LOCUS       NM_007112               3145 bp    mRNA    linear   PRI 24-SEP-2023
DEFINITION  Homo sapiens thrombospondin 3 (THBS3), transcript variant 1, mRNA.
ACCESSION   NM_007112
VERSION     NM_007112.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3145)
  AUTHORS   Yang L, Wei Q, Sun Y, Guo J, Xu X, Zhang Z, Zhu L, Zheng X, Liu F,
            Wu J, Xie X, Lin S, Li H and Wu S.
  TITLE     Hyperuricemia and coronary heart disease: The mediating role of
            blood pressure and thrombospondin 3
  JOURNAL   Nutr Metab Cardiovasc Dis 33 (10), 1969-1980 (2023)
   PUBMED   37524613
  REMARK    GeneRIF: Hyperuricemia and coronary heart disease: The mediating
            role of blood pressure and thrombospondin 3.
REFERENCE   2  (bases 1 to 3145)
  CONSRTM   COVID-19 Host Genetics Initiative
  TITLE     A first update on mapping the human genetic architecture of
            COVID-19
  JOURNAL   Nature 608 (7921), E1-E10 (2022)
   PUBMED   35922517
REFERENCE   3  (bases 1 to 3145)
  AUTHORS   Kousathanas A, Pairo-Castineira E, Rawlik K, Stuckey A, Odhams CA,
            Walker S, Russell CD, Malinauskas T, Wu Y, Millar J, Shen X,
            Elliott KS, Griffiths F, Oosthuyzen W, Morrice K, Keating S, Wang
            B, Rhodes D, Klaric L, Zechner M, Parkinson N, Siddiq A, Goddard P,
            Donovan S, Maslove D, Nichol A, Semple MG, Zainy T, Maleady-Crowe
            F, Todd L, Salehi S, Knight J, Elgar G, Chan G, Arumugam P, Patch
            C, Rendon A, Bentley D, Kingsley C, Kosmicki JA, Horowitz JE, Baras
            A, Abecasis GR, Ferreira MAR, Justice A, Mirshahi T, Oetjens M,
            Rader DJ, Ritchie MD, Verma A, Fowler TA, Shankar-Hari M, Summers
            C, Hinds C, Horby P, Ling L, McAuley D, Montgomery H, Openshaw PJM,
            Elliott P, Walsh T, Tenesa A, Fawkes A, Murphy L, Rowan K, Ponting
            CP, Vitart V, Wilson JF, Yang J, Bretherick AD, Scott RH, Hendry
            SC, Moutsianas L, Law A, Caulfield MJ and Baillie JK.
  CONSRTM   GenOMICC investigators; 23andMe investigators; COVID-19 Human
            Genetics Initiative
  TITLE     Whole-genome sequencing reveals host factors underlying critical
            COVID-19
  JOURNAL   Nature 607 (7917), 97-103 (2022)
   PUBMED   35255492
REFERENCE   4  (bases 1 to 3145)
  AUTHORS   Augusciak-Duma A, Lesiak M, Stepien K, Gutmajster E and Sieron AL.
  TITLE     mRNA Expression of thrombospondin 1, 2 and 3 from proximal to
            distal in human abdominal aortic aneurysm - preliminary report
  JOURNAL   Acta Biochim Pol 68 (4), 745-750 (2021)
   PUBMED   34669362
  REMARK    GeneRIF: mRNA Expression of thrombospondin 1, 2 and 3 from proximal
            to distal in human abdominal aortic aneurysm - preliminary report.
REFERENCE   5  (bases 1 to 3145)
  AUTHORS   Wang EY, Chen H, Sun BQ, Wang H, Qu HQ, Liu Y, Sun XZ, Qu J, Fang
            ZF, Tian L, Zeng YF, Huang SK, Hakonarson H and Liu ZG.
  TITLE     Serum levels of the IgA isotype switch factor TGF-beta1 are
            elevated in patients with COVID-19
  JOURNAL   FEBS Lett 595 (13), 1819-1824 (2021)
   PUBMED   33961290
  REMARK    GeneRIF: Serum levels of the IgA isotype switch factor TGF-beta1
            are elevated in patients with COVID-19.
            Erratum:[FEBS Lett. 2021 Nov;595(22):2844. PMID: 34747013]
REFERENCE   6  (bases 1 to 3145)
  AUTHORS   Qabar A, Derick L, Lawler J and Dixit V.
  TITLE     Thrombospondin 3 is a pentameric molecule held together by
            interchain disulfide linkage involving two cysteine residues
  JOURNAL   J Biol Chem 270 (21), 12725-12729 (1995)
   PUBMED   7759526
REFERENCE   7  (bases 1 to 3145)
  AUTHORS   Adolph KW, Long GL, Winfield S, Ginns EI and Bornstein P.
  TITLE     Structure and organization of the human thrombospondin 3 gene
            (THBS3)
  JOURNAL   Genomics 27 (2), 329-336 (1995)
   PUBMED   7558000
REFERENCE   8  (bases 1 to 3145)
  AUTHORS   O'Rourke KM, Laherty CD and Dixit VM.
  TITLE     Thrombospondin 1 and thrombospondin 2 are expressed as both homo-
            and heterotrimers
  JOURNAL   J Biol Chem 267 (35), 24921-24924 (1992)
   PUBMED   1459996
REFERENCE   9  (bases 1 to 3145)
  AUTHORS   Vos HL, Devarayalu S, de Vries Y and Bornstein P.
  TITLE     Thrombospondin 3 (Thbs3), a new member of the thrombospondin gene
            family
  JOURNAL   J Biol Chem 267 (17), 12192-12196 (1992)
   PUBMED   1601886
REFERENCE   10 (bases 1 to 3145)
  AUTHORS   McLaren,K.M.
  TITLE     Immunohistochemical localisation of thrombospondin in human
            megakaryocytes and platelets
  JOURNAL   J Clin Pathol 36 (2), 197-199 (1983)
   PUBMED   6338048
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from L38969.1, AC234582.3 and
            BC018786.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_007112.4.
            
            Summary: The protein encoded by this gene belongs to the
            thrombospondin family. Thrombospondin family members are adhesive
            glycoproteins that mediate cell-to-cell and cell-to-matrix
            interactions. This protein forms a pentameric molecule linked by a
            single disulfide bond. This gene shares a common promoter with
            metaxin 1. Alternate splicing results in coding and non-coding
            transcript variants. [provided by RefSeq, Nov 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L38969.1, AK223278.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: locus in the vicinity of
                                      disease-associated variant(s)
            MANE Ensembl match     :: ENST00000368378.7/ ENSP00000357362.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-779               L38969.1           1-779
            780-780             AC234582.3         21036-21036         c
            781-2603            L38969.1           781-2603
            2604-2604           AC234582.3         15031-15031         c
            2605-3102           L38969.1           2605-3102
            3103-3145           BC018786.1         1990-2032
FEATURES             Location/Qualifiers
     source          1..3145
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q22"
     gene            1..3145
                     /gene="THBS3"
                     /gene_synonym="TSP3"
                     /note="thrombospondin 3"
                     /db_xref="GeneID:7059"
                     /db_xref="HGNC:HGNC:11787"
                     /db_xref="MIM:188062"
     exon            1..100
                     /gene="THBS3"
                     /gene_synonym="TSP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..2892
                     /gene="THBS3"
                     /gene_synonym="TSP3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="thrombospondin-3 isoform 1 precursor"
                     /protein_id="NP_009043.1"
                     /db_xref="CCDS:CCDS1099.1"
                     /db_xref="GeneID:7059"
                     /db_xref="HGNC:HGNC:11787"
                     /db_xref="MIM:188062"
                     /translation="METQELRGALALLLLCFFTSASQDLQVIDLLTVGESRQMVAVAE
                     KIRTALLTAGDIYLLSTFRLPPKQGGVLFGLYSRQDNTRWLEASVVGKINKVLVRYQR
                     EDGKVHAVNLQQAGLADGRTHTVLLRLRGPSRPSPALHLYVDCKLGDQHAGLPALAPI
                     PPAEVDGLEIRTGQKAYLRMQGFVESMKIILGGSMARVGALSECPFQGDESIHSAVTN
                     ALHSILGEQTKALVTQLTLFNQILVELRDDIRDQVKEMSLIRNTIMECQVCGFHEQRS
                     HCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHADPCFPGSSCIN
                     TMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTV
                     GSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWAG
                     NGNVCGTDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDAD
                     GDGIKNVEDNCRLFPNKDQQNSDTDSFGDACDNCPNVPNNDQKDTDGNGEGDACDNDV
                     DGDGIPNGLDNCPKVPNPLQTDRDEDGVGDACDSCPEMSNPTQTDADSDLVGDVCDTN
                     EDSDGDGHQDTKDNCPQLPNSSQLDSDNDGLGDECDGDDDNDGIPDYVPPGPDNCRLV
                     PNPNQKDSDGNGVGDVCEDDFDNDAVVDPLDVCPESAEVTLTDFRAYQTVVLDPEGDA
                     QIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFLFSY
                     QDSGRFYVVMWKQTEQTYWQATPFRAVAQPGLQLKAVTSVSGPGEHLRNALWHTGHTP
                     DQVRLLWTDPRNVGWRDKTSYRWQLLHRPQVGYIRVKLYEGPQLVADSGVIIDTSMRG
                     GRLGVFCFSQENIIWSNLQYRCNDTVPEDFEPFRRQLLQGRV"
     exon            101..307
                     /gene="THBS3"
                     /gene_synonym="TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            308..564
                     /gene="THBS3"
                     /gene_synonym="TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            565..667
                     /gene="THBS3"
                     /gene_synonym="TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            668..694
                     /gene="THBS3"
                     /gene_synonym="TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            695..777
                     /gene="THBS3"
                     /gene_synonym="TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            778..829
                     /gene="THBS3"
                     /gene_synonym="TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            830..978
                     /gene="THBS3"
                     /gene_synonym="TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1119
                     /gene="THBS3"
                     /gene_synonym="TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1197
                     /gene="THBS3"
                     /gene_synonym="TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1350
                     /gene="THBS3"
                     /gene_synonym="TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1461
                     /gene="THBS3"
                     /gene_synonym="TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1569
                     /gene="THBS3"
                     /gene_synonym="TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1729
                     /gene="THBS3"
                     /gene_synonym="TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1848
                     /gene="THBS3"
                     /gene_synonym="TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1901
                     /gene="THBS3"
                     /gene_synonym="TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2095
                     /gene="THBS3"
                     /gene_synonym="TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2274
                     /gene="THBS3"
                     /gene_synonym="TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2323
                     /gene="THBS3"
                     /gene_synonym="TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2520
                     /gene="THBS3"
                     /gene_synonym="TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2521..2693
                     /gene="THBS3"
                     /gene_synonym="TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2694..2833
                     /gene="THBS3"
                     /gene_synonym="TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2834..3145
                     /gene="THBS3"
                     /gene_synonym="TSP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3122..3127
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THBS3"
                     /gene_synonym="TSP3"
                     /note="hexamer: CATAAA"
     polyA_site      3145
                     /gene="THBS3"
                     /gene_synonym="TSP3"
                     /note="major polyA site"
ORIGIN      
        1 gtagtgagcc ggctgagagg catggagacg caggaacttc ggggggccct ggctcttctc
       61 ctcctttgct ttttcacatc tgccagtcag gatctgcagg taattgacct gctgactgtg
      121 ggcgagtctc ggcagatggt agctgtggca gagaagatcc ggacagcctt gctcactgct
      181 ggggacatct acctcttatc caccttccgc ctgcccccca agcagggtgg tgtcctcttt
      241 ggcctctatt ctcgccaaga caacactcga tggctggagg cctctgttgt aggcaagatc
      301 aacaaagtac tggtgcgata ccagcgggag gatggcaaag tccacgccgt gaacctacag
      361 caagcgggcc tggctgatgg gcgcacacac acagttctcc tgcgactccg aggtccctcc
      421 agacccagcc ctgccctaca tctctacgtg gactgcaaac tgggtgacca acatgcaggc
      481 cttccagcac tggcccccat tcctccagcg gaggtcgatg ggctggagat taggactgga
      541 cagaaggcgt atttgaggat gcagggcttt gtggaatcta tgaaaattat tctgggtggg
      601 tccatggccc gggtaggagc cctgagtgag tgtccattcc aaggggacga gtccatccac
      661 agtgcagtga ccaatgcact gcactccatt ctaggggagc agaccaaggc gctggtcacc
      721 caactcaccc tcttcaacca gatcctggtg gagctgcggg atgatatacg agaccaggtg
      781 aaggaaatgt ccctgatccg aaacaccatt atggagtgtc aggtgtgcgg cttccatgag
      841 cagcgttccc actgcagccc caatccctgc ttccgaggtg tggactgcat ggaagtgtac
      901 gagtacccag gctaccgctg tgggccctgc ccccctggcc tgcagggcaa cggcacccac
      961 tgcagtgaca tcaatgagtg tgctcacgct gacccctgtt tcccgggctc cagctgcatc
     1021 aacaccatgc ccggcttcca ctgtgaggcc tgtcctcgag ggtacaaggg cacacaggtg
     1081 tctggtgtgg gcattgacta tgcccgggcc agcaaacagg tctgcaatga catcgatgaa
     1141 tgcaacgatg gcaacaatgg tggctgtgac ccaaactcca tctgcaccaa cactgtgggc
     1201 tctttcaagt gtggtccctg ccgcctgggt ttcctgggca accagagcca gggctgcctc
     1261 ccagcccgga cctgccacag cccagcccac agcccctgcc acatccatgc tcactgtctc
     1321 tttgaacgca atggtgcagt gtcctgccag tgtaacgtgg gctgggctgg gaatgggaac
     1381 gtgtgtggga ctgacacaga catcgatggc tacccagacc aagcactgcc ctgcatggac
     1441 aacaacaaac actgcaaaca ggacaactgc cttttgacac ccaactctgg gcaggaagat
     1501 gctgataatg atggtgtggg ggaccagtgt gatgatgatg ctgatgggga tgggatcaag
     1561 aatgttgagg acaactgccg gctgttcccc aacaaagacc agcagaactc agatacagat
     1621 tcatttggtg atgcctgtga caattgcccc aacgttccca acaatgacca gaaggacaca
     1681 gatggcaatg gggaaggaga tgcctgtgac aacgacgtgg atggggatgg catccccaat
     1741 ggattggaca attgccctaa agtccccaac ccactacaga cagacaggga tgaggacggg
     1801 gtgggagatg cttgcgacag ctgccctgaa atgagcaatc ctacccagac agatgcagac
     1861 agcgacctgg tgggggatgt ctgtgatact aatgaagaca gcgatgggga tgggcatcag
     1921 gacaccaagg acaactgccc acagctgcca aatagctccc agctggactc tgataacgat
     1981 ggacttggag atgagtgtga tggggatgat gacaatgatg gcatcccaga ttatgtgcct
     2041 cctggtcccg ataactgccg cctggtaccc aatcccaatc agaaggactc agatggcaat
     2101 ggcgttggtg atgtgtgtga ggatgacttt gacaatgatg ctgtggtcga ccccctggat
     2161 gtgtgtcctg aaagtgcaga ggtaacgctt acggattttc gggcctatca gaccgtcgtc
     2221 ctggatcctg agggtgatgc tcagattgac ccaaactggg ttgtgctcaa ccagggcatg
     2281 gaaatcgttc agaccatgaa cagtgaccct ggcttggcag ttggatacac ggccttcaat
     2341 ggtgtggact ttgaaggcac cttccatgtg aacacagtga ctgatgatga ctacgcaggc
     2401 tttctcttca gttatcaaga cagtggccgc ttctacgtag tcatgtggaa gcagaccgag
     2461 cagacctact ggcaggctac acccttccgg gcggttgccc agcccgggct gcagctcaag
     2521 gcagtgacat cagtgtctgg cccaggtgag cacctccgaa atgccctgtg gcatactggc
     2581 cacacccctg atcaggtacg actgctgtgg acagacccac gaaatgtggg ctggcgggac
     2641 aagacctcct atcgctggca gcttctgcac cggcctcaag ttggctacat tcgggtgaag
     2701 ctctatgagg gaccccagct tgtggcggat tctggggtga tcattgacac atccatgcga
     2761 ggggggcgtc ttggtgtatt ctgcttctcc caagaaaaca taatttggtc caatctccag
     2821 tatcgatgca atgacacagt gcctgaggac tttgagccat tccggaggca gctgctccag
     2881 ggaagggtgt gaggaggagg ccaccagatt cagaattcag aattttagac cctttggcct
     2941 tggggtccat cctggagacc ctgaggtcta agctacagcc cctcagccaa ccacagaccc
     3001 ttctctggct cccaaaagga gttcagtccc agaggggtgg tcaccccacc cttcagggga
     3061 tgagaagttt tcaaggggta ttactcaggc actaacccca ggaaagatga cagcacattg
     3121 ccataaagtt ttggttgttt tctaa
//
