LOCUS       NM_016647               2239 bp    mRNA    linear   PRI 25-DEC-2023
DEFINITION  Homo sapiens thioesterase superfamily member 6 (THEM6), transcript
            variant 1, mRNA.
ACCESSION   NM_016647
VERSION     NM_016647.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2239)
  AUTHORS   Lu X, Chen W, Tian G and Ge F.
  TITLE     THEM6 is a prognostic biomarker for breast cancer and is associated
            with immune infiltration
  JOURNAL   Sci Rep 13 (1), 21974 (2023)
   PUBMED   38081884
  REMARK    GeneRIF: THEM6 is a prognostic biomarker for breast cancer and is
            associated with immune infiltration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2239)
  AUTHORS   Blomme A, Peter C, Mui E, Rodriguez Blanco G, An N, Mason LM,
            Jamieson LE, McGregor GH, Lilla S, Ntala C, Patel R, Thiry M, Kung
            SHY, Leclercq M, Ford CA, Rushworth LK, McGarry DJ, Mason S,
            Repiscak P, Nixon C, Salji MJ, Markert E, MacKay GM, Kamphorst JJ,
            Graham D, Faulds K, Fazli L, Gleave ME, Avezov E, Edwards J, Yin H,
            Sumpton D, Blyth K, Close P, Murphy DJ, Zanivan S and Leung HY.
  TITLE     THEM6-mediated reprogramming of lipid metabolism supports treatment
            resistance in prostate cancer
  JOURNAL   EMBO Mol Med 14 (3), e14764 (2022)
   PUBMED   35014179
REFERENCE   3  (bases 1 to 2239)
  AUTHORS   Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS,
            Noh SM, Kim S, Yoo HS, Kim YS and Kim NS.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC001311.1 and AF242773.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016647.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001311.1, SRR3476690.14088.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336138.4/ ENSP00000338607.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1699              BC001311.1         21-1719
            1700-2239           AF242773.1         1653-2192
FEATURES             Location/Qualifiers
     source          1..2239
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..2239
                     /gene="THEM6"
                     /gene_synonym="C8orf55; DSCD75"
                     /note="thioesterase superfamily member 6"
                     /db_xref="GeneID:51337"
                     /db_xref="HGNC:HGNC:29656"
     exon            1..637
                     /gene="THEM6"
                     /gene_synonym="C8orf55; DSCD75"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..751
                     /gene="THEM6"
                     /gene_synonym="C8orf55; DSCD75"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mesenchymal stem cell protein DSCD75; UPF0670 protein
                     C8orf55; UPF0670 protein THEM6"
                     /codon_start=1
                     /product="protein THEM6 isoform 1"
                     /protein_id="NP_057731.1"
                     /db_xref="CCDS:CCDS6386.1"
                     /db_xref="GeneID:51337"
                     /db_xref="HGNC:HGNC:29656"
                     /translation="MLGLLVALLALGLAVFALLDVWYLVRLPCAVLRARLLQPRVRDL
                     LAEQRFPGRVLPSDLDLLLHMNNARYLREADFARVAHLTRCGVLGALRELRAHTVLAA
                     SCARHRRSLRLLEPFEVRTRLLGWDDRAFYLEARFVSLRDGFVCALLRFRQHLLGTSP
                     ERVVQHLCQRRVEPPELPADLQHWISYNEASSQLLRMESGLSDVTKDQ"
     exon            638..2239
                     /gene="THEM6"
                     /gene_synonym="C8orf55; DSCD75"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2219..2224
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THEM6"
                     /gene_synonym="C8orf55; DSCD75"
                     /note="hexamer: ATTAAA"
     polyA_site      2239
                     /gene="THEM6"
                     /gene_synonym="C8orf55; DSCD75"
                     /note="major polyA site"
ORIGIN      
        1 ggttcgctcc gggcgcgctg cgctcgtgag ttcccaggag gcctggcggg caccgtaacc
       61 agcgccgcgg acaccggcac cggcgccacg gactccgcag gaccccgcgc ccgccgccgc
      121 cgctatgctg gggctgctgg tggcgttgct ggccctgggg ctcgctgtct ttgcgctgct
      181 ggacgtctgg tacctggtgc gccttccgtg cgccgtgctg cgcgcgcgcc tgctgcagcc
      241 gcgcgtccgt gacctgctag ctgagcagcg cttcccgggc cgcgtgctgc cctcggactt
      301 ggacctgctg ctgcacatga acaacgcgcg ctacctgcgc gaggccgact ttgcgcgcgt
      361 cgcgcacctg acccgctgcg gggtgctcgg ggcgctgagg gagttgcggg cgcacacggt
      421 gctggcggcc tcgtgcgcgc gccaccgccg ctcgctgcgc ctgctggagc ccttcgaggt
      481 gcgcacccgc ctgctgggct gggacgaccg cgcgttctac ctggaggcgc gctttgtcag
      541 cctgcgggac ggcttcgtgt gcgcgctgct gcgcttccgg cagcacctgc tgggcacctc
      601 acccgagcgc gtcgtgcagc acctgtgcca gcgcagggtg gagccccctg agctgcccgc
      661 tgatctgcag cactggatct cctacaacga ggccagcagc cagctgctcc gcatggagag
      721 tgggctcagt gatgtcacca aggaccagtg accgccacct tcacaccgtc tgccctggcc
      781 accatcctgg gcctgggggc tgcccacaga tgggcagtct cagccatact ctgttccagc
      841 tggagtagcc tcctgaccag cctggcccac cctgctccac ccactgggcc cccccagtta
      901 ttgatacccc tctgtgctgg gctccacgct aggcagaagg aggagtggca ttggcatcct
      961 gacccagctc tgccctcaag gtggggatgg atgggcaaag gagagtcctg cctggcccta
     1021 cgatgaggcc actcatgtgg gcctaggtag gggaggatgg tgcctggagc agagggaccc
     1081 acaagtgcct cccgagccta gatcctggct cggaccactg caagggccga ggcagggcca
     1141 gaccagagca tcctgggtac aggcctgggc tctccagggc ctgggcctga ttcaggtgca
     1201 gtgggcactc ctgaagggtc agagcggcat ctgccaggca gcccctctgg cttccgctga
     1261 ggtggttgca ggcctggggc agagcctggg tggtcagagg ccggggctag aggcagatgg
     1321 aagggaggca tttgctgaca gaggacgggg cacccgggct ccccactgca gtcggccttg
     1381 cctcctcctc ctcctctacc tccagtcagg ctggacggga gggtagcctt gtggctgaga
     1441 ggggtcagac taggtggcac aggggctcct ggaaagacag caggcttcct gctgggcgtt
     1501 cccttgttgg agggaataga gtgggggtgg gactctgcag gggtgtcctt gtccactcgc
     1561 acccctcgcc gcccaccagg gccatgctct gtgacttggg ctgatcccca ccctttctgg
     1621 gcctacagca ccacaggccg ctgtaccccc ttagagctgc ccctctctgg cctggccggc
     1681 aggcgtcttc ttaactcctc tgtcctctat attcagcatg ttccttgtca gctgctgggc
     1741 cggccctgcc ttgcgctagc agagcctctc ctggcagctt ctcaggtctc cctaatggag
     1801 acaccaggct actaggacac tggctggggc caccccctcc tgcctaatgc ctcaccttac
     1861 agctggggaa actgaggcct ggaatggccc agagtcacca aggcaaagtt ggggctggtc
     1921 ccagcctgag gctccagctg atgccctcag ctcccagaga gggggtgccc catctagctg
     1981 ggtgcagggg tcactgcttg tcagctcagg gccctgtgcc cgcttgcctg ttcccctaca
     2041 tctgtgcctg cacatccaga actgcctcct tgccgctgcc tccaggaagc ccaccttgag
     2101 ccagagtcaa gggctgcagc actgcccgat agaacacgcc cgccctcact gctgttcttg
     2161 ccttacagcc accatgggaa agctgcaacc tttctgtttt atttaaagaa agcccaacat
     2221 taaagggttt tcattgcaa
//
