LOCUS       NM_024672               3825 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens THAP domain containing 9 (THAP9), transcript variant
            1, mRNA.
ACCESSION   NM_024672
VERSION     NM_024672.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3825)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   2  (bases 1 to 3825)
  AUTHORS   Yang,S., Wang,B., Liu,C., Wang,Q., Wang,R., Su,W., Zhu,Y., Li,M.,
            Guo,Z., Wu,X. and Chen,F.
  TITLE     THAP9-AS1 Promotes Tumorigenesis and Reduces ROS Generation through
            the JAK2/STAT3 Signaling Pathway by Increasing SOCS3 Promoter
            Methylation in Osteosarcoma
  JOURNAL   Oxid Med Cell Longev 2021, 5620475 (2021)
   PUBMED   34691358
  REMARK    GeneRIF: THAP9-AS1 Promotes Tumorigenesis and Reduces ROS
            Generation through the JAK2/STAT3 Signaling Pathway by Increasing
            SOCS3 Promoter Methylation in Osteosarcoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3825)
  AUTHORS   Sanghavi,H.M. and Majumdar,S.
  TITLE     Oligomerization of THAP9 Transposase via Amino-Terminal Domains
  JOURNAL   Biochemistry 60 (23), 1822-1835 (2021)
   PUBMED   34033475
  REMARK    GeneRIF: Oligomerization of THAP9 Transposase via Amino-Terminal
            Domains.
REFERENCE   4  (bases 1 to 3825)
  AUTHORS   Sharma,V., Thakore,P. and Majumdar,S.
  TITLE     THAP9 Transposase Cleaves DNA via Conserved Acidic Residues in an
            RNaseH-Like Domain
  JOURNAL   Cells 10 (6), 1351 (2021)
   PUBMED   34072453
  REMARK    GeneRIF: THAP9 Transposase Cleaves DNA via Conserved Acidic
            Residues in an RNaseH-Like Domain.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3825)
  AUTHORS   Cheng,J., Ma,H., Yan,M. and Xing,W.
  TITLE     THAP9-AS1/miR-133b/SOX4 positive feedback loop facilitates the
            progression of esophageal squamous cell carcinoma
  JOURNAL   Cell Death Dis 12 (4), 401 (2021)
   PUBMED   33854048
  REMARK    GeneRIF: THAP9-AS1/miR-133b/SOX4 positive feedback loop facilitates
            the progression of esophageal squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3825)
  AUTHORS   Majumdar,S., Singh,A. and Rio,D.C.
  TITLE     The human THAP9 gene encodes an active P-element DNA transposase
  JOURNAL   Science 339 (6118), 446-448 (2013)
   PUBMED   23349291
  REMARK    GeneRIF: results indicate that human THAP9 is an active DNA
            transposase that, although 'domesticated,' still retains the
            catalytic activity to mobilize P transposable elements across
            species
REFERENCE   7  (bases 1 to 3825)
  AUTHORS   Sabogal,A., Lyubimov,A.Y., Corn,J.E., Berger,J.M. and Rio,D.C.
  TITLE     THAP proteins target specific DNA sites through bipartite
            recognition of adjacent major and minor grooves
  JOURNAL   Nat Struct Mol Biol 17 (1), 117-123 (2010)
   PUBMED   20010837
REFERENCE   8  (bases 1 to 3825)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   9  (bases 1 to 3825)
  AUTHORS   Hammer,S.E., Strehl,S. and Hagemann,S.
  TITLE     Homologs of Drosophila P transposons were mobile in zebrafish but
            have been domesticated in a common ancestor of chicken and human
  JOURNAL   Mol Biol Evol 22 (4), 833-844 (2005)
   PUBMED   15616143
REFERENCE   10 (bases 1 to 3825)
  AUTHORS   Roussigne,M., Kossida,S., Lavigne,A.C., Clouaire,T., Ecochard,V.,
            Glories,A., Amalric,F. and Girard,J.P.
  TITLE     The THAP domain: a novel protein motif with similarity to the
            DNA-binding domain of P element transposase
  JOURNAL   Trends Biochem Sci 28 (2), 66-69 (2003)
   PUBMED   12575992
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA317935.1, DB154392.1, AC021105.13 and AA478110.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024672.5.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The extent of this transcript
            is supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.156336.1,
                                           SRR1660805.76018.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302236.10/ ENSP00000305533.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-489               DA317935.1         52-540
            490-919             DB154392.1         50-479
            920-3440            AC021105.13        130382-132902       c
            3441-3825           AA478110.1         6-390               c
FEATURES             Location/Qualifiers
     source          1..3825
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.22"
     gene            1..3825
                     /gene="THAP9"
                     /gene_synonym="hTh9"
                     /note="THAP domain containing 9"
                     /db_xref="GeneID:79725"
                     /db_xref="HGNC:HGNC:23192"
                     /db_xref="MIM:612537"
     exon            1..148
                     /gene="THAP9"
                     /gene_synonym="hTh9"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..2780
                     /gene="THAP9"
                     /gene_synonym="hTh9"
                     /note="isoform 1 is encoded by transcript variant 1; THAP
                     domain-containing protein 9; DNA transposase THAP9"
                     /codon_start=1
                     /product="DNA transposase THAP9 isoform 1"
                     /protein_id="NP_078948.3"
                     /db_xref="CCDS:CCDS3598.1"
                     /db_xref="GeneID:79725"
                     /db_xref="HGNC:HGNC:23192"
                     /db_xref="MIM:612537"
                     /translation="MTRSCSAVGCSTRDTVLSRERGLSFHQFPTDTIQRSKWIRAVNR
                     VDPRSKKIWIPGPGAILCSKHFQESDFESYGIRRKLKKGAVPSVSLYKIPQGVHLKGK
                     ARQKILKQPLPDNSQEVATEDHNYSLKTPLTIGAEKLAEVQQMLQVSKKRLISVKNYR
                     MIKKRKGLRLIDALVEEKLLSEETECLLRAQFSDFKWELYNWRETDEYSAEMKQFACT
                     LYLCSSKVYDYVRKILKLPHSSILRTWLSKCQPSPGFNSNIFSFLQRRVENGDQLYQY
                     CSLLIKSMPLKQQLQWDPSSHSLQGFMDFGLGKLDADETPLASETVLLMAVGIFGHWR
                     TPLGYFFVNRASGYLQAQLLRLTIGKLSDIGITVLAVTSDATAHSVQMAKALGIHIDG
                     DDMKCTFQHPSSSSQQIAYFFDSCHLLRLIRNAFQNFQSIQFINGIAHWQHLVELVAL
                     EEQELSNMERIPSTLANLKNHVLKVNSATQLFSESVASALEYLLSLDLPPFQNCIGTI
                     HFLRLINNLFDIFNSRNCYGKGLKGPLLPETYSKINHVLIEAKTIFVTLSDTSNNQII
                     KGKQKLGFLGFLLNAESLKWLYQNYVFPKVMPFPYLLTYKFSHDHLELFLKMLRQVLV
                     TSSSPTCMAFQKAYYNLETRYKFQDEVFLSKVSIFDISIARRKDLALWTVQRQYGVSV
                     TKTVFHEEGICQDWSHCSLSEALLDLSDHRRNLICYAGYVANKLSALLTCEDCITALY
                     ASDLKASKIGSLLFVKKKNGLHFPSESLCRVINICERVVRTHSRMAIFELVSKQRELY
                     LQQKILCELSGHINLFVDVNKHLFDGEVCAINHFVKLLKDIIICFLNIRAKNVAQNPL
                     KHHSERTDMKTLSRKHWSSVQDYKCSSFANTSSKFRHLLSNDGYPFK"
     exon            149..344
                     /gene="THAP9"
                     /gene_synonym="hTh9"
                     /inference="alignment:Splign:2.1.0"
     exon            345..648
                     /gene="THAP9"
                     /gene_synonym="hTh9"
                     /inference="alignment:Splign:2.1.0"
     exon            649..799
                     /gene="THAP9"
                     /gene_synonym="hTh9"
                     /inference="alignment:Splign:2.1.0"
     exon            800..3825
                     /gene="THAP9"
                     /gene_synonym="hTh9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2902..2907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THAP9"
                     /gene_synonym="hTh9"
                     /note="hexamer: ATTAAA"
     polyA_site      2927
                     /gene="THAP9"
                     /gene_synonym="hTh9"
     regulatory      3803..3808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THAP9"
                     /gene_synonym="hTh9"
                     /note="hexamer: ATTAAA"
     polyA_site      3825
                     /gene="THAP9"
                     /gene_synonym="hTh9"
                     /note="major polyA site"
ORIGIN      
        1 ggagctaaag tggtcgtgat tcatgctgtc gcgggaaccc cgaaggtggg gccccacgta
       61 acaagaagat gacccgaagt tgctccgcag tgggctgcag cacccgtgac accgtgctca
      121 gccgggagcg cggcctctcc ttccaccaat ttccaactga taccatacag cgctcaaaat
      181 ggatcagggc tgttaatcgt gtggacccca gaagcaaaaa gatttggatt ccaggaccag
      241 gtgctatact gtgttccaaa cattttcaag aaagtgactt tgagtcatat ggcataagaa
      301 gaaagctgaa aaaaggagct gtgccttctg tttctctata caagattcct caaggtgtac
      361 atcttaaagg taaagcaaga caaaaaatcc taaaacaacc tcttccagac aattctcaag
      421 aagttgctac tgaggaccat aactatagtt taaagacacc tttgacgata ggtgcagaga
      481 aactggctga ggtgcaacaa atgttacaag tgtccaaaaa aagacttatc tccgtaaaga
      541 actacaggat gatcaagaag agaaagggtt tacgattaat tgatgcactt gtagaagaga
      601 aactactttc tgaagaaaca gagtgtctgc tacgagctca attttcagat tttaagtggg
      661 agttatataa ttggagagaa acagatgagt actccgcaga aatgaaacaa tttgcatgta
      721 cactctactt gtgcagtagc aaagtctatg attatgtaag aaagattctt aagctgcctc
      781 attcttccat cctcagaacg tggttatcca aatgccaacc cagtccaggt ttcaacagca
      841 acattttttc ttttcttcaa cgaagagtag agaatggaga tcagctctat caatactgtt
      901 cattgttaat aaaaagtatg cctctcaagc aacagcttca gtgggatcct agcagtcaca
      961 gtttgcaggg gtttatggac tttggtcttg gaaaacttga tgctgatgaa acgccacttg
     1021 cttcagaaac tgttttgtta atggcagtgg gtatttttgg ccattggaga acacctcttg
     1081 gttatttttt tgtaaacaga gcatctggat atttgcaggc tcagctgctt cgtctgacta
     1141 ttggtaaact gagtgacata ggaatcacag ttctggctgt tacatctgat gccacagcac
     1201 atagtgttca gatggcaaaa gcattgggga tacatattga tggagacgac atgaaatgta
     1261 catttcagca tccttcatct tctagtcaac agattgcata cttctttgac tcttgccact
     1321 tgctaagatt aataagaaat gcatttcaga attttcaaag cattcagttt attaatggta
     1381 tagcacattg gcagcacctc gtggagttag tagcactgga ggaacaggaa ttatcaaata
     1441 tggaaagaat accaagtaca cttgcaaatt tgaaaaatca tgtactgaaa gtgaatagtg
     1501 ccacccaact ctttagtgag agtgtagcca gtgcattaga atatttgtta tccttagacc
     1561 tgccaccttt tcaaaactgt attggtacca tccatttttt acgtttaatt aacaatctgt
     1621 ttgacatctt taatagtagg aactgttatg gaaagggact taaagggcct ctgttgcctg
     1681 aaacttacag taaaataaac cacgtgttaa ttgaagccaa gactattttt gttacattat
     1741 ctgacactag caataatcaa ataattaaag gtaagcaaaa actaggattc ctgggatttt
     1801 tgctcaatgc tgagagctta aaatggctct accaaaatta tgttttccca aaggtcatgc
     1861 cttttcctta tcttctgact tacaaattca gtcatgatca tctggaatta tttctaaaga
     1921 tgcttaggca ggtattagta acaagttcta gccctacctg catggcattc cagaaagctt
     1981 actataattt ggagaccaga tacaaatttc aagatgaagt ttttctaagc aaagtaagca
     2041 tctttgacat ttcaattgct cgaaggaaag acttggcgct ttggacagtt caacgtcagt
     2101 atggtgtcag cgttacaaag actgtctttc acgaagaggg tatttgtcaa gactggtctc
     2161 attgttcact aagtgaggca ttactagacc tgtcagatca taggcgaaat ctcatctgtt
     2221 atgctggtta tgttgcaaac aagttatcag ctcttttaac ttgtgaggac tgcatcactg
     2281 cactgtatgc atcggatctc aaagcctcta aaattgggtc actattattt gttaaaaaga
     2341 agaatggttt gcattttcct tcagaaagtc tgtgtcgggt cataaatatt tgtgagcgag
     2401 ttgtaagaac ccattcaaga atggcaattt ttgaactagt ttctaaacaa agggaattgt
     2461 atcttcaaca gaaaatatta tgtgagcttt ctgggcatat taatcttttt gtagatgtga
     2521 ataagcatct ctttgatgga gaagtgtgtg ccatcaatca ctttgtcaag ttgctaaagg
     2581 atataataat ctgtttctta aatatcagag ctaaaaatgt tgcacagaat cctttaaaac
     2641 atcattcaga gagaactgat atgaaaactt tatcaaggaa acactggtca tctgtacagg
     2701 attataaatg ttcaagtttt gctaatacca gtagtaaatt caggcatttg ctaagtaacg
     2761 atggatatcc attcaaatga gagacctaaa atatattaac attttaatta agaatacttg
     2821 atcaacattt tttgaagttc aatttaccat attttataaa ttgcgcattc tgcacagtgg
     2881 acaagtttgc aattctgact tattaaaatt tcaaattctg catatcacaa aatctcctta
     2941 tacttttggt atggcttgca gcatttatga gttttccaaa atatagaaag cagtaggtca
     3001 gtaggagcaa actagccaac aggtactgtc tttgaattta ctactgtaag actaagcagt
     3061 gttactggac acagttttaa cttgttcaat ctgcttcaaa aacaagaaaa acaacaacta
     3121 tgagttatca aaatattgac tccatttatg actagactac atttctgaaa gatctttggt
     3181 ttatgattct taagaatatt gacaatacct ataaaacttt gaagataact tttacttaaa
     3241 tatgaaaatt atagtttgaa aattaggctc aagcaaatat caaatactgc aaaaatcccc
     3301 ttgtcccagg ataccctaaa atagaagtgc ttaaactttg tcaggcagaa ggtaaagtac
     3361 atgagccatg agattcttcc ttgtgctgca gccacgctgg ggagtgcaat ctggaaagaa
     3421 catacctaat gtgtttttca ccatccatta tctctgaact ttgaaatatt acttttgaat
     3481 aataggctgg acacttagtt tgacttgaaa gagctcaatg ctcatcggaa aacagggaga
     3541 aacctaatct gaagatggaa gcatactaag gacaattttc tccactcaca tccacatttg
     3601 aaaagaggga cagaaaaaca taggtaactc tactttcaca aatgaggata gtttaacgga
     3661 tagaagaaac aagcacatta ttcacctgtg ttgtaaaaca tctactcttt tttgtcactg
     3721 aataagtgtt cccaaagtac agttaatcct aatatgaaaa cttagaattg taaaagatta
     3781 atgataacgt aaaagtatat tgattaaaat tccccttaca aagta
//
