LOCUS       NM_053055               4798 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens thioesterase superfamily member 4 (THEM4), mRNA.
ACCESSION   NM_053055
VERSION     NM_053055.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4798)
  AUTHORS   Nguyen,H., Kim,S.H., Juang,U., Gwon,S., Jung,W., Huang,Q., Lee,S.,
            Lee,B., Kwon,S.H. and Park,J.
  TITLE     Overview of carboxyl-terminal modulator protein 1 and its
            importance in various metabolic regulations (Review)
  JOURNAL   Mol Med Rep 30 (3) (2024)
   PUBMED   38994770
  REMARK    GeneRIF: Overview of carboxyl-terminal modulator protein 1 and its
            importance in various metabolic regulations (Review).
            Review article
REFERENCE   2  (bases 1 to 4798)
  AUTHORS   Lin,C.H., Lin,W.D., Huang,Y.C., Chen,Y.C., Loh,Z.J., Ger,L.P.,
            Lin,F.C., Li,H.Y., Cheng,H.C., Lee,K.H., Hsiao,M. and Lu,P.J.
  TITLE     Carboxyl-terminal modulator protein facilitates tumor metastasis in
            triple-negative breast cancer
  JOURNAL   Cancer Gene Ther 30 (3), 404-413 (2023)
   PUBMED   36400965
  REMARK    GeneRIF: Carboxyl-terminal modulator protein facilitates tumor
            metastasis in triple-negative breast cancer.
REFERENCE   3  (bases 1 to 4798)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 4798)
  AUTHORS   Wang,B., Xu,X., Liu,X., Wang,D., Zhuang,H., He,X., Han,T. and
            Hong,J.
  TITLE     Enolase-phosphatase 1 acts as an oncogenic driver in glioma
  JOURNAL   J Cell Physiol 236 (2), 1184-1194 (2021)
   PUBMED   32654229
  REMARK    GeneRIF: Enolase-phosphatase 1 acts as an oncogenic driver in
            glioma.
REFERENCE   5  (bases 1 to 4798)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 4798)
  AUTHORS   Parcellier,A., Tintignac,L.A., Zhuravleva,E., Cron,P., Schenk,S.,
            Bozulic,L. and Hemmings,B.A.
  TITLE     Carboxy-Terminal Modulator Protein (CTMP) is a mitochondrial
            protein that sensitizes cells to apoptosis
  JOURNAL   Cell Signal 21 (4), 639-650 (2009)
   PUBMED   19168129
  REMARK    GeneRIF: Proper maturation of CTMP is essential for its
            pro-apoptotic function. CTMP delays PKB phosphorylation following
            cell death induction, suggesting that CTMP regulates apoptosis via
            inhibition of PKB.
REFERENCE   7  (bases 1 to 4798)
  AUTHORS   Ono,H., Sakoda,H., Fujishiro,M., Anai,M., Kushiyama,A.,
            Fukushima,Y., Katagiri,H., Ogihara,T., Oka,Y., Kamata,H.,
            Horike,N., Uchijima,Y., Kurihara,H. and Asano,T.
  TITLE     Carboxy-terminal modulator protein induces Akt phosphorylation and
            activation, thereby enhancing antiapoptotic, glycogen synthetic,
            and glucose uptake pathways
  JOURNAL   Am J Physiol Cell Physiol 293 (5), C1576-C1585 (2007)
   PUBMED   17615157
  REMARK    GeneRIF: CTMP induces translocation of Akt to the membrane and
            thereby increases the level of Akt phosphorylation. As a result,
            CTMP enhances various cellular activities that are principally
            mediated by the PI3-kinase/Akt pathway.
REFERENCE   8  (bases 1 to 4798)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   9  (bases 1 to 4798)
  AUTHORS   Knobbe,C.B., Reifenberger,J., Blaschke,B. and Reifenberger,G.
  TITLE     Hypermethylation and transcriptional downregulation of the
            carboxyl-terminal modulator protein gene in glioblastomas
  JOURNAL   J Natl Cancer Inst 96 (6), 483-486 (2004)
   PUBMED   15026474
REFERENCE   10 (bases 1 to 4798)
  AUTHORS   Maira,S.M., Galetic,I., Brazil,D.P., Kaech,S., Ingley,E., Thelen,M.
            and Hemmings,B.A.
  TITLE     Carboxyl-terminal modulator protein (CTMP), a negative regulator of
            PKB/Akt and v-Akt at the plasma membrane
  JOURNAL   Science 294 (5541), 374-380 (2001)
   PUBMED   11598301
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC353229.1, AL450992.17,
            AJ313515.1 and AF075119.1.
            
            On Nov 23, 2018 this sequence version replaced NM_053055.4.
            
            Summary: Protein kinase B (PKB) is a major downstream target of
            receptor tyrosine kinases that signal via phosphatidylinositol
            3-kinase. Upon cell stimulation, PKB is translocated to the plasma
            membrane, where it is phosphorylated in the C-terminal regulatory
            domain. The protein encoded by this gene negatively regulates PKB
            activity by inhibiting phosphorylation. Transcription of this gene
            is commonly downregulated in glioblastomas. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2136289.1,
                                           SRR14038193.3264914.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368814.8/ ENSP00000357804.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               DC353229.1         333-434
            103-103             AL450992.17        70395-70395         c
            104-262             AJ313515.1         97-255
            263-263             AL450992.17        56070-56070         c
            264-959             AJ313515.1         257-952
            960-1573            AL450992.17        35077-35690         c
            1574-2077           AF075119.1         1-504
            2078-4798           AL450992.17        31852-34572         c
FEATURES             Location/Qualifiers
     source          1..4798
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..4798
                     /gene="THEM4"
                     /gene_synonym="CTMP"
                     /note="thioesterase superfamily member 4"
                     /db_xref="GeneID:117145"
                     /db_xref="HGNC:HGNC:17947"
                     /db_xref="MIM:606388"
     exon            1..152
                     /gene="THEM4"
                     /gene_synonym="CTMP"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..776
                     /gene="THEM4"
                     /gene_synonym="CTMP"
                     /EC_number="3.1.2.2"
                     /note="C-terminal modulator protein; carboxyl-terminal
                     modulator protein; acyl-CoA thioesterase THEM4"
                     /codon_start=1
                     /product="acyl-coenzyme A thioesterase THEM4"
                     /protein_id="NP_444283.2"
                     /db_xref="CCDS:CCDS1006.1"
                     /db_xref="GeneID:117145"
                     /db_xref="HGNC:HGNC:17947"
                     /db_xref="MIM:606388"
                     /translation="MLRSCAARLRTLGALCLPPVGRRLPGSEPRPELRSFSSEEVILK
                     DCSVPNPSWNKDLRLLFDQFMKKCEDGSWKRLPSYKRTPTEWIQDFKTHFLDPKLMKE
                     EQMSQAQLFTRSFDDGLGFEYVMFYNDIEKRMVCLFQGGPYLEGPPGFIHGGAIATMI
                     DATVGMCAMMAGGIVMTANLNINYKRPIPLCSVVMINSQLDKVEGRKFFVSCNVQSVD
                     EKTLYSEATSLFIKLNPAKSLT"
     exon            153..339
                     /gene="THEM4"
                     /gene_synonym="CTMP"
                     /inference="alignment:Splign:2.1.0"
     exon            340..499
                     /gene="THEM4"
                     /gene_synonym="CTMP"
                     /inference="alignment:Splign:2.1.0"
     exon            500..610
                     /gene="THEM4"
                     /gene_synonym="CTMP"
                     /inference="alignment:Splign:2.1.0"
     exon            611..735
                     /gene="THEM4"
                     /gene_synonym="CTMP"
                     /inference="alignment:Splign:2.1.0"
     exon            736..4798
                     /gene="THEM4"
                     /gene_synonym="CTMP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1586..1591
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THEM4"
                     /gene_synonym="CTMP"
                     /note="hexamer: ATTAAA"
     polyA_site      1609
                     /gene="THEM4"
                     /gene_synonym="CTMP"
                     /note="major polyA site"
     regulatory      2056..2061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THEM4"
                     /gene_synonym="CTMP"
                     /note="hexamer: AATAAA"
     polyA_site      2080
                     /gene="THEM4"
                     /gene_synonym="CTMP"
     regulatory      4773..4778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THEM4"
                     /gene_synonym="CTMP"
                     /note="hexamer: AATAAA"
     polyA_site      4798
                     /gene="THEM4"
                     /gene_synonym="CTMP"
ORIGIN      
        1 ggtagagtgc gccgtccagg gctagagcaa gcgcggcccc gcggcccgga gccatgctga
       61 ggagctgcgc cgcgcgcctc cgcacgctgg gggctctgtg cctgccgcca gtaggccggc
      121 gcctgccggg aagcgagccg cgacccgagc tgaggtcatt ttcttctgag gaagtcattc
      181 ttaaggactg ttctgtcccc aaccccagct ggaacaagga cctaagactg ctctttgacc
      241 agtttatgaa gaaatgtgaa gacggctcct ggaaacgttt gccttcatat aaacgtacac
      301 ctactgaatg gattcaagac ttcaaaaccc attttcttga cccaaagctt atgaaagaag
      361 aacaaatgtc acaggcccag ctcttcacca gaagctttga tgatggcctg ggctttgaat
      421 acgtgatgtt ctacaatgac attgagaaaa ggatggtttg cttatttcaa ggaggccctt
      481 acctggaagg accacctgga ttcattcatg gaggtgccat tgcaaccatg attgatgcta
      541 ctgttggtat gtgtgcaatg atggctgggg gaatcgtcat gactgccaat ctcaacatca
      601 attataaaag acctatccct ctttgttctg ttgttatgat aaatagccaa cttgataaag
      661 ttgaaggaag gaaatttttt gtttcctgta atgttcagag tgttgatgag aagaccctat
      721 actcagaggc gacaagctta tttataaagc tgaatcctgc taaaagtctg acataaagag
      781 ctgctggtga actccatctc attctcgccc ctccagaaga agcagttgtc ccccaaatac
      841 tctgctccct cactgctgaa tccctgtagg gagaagcctg ccaacagtga ccttccgaaa
      901 cagccttctg aatacaaaga ggattcagtt tccatcttct caacttttta acacagaaat
      961 acttcctgcg agcatatcga caactctcgg gccaggcgct gtggctcaca cctataatcc
     1021 cagcacttta ggaggccgag gcaggcggat tgcctgagct caggagttca agatcagtct
     1081 gggcaacacg atgaaactcc gtctctacta aaatacaaaa aattatccag gcatggtggc
     1141 gtacgcctgt agtcccagct actcaggagg ctgaggcagg agaattgctt gaacccagga
     1201 ggaagaggtt gcagtgagcc aagatcatgc cacatcactc caacctgggc aacagaacaa
     1261 gaacccatct caaacaaaca aacaaacaaa aaaaaaaaac tcttgtctcc ttaggatatg
     1321 ttacctgctc cactgcagac tagagaaata aatgtgtatt gaacctttta ctgcaaactt
     1381 gaaaatgcta gaaaaccaag catgaagaat aaatacatgg tgggaaacac acaggcatgt
     1441 gcatatgcat atacattgta agttagtaag ttagaaagct agctttgttg tatctgaaca
     1501 catgaatctt ttttggtcag tgtaggaagc acagccagat cctataggaa tgaatacctc
     1561 aaatctgttg tctgagattc tagagattaa accactgtgc catttttaac ccaggctgta
     1621 ctgttgtttc ttaccaacag cataggtttt catcactgga aggagcctgt gttcatttcc
     1681 tagggctgct gtagcaaagt agtacaaact ggattgttta aaccaacaaa aactcattgt
     1741 ctctcagttc tggaggccag aagttcaaaa tcaaggtgtt gaccaaggcc attctcctga
     1801 aagtgctagg gaaggagctg tccacgcctc cctcctggct tctgggagcc tcaggtgttc
     1861 cttggcttct agatgcatca ttccagtcct ccatcttcac atggcattcc ctctgtgtgt
     1921 ctccacagtg tcttccctct gtgcagatct atctctgtgt ccaagtctcc tctttttata
     1981 aggaaaccag tcataatgga cccacctgaa tgacctcatt ttaacttgat tacctctgta
     2041 aaaaatgtat ttccaaataa agtgacctta tgaggtattg gagattagga ccacaacata
     2101 ccttttttgg gaggacacaa ttcaacctgt aaaagagcct caacaaaact aaaaaatgaa
     2161 cggagagttg aagggggcca gcccctccac acctgtgggt gtttctcatc aggtgggatg
     2221 agagactgag aaaagaaata aggcacagag acaaagtata aagaaagaac cctgggccca
     2281 ggggaccggt gctcagcata cagaggaccc gcaccggccc cagtctcagc tctctcagta
     2341 tttattgatt actgttttca ctatctcggc aaggggaatg cagcaggaga acagggtgat
     2401 agtggggaga aggtcagcag gaaaatctgt gagcaaagga atctgtgtta caaataagtt
     2461 caagggaagg tactatgccc agatgtgtac gtaggccaga tttatgcttc tctccaccca
     2521 aacatctcag tgtagcaaag agtaacagca gcattgccgc cagcgtatct tggctccagc
     2581 cacagggtgg ttttctccta tctcagaatg gaacgaacat aggatcgggt tttacaccaa
     2641 gacatgctgt tcccaggggc atgcaggaga cagaggcctt cctcatctca accacaagag
     2701 gccttcctct tttactaatc cccctcagca cagacccttt gcgggtgtcg ggctggggga
     2761 tggtcaggtc tttcccttcc cgggaggcca tatctcaggc tgtctcagtg gggggaaacc
     2821 ttggacaata cccaggcttt cttgggcaga ggtccctgcg gctttccaca gtgcattttg
     2881 cccctggtta attgagaatg gagaatggcg atgactttta ccaagcatac tgcctgtaaa
     2941 catactgtta atgaggcacg tcctgcacag tcctagatcc cttaaacctt gattccatac
     3001 agcacatgtt tctgtaagca cagggttggg gctaaagtta cagattaaca gcatctcaag
     3061 gcaaagcaat tttcttagaa cagatcaaaa tggaatttct catgtcttcc tttctacata
     3121 gacacagtaa cagtctgatc tctcttttcc ctacagagac taatgttctg gaaaatatat
     3181 tctgcttcct agtgcaggca atagattatt tgggcttcca tttctttcct ttctttcccc
     3241 atattagaaa tttaagctga accatatgaa atcactattt cgaagaacag aatggtcaaa
     3301 tattgacaat ttcctatggt tcaacctaat aacttaggga cagccttgtg gtaccctacc
     3361 cagtcatcct tccacagcca aaagatcagc tggagccctc cattgccaga gctgactgac
     3421 ctgggatggc caagccagag gaagacccac atcctggaag ccctgtctct agtgcccaac
     3481 tccagttctc aagttgcaag ggcccagcag acatgggggc actgcagggg tgaagctggc
     3541 agttccttct cccagaaatt ctgagagagc ctgggaaagt gccccaggag atggctgggc
     3601 tcacagctct acaagttaca ggtctggcaa tggccaccct ctattcccag tcttccaaca
     3661 aatcctgaaa cttaagagag tggactctta caataattat atttcacatg ttaaaaaata
     3721 tgactccgaa ggaataagcc agcgctgctc atttagctag tttcacttaa ctagttggga
     3781 ggaagtttag acaatgaagg tactgtactc tcatcgttag atttctctgg caggcttgca
     3841 gaactgctat ggcacaccag acctccagcc aagtgaaaga acctaactga aagagtgcca
     3901 aatgaccagg ttttcttcat gttaagtatg cctgcctccc ttcgtatcca cttttttccc
     3961 tttacagttt catttcttac actggtttgc tcacatccag gttagatgct gcacaagatc
     4021 aactaaggaa aaagctcagt cactgttaac atagggttcc ccatagccag tgagggaaaa
     4081 atggcttccc tgctttgcag cagactattc ctagccttca ccatgccctg gcactcttgc
     4141 tttcctcagg ttgtattttg acaagtatgt aagataacaa aaggtggcag aacaggtaga
     4201 aagaaggaga gagatgctat cagaattgcc agctccactc catcactggc ttgctgtgtg
     4261 acctaatgga actattcctc atttcctgtt tccttctttt tcctttcttt tttctttttc
     4321 tttttttttt ttttttttca agacagggtc tggctctgtc gcctgggctg gaatgcagag
     4381 acacaatctc agctcaatgc aacctccacc tcccaggttc aagcgattct cctgcctcag
     4441 cctcccaagt agctgggact ataggcatac accaccaaac ccagctaatt tttgtattgt
     4501 ttgtagagac agggttttgc catgttgccc agtctggtct caaactcctg ggctcaagtg
     4561 atctgcccac ctcagcctgc caaagtactg ggattacagg catgagccac cttgctcaac
     4621 ctgtttcctt ctttatacca agtgctaaca ttttgaatga atattaggaa ttgatgctgg
     4681 ttagtgctaa aatatcttta aactatcagt gtaaacataa ttaggccgtg agtttttgct
     4741 cttactccca ggtttctaaa tgtctaagaa acaataaaat gagagtcatg tacagaaa
//
