LOCUS       NM_144721               3549 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens THAP domain containing 6 (THAP6), transcript variant
            1, mRNA.
ACCESSION   NM_144721
VERSION     NM_144721.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3549)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 3549)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3549)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   4  (bases 1 to 3549)
  AUTHORS   Roussigne,M., Kossida,S., Lavigne,A.C., Clouaire,T., Ecochard,V.,
            Glories,A., Amalric,F. and Girard,J.P.
  TITLE     The THAP domain: a novel protein motif with similarity to the
            DNA-binding domain of P element transposase
  JOURNAL   Trends Biochem Sci 28 (2), 66-69 (2003)
   PUBMED   12575992
REFERENCE   5  (bases 1 to 3549)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC308535.1, AL833350.1, AC096759.3 and AI743405.1.
            
            On Nov 23, 2018 this sequence version replaced NM_144721.5.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL833350.1, SRR1803613.90867.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311638.7/ ENSP00000309007.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               DC308535.1         41-140
            101-758             AL833350.1         101-758
            759-3035            AC096759.3         134729-137005
            3036-3549           AI743405.1         8-521               c
FEATURES             Location/Qualifiers
     source          1..3549
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.1"
     gene            1..3549
                     /gene="THAP6"
                     /note="THAP domain containing 6"
                     /db_xref="GeneID:152815"
                     /db_xref="HGNC:HGNC:23189"
                     /db_xref="MIM:612535"
     exon            1..48
                     /gene="THAP6"
                     /inference="alignment:Splign:2.1.0"
     exon            49..148
                     /gene="THAP6"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..737
                     /gene="THAP6"
                     /note="isoform 1 is encoded by transcript variant 1; THAP
                     domain-containing protein 6"
                     /codon_start=1
                     /product="THAP domain-containing protein 6 isoform 1"
                     /protein_id="NP_653322.1"
                     /db_xref="CCDS:CCDS3568.1"
                     /db_xref="GeneID:152815"
                     /db_xref="HGNC:HGNC:23189"
                     /db_xref="MIM:612535"
                     /translation="MVKCCSAIGCASRCLPNSKLKGLTFHVFPTDENIKRKWVLAMKR
                     LDVNAAGIWEPKKGDVLCSRHFKKTDFDRSAPNIKLKPGVIPSIFDSPYHLQGKREKL
                     HCRKNFTLKTVPATNYNHHLVGASSCIEEFQSQFIFEHSYSVMDSPKKLKHKLDHVIG
                     ELEDTKESLRNVLDREKRFQKSLRKTIRELKDECLISQETANRLDTFCWDCCQESIEQ
                     DYIS"
     exon            149..356
                     /gene="THAP6"
                     /inference="alignment:Splign:2.1.0"
     exon            357..482
                     /gene="THAP6"
                     /inference="alignment:Splign:2.1.0"
     exon            483..3549
                     /gene="THAP6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3470..3475
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THAP6"
                     /note="hexamer: GATAAA"
     polyA_site      3488
                     /gene="THAP6"
     regulatory      3528..3533
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THAP6"
                     /note="hexamer: AATAAA"
     polyA_site      3549
                     /gene="THAP6"
                     /note="major polyA site"
ORIGIN      
        1 agacgcagtc tccgtcgttg acgttagtcg cagtcttcgc tgctaacgtt ttgttatgag
       61 ttgctaaaat ggtgaaatgc tgctccgcca ttggatgtgc ttctcgctgc ttgccaaatt
      121 cgaagttaaa aggactgaca tttcacgtat tccccacaga tgaaaacatc aaaaggaaat
      181 gggtattagc aatgaaaaga cttgatgtga atgcagccgg catttgggag cctaaaaaag
      241 gagatgtgtt gtgttcgagg cactttaaga agacagattt tgacagaagt gctccaaata
      301 ttaaactgaa acctggagtc ataccttcta tctttgattc tccatatcac ctacagggga
      361 aaagagaaaa acttcattgt agaaaaaact tcaccctcaa aaccgttcca gccactaact
      421 acaatcacca tcttgttggt gcttcctcat gtattgaaga attccaatcc cagttcattt
      481 ttgaacatag ctacagtgta atggacagtc caaagaaact taagcataaa ttagatcatg
      541 tgatcggcga gctagaggat acaaaggaaa gtctacggaa tgttttagac cgagaaaaac
      601 gttttcagaa atcattgagg aagacaatca gggaattaaa ggatgaatgt ctgatcagcc
      661 aagaaacagc aaatagactg gacactttct gttgggactg ttgtcaggag agcatagaac
      721 aggactatat ttcatgaaat aatttcatgt tacgttccac ctaaaattgt cattggtaca
      781 aatttttata aaatctcatt taccatcact aaataatatc catcatttaa agtgctgctt
      841 tggattctct ggagcattat gcattatagt tgttatccaa agactttttt gaaaatatgc
      901 agaaatttgt ggtaattatg tatttgtgtc ttgtgacaat tatgttttat agacctacac
      961 tagtgccagg tcactattgt aagatgttaa aatctcaaga aaatttcaca gagctaaaga
     1021 aatgatgtca aattagtcac attaagctat agtagaagga attggacact tctccagata
     1081 tttggcttca aaggagtacc tttacttaca tgtgctttat ggtaagtaca ttgaatttta
     1141 ctttaaatgc attttactac aaagcacaat tcatttgtaa tgcatatcca tcttggattc
     1201 aatccaaggt gctttagcta tcagtagtac caaaggatct ttttacaagg cttcctgtgg
     1261 tattgactct gagaataaca catagtgaag atctgtgggc ttttaaaatt gttcacagcc
     1321 aatttaagaa gacccctcat gaagtctcag ttttcagtac agtacatcat tcctcctcac
     1381 taggagcact ttgatgtaaa ccagaatagc tttaaaaaga caaaaaggat cgtagatctg
     1441 atttttaaat ggttggttgc tctgacagat ctgaacactt tgcttcatga ctatttcgtc
     1501 ataaaggtat atgtttaaaa tctgaatggc agtactagct ctatactttt aatactgctt
     1561 tgtattttat atgtaaagta gtattgctga cattttaaaa aaatacaaaa tacaaaagaa
     1621 accattagaa attaataact gtggctcttc cagttgaaat aggaattgga gagaaaggat
     1681 tagaatattt taattagggg agtagattat tgtccaaagg cttttattta gagaaacggg
     1741 taattaaaac agcagcttta gaatagcttc ttactgaata tgcaaaagaa taattccttg
     1801 ttatttccta attgatccaa gtctcataaa tttagctttt gtcataattc cttaccgaaa
     1861 acaactgaaa ttgagagtca taaatactgt gggttagaat aaaaaccatt tgccaaagca
     1921 acactctact tagaagcaca tgtacataca tggacctcat tcagaagtcc atgttgtagc
     1981 agttagaatt tgagtatcag ccatttcatt gtagtaacaa aaattgaatt gcattttgtg
     2041 ctcagttgtt tattgtaatt ttatttttgt tacattaata ttagttaaga tatggtcact
     2101 tgaatttttt gtatttaaga attttctgtt ttaatgcatg ttatactttt atgtaggatt
     2161 ccaaaccttc cctctaaatg ggatttaacc cacatctgcg agatcagcgt tatgctaaga
     2221 ggaaatcact gaggccatat ctttttacaa tctgaaaaaa aagtagtaaa aaggtagtta
     2281 aaaaaaaaaa aggccgggtg gtggctcata cctgtaatcc tagcactttg ggaggccaag
     2341 gcaggcagat cacttgaggt caggggttca aaaccagcct ggccaagatg gtgaaacccc
     2401 atctctgcta aaaatacaaa aaaaaattag ccgggcatgg tggcacgtgc ctgtaatccc
     2461 agctacttgg gagactgagg caggagaatt gcttgaaccc gggaggcgga gattgcagtg
     2521 agccaagatc acgccgttgc actccagcct gagcaacaga gcaagactcc atctcaaaaa
     2581 aacaaaacta ctttcattaa ttacccatta tttattttag ttacttaatt ttgagttcat
     2641 aaatggccac cctaatggaa agtttgggta tgatcttagg ttttatggag atgttttcaa
     2701 tagagattat ttttccctca ccctatttgt gaatatataa attaaagtaa gacaatggag
     2761 taagtaagag ggtagatcca aacacagtat gtctaaattc tagcactcta ctggctgctt
     2821 agaatacacc aaacctggaa gacctttcca agagtaaaat cccagtctgc cactatcaaa
     2881 attgccacag tcacttttac tacttgtgtt catagtagac tcagcacttc tttttcactg
     2941 gacctagtat aactgagaaa taaataactg tgtgcaaaat attggtatca ttaaggaccc
     3001 agagctgccc attttctctt tgttctaata gggaagcaat tactgataga aatgtgagat
     3061 taaaaatagg gtcctccctg ctgctccaaa caaatgccta aacacagtat gtatctcagt
     3121 cctctgttcc cagagattcc accctagccc aggaaagaac tggcctgtgt aaagcaaaac
     3181 ccaagtcatc cccctccaga aatttctctg gcagccaagc ctgaccctaa gggttccact
     3241 ttgctttaaa agctaggagt ggcctctaga gccaggaaca cattaataca acagttcaac
     3301 ctcagcacca agtcaggtac gaagcgcttg atacgtggaa tttttctcta tatcaagttt
     3361 aaatttctgg aaatagactt tggttgctaa tgacaattac agttatacca tagtctgtaa
     3421 tttgagaaaa ggtgaaatgt atttaatata tatttagttt taataaaaag ataaaattat
     3481 tacagaaata attgagagag agaaaatcta ttataattta tttgaaaaat aaaacatttt
     3541 atccagtaa
//
