LOCUS       NM_024838               3737 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens threonine synthase like 1 (THNSL1), mRNA.
ACCESSION   NM_024838
VERSION     NM_024838.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3737)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 3737)
  AUTHORS   Donini,S., Percudani,R., Credali,A., Montanini,B., Sartori,A. and
            Peracchi,A.
  TITLE     A threonine synthase homolog from a mammalian genome
  JOURNAL   Biochem Biophys Res Commun 350 (4), 922-928 (2006)
   PUBMED   17034760
REFERENCE   3  (bases 1 to 3737)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 3737)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA496769.1, AK125249.1, BX647989.1 and AK025655.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024838.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.187176.1,
                                           SRR1660807.244171.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376356.5/ ENSP00000365534.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                DA496769.1         47-85
            40-2596             AK125249.1         1-2557
            2597-3044           BX647989.1         2543-2990
            3045-3737           AK025655.1         1302-1994
FEATURES             Location/Qualifiers
     source          1..3737
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p12.1"
     gene            1..3737
                     /gene="THNSL1"
                     /gene_synonym="TSH1"
                     /note="threonine synthase like 1"
                     /db_xref="GeneID:79896"
                     /db_xref="HGNC:HGNC:26160"
                     /db_xref="MIM:611260"
     exon            1..81
                     /gene="THNSL1"
                     /gene_synonym="TSH1"
                     /inference="alignment:Splign:2.1.0"
     exon            82..248
                     /gene="THNSL1"
                     /gene_synonym="TSH1"
                     /inference="alignment:Splign:2.1.0"
     exon            249..3737
                     /gene="THNSL1"
                     /gene_synonym="TSH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             297..2528
                     /gene="THNSL1"
                     /gene_synonym="TSH1"
                     /codon_start=1
                     /product="threonine synthase-like 1"
                     /protein_id="NP_079114.3"
                     /db_xref="CCDS:CCDS7147.1"
                     /db_xref="GeneID:79896"
                     /db_xref="HGNC:HGNC:26160"
                     /db_xref="MIM:611260"
                     /translation="MLHFNRCHHLKKITQKCFSSIHVKTDKHAQRFLSRTFALAELRK
                     SWYSTHSLVGDKNIILMGPPGAGKTTVGRIIGQKLGCCVIDVDDDILEKTWNMSVSEK
                     LQDVGNEQFLEEEGKAVLNFSASGSVISLTGSNPMHDASMWHLKKNGIIVYLDVPLLD
                     LICRLKLMKTDRIVGQNSGTSMKDLLKFRRQYYKKWYDARVFCESGASPEEVADKVLN
                     AIKRYQDVDSETFISTRHVWPEDCEQKVSAKFFSEAVIEGLASDGGLFVPAKEFPKLS
                     CGEWKSLVGATYVERAQILLERCIHPADIPAARLGEMIETAYGENFACSKIAPVRHLS
                     GNQFILELFHGPTGSFKDLSLQLMPHIFAHCIPPSCNYMILVATSGDTGSAVLNGFSR
                     LNKNDKQRIAVVAFFPENGVSDFQKAQIIGSQRENGWAVGVESDFDFCQTAIKRIFND
                     SDFTGFLTVEYGTILSSANSINWGRLLPQVVYHASAYLDLVSQGFISFGSPVDVCIPT
                     GNFGNILAAVYAKMMGIPIRKFICASNQNHVLTDFIKTGHYDLRERKLAQTFSPSIDI
                     LKSSNLERHLHLMANKDGQLMTELFNRLESQHHFQIEKALVEKLQQDFVADWCSEGEC
                     LAAINSTYNTSGYILDPHTAVAKVVADRVQDKTCPVIISSTAHYSKFAPAIMQALKIK
                     EINETSSSQLYLLGSYNALPPLHEALLERTKQQEKMEYQVCAADMNVLKSHVEQLVQN
                     QFI"
     regulatory      2573..2578
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THNSL1"
                     /gene_synonym="TSH1"
                     /note="hexamer: AATAAA"
     polyA_site      2597
                     /gene="THNSL1"
                     /gene_synonym="TSH1"
                     /note="major polyA site"
     regulatory      3717..3722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THNSL1"
                     /gene_synonym="TSH1"
                     /note="hexamer: ATTAAA"
     polyA_site      3737
                     /gene="THNSL1"
                     /gene_synonym="TSH1"
                     /note="major polyA site"
ORIGIN      
        1 gtggagcgga ggcacgctgg ccgccgcagg cacaggcgca gagtccactg cgcgggggcg
       61 ggaccgggga gctagctgca gactccacgt tttgcaaaga tcggttttgc ctcagagtca
      121 acaaactctt cagattggtt ccggtgtgtc ctatgtttac aagtcagtgg aaattaagca
      181 caacacatat aaattgaaaa gtcaaataag gaaatgaatt acctcccttg acggctctaa
      241 ttttacttgg ctaaagccaa tttttaggtt ggcttgggca gaaaagtgaa aagagaatgc
      301 tccactttaa ccgatgtcat catctgaaaa agataacaca gaaatgtttt tctagtatac
      361 atgttaaaac ggataaacat gcacagcgat ttctttcaag aacctttgca cttgcggaat
      421 tgaggaagtc atggtattca acccactctc ttgttggaga caaaaatatt atcctgatgg
      481 gacctcctgg tgctgggaaa acaacagtag gcagaataat aggtcagaaa ctaggttgtt
      541 gtgtcataga tgtggatgat gatatccttg aaaaaacctg gaatatgagt gtgtctgaaa
      601 aattacagga tgttggtaat gagcaatttt tagaagagga aggaaaagct gtgttaaact
      661 tctctgcatc tggaagtgtg atttccctta ctgggtccaa tccaatgcat gatgctagca
      721 tgtggcatct gaagaaaaat ggaataattg tatacctgga tgtacctcta ctagatctaa
      781 tttgtcgtct aaaattaatg aagacagata ggattgtagg tcagaattct ggaacatcta
      841 tgaaagactt acttaaattt agaagacagt attataagaa gtggtatgat gctcgtgttt
      901 tctgtgaaag tggggcttcc ccagaggagg tagctgacaa agtgctgaat gcaattaaaa
      961 gataccaaga tgtggactcg gaaacattca tttcaacaag acacgtttgg cctgaagact
     1021 gtgaacagaa ggtttcagca aaattcttta gtgaagctgt aattgagggg ttggcttctg
     1081 atggtggcct ctttgttcct gcaaaggagt ttccaaaatt aagctgcggg gagtggaaaa
     1141 gcctagtagg agcaacctac gtagaaagag cacagatact gttggaaaga tgtatccatc
     1201 ctgcagacat acctgctgcc aggttgggag aaatgattga aactgcttat ggggaaaact
     1261 ttgcctgctc aaaaattgct cctgtcaggc acctttcagg caaccagttc atcctggagt
     1321 tgtttcatgg accaacagga tcatttaaag atttgtcttt acagcttatg cctcatattt
     1381 ttgcacactg tatcccacca agttgcaatt atatgatact tgtagctact tcaggagaca
     1441 cagggagtgc agtcttaaat ggttttagtc gtctaaataa gaatgataag caaaggatag
     1501 ctgtggttgc attttttcct gagaatggag taagtgattt tcaaaaagca caaataattg
     1561 gcagtcagag agaaaatgga tgggcagtgg gtgttgagtc agattttgat ttttgccaga
     1621 cagctataaa aagaattttt aatgattctg attttactgg ctttcttact gtggaatatg
     1681 gaacaatctt aagttcggct aactccataa actggggccg actacttccg caggtagttt
     1741 atcatgcttc cgcatatctt gatcttgtta gtcaaggatt tatttctttt ggaagcccag
     1801 tcgatgtctg tattcccaca ggaaactttg gtaacatttt agcagcagtg tatgccaaaa
     1861 tgatgggaat cccgattcga aaatttatct gtgcctctaa tcagaaccat gttttgactg
     1921 attttataaa aacaggacat tatgatctaa gggaaagaaa actagcacaa accttttcac
     1981 cgtcaataga tattctcaaa tcttcaaacc tagaacgaca tttacacttg atggctaata
     2041 aagatggaca gctaatgaca gaattattta atcgattaga aagtcagcat catttccaga
     2101 tagaaaaggc tctagttgag aaacttcagc aggattttgt agctgactgg tgctctgagg
     2161 gagagtgcct agcagctatt aactccacct ataatacttc agggtatatt ttggatccac
     2221 acactgctgt tgcaaaagtg gttgcagata gggtgcaaga caaaacttgc cctgtgatta
     2281 tctcatctac agcccattac tcaaagtttg cacctgctat catgcaggct ttaaagatta
     2341 aagaaatcaa tgagacttca tcaagtcagc tctatttgct gggttcatac aatgcattac
     2401 ctccactgca tgaggcttta ttagagagaa caaaacagca agagaagatg gagtaccagg
     2461 tctgtgcagc tgatatgaat gtcttgaaga gtcatgtgga acaacttgtc caaaatcaat
     2521 tcatatgaaa gctttcagag taaatttttt tttctagcta taagcatgca ataataaatc
     2581 tcaaacactg atttggagta cagtagcatt ttgtctttta tgtaaatatc tctatatctg
     2641 tttggaattt caaaagtctg atctctaggg ctgacatgag aactccatgt cacctcctca
     2701 gatctttaat ctggaagtga caaaaggtaa cacagtgcac ggacctttga gctatcatac
     2761 ttttgccttc tgctcatgag gggtgtatca atttccactc ccacaccctc actgttatgt
     2821 ggaccaaaat gtctggtata ctatttggcg attaaaatat ttaagcccag ttttcaggta
     2881 ctacatctgt aactagtgaa tactctgttg attagaaagt taatttacca ctcaaaatgg
     2941 ctaacttgaa tggaggaagt agtaaactct tctattagga tttgggccag tgttttttgt
     3001 ttgttttttg gtgcagtttc agctcactgc aacctccgcc tcccaggttc aagtgattct
     3061 cctgcctcag cctcccaggt agctgggatt acaggcatgc aacaccacac atggctaatt
     3121 tttttatttt taatagagat gaggtttcgc catgttttcc aggctgatct tgaacctctg
     3181 acctcaggtg atccatccac ctcggcctcc caaagtgcta ggattacagg cgtgagcctc
     3241 tgcacctggc tagggccagt gtttttaacc ctcctcaaat tccattttgg actacaacta
     3301 atgtgtatct cacactgtcc aaattaaaga tgtactctgt ccttcactct cctttggatg
     3361 tgtacggtta gggtgacgat gtttgaaaat caacacataa ctgaaatcca ggatgaaaca
     3421 gtaagcagaa ctacttagaa gtgaatacag aaatgatcta tttcaagagg aaggttttcc
     3481 aaaattaaga gtacttgagt agtctcaata ggagtgtatt tgtagacagc agtttcccta
     3541 tattatttgg agtcaattct tacgtaattt gttgtttatt tcttcagtga acattgtctt
     3601 tttctggcag ctgaaactgc acacaactga tacacatatt taatttgtat tcctttgtag
     3661 taatacattt taaccatgat ttatgtttgt gaatttactg gatgttttct ttctgaatta
     3721 aagattgtca agaccaa
//
