LOCUS       NM_030573               1913 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens THAP domain containing 7 (THAP7), transcript variant
            1, mRNA.
ACCESSION   NM_030573
VERSION     NM_030573.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1913)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1913)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1913)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1913)
  AUTHORS   Michel,A.M., Choudhury,K.R., Firth,A.E., Ingolia,N.T., Atkins,J.F.
            and Baranov,P.V.
  TITLE     Observation of dually decoded regions of the human genome using
            ribosome profiling data
  JOURNAL   Genome Res 22 (11), 2219-2229 (2012)
   PUBMED   22593554
REFERENCE   5  (bases 1 to 1913)
  AUTHORS   Wang,J., Huo,K., Ma,L., Tang,L., Li,D., Huang,X., Yuan,Y., Li,C.,
            Wang,W., Guan,W., Chen,H., Jin,C., Wei,J., Zhang,W., Yang,Y.,
            Liu,Q., Zhou,Y., Zhang,C., Wu,Z., Xu,W., Zhang,Y., Liu,T., Yu,D.,
            Zhang,Y., Chen,L., Zhu,D., Zhong,X., Kang,L., Gan,X., Yu,X., Ma,Q.,
            Yan,J., Zhou,L., Liu,Z., Zhu,Y., Zhou,T., He,F. and Yang,X.
  TITLE     Toward an understanding of the protein interaction network of the
            human liver
  JOURNAL   Mol Syst Biol 7, 536 (2011)
   PUBMED   21988832
  REMARK    Erratum:[Mol Syst Biol. 2017 Dec 18;13(12):965. doi:
            10.15252/msb.20178107.. PMID: 29254952]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1913)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 1913)
  AUTHORS   Macfarlan,T., Parker,J.B., Nagata,K. and Chakravarti,D.
  TITLE     Thanatos-associated protein 7 associates with template activating
            factor-Ibeta and inhibits histone acetylation to repress
            transcription
  JOURNAL   Mol Endocrinol 20 (2), 335-347 (2006)
   PUBMED   16195249
  REMARK    GeneRIF: THAP7 may represent a novel class of transcription factor
            that uses TAF-Ibeta as a corepressor to maintain histones in a
            hypoacetylated, repressed state.
REFERENCE   8  (bases 1 to 1913)
  AUTHORS   Macfarlan,T., Kutney,S., Altman,B., Montross,R., Yu,J. and
            Chakravarti,D.
  TITLE     Human THAP7 is a chromatin-associated, histone tail-binding protein
            that represses transcription via recruitment of HDAC3 and nuclear
            hormone receptor corepressor
  JOURNAL   J Biol Chem 280 (8), 7346-7358 (2005)
   PUBMED   15561719
  REMARK    GeneRIF: demonstration of the transcriptional regulatory properties
            of a human THAP domain protein, and a critical identification of a
            potential transducer of the repressive signal of hypoacetylated
            histone H4 in higher eukaryotes
REFERENCE   9  (bases 1 to 1913)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   10 (bases 1 to 1913)
  AUTHORS   Roussigne,M., Kossida,S., Lavigne,A.C., Clouaire,T., Ecochard,V.,
            Glories,A., Amalric,F. and Girard,J.P.
  TITLE     The THAP domain: a novel protein motif with similarity to the
            DNA-binding domain of P element transposase
  JOURNAL   Trends Biochem Sci 28 (2), 66-69 (2003)
   PUBMED   12575992
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC002472.8, BM790105.1, BC004346.1, BE264280.1 and AC002470.17.
            
            On May 17, 2019 this sequence version replaced NM_030573.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 2
            both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.975897.1, BC004346.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2161674 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000215742.9/ ENSP00000215742.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC002472.8         46265-46267         c
            4-32                BM790105.1         1-29
            33-549              BC004346.1         1-517
            550-674             BE264280.1         446-570
            675-1245            BC004346.1         643-1213
            1246-1299           AC002472.8         43867-43920         c
            1300-1913           AC002470.17        234782-235395       c
FEATURES             Location/Qualifiers
     source          1..1913
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.21"
     gene            1..1913
                     /gene="THAP7"
                     /note="THAP domain containing 7"
                     /db_xref="GeneID:80764"
                     /db_xref="HGNC:HGNC:23190"
                     /db_xref="MIM:609518"
     exon            1..287
                     /gene="THAP7"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..1137
                     /gene="THAP7"
                     /codon_start=1
                     /product="THAP domain-containing protein 7"
                     /protein_id="NP_085050.2"
                     /db_xref="CCDS:CCDS13787.1"
                     /db_xref="GeneID:80764"
                     /db_xref="HGNC:HGNC:23190"
                     /db_xref="MIM:609518"
                     /translation="MPRHCSAAGCCTRDTRETRNRGISFHRLPKKDNPRRGLWLANCQ
                     RLDPSGQGLWDPASEYIYFCSKHFEEDCFELVGISGYHRLKEGAVPTIFESFSKLRRT
                     TKTKGHSYPPGPAEVSRLRRCRKRCSEGRGPTTPFSPPPPADVTCFPVEEASAPATLP
                     ASPAGRLEPGLSSPFSDLLGPLGAQADEAGCSAQPSPERQPSPLEPRPVSPSAYMLRL
                     PPPAGAYIQNEHSYQVGSALLWKRRAEAALDALDKAQRQLQACKRREQRLRLRLTKLQ
                     QERAREKRAQADARQTLKEHVQDFAMQLSSSMA"
     exon            288..443
                     /gene="THAP7"
                     /inference="alignment:Splign:2.1.0"
     exon            444..584
                     /gene="THAP7"
                     /inference="alignment:Splign:2.1.0"
     exon            585..1913
                     /gene="THAP7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1223..1228
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THAP7"
                     /note="hexamer: AATAAA"
     polyA_site      1244
                     /gene="THAP7"
                     /note="major polyA site"
ORIGIN      
        1 gcgagacttc ggcggcgcag caatggccag agcgtgagtg ccgctgacag aagtcaagag
       61 aatcggctgg gacggggttg gggcgacaac gggccggggg ggacccgaca ggccagagcc
      121 ccttggggag gagcggcggc tggaggcgcg aggctcctcc ggatgcccgg agagccgctt
      181 gcgacttaac tcccgcctct ttcccagatg ccgcgtcact gctccgccgc cggctgctgc
      241 acacgggaca cgcgcgagac gcgcaaccgc ggcatctcct tccacagact tcccaagaag
      301 gacaacccga ggcgaggctt gtggctggcc aactgccagc ggctggaccc cagcggccag
      361 ggcctgtggg acccggcatc cgagtacatc tacttctgct ccaaacactt tgaggaggac
      421 tgctttgagc tggtgggaat cagtggatat cacaggctaa aggagggggc agtccccacc
      481 atatttgagt ctttctccaa gttgcgccgg acaaccaaga ccaaaggaca cagttaccca
      541 cctggccccg ctgaagtcag ccggctcaga cgatgcagga agcgctgctc cgagggccga
      601 gggcccacaa ctccattttc tccacctcca cctgctgatg tcacctgctt tcctgtggaa
      661 gaggcctcag cacctgccac tttgccggcc tccccagctg ggaggctgga gcctggcctt
      721 agcagcccct tttcagacct actgggcccc ttgggtgccc aggcagatga agcaggctgc
      781 agcgcccagc cttcaccaga gcggcagccc tcccctctcg aaccacggcc agtctccccc
      841 tcagcgtata tgctgcgcct gcccccaccc gccggagcct acatccagaa tgaacacagc
      901 taccaggtgg gcagcgcctt actctggaag cggcgagccg aggcagccct tgatgccctt
      961 gacaaggccc agcgccagct gcaggcctgc aagcggcggg agcagcggct gcggttgaga
     1021 ctgaccaagc tgcagcagga gcgggcacgg gagaagcggg cacaggcaga tgcccgccag
     1081 actctgaagg agcatgtgca ggactttgcc atgcagctga gcagcagcat ggcctgaggg
     1141 gctgctggac tgaccgaggg gctgcccagc aagactgcag cctcttcctc cctcagatcc
     1201 caccagaccc accaggtgcc ataataaagc ggattctaga cggagggcct gctgtctggc
     1261 tcagctgggg gctggagccc ctctgagtac taagcttgct gccccagaca gtggctgcag
     1321 ctcctagagg gctcagtcca agctctttgc caaggagaac agggagcctg gctctcaccc
     1381 ctcagagcta ctggtagaca ggtggcagtc agccctgcta gcgcagctcc gtgccccaca
     1441 gggttctctg aaggggcagg atggtgtgag taggggccag gaagacagct ccaggcgccc
     1501 tttccatagg atctgaaaca gccctgactt aaaccagcca gcccctttga gaacacttct
     1561 aaaacccagt ctagatccgg ttctcaagca ggagcatgac aggcttctgt ccacaggccc
     1621 catcagcctg gtgggtaagc tggacaaccc tctccccgcc cccttcacta ccatctctat
     1681 ttgaaaaacg gggatgatga tgacaatcat caacctcctg ggtcatgtca gcaggtagta
     1741 aagccccaac aagctagtcc ctggaaatct aggaagaggt ggccagaaca tggagacaag
     1801 cactcaggtc ctggcctcag catccttttc cttcaactcc caggaacctg gaaggccttg
     1861 ctgcagctgc agttctcaaa cagctccgtc ttggggtgac tcactgcaag tat
//
