWNSWK
                     NEGCPSFVKERTSDTKPTRIIRKRTAPEDFLGKGPTKKILMGNEELTRLWNLCPDNME
                     ACKSETREHMPTLEEFFEEAIEQADPENMVENEYKAVNNSNYGWRALRLLARRSPHFF
                     QPTNQQFKSLPEYLENMVIKLAKELPPPSEEIKTGEDEDEEDNDALLKENESPDVRRD
                     KPVTGEQIEVFANKLGEQWKILAPYLEMKDSEIRQIECDSEDMKMRAKQLLVAWQDQE
                     GVHATPENLINALNKSGLSDLAESLTNDNETNS"
     exon            83..156
                     /gene="THOC1"
                     /gene_synonym="DFNA86; HPR1; P84; P84N5"
                     /inference="alignment:Splign:2.1.0"
     exon            157..217
                     /gene="THOC1"
                     /gene_synonym="DFNA86; HPR1; P84; P84N5"
                     /inference="alignment:Splign:2.1.0"
     exon            218..284
                     /gene="THOC1"
                     /gene_synonym="DFNA86; HPR1; P84; P84N5"
                     /inference="alignment:Splign:2.1.0"
     exon            285..403
                     /gene="THOC1"
                     /gene_synonym="DFNA86; HPR1; P84; P84N5"
                     /inference="alignment:Splign:2.1.0"
     exon            404..452
                     /gene="THOC1"
                     /gene_synonym="DFNA86; HPR1; P84; P84N5"
                     /inference="alignment:Splign:2.1.0"
     exon            453..548
                     /gene="THOC1"
                     /gene_synonym="DFNA86; HPR1; P84; P84N5"
                     /inference="alignment:Splign:2.1.0"
     exon            549..631
                     /gene="THOC1"
                     /gene_synonym="DFNA86; HPR1; P84; P84N5"
                     /inference="alignment:Splign:2.1.0"
     exon            632..705
                     /gene="THOC1"
                     /gene_synonym="DFNA86; HPR1; P84; P84N5"
                     /inference="alignment:Splign:2.1.0"
     exon            706..814
                     /gene="THOC1"
                     /gene_synonym="DFNA86; HPR1; P84; P84N5"
                     /inference="alignment:Splign:2.1.0"
     exon            815..946
                     /gene="THOC1"
                     /gene_synonym="DFNA86; HPR1; P84; P84N5"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1047
                     /gene="THOC1"
                     /gene_synonym="DFNA86; HPR1; P84; P84N5"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1114
                     /gene="THOC1"
                     /gene_synonym="DFNA86; HPR1; P84; P84N5"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1165
                     /gene="THOC1"
                     /gene_synonym="DFNA86; HPR1; P84; P84N5"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1236
                     /gene="THOC1"
                     /gene_synonym="DFNA86; HPR1; P84; P84N5"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1332
                     /gene="THOC1"
                     /gene_synonym="DFNA86; HPR1; P84; P84N5"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1398
                     /gene="THOC1"
                     /gene_synonym="DFNA86; HPR1; P84; P84N5"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1482
                     /gene="THOC1"
                     /gene_synonym="DFNA86; HPR1; P84; P84N5"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1630
                     /gene="THOC1"
                     /gene_synonym="DFNA86; HPR1; P84; P84N5"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1706
                     /gene="THOC1"
                     /gene_synonym="DFNA86; HPR1; P84; P84N5"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..2108
                     /gene="THOC1"
                     /gene_synonym="DFNA86; HPR1; P84; P84N5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2089..2094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THOC1"
                     /gene_synonym="DFNA86; HPR1; P84; P84N5"
                     /note="hexamer: AATAAA"
     polyA_site      2108
                     /gene="THOC1"
                     /gene_synonym="DFNA86; HPR1; P84; P84N5"
                     /note="major polyA site"
ORIGIN      
        1 gcagtggcgg gcacgcgcag ccgagaagat gtctccgacg ccgccgctct tcagtttgcc
       61 cgaagcgcgg acgcggttta cgaagtctac cagagaggcc ttgaacaaca aaaacatcaa
      121 gccattgtta agtaccttca gccaggtacc tggcagtgaa aatgaaaaaa aatgtaccct
      181 tgaccaagct ttcagaggta ttctagaaga agaaattata aatcattcat catgtgaaaa
      241 cgttttagct attatttctc ttgctattgg gggagtaact gaaggtattt gtaccgcatc
      301 tacacctttt gtattgttgg gagatgtttt ggattgtctt cctttggatc agtgtgacac
      361 aatattcact tttgtggaaa aaaatgttgc tacttggaaa tcaaatacat tctattctgc
      421 tgggaaaaat tacttactac gtatgtgcaa tgatctccta agaagattgt ctaaatccca
      481 gaatacagtc ttctgtggac ggattcagct ctttttggcc aggcttttcc ctctgtctga
      541 gaaatcaggt cttaacttgc agagtcagtt taatctggaa aatgtcactg ttttcaatac
      601 aaatgagcag gaaagcaccc tgggtcagaa gcacactgaa gatagagaag aaggaatgga
      661 tgtagaagaa ggcgaaatgg gagacgagga agctccaaca acgtgctcta ttccaattga
      721 ttacaacctg tatcgaaaat tctggtcact tcaggattac ttcaggaacc ctgtgcaatg
      781 ctatgagaag atttcatgga aaacttttct caagtattct gaagaagttt tagctgtttt
      841 taagagttat aaattagatg atactcaggc ctcaagaaaa aagatggaag aattgaaaac
      901 aggaggagaa catgtatatt ttgcaaaatt tttaacaagt gaaaagctga tggatttaca
      961 actgagtgac agtaactttc gtcgacacat cctgttgcag tatctcattt tattccaata
     1021 tctcaagggg caggtcaaat tcaaaagttc aaactatgtt ttaactgatg agcaatcact
     1081 ttggattgaa gatactacaa aatcagttta tcaactacta tctgaaaacc cccccgatgg
     1141 agaaagattt tcaaagatgg tagagcatat attaaacact gaagaaaact ggaactcgtg
     1201 gaaaaatgaa ggttgcccaa gttttgtgaa agaaagaaca tcagatacca aacctacgag
     1261 aataattcgg aagagaacag cacccgagga cttcctaggg aaaggaccca ccaaaaaaat
     1321 tctgatggga aatgaggagt taacaaggct ttggaatctt tgccctgata atatggaagc
     1381 ctgtaaatca gagacaaggg aacacatgcc cactttggag gaattctttg aagaagccat
     1441 tgaacaggca gaccctgaaa atatggtgga aaatgaatat aaggctgtga acaattcaaa
     1501 ttatggttgg agagccctga gactattagc acggagaagc cctcacttct tccagccaac
     1561 caaccagcag tttaaaagtt taccagaata tcttgaaaat atggtaataa agctagccaa
     1621 ggaattaccg cctccttctg aagaaataaa aacaggtgag gatgaagatg aggaagataa
     1681 tgatgctcta ctgaaggaaa atgaaagtcc tgatgttcgg cgagacaaac ctgtaacagg
     1741 agaacaaata gaggtatttg ccaacaagct gggtgaacaa tggaagattc tggctcccta
     1801 cttggaaatg aaagactcag aaattaggca gattgagtgt gacagtgaag acatgaagat
     1861 gagagctaag cagctcctgg ttgcctggca agatcaagag ggagttcatg caacacctga
     1921 gaatctgatt aatgcactga ataagtctgg attaagtgac cttgcagaaa gtctaactaa
     1981 tgacaatgag acaaatagtt agcttctttt ttttttcttt ttattaaaac tgtgatagat
     2041 tttgttacca agcagcattt gataagaggt ccactggttt tggtaaacaa taaacatttt
     2101 tataacaa
//
