LOCUS       NP_001099026             643 aa            linear   PRI 01-JUN-2024
DEFINITION  protein THEMIS2 isoform 3 [Homo sapiens].
ACCESSION   NP_001099026
VERSION     NP_001099026.1
DBSOURCE    REFSEQ: accession NM_001105556.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 643)
  AUTHORS   Riedmeier,M., Skrzypczak,M., Schuler-Toprak,S., Ortmann,O. and
            Treeck,O.
  TITLE     Icb-1 expression inhibits growth and fulvestrant response of breast
            cancer cells and affects survival of breast cancer patients
  JOURNAL   Arch Gynecol Obstet 304 (1), 203-213 (2021)
   PUBMED   33389102
  REMARK    GeneRIF: Icb-1 expression inhibits growth and fulvestrant response
            of breast cancer cells and affects survival of breast cancer
            patients.
REFERENCE   2  (residues 1 to 643)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 643)
  AUTHORS   Schuler,S., Lattrich,C., Skrzypczak,M., Fehm,T., Ortmann,O. and
            Treeck,O.
  TITLE     Icb-1 gene polymorphism rs1467465 is associated with susceptibility
            to ovarian cancer
  JOURNAL   J Ovarian Res 7, 42 (2014)
   PUBMED   24826199
  REMARK    GeneRIF: SNP rs1467465 of the human gene icb-1 might affect
            susceptibility to ovarian cancer.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 643)
  AUTHORS   Treeck,O., Schuler,S., Haring,J., Skrzypczak,M., Lattrich,C. and
            Ortmann,O.
  TITLE     icb-1 Gene counteracts growth of ovarian cancer cell lines
  JOURNAL   Cancer Lett 335 (2), 441-446 (2013)
   PUBMED   23474491
  REMARK    GeneRIF: Loss of icb-1 expression accelerated proliferation of
            SK-OV-3, OVCAR-3 and OAW-42 cells and led to upregulation of
            ovarian cancer biomarkers like KLK10 and CLDN16.
REFERENCE   5  (residues 1 to 643)
  AUTHORS   Lesourne,R., Zvezdova,E., Song,K.D., El-Khoury,D., Uehara,S.,
            Barr,V.A., Samelson,L.E. and Love,P.E.
  TITLE     Interchangeability of Themis1 and Themis2 in thymocyte development
            reveals two related proteins with conserved molecular function
  JOURNAL   J Immunol 189 (3), 1154-1161 (2012)
   PUBMED   22732588
  REMARK    GeneRIF: Themis2 and Themis1 exhibit the same potential to restore
            T cell development and T cell receptor-mediated signaling in
            Themis1-deficient mice.
REFERENCE   6  (residues 1 to 643)
  AUTHORS   Konwisorz,A., Springwald,A., Haselberger,M., Goerse,R., Ortmann,O.
            and Treeck,O.
  TITLE     Knockdown of ICB-1 gene enhanced estrogen responsiveness of ovarian
            and breast cancer cells
  JOURNAL   Endocr Relat Cancer 17 (1), 147-157 (2010)
   PUBMED   19942713
  REMARK    GeneRIF: Identification of ICB-1 as a new player in
            endocrine-related cancer.
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 643)
  AUTHORS   Springwald,A., Lattrich,C., Seitz,S., Ortmann,O. and Treeck,O.
  TITLE     Single nucleotide polymorphisms in human gene icb-1 and breast
            cancer susceptibility
  JOURNAL   Cancer Invest 27 (6), 669-672 (2009)
   PUBMED   19308812
  REMARK    GeneRIF: Data suggest that SNP rs1467465 of human gene icb-1 might
            affect breast cancer susceptibility.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (residues 1 to 643)
  AUTHORS   Treeck,O., Kindzorra,I., Pauser,K., Treeck,L. and Ortmann,O.
  TITLE     Expression of icb-1 gene is interferon-gamma inducible in breast
            and ovarian cancer cell lines and affects the IFN gamma-response of
            SK-OV-3 ovarian cancer cells
  JOURNAL   Cytokine 32 (3-4), 137-142 (2005)
   PUBMED   16219472
  REMARK    GeneRIF: The novel interferon-gamma inducible gene icb-1 is
            identified and its effects on the response of ovarian cancer cells
            to interferon-gamma are described
REFERENCE   9  (residues 1 to 643)
  AUTHORS   Treeck,O., Odani,T., Itoh,N., Imai,H., Fujita,S., Kohroki,J.,
            Nakanishi,T., Diedrich,K., Ortmann,O., Tanaka,K. and Vollmer,G.
  TITLE     Detection of increased icb-1 transcript levels in maturing HL-60
            cells: a novel marker for granulocytic and monocytic in vitro
            differentiation
  JOURNAL   Leuk Res 26 (8), 765-769 (2002)
   PUBMED   12191572
  REMARK    GeneRIF: Increased icb-1 mRNA levels could be observed both in
            monocytic and granulocytic differentiation in maturing HL-60 cells.
REFERENCE   10 (residues 1 to 643)
  AUTHORS   Treeck,O., Strunck,E. and Vollmer,G.
  TITLE     A novel basement membrane-induced gene identified in the human
            endometrial adenocarcinoma cell line HEC1B
  JOURNAL   FEBS Lett 425 (3), 426-430 (1998)
   PUBMED   9563507
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL109927.61, AL554503.3 and BI908174.1.
            
            Transcript Variant: This variant (3) encodes the longest isoform
            (3).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.603122.1,
                                           SRR1660805.197663.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373921.8/ ENSP00000363031.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..643
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.3"
     Protein         1..643
                     /product="protein THEMIS2 isoform 3"
                     /note="basement membrane-induced; protein THEMIS2; protein
                     ICB-1; induced by contact to basement membrane 1 protein;
                     thymocyte-expressed molecule involved in selection protein
                     2"
                     /calculated_mol_wt=71918
     Region          1..238
                     /region_name="CABIT 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5TEJ8.1)"
     Region          18..235
                     /region_name="CABIT"
                     /note="Cell-cycle sustaining, positive selection;
                     pfam12736"
                     /db_xref="CDD:463686"
     Region          239..514
                     /region_name="CABIT 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5TEJ8.1)"
     Region          265..515
                     /region_name="CABIT"
                     /note="Cell-cycle sustaining, positive selection;
                     pfam12736"
                     /db_xref="CDD:463686"
     Region          546..631
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5TEJ8.1)"
     Site            593
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q5TEJ8.1)"
     Site            632
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q91YX0; propagated from
                     UniProtKB/Swiss-Prot (Q5TEJ8.1)"
     CDS             1..643
                     /gene="THEMIS2"
                     /gene_synonym="C1orf38; ICB-1; ICB1"
                     /coded_by="NM_001105556.3:29..1960"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS41290.1"
                     /db_xref="GeneID:9473"
                     /db_xref="HGNC:HGNC:16839"
                     /db_xref="MIM:617856"
ORIGIN      
        1 mepvplqdfv raldpaslpr vlrvcsgvyf egsiyeisgn ecclstgdli kvtqvrlqkv
       61 vcenpktsqt melapnfqgy ftplntpqsy etleelvsat tqsskqlptc fmsthrivte
      121 grvvtedqll mleavvmhlg irsarcvlgm egqqvilhlp lsqkgpfwtw epsaprtllq
      181 vlqdpalkdl vltcptlpwh slilrpqyei qaimhmrrti vkipstlevd vedvtassrh
      241 vhfikpllls evlawegpfp lsmeilevpe grpiflspwv gslqkgqrlc vyglasppwr
      301 vlasskgrkv prhflvsggy qgklrrrpre fptaydllga fqpgrplrvv atkdcegere
      361 enpeftslav gdrlevlgpg qahgaqgsdv dvlvcqrlsd qagedeeeec keeaesperv
      421 llpfhfpgsf veemsdsrry sladltaqfs lpcevkvvak dtshptdplt sflglrleek
      481 itepflvvsl dsepgmcfei pprwldltvv kakgqpdlpe gslpiatvee ltdtfyyrlr
      541 klpaceiqap pprppknqgl skqrrhsseg gvkssqvlgl qqharlpkpk aktlpefikd
      601 gsstyskipa hrkghrpakp qrqdldddeh dyeeileqfq kti
//
