LOCUS       NM_152658               1349 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens THAP domain containing 8 (THAP8), transcript variant
            1, mRNA.
ACCESSION   NM_152658
VERSION     NM_152658.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1349)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1349)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1349)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   4  (bases 1 to 1349)
  AUTHORS   Roussigne,M., Kossida,S., Lavigne,A.C., Clouaire,T., Ecochard,V.,
            Glories,A., Amalric,F. and Girard,J.P.
  TITLE     The THAP domain: a novel protein motif with similarity to the
            DNA-binding domain of P element transposase
  JOURNAL   Trends Biochem Sci 28 (2), 66-69 (2003)
   PUBMED   12575992
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK093048.1 and AC002116.1.
            
            On May 17, 2019 this sequence version replaced NM_152658.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.319325.1, BC072416.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2156099 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000292894.2/ ENSP00000292894.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1348              AK093048.1         479-1826
            1349-1349           AC002116.1         36228-36228         c
FEATURES             Location/Qualifiers
     source          1..1349
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..1349
                     /gene="THAP8"
                     /note="THAP domain containing 8"
                     /db_xref="GeneID:199745"
                     /db_xref="HGNC:HGNC:23191"
                     /db_xref="MIM:612536"
     exon            1..151
                     /gene="THAP8"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..893
                     /gene="THAP8"
                     /note="isoform a is encoded by transcript variant 1; THAP
                     domain-containing protein 8"
                     /codon_start=1
                     /product="THAP domain-containing protein 8 isoform a"
                     /protein_id="NP_689871.1"
                     /db_xref="CCDS:CCDS33000.1"
                     /db_xref="GeneID:199745"
                     /db_xref="HGNC:HGNC:23191"
                     /db_xref="MIM:612536"
                     /translation="MPKYCRAPNCSNTAGRLGADNRPVSFYKFPLKDGPRLQAWLQHM
                     GCEHWVPSCHQHLCSEHFTPSCFQWRWGVRYLRPDAVPSIFSRGPPAKSQRRTRSTQK
                     PVSPPPPLQKNTPLPQSPAIPVSGPVRLVVLGPTSGSPKTVATMLLTPLAPAPTPERS
                     QPEVPAQQAQTGLGPVLGALQRRVRRLQRCQERHQAQLQALERLAQQLHGESLLARAR
                     RGLQRLTTAQTLGPEESQTFTIICGGPDIAMVLAQDPAPATVDAKPELLDTRIPSA"
     exon            152..344
                     /gene="THAP8"
                     /inference="alignment:Splign:2.1.0"
     exon            345..740
                     /gene="THAP8"
                     /inference="alignment:Splign:2.1.0"
     exon            741..1349
                     /gene="THAP8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1324..1329
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THAP8"
                     /note="hexamer: AATAAA"
     polyA_site      1349
                     /gene="THAP8"
                     /note="major polyA site"
ORIGIN      
        1 aggcggcgct ccgcgagaac caaagtgcag ccgctgaccc ggcaaaactc agcgggggct
       61 ggatagccat gcccaagtac tgcagggcgc cgaactgctc caacactgcg ggccgcctgg
      121 gtgcagacaa ccgccctgtg agcttctaca agttcccact gaaggatggt ccccggctgc
      181 aggcctggct gcagcacatg ggctgtgagc actgggtgcc cagctgccac cagcacttgt
      241 gcagcgagca cttcacaccc tcctgcttcc agtggcgctg gggtgtgcgc tacctgcggc
      301 ctgatgcagt gccctccatc ttctcccggg gaccacctgc caagagtcag cggaggaccc
      361 gaagcaccca gaagccagtc tcgccgccgc ctcccctaca gaagaataca cccctgcccc
      421 agagccctgc catcccagtc tctggcccag tgcgcctagt ggtgctgggc cccacatcgg
      481 ggagccccaa gactgtggcc accatgctcc tgacccccct ggcccctgcg ccaactcctg
      541 agcggtcaca acctgaagtc cctgcccaac aggcccagac cgggctgggc ccagtgctgg
      601 gagcactgca acgccgggtg cggaggctgc aacggtgcca ggagcggcac caggcgcagc
      661 tgcaggccct ggaacggctg gcacagcagc tacacgggga gagcctgctg gcacgggcac
      721 gccggggtct gcagcgcctg acaacagccc agacccttgg acctgaggaa tcccaaacct
      781 tcaccatcat ctgtggaggg cctgacatag ccatggtcct tgcccaggac cctgcacctg
      841 ccacagtgga tgccaagccg gagctcctgg acactcggat ccccagtgca taaggatcaa
      901 gacagacaat gtcgagggac aaaagataga agatggagga ggaaagacat tatacgtggg
      961 cttggcccag ccccaccgcc cacgcctggg tagtagcagt gcctccctca agggcctggg
     1021 ttctaccacc ccactcctag ggatctcttg aaccttaggg gtgacctggg cccaagtctc
     1081 tcatcagccc ccaatcccct gggtaccagg cttctgccac ccccggctca gatctttgca
     1141 aatcagtacg acagcctcag agcagagcaa gggttgtttg ggagaatcat acctggttct
     1201 aaggagtccc acgctttttg ccaagcctgg tactgagttc atgataccat ggtggacaca
     1261 gctgagaaaa tccctgccct catggtgctc attctacttg agtagacgat gaactagtaa
     1321 acaaataaac aagaacactg cagacatga
//
