LOCUS       NM_001105556            2713 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens thymocyte selection associated family member 2
            (THEMIS2), transcript variant 3, mRNA.
ACCESSION   NM_001105556
VERSION     NM_001105556.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2713)
  AUTHORS   Riedmeier,M., Skrzypczak,M., Schuler-Toprak,S., Ortmann,O. and
            Treeck,O.
  TITLE     Icb-1 expression inhibits growth and fulvestrant response of breast
            cancer cells and affects survival of breast cancer patients
  JOURNAL   Arch Gynecol Obstet 304 (1), 203-213 (2021)
   PUBMED   33389102
  REMARK    GeneRIF: Icb-1 expression inhibits growth and fulvestrant response
            of breast cancer cells and affects survival of breast cancer
            patients.
REFERENCE   2  (bases 1 to 2713)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2713)
  AUTHORS   Schuler,S., Lattrich,C., Skrzypczak,M., Fehm,T., Ortmann,O. and
            Treeck,O.
  TITLE     Icb-1 gene polymorphism rs1467465 is associated with susceptibility
            to ovarian cancer
  JOURNAL   J Ovarian Res 7, 42 (2014)
   PUBMED   24826199
  REMARK    GeneRIF: SNP rs1467465 of the human gene icb-1 might affect
            susceptibility to ovarian cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2713)
  AUTHORS   Treeck,O., Schuler,S., Haring,J., Skrzypczak,M., Lattrich,C. and
            Ortmann,O.
  TITLE     icb-1 Gene counteracts growth of ovarian cancer cell lines
  JOURNAL   Cancer Lett 335 (2), 441-446 (2013)
   PUBMED   23474491
  REMARK    GeneRIF: Loss of icb-1 expression accelerated proliferation of
            SK-OV-3, OVCAR-3 and OAW-42 cells and led to upregulation of
            ovarian cancer biomarkers like KLK10 and CLDN16.
REFERENCE   5  (bases 1 to 2713)
  AUTHORS   Lesourne,R., Zvezdova,E., Song,K.D., El-Khoury,D., Uehara,S.,
            Barr,V.A., Samelson,L.E. and Love,P.E.
  TITLE     Interchangeability of Themis1 and Themis2 in thymocyte development
            reveals two related proteins with conserved molecular function
  JOURNAL   J Immunol 189 (3), 1154-1161 (2012)
   PUBMED   22732588
  REMARK    GeneRIF: Themis2 and Themis1 exhibit the same potential to restore
            T cell development and T cell receptor-mediated signaling in
            Themis1-deficient mice.
REFERENCE   6  (bases 1 to 2713)
  AUTHORS   Konwisorz,A., Springwald,A., Haselberger,M., Goerse,R., Ortmann,O.
            and Treeck,O.
  TITLE     Knockdown of ICB-1 gene enhanced estrogen responsiveness of ovarian
            and breast cancer cells
  JOURNAL   Endocr Relat Cancer 17 (1), 147-157 (2010)
   PUBMED   19942713
  REMARK    GeneRIF: Identification of ICB-1 as a new player in
            endocrine-related cancer.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2713)
  AUTHORS   Springwald,A., Lattrich,C., Seitz,S., Ortmann,O. and Treeck,O.
  TITLE     Single nucleotide polymorphisms in human gene icb-1 and breast
            cancer susceptibility
  JOURNAL   Cancer Invest 27 (6), 669-672 (2009)
   PUBMED   19308812
  REMARK    GeneRIF: Data suggest that SNP rs1467465 of human gene icb-1 might
            affect breast cancer susceptibility.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 2713)
  AUTHORS   Treeck,O., Kindzorra,I., Pauser,K., Treeck,L. and Ortmann,O.
  TITLE     Expression of icb-1 gene is interferon-gamma inducible in breast
            and ovarian cancer cell lines and affects the IFN gamma-response of
            SK-OV-3 ovarian cancer cells
  JOURNAL   Cytokine 32 (3-4), 137-142 (2005)
   PUBMED   16219472
  REMARK    GeneRIF: The novel interferon-gamma inducible gene icb-1 is
            identified and its effects on the response of ovarian cancer cells
            to interferon-gamma are described
REFERENCE   9  (bases 1 to 2713)
  AUTHORS   Treeck,O., Odani,T., Itoh,N., Imai,H., Fujita,S., Kohroki,J.,
            Nakanishi,T., Diedrich,K., Ortmann,O., Tanaka,K. and Vollmer,G.
  TITLE     Detection of increased icb-1 transcript levels in maturing HL-60
            cells: a novel marker for granulocytic and monocytic in vitro
            differentiation
  JOURNAL   Leuk Res 26 (8), 765-769 (2002)
   PUBMED   12191572
  REMARK    GeneRIF: Increased icb-1 mRNA levels could be observed both in
            monocytic and granulocytic differentiation in maturing HL-60 cells.
REFERENCE   10 (bases 1 to 2713)
  AUTHORS   Treeck,O., Strunck,E. and Vollmer,G.
  TITLE     A novel basement membrane-induced gene identified in the human
            endometrial adenocarcinoma cell line HEC1B
  JOURNAL   FEBS Lett 425 (3), 426-430 (1998)
   PUBMED   9563507
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL109927.61, AL554503.3 and BI908174.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001105556.2.
            
            Transcript Variant: This variant (3) encodes the longest isoform
            (3).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.603122.1,
                                           SRR1660805.197663.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373921.8/ ENSP00000363031.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AL109927.61        29570-29604
            36-282              AL554503.3         1-247
            283-611             AL109927.61        36689-37017
            612-925             AL554503.3         577-890
            926-1478            AL109927.61        39248-39800
            1479-2151           BI908174.1         2-674
            2152-2713           AL109927.61        43140-43701
FEATURES             Location/Qualifiers
     source          1..2713
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.3"
     gene            1..2713
                     /gene="THEMIS2"
                     /gene_synonym="C1orf38; ICB-1; ICB1"
                     /note="thymocyte selection associated family member 2"
                     /db_xref="GeneID:9473"
                     /db_xref="HGNC:HGNC:16839"
                     /db_xref="MIM:617856"
     exon            1..122
                     /gene="THEMIS2"
                     /gene_synonym="C1orf38; ICB-1; ICB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1960
                     /gene="THEMIS2"
                     /gene_synonym="C1orf38; ICB-1; ICB1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     basement membrane-induced; protein THEMIS2; protein ICB-1;
                     induced by contact to basement membrane 1 protein;
                     thymocyte-expressed molecule involved in selection protein
                     2"
                     /codon_start=1
                     /product="protein THEMIS2 isoform 3"
                     /protein_id="NP_001099026.1"
                     /db_xref="CCDS:CCDS41290.1"
                     /db_xref="GeneID:9473"
                     /db_xref="HGNC:HGNC:16839"
                     /db_xref="MIM:617856"
                     /translation="MEPVPLQDFVRALDPASLPRVLRVCSGVYFEGSIYEISGNECCL
                     STGDLIKVTQVRLQKVVCENPKTSQTMELAPNFQGYFTPLNTPQSYETLEELVSATTQ
                     SSKQLPTCFMSTHRIVTEGRVVTEDQLLMLEAVVMHLGIRSARCVLGMEGQQVILHLP
                     LSQKGPFWTWEPSAPRTLLQVLQDPALKDLVLTCPTLPWHSLILRPQYEIQAIMHMRR
                     TIVKIPSTLEVDVEDVTASSRHVHFIKPLLLSEVLAWEGPFPLSMEILEVPEGRPIFL
                     SPWVGSLQKGQRLCVYGLASPPWRVLASSKGRKVPRHFLVSGGYQGKLRRRPREFPTA
                     YDLLGAFQPGRPLRVVATKDCEGEREENPEFTSLAVGDRLEVLGPGQAHGAQGSDVDV
                     LVCQRLSDQAGEDEEEECKEEAESPERVLLPFHFPGSFVEEMSDSRRYSLADLTAQFS
                     LPCEVKVVAKDTSHPTDPLTSFLGLRLEEKITEPFLVVSLDSEPGMCFEIPPRWLDLT
                     VVKAKGQPDLPEGSLPIATVEELTDTFYYRLRKLPACEIQAPPPRPPKNQGLSKQRRH
                     SSEGGVKSSQVLGLQQHARLPKPKAKTLPEFIKDGSSTYSKIPAHRKGHRPAKPQRQD
                     LDDDEHDYEEILEQFQKTI"
     exon            123..263
                     /gene="THEMIS2"
                     /gene_synonym="C1orf38; ICB-1; ICB1"
                     /inference="alignment:Splign:2.1.0"
     exon            264..674
                     /gene="THEMIS2"
                     /gene_synonym="C1orf38; ICB-1; ICB1"
                     /inference="alignment:Splign:2.1.0"
     exon            675..1747
                     /gene="THEMIS2"
                     /gene_synonym="C1orf38; ICB-1; ICB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1904
                     /gene="THEMIS2"
                     /gene_synonym="C1orf38; ICB-1; ICB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2713
                     /gene="THEMIS2"
                     /gene_synonym="C1orf38; ICB-1; ICB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2687..2692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THEMIS2"
                     /gene_synonym="C1orf38; ICB-1; ICB1"
                     /note="hexamer: AATAAA"
     polyA_site      2713
                     /gene="THEMIS2"
                     /gene_synonym="C1orf38; ICB-1; ICB1"
                     /note="major polyA site"
ORIGIN      
        1 agtctgagcc cagagagccg cggggaccat ggagccggtg ccgctgcagg acttcgtgcg
       61 cgccttggac cccgcctccc tcccgcgcgt gctgcgggtc tgctcggggg tctacttcga
      121 gggctccatc tatgagatct ctgggaatga gtgctgcctc tccacggggg acctgatcaa
      181 ggtcacccag gtccgcctcc agaaggtggt ctgtgagaac ccgaagacca gccagaccat
      241 ggagctcgcc cccaacttcc agggctactt cacccccctc aacaccccac agagctatga
      301 aaccctggag gagctggtct ctgccacaac tcagagctcc aagcagctgc ccacttgctt
      361 catgtcgacc cacaggattg tcacagaggg cagggtggtg actgaggacc agctcctcat
      421 gcttgaggct gtggtgatgc acctcgggat ccgctctgcc cgctgtgtcc tgggcatgga
      481 gggtcagcag gtcatcctgc acctgcccct atcccagaag gggcccttct ggacatggga
      541 gcctagtgcc cctcgaactc tgctccaggt cctacaggat ccagccctga aagacctcgt
      601 cctcacctgc cccaccctgc cctggcattc cctgatcctg cggccccagt atgagatcca
      661 agccatcatg cacatgcgca ggaccattgt caagatccct tctaccctgg aggtcgacgt
      721 ggaggacgtc accgcctcct cccggcacgt ccactttatc aaaccgctgc tgctgagcga
      781 ggtcctggcc tgggaaggcc ctttccccct gtccatggag atcctggagg ttcctgaggg
      841 ccgccccatc ttcctcagcc cgtgggtggg ctccttgcaa aaaggccaga ggctttgcgt
      901 ctatggccta gcctcaccac cctggcgggt cctggcctca agcaagggcc gcaaggtgcc
      961 caggcacttc ctggtgtcag ggggctacca aggcaagctg cggcggcggc caagggagtt
     1021 ccccacggcc tatgacctcc taggtgcttt ccagccaggc cggccactcc gggtggtggc
     1081 cacaaaggac tgtgagggcg agagggagga gaatcccgag ttcacgtccc tggctgtggg
     1141 tgaccggctg gaggtgctgg ggcctggcca ggcccatggg gcccagggca gtgacgtgga
     1201 tgtcttggtt tgtcagcggc tgagtgacca ggctggggag gatgaggagg aagagtgcaa
     1261 agaggaggca gagagcccag agcgggtcct gctgcccttc cacttccctg gcagtttcgt
     1321 ggaggagatg agtgacagcc ggcgctacag cctggcagat ctgactgccc agttttcact
     1381 gccttgtgag gtcaaggtgg tggccaagga caccagccac cccactgacc ctctgacctc
     1441 cttcctgggc ctgcggctgg aggagaagat cacagagcca ttcttggtgg tgagcctaga
     1501 ctctgagcct gggatgtgct ttgagatccc tccccggtgg ctggacctga ctgttgtgaa
     1561 ggccaagggg cagccagact tgccagaggg gtctctcccc atagccacag tggaggagct
     1621 gacagacacc ttctattatc gtcttcggaa gttaccagcc tgtgagatcc aagccccccc
     1681 acccaggccc cctaaaaatc agggcctcag caagcagagg agacacagca gtgagggagg
     1741 cgtcaagtct tctcaagtct taggattgca gcaacacgct cggctgccca aacccaaggc
     1801 gaagaccttg ccagagttca tcaaggatgg ctccagtacg tacagcaaga ttcctgccca
     1861 caggaagggc cacaggcccg ctaagcccca aaggcaggat ctagatgatg atgaacatga
     1921 ttatgaagaa atacttgagc aatttcagaa aaccatctaa gtgctggagg aaccacgctt
     1981 cctaactgct gcttctcagg gaatccgaca ccagccaacc attttaagcc tctaaaagac
     2041 ctcgggcaag tctcacagaa actgagctgc agacggggag tagctttgtg gaaactgatt
     2101 tgatggacac tgcaccagct tccttcaggt tctagattct tgctacttag ggcgggctgg
     2161 tttggaccta acatctcgca cgtgactccc tcagcctcag agccttggga tgcagagcag
     2221 ctggcagggt tcctctcaat cctgcaaccc cagctgtccc accggtggat gcagagggga
     2281 atccgaggcc atcaaccttg gtgacagcag cgcagtgcca atgctgatca cactgcatgg
     2341 gagattttgt taacgtctgc cacccccact ctcaccccca agctctaagc ccccgggagg
     2401 cctggactgt cttcctcatc tctgtagcac caagcctgat agatctgtat atggtaaaca
     2461 ggggtttaac cacatgtggt taacatggat taatgtggga acttggcttc aagaacacaa
     2521 ccttaggacc ttgggcccca aaagctggtg gtgaaatgag gaggagccaa tttaagaaga
     2581 cccttatgga gacctgaggc tgcagaaact ggtaggtttc atcaggtggt taaagtcgtc
     2641 aaagttgtaa gtgactaacc aagattattt cattttaaaa ccatagaata aaaatgacac
     2701 ctgagcttct cta
//
