LOCUS       NM_015963               2076 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens THAP domain containing 4 (THAP4), transcript variant
            1, mRNA.
ACCESSION   NM_015963
VERSION     NM_015963.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2076)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2076)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2076)
  AUTHORS   De Simone,G., di Masi,A., Polticelli,F. and Ascenzi,P.
  TITLE     Human nitrobindin: the first example of an all-beta-barrel ferric
            heme-protein that catalyzes peroxynitrite detoxification
  JOURNAL   FEBS Open Bio 8 (12), 2002-2010 (2018)
   PUBMED   30524950
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2076)
  AUTHORS   Eeles,R.A., Olama,A.A., Benlloch,S., Saunders,E.J.,
            Leongamornlert,D.A., Tymrakiewicz,M., Ghoussaini,M., Luccarini,C.,
            Dennis,J., Jugurnauth-Little,S., Dadaev,T., Neal,D.E., Hamdy,F.C.,
            Donovan,J.L., Muir,K., Giles,G.G., Severi,G., Wiklund,F.,
            Gronberg,H., Haiman,C.A., Schumacher,F., Henderson,B.E., Le
            Marchand,L., Lindstrom,S., Kraft,P., Hunter,D.J., Gapstur,S.,
            Chanock,S.J., Berndt,S.I., Albanes,D., Andriole,G., Schleutker,J.,
            Weischer,M., Canzian,F., Riboli,E., Key,T.J., Travis,R.C.,
            Campa,D., Ingles,S.A., John,E.M., Hayes,R.B., Pharoah,P.D.,
            Pashayan,N., Khaw,K.T., Stanford,J.L., Ostrander,E.A.,
            Signorello,L.B., Thibodeau,S.N., Schaid,D., Maier,C., Vogel,W.,
            Kibel,A.S., Cybulski,C., Lubinski,J., Cannon-Albright,L.,
            Brenner,H., Park,J.Y., Kaneva,R., Batra,J., Spurdle,A.B.,
            Clements,J.A., Teixeira,M.R., Dicks,E., Lee,A., Dunning,A.M.,
            Baynes,C., Conroy,D., Maranian,M.J., Ahmed,S., Govindasami,K.,
            Guy,M., Wilkinson,R.A., Sawyer,E.J., Morgan,A., Dearnaley,D.P.,
            Horwich,A., Huddart,R.A., Khoo,V.S., Parker,C.C., Van As,N.J.,
            Woodhouse,C.J., Thompson,A., Dudderidge,T., Ogden,C., Cooper,C.S.,
            Lophatananon,A., Cox,A., Southey,M.C., Hopper,J.L., English,D.R.,
            Aly,M., Adolfsson,J., Xu,J., Zheng,S.L., Yeager,M., Kaaks,R.,
            Diver,W.R., Gaudet,M.M., Stern,M.C., Corral,R., Joshi,A.D.,
            Shahabi,A., Wahlfors,T., Tammela,T.L., Auvinen,A., Virtamo,J.,
            Klarskov,P., Nordestgaard,B.G., Roder,M.A., Nielsen,S.F.,
            Bojesen,S.E., Siddiq,A., Fitzgerald,L.M., Kolb,S., Kwon,E.M.,
            Karyadi,D.M., Blot,W.J., Zheng,W., Cai,Q., McDonnell,S.K.,
            Rinckleb,A.E., Drake,B., Colditz,G., Wokolorczyk,D.,
            Stephenson,R.A., Teerlink,C., Muller,H., Rothenbacher,D.,
            Sellers,T.A., Lin,H.Y., Slavov,C., Mitev,V., Lose,F.,
            Srinivasan,S., Maia,S., Paulo,P., Lange,E., Cooney,K.A.,
            Antoniou,A.C., Vincent,D., Bacot,F., Tessier,D.C., Kote-Jarai,Z.
            and Easton,D.F.
  CONSRTM   COGS-Cancer Research UK GWAS-ELLIPSE (part of GAME-ON) Initiative;
            Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer
            Study Collaborators/British Association of Urological Surgeons'
            Section of Oncology; UK ProtecT (Prostate testing for cancer and
            Treatment) Study Collaborators; PRACTICAL (Prostate Cancer
            Association Group to Investigate Cancer-Associated Alterations in
            the Genome) Consortium
  TITLE     Identification of 23 new prostate cancer susceptibility loci using
            the iCOGS custom genotyping array
  JOURNAL   Nat Genet 45 (4), 385-391 (2013)
   PUBMED   23535732
REFERENCE   5  (bases 1 to 2076)
  AUTHORS   Bianchetti,C.M., Bingman,C.A. and Phillips,G.N. Jr.
  TITLE     Structure of the C-terminal heme-binding domain of THAP domain
            containing protein 4 from Homo sapiens
  JOURNAL   Proteins 79 (4), 1337-1341 (2011)
   PUBMED   21387410
REFERENCE   6  (bases 1 to 2076)
  AUTHORS   Stein,J.L., Hua,X., Lee,S., Ho,A.J., Leow,A.D., Toga,A.W.,
            Saykin,A.J., Shen,L., Foroud,T., Pankratz,N., Huentelman,M.J.,
            Craig,D.W., Gerber,J.D., Allen,A.N., Corneveaux,J.J.,
            Dechairo,B.M., Potkin,S.G., Weiner,M.W. and Thompson,P.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative
  TITLE     Voxelwise genome-wide association study (vGWAS)
  JOURNAL   Neuroimage 53 (3), 1160-1174 (2010)
   PUBMED   20171287
REFERENCE   7  (bases 1 to 2076)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   8  (bases 1 to 2076)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE   9  (bases 1 to 2076)
  AUTHORS   Roussigne,M., Kossida,S., Lavigne,A.C., Clouaire,T., Ecochard,V.,
            Glories,A., Amalric,F. and Girard,J.P.
  TITLE     The THAP domain: a novel protein motif with similarity to the
            DNA-binding domain of P element transposase
  JOURNAL   Trends Biochem Sci 28 (2), 66-69 (2003)
   PUBMED   12575992
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC069235.1 and BC009439.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015963.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069235.1, SRR1163658.263702.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155550 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000407315.6/ ENSP00000385006.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-501               BC069235.1         83-583
            502-866             BC009439.1         192-556
            867-2076            BC069235.1         949-2158
FEATURES             Location/Qualifiers
     source          1..2076
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..2076
                     /gene="THAP4"
                     /gene_synonym="CGI-36; Nb(III); PP238"
                     /note="THAP domain containing 4"
                     /db_xref="GeneID:51078"
                     /db_xref="HGNC:HGNC:23187"
                     /db_xref="MIM:612533"
     exon            1..218
                     /gene="THAP4"
                     /gene_synonym="CGI-36; Nb(III); PP238"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..1875
                     /gene="THAP4"
                     /gene_synonym="CGI-36; Nb(III); PP238"
                     /note="isoform 1 is encoded by transcript variant 1; THAP
                     domain-containing protein 4; epididymis secretory sperm
                     binding protein; nitrobindin; peroxynitrite isomerase
                     THAP4; hs-Nb(III); ferric Homo sapiens nitrobindin"
                     /codon_start=1
                     /product="peroxynitrite isomerase THAP4 isoform 1"
                     /protein_id="NP_057047.4"
                     /db_xref="CCDS:CCDS2551.1"
                     /db_xref="GeneID:51078"
                     /db_xref="HGNC:HGNC:23187"
                     /db_xref="MIM:612533"
                     /translation="MVICCAAVNCSNRQGKGEKRAVSFHRFPLKDSKRLIQWLKAVQR
                     DNWTPTKYSFLCSEHFTKDSFSKRLEDQHRLLKPTAVPSIFHLTEKKRGAGGHGRTRR
                     KDASKATGGVRGHSSAATSRGAAGWSPSSSGNPMAKPESRRLKQAALQGEATPRAAQE
                     AASQEQAQQALERTPGDGLATMVAGSQGKAEASATDAGDESATSSIEGGVTDKSGISM
                     DDFTPPGSGACKFIGSLHSYSFSSKHTRERPSVPREPIDRKRLKKDVEPSCSGSSLGP
                     DKGLAQSPPSSSLTATPQKPSQSPSAPPADVTPKPATEAVQSEHSDASPMSINEVILS
                     ASGACKLIDSLHSYCFSSRQNKSQVCCLREQVEKKNGELKSLRQRVSRSDSQVRKLQE
                     KLDELRRVSVPYPSSLLSPSREPPKMNPVVEPLSWMLGTWLSDPPGAGTYPTLQPFQY
                     LEEVHISHVGQPMLNFSFNSFHPDTRKPMHRECGFIRLKPDTNKVAFVSAQNTGVVEV
                     EEGEVNGQELCIASHSIARISFAKEPHVEQITRKFRLNSEGKLEQTVSMATTTQPMTQ
                     HLHVTYKKVTP"
     exon            219..1381
                     /gene="THAP4"
                     /gene_synonym="CGI-36; Nb(III); PP238"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1541
                     /gene="THAP4"
                     /gene_synonym="CGI-36; Nb(III); PP238"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1651
                     /gene="THAP4"
                     /gene_synonym="CGI-36; Nb(III); PP238"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1755
                     /gene="THAP4"
                     /gene_synonym="CGI-36; Nb(III); PP238"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..2076
                     /gene="THAP4"
                     /gene_synonym="CGI-36; Nb(III); PP238"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2034..2039
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THAP4"
                     /gene_synonym="CGI-36; Nb(III); PP238"
                     /note="hexamer: AATAAA"
     polyA_site      2076
                     /gene="THAP4"
                     /gene_synonym="CGI-36; Nb(III); PP238"
                     /note="major polyA site"
ORIGIN      
        1 atcttgccgt acggcgcgga cgccgcgggc cggcccacgt cccgagccgt gtcgccgccg
       61 cgctccctcc ctcggggcgg tccgcgggcg ggcgggcggc tagggccggg gcctggctgc
      121 gcggctgggc caaggcccgc gatggtgatc tgctgtgcgg ccgtgaactg ctccaaccgg
      181 cagggaaagg gcgagaagcg cgccgtctcc ttccacaggt tccccctaaa ggactcaaaa
      241 cgtctaatcc aatggttaaa agctgttcag agggataact ggactcccac taagtattca
      301 tttctctgta gtgagcattt caccaaagac agcttctcca agaggctgga ggaccagcat
      361 cgcctgctga agcccacggc cgtgccatcc atcttccacc tgaccgagaa gaagaggggg
      421 gctggaggcc atggccgcac ccggagaaaa gatgccagca aggccacagg gggtgtgagg
      481 ggacactcga gtgccgccac cagcagagga gctgcaggtt ggtcaccgtc ctcgagtgga
      541 aacccgatgg ccaagccaga gtcccgcagg ttgaagcaag ctgctctgca aggtgaagcc
      601 acacccaggg cggcccagga ggccgccagc caggagcagg cccagcaagc tctggaacgg
      661 actccaggag atggactggc caccatggtg gcaggcagtc agggaaaagc agaagcgtct
      721 gccacagatg ctggcgatga gagcgccact tcctccatcg aagggggcgt gacagataag
      781 agtggcattt ctatggatga ctttacgccc ccaggatctg gggcgtgcaa atttatcggc
      841 tcacttcatt cgtacagttt ctcctctaag cacacccgag aaaggccatc tgtcccccga
      901 gagcccattg accgcaagag gctgaagaaa gatgtggaac caagctgcag tgggagcagc
      961 ctgggacccg acaagggcct ggcccagagc cctcccagct catcacttac cgcgacaccg
     1021 cagaagcctt cccagagccc ctctgcccct cctgccgacg tcaccccaaa gccagccacg
     1081 gaagccgtgc agagcgagca cagcgacgcc agccccatgt ccatcaacga ggtcatcctg
     1141 tcggcgtcag gggcctgcaa gctcatcgac tcactgcact cctactgctt ctcctcccgg
     1201 cagaacaaga gccaggtgtg ctgcctgcgg gagcaggtgg agaagaagaa cggcgagctg
     1261 aagagcctgc ggcagagggt cagccgctcc gacagccagg tgcggaagct acaggagaag
     1321 ctggatgagc tgaggagagt gagcgtcccc tatccaagta gcctgctgtc gcccagccgc
     1381 gagcccccca agatgaaccc agtggtggag ccactgtcct ggatgctggg cacctggctg
     1441 tcggacccac ctggagccgg gacctacccc acactgcagc ccttccagta cctggaggag
     1501 gttcacatct cccacgtggg ccagcccatg ctgaacttct cgttcaactc cttccacccg
     1561 gacacgcgca agccgatgca cagagagtgt ggcttcattc gcctcaagcc cgacaccaac
     1621 aaggtggcct ttgtcagcgc ccagaacaca ggcgtggtgg aagtggagga gggcgaggtg
     1681 aacgggcagg agctgtgcat cgcatcccac tccatcgcca ggatctcctt cgccaaggag
     1741 ccccacgtag agcagatcac ccggaagttc aggctgaatt ctgaaggcaa acttgagcag
     1801 acggtctcca tggcaaccac gacacagcca atgactcagc atcttcacgt cacctacaag
     1861 aaggtgaccc cgtaaaccta gagcttctgg agccctcggg agggcctggc tactgtgcct
     1921 caacggttcg gctcctcaac agacagtccc tgcggcagaa gtgggtgtgg ccgtgagcct
     1981 ctgcaggctc aagagtgttg tccagatgtt tctgtactgg catagaaaaa ccaaataaaa
     2041 ggcctttatt tttatggctg aggattttga atatta
//
