LOCUS       NM_182578               1161 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens thioesterase superfamily member 5 (THEM5), mRNA.
ACCESSION   NM_182578
VERSION     NM_182578.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1161)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1161)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1161)
  AUTHORS   Zhuravleva,E., Gut,H., Hynx,D., Marcellin,D., Bleck,C.K.,
            Genoud,C., Cron,P., Keusch,J.J., Dummler,B., Esposti,M.D. and
            Hemmings,B.A.
  TITLE     Acyl coenzyme A thioesterase Them5/Acot15 is involved in
            cardiolipin remodeling and fatty liver development
  JOURNAL   Mol Cell Biol 32 (14), 2685-2697 (2012)
   PUBMED   22586271
  REMARK    GeneRIF: In vitro, Them5 shows strong thioesterase activity with
            long-chain acyl-CoAs. Loss of Them5 specifically alters the
            remodeling process of the mitochondrial phospholipid cardiolipin.
REFERENCE   4  (bases 1 to 1161)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1161)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL450992.17.
            
            On Nov 23, 2018 this sequence version replaced NM_182578.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC112239.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368817.10/ ENSP00000357807.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               AL450992.17        14429-14698         c
            271-472             AL450992.17        13244-13445         c
            473-611             AL450992.17        12039-12177         c
            612-722             AL450992.17        9168-9278           c
            723-847             AL450992.17        8724-8848           c
            848-1161            AL450992.17        8087-8400           c
FEATURES             Location/Qualifiers
     source          1..1161
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..1161
                     /gene="THEM5"
                     /gene_synonym="ACOT15"
                     /note="thioesterase superfamily member 5"
                     /db_xref="GeneID:284486"
                     /db_xref="HGNC:HGNC:26755"
                     /db_xref="MIM:615653"
     exon            1..270
                     /gene="THEM5"
                     /gene_synonym="ACOT15"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..891
                     /gene="THEM5"
                     /gene_synonym="ACOT15"
                     /EC_number="3.1.2.2"
                     /note="acyl-CoA thioesterase THEM5; acyl-coenzyme A
                     thioesterase 15"
                     /codon_start=1
                     /product="acyl-coenzyme A thioesterase THEM5"
                     /protein_id="NP_872384.2"
                     /db_xref="CCDS:CCDS1005.1"
                     /db_xref="GeneID:284486"
                     /db_xref="HGNC:HGNC:26755"
                     /db_xref="MIM:615653"
                     /translation="MIRRCFQVAARLGHHRGLLEAPRILPRLNPASAFGSSTDSMFSR
                     FLPEKTDLKDYALPNASWCSDMLSLYQEFLEKTKSSGWIKLPSFKSNRDHIRGLKLPS
                     GLAVSSDKGDCRIFTRCIQVEGQGFEYVIFFQPTQKKSVCLFQPGSYLEGPPGFAHGG
                     SLAAMMDETFSKTAFLAGEGLFTLSLNIRFKNLIPVDSLVVMDVELDKIEDQKLYMSC
                     IAHSRDQQTVYAKSSGVFLQLQLEEESPQ"
     exon            271..472
                     /gene="THEM5"
                     /gene_synonym="ACOT15"
                     /inference="alignment:Splign:2.1.0"
     exon            473..611
                     /gene="THEM5"
                     /gene_synonym="ACOT15"
                     /inference="alignment:Splign:2.1.0"
     exon            612..722
                     /gene="THEM5"
                     /gene_synonym="ACOT15"
                     /inference="alignment:Splign:2.1.0"
     exon            723..847
                     /gene="THEM5"
                     /gene_synonym="ACOT15"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1161
                     /gene="THEM5"
                     /gene_synonym="ACOT15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1142..1147
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THEM5"
                     /gene_synonym="ACOT15"
                     /note="hexamer: AATAAA"
     polyA_site      1161
                     /gene="THEM5"
                     /gene_synonym="ACOT15"
                     /note="major polyA site"
ORIGIN      
        1 gcagcacacc agcccagcct cgcctagctc tctgaaagaa agcctgcaac agaagggaga
       61 gaagcggccc caagtgcagc tgaaagcact ccttgggagt cagccaagac cctccatcca
      121 agcagggctg gatccttgca cttggccatg ataaggagat gcttccaggt ggcagcaaga
      181 cttggccacc acagaggcct tcttgaggcc ccccgtatcc tgcccagact caaccctgcc
      241 tcagcatttg gatcctccac agactccatg ttctcaagat tcttgccaga gaagacagac
      301 ttgaaggatt atgctcttcc caatgccagc tggtgttcgg acatgctgag cctgtaccaa
      361 gaatttctgg agaagactaa gtctagcggc tggatcaagc tgccctcctt caagtccaac
      421 agagaccaca tccggggact caagctccca tctggactgg cagtttcctc agacaaaggt
      481 gactgtcgca tcttcaccag gtgcatccaa gtggaaggac aaggctttga gtatgtcatc
      541 tttttccagc caacccagaa gaagtcggtc tgtcttttcc aaccaggctc ctacctggag
      601 gggcccccag ggtttgctca cggcgggtcc ctggcagcca tgatggacga gaccttttct
      661 aaaactgcct tcctggctgg agaggggctg ttcacactaa gtctcaacat caggttcaaa
      721 aacttgatcc ccgtggactc tctggttgta atggacgtag aactggacaa gattgaggac
      781 cagaagcttt acatgtcctg catcgcccac agcagagacc agcagacagt ttatgccaag
      841 tcctcaggtg ttttccttca gctgcagttg gaagaagagt ctccccagta acagtcactg
      901 tgcctgcagg agagccactg cctcccctgc ctgcctcctg cctcctgcct cccctgcctg
      961 cctcctgcct cctgcctccc ctgcctgcct cctgcctccc ctgcctgcct cctgcctcct
     1021 gcctcccctg cctgcctcct gcctcctgcc tcccctgcct gcctgggacc catcaaagag
     1081 cagggagggg tcctcaagca gcaattggtg aggcgaggga aaggaccctt ttctctgagt
     1141 aaataaagtc tcacagtccc a
//
