LOCUS       NM_001130475            3384 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens THAP domain containing 5 (THAP5), transcript variant
            1, mRNA.
ACCESSION   NM_001130475
VERSION     NM_001130475.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3384)
  AUTHORS   Yoon,D., Kim,Y.J., Cui,W.Y., Van der Vaart,A., Cho,Y.S., Lee,J.Y.,
            Ma,J.Z., Payne,T.J., Li,M.D. and Park,T.
  TITLE     Large-scale genome-wide association study of Asian population
            reveals genetic factors in FRMD4A and other loci influencing
            smoking initiation and nicotine dependence
  JOURNAL   Hum Genet 131 (6), 1009-1021 (2012)
   PUBMED   22006218
REFERENCE   2  (bases 1 to 3384)
  AUTHORS   Cilenti,L., Balakrishnan,M.P., Wang,X.L., Ambivero,C.,
            Sterlicchi,M., del Monte,F., Ma,X.L. and Zervos,A.S.
  TITLE     Regulation of Abro1/KIAA0157 during myocardial infarction and cell
            death reveals a novel cardioprotective mechanism for Lys63-specific
            deubiquitination
  JOURNAL   J Mol Cell Cardiol 50 (4), 652-661 (2011)
   PUBMED   21195082
  REMARK    GeneRIF: Study identified Abro1 as a specific interactor of THAP5,
            a zinc finger transcription factor that is involved in G2/M control
            and apoptosis.
REFERENCE   3  (bases 1 to 3384)
  AUTHORS   Balakrishnan,M.P., Cilenti,L., Ambivero,C., Goto,Y., Takata,M.,
            Turkson,J., Li,X.S. and Zervos,A.S.
  TITLE     THAP5 is a DNA-binding transcriptional repressor that is regulated
            in melanoma cells during DNA damage-induced cell death
  JOURNAL   Biochem Biophys Res Commun 404 (1), 195-200 (2011)
   PUBMED   21110952
  REMARK    GeneRIF: this work suggests that THAP5 is a DNA-binding protein and
            a transcriptional repressor. THAP5 has a pro-apoptotic function and
            it was induced in melanoma cells under conditions that promoted
            cell death.
REFERENCE   4  (bases 1 to 3384)
  AUTHORS   Docherty,S.J., Kovas,Y., Petrill,S.A. and Plomin,R.
  TITLE     Generalist genes analysis of DNA markers associated with
            mathematical ability and disability reveals shared influence across
            ages and abilities
  JOURNAL   BMC Genet 11, 61 (2010)
   PUBMED   20602751
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3384)
  AUTHORS   Balakrishnan,M.P., Cilenti,L., Mashak,Z., Popat,P., Alnemri,E.S.
            and Zervos,A.S.
  TITLE     THAP5 is a human cardiac-specific inhibitor of cell cycle that is
            cleaved by the proapoptotic Omi/HtrA2 protease during cell death
  JOURNAL   Am J Physiol Heart Circ Physiol 297 (2), H643-H653 (2009)
   PUBMED   19502560
  REMARK    GeneRIF: THAP5 and its regulation by Omi/HtrA2 provide a new link
            between cell cycle control and apoptosis in cardiomyocytes
REFERENCE   6  (bases 1 to 3384)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 3384)
  AUTHORS   Roussigne,M., Kossida,S., Lavigne,A.C., Clouaire,T., Ecochard,V.,
            Glories,A., Amalric,F. and Girard,J.P.
  TITLE     The THAP domain: a novel protein motif with similarity to the
            DNA-binding domain of P element transposase
  JOURNAL   Trends Biochem Sci 28 (2), 66-69 (2003)
   PUBMED   12575992
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL833137.1 and AC005058.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001130475.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.171430.1,
                                           SRR1803616.65885.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2147920, SAMEA2155371
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000415914.4/ ENSP00000400500.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1272              AL833137.1         18-1289
            1273-3384           AC005058.1         169402-171513       c
FEATURES             Location/Qualifiers
     source          1..3384
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.1"
     gene            1..3384
                     /gene="THAP5"
                     /note="THAP domain containing 5"
                     /db_xref="GeneID:168451"
                     /db_xref="HGNC:HGNC:23188"
                     /db_xref="MIM:612534"
     exon            1..217
                     /gene="THAP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1325
                     /gene="THAP5"
                     /note="isoform 1 is encoded by transcript variant 1; THAP
                     domain-containing protein 5"
                     /codon_start=1
                     /product="THAP domain-containing protein 5 isoform 1"
                     /protein_id="NP_001123947.1"
                     /db_xref="CCDS:CCDS47687.1"
                     /db_xref="GeneID:168451"
                     /db_xref="HGNC:HGNC:23188"
                     /db_xref="MIM:612534"
                     /translation="MPRYCAAICCKNRRGRNNKDRKLSFYPFPLHDKERLEKWLKNMK
                     RDSWVPSKYQFLCSDHFTPDSLDIRWGIRYLKQTAVPTIFSLPEDNQGKDPSKKKSQK
                     KNLEDEKEVCPKAKSEESFVLNETKKNIVNTDVPHQHPELLHSSSLVKPPAPKTGSIQ
                     NNMLTLNLVKQHTGKPESTLETSVNQDTGRGGFHTCFENLNSTTITLTTSNSESIHQS
                     LETQEVLEVTTSHLANPNFTSNSMEIKSAQENPFLFSTINQTVEELNTNKESVIAIFV
                     PAENSKPSVNSFISAQKETTEMEDTDIEDSLYKDVDYGTEVLQIEHSYCRQDINKEHL
                     WQKVSKLHSKITLLELKEQQTLGRLKSLEALIRQLKQENWLSEENVKIIENHFTTYEV
                     TMI"
     exon            218..410
                     /gene="THAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            411..3384
                     /gene="THAP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2973..2978
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THAP5"
                     /note="hexamer: AATAAA"
     polyA_site      3001
                     /gene="THAP5"
                     /note="major polyA site"
     regulatory      3262..3267
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THAP5"
                     /note="hexamer: AATAAA"
     polyA_site      3289
                     /gene="THAP5"
                     /note="major polyA site"
     regulatory      3362..3367
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THAP5"
                     /note="hexamer: AATAAA"
     polyA_site      3384
                     /gene="THAP5"
ORIGIN      
        1 agacgaggcg gctttcccgg cagaatgcta gcgcaggcgc aggggctcga gaggcctgga
       61 cctgtggcgc atcctcagtg aggagggccg ccctgcatcc gtcgccggcc ccggtctcca
      121 ggggcctcac ccgagtcatg ccccgctatt gcgcagcgat ttgttgtaag aaccgccggg
      181 gacgaaacaa taaagaccgg aagctgagtt tttatccatt tcctctacat gacaaagaaa
      241 gactggaaaa gtggttaaag aatatgaagc gagattcatg ggttcccagt aaataccagt
      301 ttctatgtag tgaccatttt actcctgact ctcttgacat cagatggggt attcgatatt
      361 taaaacaaac tgcagttcca acaatatttt ctttgcctga agacaatcag ggaaaagacc
      421 cttctaaaaa aaaatcccag aagaaaaact tggaagatga gaaagaagta tgcccaaaag
      481 ccaagtcaga agaatcattt gtattaaatg agacaaagaa aaatatagtt aacacagatg
      541 tgccccatca acatccagaa ttacttcatt catcttcctt ggtaaagcca ccagctccca
      601 aaacaggaag tatacaaaat aacatgttaa ctcttaatct agttaaacaa catactggga
      661 aaccagaatc taccttggaa acatcagtta accaagatac aggtagaggt ggttttcaca
      721 catgttttga gaatctaaat tctacaacta ttactttgac aacttcaaat tcagaaagta
      781 ttcatcaatc tttggaaact caagaagttc ttgaagtaac taccagtcat cttgctaatc
      841 caaactttac aagtaattcc atggaaataa agtcagcaca ggaaaatcca ttcttattca
      901 gcacaattaa tcaaacagtt gaagaattaa acacaaataa agaatctgtt attgccattt
      961 ttgtacctgc tgaaaattct aaaccctcag ttaattcttt tatatctgca caaaaagaaa
     1021 ccacggaaat ggaagacaca gacattgaag actccttgta taaggatgta gactatggga
     1081 cagaagtttt acaaatcgaa cattcttact gcagacaaga tataaataag gaacatcttt
     1141 ggcagaaagt ctctaagcta cattcaaaga taactcttct agagttaaaa gagcaacaaa
     1201 ctctaggtag attgaagtct ttggaagctc ttataaggca gctaaagcag gaaaactggc
     1261 tatctgaaga aaacgtcaag attatagaaa accattttac aacatatgaa gtcactatga
     1321 tatagaataa ctaggtttta aaactatggc tgttaaataa gctttttcca gccaaaccaa
     1381 actacatgta aagtgaactg tttcctgtat aaagttctca tcttaatgaa cctatgagag
     1441 tgttgtaaag ttatgaactg tatcctattc ttgtaatact tatttaagaa aaaccagaga
     1501 gttgggctgg agagaaaagc agttttatta cttgataatt ttccaaatta aaatttagca
     1561 catagaagga ttcagttata acatgagaaa acaaagaagt gttcaaagag cacagactag
     1621 aagtcaggtt caggaatcag tcctggttct accactggca tatgacttgg gcaagttact
     1681 tatgattgtg cctcagtccc taatttgtaa aataagcact tactggattt gtaattggtt
     1741 atttatagtc ccttcccttt ttattaagat aattctatta gaacacattt tctgtaagat
     1801 aatatatacg taatactaga agttggctag aatttgatga tattaaccat gtattatttt
     1861 cagtatttat tgaattctgt ggtctttgac cttttggcta tagttacata ttacagttat
     1921 attatctgta atagaaagga agataaactt tttttttttt tttttttttt ttttttttga
     1981 gatggagtct cactctgtaa cccaggctgg agtgcagtgg cctgatcttg gctcactgca
     2041 gcctctgcct cccgggttca agtgattctt ctgcctcagc ttcccgagta gctgggatta
     2101 taggcacaca ccaccacatc cagcttattt ttgtattttt agtagaaacg gggtttcacc
     2161 atgttggccg ggctggcctc gaactcctga ccccaggtga tccacctacc ttggcctccc
     2221 aaagtgctgg gattacaggc gtgagccacc gcgcctggcc aagatagaac ttttataatt
     2281 ttattccagt tgaactaaac taaggaacca cccattagcc cagttcttag gagaggtact
     2341 tcaaacttga aagaatatgt atttcggtaa cttatatgtg gctaaccatc aaatacatag
     2401 tcatctaagc taaactttct gtatttatac agttaaactt ataaaccaaa aattttaatg
     2461 aggttaattt taaatatatt ttagaaatta cagtttgtat ctgtttctta gtaggtgtgg
     2521 cctttaaaat atgtgcttat tcattgttaa attccagaat aatagagtaa tacttaatac
     2581 tgtacattcc cacttacgta tattttatta aaatttataa gcaagaaatt atacataagt
     2641 ggtcatgatc ttagggagac aaagaatttc tcttagaaaa gagaagtaat ggtaatgtaa
     2701 ataaaaatac tgtttatatt cacatgattt taagaaaact gtaaaagcaa agattttgta
     2761 gtaatgacac aaatgtaaca aatagatgtt ttcttaaaat tggcagtcag tataattatg
     2821 tttctgccta tgatgttgag gaagttgtat cagtctgatt cttagttttt tcatctgtta
     2881 agtagaacgt actattactt accttaaaga gtggctttga gaattttgta aggaacaaac
     2941 atgtttttgg ttctggaata taggaggtgc tcaataaaag ttgactctga ctggcaaata
     3001 atattgtttt gtaaatgcat gatgattatt tttggccata tttgacttag tttcattagg
     3061 ctaatattaa ttggtactat atgaaagtga gtcaactaat tataaaagat tagaaatgtc
     3121 ttaggtgacg atgggggaaa aacttaaaat ttttgcataa attatgggga gatgatagag
     3181 ttattacagt gttattaagt attcctatgt tgcattttgc aaatacttaa tttaatacag
     3241 atgaaaataa tcttgagtca caataaagta atgatatgtt aagtttcaac agtgtacatt
     3301 gtagtaattt tctgaaagtt acaggttcct cagaaaaaat ttaaactagc tttatttctt
     3361 taataaatta taagtaaaag ttga
//
