LOCUS       NM_000361               4040 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens thrombomodulin (THBD), mRNA.
ACCESSION   NM_000361
VERSION     NM_000361.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4040)
  AUTHORS   Oda,H., Nagamatsu,T., Iriyama,T. and Osuga,Y.
  TITLE     Altered release of thrombomodulin and HMGB1 in the placenta
            complicated with preeclampsia
  JOURNAL   Placenta 148, 12-19 (2024)
   PUBMED   38330539
  REMARK    GeneRIF: Altered release of thrombomodulin and HMGB1 in the
            placenta complicated with preeclampsia.
REFERENCE   2  (bases 1 to 4040)
  AUTHORS   Biswas,I., Giri,H., Panicker,S.R. and Rezaie,A.R.
  TITLE     Thrombomodulin Switches Signaling and Protease-Activated Receptor 1
            Cleavage Specificity of Thrombin
  JOURNAL   Arterioscler Thromb Vasc Biol 44 (3), 603-616 (2024)
   PUBMED   38174561
  REMARK    GeneRIF: Thrombomodulin Switches Signaling and Protease-Activated
            Receptor 1 Cleavage Specificity of Thrombin.
REFERENCE   3  (bases 1 to 4040)
  AUTHORS   Chang,Y.J., Prince,G.M.S.H., Wei,P.L., Batzorig,U., Huang,C.Y.,
            Hung,C.S. and Chang,T.C.
  TITLE     The role of thrombomodulin in modulating ITGB3 expression and its
            implications for triple-negative breast cancer progression
  JOURNAL   Cell Biol Int 48 (2), 216-228 (2024)
   PUBMED   38081783
  REMARK    GeneRIF: The role of thrombomodulin in modulating ITGB3 expression
            and its implications for triple-negative breast cancer progression.
REFERENCE   4  (bases 1 to 4040)
  AUTHORS   Riguetti,M.T.P., Varela-Calais,P., Fernandes,D.E., da Silva
            Franco,J.F., Ribeiro Nogueira,B., Pesquero,J.B. and
            Mastroianni-Kirsztajn,G.
  TITLE     Thrombomodulin Gene Mutation and Associated Predisposing Factors in
            Familial Collapsing Glomerulopathy
  JOURNAL   Nephron 148 (7), 508-514 (2024)
   PUBMED   38373411
  REMARK    GeneRIF: Thrombomodulin Gene Mutation and Associated Predisposing
            Factors in Familial Collapsing Glomerulopathy.
REFERENCE   5  (bases 1 to 4040)
  AUTHORS   Yamazaki,A., Nukui,Y., Kameda,T., Saito,R., Koda,Y., Ichimura,N.,
            Tohda,S. and Ohkawa,R.
  TITLE     Variation in presepsin and thrombomodulin levels for predicting
            COVID-19 mortality
  JOURNAL   Sci Rep 13 (1), 21493 (2023)
   PUBMED   38057335
  REMARK    GeneRIF: Variation in presepsin and thrombomodulin levels for
            predicting COVID-19 mortality.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4040)
  AUTHORS   Noris,M., Bresin,E., Mele,C. and Remuzzi,G.
  TITLE     Genetic Atypical Hemolytic-Uremic Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301541
REFERENCE   7  (bases 1 to 4040)
  AUTHORS   Boffa,M.C., Jackman,R.W., Peyri,N., Boffa,J.F. and George,B.
  TITLE     Thrombomodulin in the central nervous system
  JOURNAL   Nouv Rev Fr Hematol (1978) 33 (6), 423-429 (1991)
   PUBMED   1667949
REFERENCE   8  (bases 1 to 4040)
  AUTHORS   Jakubowski,H.V. and Owen,W.G.
  TITLE     Macromolecular specificity determinants on thrombin for fibrinogen
            and thrombomodulin
  JOURNAL   J Biol Chem 264 (19), 11117-11121 (1989)
   PUBMED   2544585
REFERENCE   9  (bases 1 to 4040)
  AUTHORS   Esmon,C.T.
  TITLE     The roles of protein C and thrombomodulin in the regulation of
            blood coagulation
  JOURNAL   J Biol Chem 264 (9), 4743-4746 (1989)
   PUBMED   2538457
  REMARK    Review article
REFERENCE   10 (bases 1 to 4040)
  AUTHORS   Jackman,R.W., Beeler,D.L., Fritze,L., Soff,G. and Rosenberg,R.D.
  TITLE     Human thrombomodulin gene is intron depleted: nucleic acid
            sequences of the cDNA and gene predict protein structure and
            suggest sites of regulatory control
  JOURNAL   Proc Natl Acad Sci U S A 84 (18), 6425-6429 (1987)
   PUBMED   2819876
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL049651.2, BG771668.1,
            M16552.1 and AI285986.1.
            
            On Aug 31, 2019 this sequence version replaced NM_000361.2.
            
            Summary: The protein encoded by this intronless gene is an
            endothelial-specific type I membrane receptor that binds thrombin.
            This binding results in the activation of protein C, which degrades
            clotting factors Va and VIIIa and reduces the amount of thrombin
            generated. Mutations in this gene are a cause of thromboembolic
            disease, also known as inherited thrombophilia. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: M16552.1, BC035602.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000377103.3/
                                                ENSP00000366307.2
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AL049651.2         78706-78713         c
            9-27                BG771668.1         9-27
            28-3675             M16552.1           6-3653
            3676-4040           AI285986.1         21-385              c
FEATURES             Location/Qualifiers
     source          1..4040
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p11.21"
     gene            1..4040
                     /gene="THBD"
                     /gene_synonym="AHUS6; BDCA-3; BDCA3; CD141; THPH12; THRM;
                     TM"
                     /note="thrombomodulin"
                     /db_xref="GeneID:7056"
                     /db_xref="HGNC:HGNC:11784"
                     /db_xref="MIM:188040"
     exon            1..4040
                     /gene="THBD"
                     /gene_synonym="AHUS6; BDCA-3; BDCA3; CD141; THPH12; THRM;
                     TM"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..1896
                     /gene="THBD"
                     /gene_synonym="AHUS6; BDCA-3; BDCA3; CD141; THPH12; THRM;
                     TM"
                     /note="fetomodulin; CD141 antigen"
                     /codon_start=1
                     /product="thrombomodulin precursor"
                     /protein_id="NP_000352.1"
                     /db_xref="CCDS:CCDS13148.1"
                     /db_xref="GeneID:7056"
                     /db_xref="HGNC:HGNC:11784"
                     /db_xref="MIM:188040"
                     /translation="MLGVLVLGALALAGLGFPAPAEPQPGGSQCVEHDCFALYPGPAT
                     FLNASQICDGLRGHLMTVRSSVAADVISLLLNGDGGVGRRRLWIGLQLPPGCGDPKRL
                     GPLRGFQWVTGDNNTSYSRWARLDLNGAPLCGPLCVAVSAAEATVPSEPIWEEQQCEV
                     KADGFLCEFHFPATCRPLAVEPGAAAAAVSITYGTPFAARGADFQALPVGSSAAVAPL
                     GLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQAD
                     GRSCTASATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEPS
                     PCPQRCVNTQGGFECHCYPNYDLVDGECVEPVDPCFRANCEYQCQPLNQTSYLCVCAE
                     GFAPIPHEPHRCQMFCNQTACPADCDPNTQASCECPEGYILDDGFICTDIDECENGGF
                     CSGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDGGDSGSGEPPPSPTPGSTLTPP
                     AVGLVHSGLLIGISIASLCLVVALLALLCHLRKKQGAARAKMEYKCAAPSKEVVLQHV
                     RTERTPQRL"
     regulatory      3656..3661
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THBD"
                     /gene_synonym="AHUS6; BDCA-3; BDCA3; CD141; THPH12; THRM;
                     TM"
                     /note="hexamer: AATAAA"
     polyA_site      3675
                     /gene="THBD"
                     /gene_synonym="AHUS6; BDCA-3; BDCA3; CD141; THPH12; THRM;
                     TM"
                     /note="major polyA site"
     regulatory      4007..4012
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THBD"
                     /gene_synonym="AHUS6; BDCA-3; BDCA3; CD141; THPH12; THRM;
                     TM"
                     /note="hexamer: AATAAA"
     polyA_site      4040
                     /gene="THBD"
                     /gene_synonym="AHUS6; BDCA-3; BDCA3; CD141; THPH12; THRM;
                     TM"
                     /note="major polyA site"
ORIGIN      
        1 atgtcagagg ctgcctcgca ggggctgcgc gcagcggcaa gaagtgtctg ggctgggacg
       61 gacaggagag gctgtcgcca tcggcgtcct gtgcccctct gctccggcac ggccctgtcg
      121 cagtgcccgc gctttccccg gcgcctgcac gcggcgcgcc tgggtaacat gcttggggtc
      181 ctggtccttg gcgcgctggc cctggccggc ctggggttcc ccgcacccgc agagccgcag
      241 ccgggtggca gccagtgcgt cgagcacgac tgcttcgcgc tctacccggg ccccgcgacc
      301 ttcctcaatg ccagtcagat ctgcgacgga ctgcggggcc acctaatgac agtgcgctcc
      361 tcggtggctg ccgatgtcat ttccttgcta ctgaacggcg acggcggcgt tggccgccgg
      421 cgcctctgga tcggcctgca gctgccaccc ggctgcggcg accccaagcg cctcgggccc
      481 ctgcgcggct tccagtgggt tacgggagac aacaacacca gctatagcag gtgggcacgg
      541 ctcgacctca atggggctcc cctctgcggc ccgttgtgcg tcgctgtctc cgctgctgag
      601 gccactgtgc ccagcgagcc gatctgggag gagcagcagt gcgaagtgaa ggccgatggc
      661 ttcctctgcg agttccactt cccagccacc tgcaggccac tggctgtgga gcccggcgcc
      721 gcggctgccg ccgtctcgat cacctacggc accccgttcg cggcccgcgg agcggacttc
      781 caggcgctgc cggtgggcag ctccgccgcg gtggctcccc tcggcttaca gctaatgtgc
      841 accgcgccgc ccggagcggt ccaggggcac tgggccaggg aggcgccggg cgcttgggac
      901 tgcagcgtgg agaacggcgg ctgcgagcac gcgtgcaatg cgatccctgg ggctccccgc
      961 tgccagtgcc cagccggcgc cgccctgcag gcagacgggc gctcctgcac cgcatccgcg
     1021 acgcagtcct gcaacgacct ctgcgagcac ttctgcgttc ccaaccccga ccagccgggc
     1081 tcctactcgt gcatgtgcga gaccggctac cggctggcgg ccgaccaaca ccggtgcgag
     1141 gacgtggatg actgcatact ggagcccagt ccgtgtccgc agcgctgtgt caacacacag
     1201 ggtggcttcg agtgccactg ctaccctaac tacgacctgg tggacggcga gtgtgtggag
     1261 cccgtggacc cgtgcttcag agccaactgc gagtaccagt gccagcccct gaaccaaact
     1321 agctacctct gcgtctgcgc cgagggcttc gcgcccattc cccacgagcc gcacaggtgc
     1381 cagatgtttt gcaaccagac tgcctgtcca gccgactgcg accccaacac ccaggctagc
     1441 tgtgagtgcc ctgaaggcta catcctggac gacggtttca tctgcacgga catcgacgag
     1501 tgcgaaaacg gcggcttctg ctccggggtg tgccacaacc tccccggtac cttcgagtgc
     1561 atctgcgggc ccgactcggc ccttgcccgc cacattggca ccgactgtga ctccggcaag
     1621 gtggacggtg gcgacagcgg ctctggcgag cccccgccca gcccgacgcc cggctccacc
     1681 ttgactcctc cggccgtggg gctcgtgcat tcgggcttgc tcataggcat ctccatcgcg
     1741 agcctgtgcc tggtggtggc gcttttggcg ctcctctgcc acctgcgcaa gaagcagggc
     1801 gccgccaggg ccaagatgga gtacaagtgc gcggcccctt ccaaggaggt agtgctgcag
     1861 cacgtgcgga ccgagcggac gccgcagaga ctctgagcgg cctccgtcca ggagcctggc
     1921 tccgtccagg agcctgtgcc tcctcacccc cagctttgct accaaagcac cttagctggc
     1981 attacagctg gagaagaccc tccccgcacc ccccaagctg ttttcttcta ttccatggct
     2041 aactggcgag ggggtgatta gagggaggag aatgagcctc ggcctcttcc gtgacgtcac
     2101 tggaccactg ggcaatgatg gcaattttgt aacgaagaca cagactgcga tttgtcccag
     2161 gtcctcacta ccgggcgcag gagggtgagc gttattggtc ggcagccttc tgggcagacc
     2221 ttgacctcgt gggctaggga tgactaaaat atttattttt tttaagtatt taggtttttg
     2281 tttgtttcct ttgttcttac ctgtatgtct ccagtatcca ctttgcacag ctctccggtc
     2341 tctctctctc tacaaactcc cacttgtcat gtgacaggta aactatcttg gtgaattttt
     2401 ttttcctagc cctctcacat ttatgaagca agccccactt attccccatt cttcctagtt
     2461 ttctcctccc aggaactggg ccaactcacc tgagtcaccc tacctgtgcc tgaccctact
     2521 tcttttgctc ttagctgtct gctcagacag aacccctaca tgaaacagaa acaaaaacac
     2581 taaaaataaa aatggccatt tgctttttca ccagatttgc taatttatcc tgaaatttca
     2641 gattcccaga gcaaaataat tttaaacaaa ggttgagatg taaaaggtat taaattgatg
     2701 ttgctggact gtcatagaaa ttacacccaa agaggtattt atctttactt ttaaacagtg
     2761 agcctgaatt ttgttgctgt tttgatttgt actgaaaaat ggtaattgtt gctaatcttc
     2821 ttatgcaatt tccttttttg ttattattac ttatttttga cagtgttgaa aatgttcaga
     2881 aggttgctct agattgagag aagagacaaa cacctcccag gagacagttc aagaaagctt
     2941 caaactgcat gattcatgcc aattagcaat tgactgtcac tgttccttgt cactggtaga
     3001 ccaaaataaa accagctcta ctggtcttgt ggaattggga gcttgggaat ggatcctgga
     3061 ggatgcccaa ttagggccta gccttaatca ggtcctcaga gaatttctac catttcagag
     3121 aggccttttg gaatgtggcc cctgaacaag aattggaagc tgccctgccc atgggagctg
     3181 gttagaaatg cagaatccta ggctccaccc catccagttc atgagaatct atatttaaca
     3241 agatctgcag ggggtgtgtc tgctcagtaa tttgaggaca accattccag actgcttcca
     3301 attttctgga atacatgaaa tatagatcag ttataagtag caggccaagt caggccctta
     3361 ttttcaagaa actgaggaat tttctttgtg tagctttgct ctttggtaga aaaggctagg
     3421 tacacagctc tagacactgc cacacagggt ctgcaaggtc tttggttcag ctaagctagg
     3481 aatgaaatcc tgcttcagtg tatggaaata aatgtatcat agaaatgtaa cttttgtaag
     3541 acaaaggttt tcctcttcta ttttgtaaac tcaaaatatt tgtacatagt tatttattta
     3601 ttggagataa tctagaacac aggcaaaatc cttgcttatg acatcacttg tacaaaataa
     3661 acaaataaca atgtgctctc gggttgtgtg tctgttcact tttcctccct cagtgccctc
     3721 attttatgtc attaaatggg gctcacaaac catgcaaatg ctatgagatg catggagggc
     3781 tgccctgtac cccagcactt gtgttgtctg gtggtggcac catctctgat tttcaaagct
     3841 ttttccagag gctattattt tcactgtaga atgatttcat gctatctctg tgtgcacaaa
     3901 tatttatttt ctttctgtaa ccataacaac ttcatatatg aggacttgtg tctctgtgct
     3961 tttaaatgca taaatgcatt ataggatcat ttgttggaat gaattaaata aacccttcct
     4021 ggggcatctg gcgaatccca
//
