LOCUS       NM_001394499            1123 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens THAP domain containing 3 (THAP3), transcript variant
            7, mRNA.
ACCESSION   NM_001394499 XM_011542401
VERSION     NM_001394499.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1123)
  AUTHORS   Wang,Z.H., Wang,J., Liu,F., Sun,S., Zheng,Q., Hu,X., Yin,Z.,
            Xie,C., Wang,H., Wang,T., Zhang,S. and Wang,Y.P.
  TITLE     THAP3 recruits SMYD3 to OXPHOS genes and epigenetically promotes
            mitochondrial respiration in hepatocellular carcinoma
  JOURNAL   FEBS Lett 598 (12), 1513-1531 (2024)
   PUBMED   38664231
  REMARK    GeneRIF: THAP3 recruits SMYD3 to OXPHOS genes and epigenetically
            promotes mitochondrial respiration in hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 1123)
  AUTHORS   Qin,Y., Huttlin,E.L., Winsnes,C.F., Gosztyla,M.L., Wacheul,L.,
            Kelly,M.R., Blue,S.M., Zheng,F., Chen,M., Schaffer,L.V., Licon,K.,
            Backstrom,A., Vaites,L.P., Lee,J.J., Ouyang,W., Liu,S.N., Zhang,T.,
            Silva,E., Park,J., Pitea,A., Kreisberg,J.F., Gygi,S.P., Ma,J.,
            Harper,J.W., Yeo,G.W., Lafontaine,D.L.J., Lundberg,E. and Ideker,T.
  TITLE     A multi-scale map of cell structure fusing protein images and
            interactions
  JOURNAL   Nature 600 (7889), 536-542 (2021)
   PUBMED   34819669
REFERENCE   3  (bases 1 to 1123)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1123)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1123)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1123)
  AUTHORS   Mazars,R., Gonzalez-de-Peredo,A., Cayrol,C., Lavigne,A.C.,
            Vogel,J.L., Ortega,N., Lacroix,C., Gautier,V., Huet,G., Ray,A.,
            Monsarrat,B., Kristie,T.M. and Girard,J.P.
  TITLE     The THAP-zinc finger protein THAP1 associates with coactivator
            HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3
            dystonias
  JOURNAL   J Biol Chem 285 (18), 13364-13371 (2010)
   PUBMED   20200153
REFERENCE   7  (bases 1 to 1123)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   8  (bases 1 to 1123)
  AUTHORS   Roussigne,M., Kossida,S., Lavigne,A.C., Clouaire,T., Ecochard,V.,
            Glories,A., Amalric,F. and Girard,J.P.
  TITLE     The THAP domain: a novel protein motif with similarity to the
            DNA-binding domain of P element transposase
  JOURNAL   Trends Biochem Sci 28 (2), 66-69 (2003)
   PUBMED   12575992
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL031447.4.
            
            On Apr 22, 2021 this sequence version replaced XM_011542401.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.2677610.1,
                                           SRR18074967.3355468.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               AL031447.4         75593-75702         c
            111-303             AL031447.4         72194-72386         c
            304-369             AL031447.4         70532-70597         c
            370-474             AL031447.4         68390-68494         c
            475-1123            AL031447.4         67323-67971         c
FEATURES             Location/Qualifiers
     source          1..1123
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.31"
     gene            1..1123
                     /gene="THAP3"
                     /note="THAP domain containing 3"
                     /db_xref="GeneID:90326"
                     /db_xref="HGNC:HGNC:20855"
                     /db_xref="MIM:612532"
     exon            1..110
                     /gene="THAP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..483
                     /gene="THAP3"
                     /note="isoform 7 is encoded by transcript variant 7; THAP
                     domain-containing protein 3; THAP domain containing,
                     apoptosis associated protein 3"
                     /codon_start=1
                     /product="THAP domain-containing protein 3 isoform 7"
                     /protein_id="NP_001381428.1"
                     /db_xref="GeneID:90326"
                     /db_xref="HGNC:HGNC:20855"
                     /db_xref="MIM:612532"
                     /translation="MPKSCAARQCCNRYSSRRKQLTFHRFPFSRPELLKEWVLNIGRG
                     NFKPKQHTVICSEHFRPECFSAFGNRKNLKHNAVPTVFAFQDPTQQVRENTDPASERG
                     NASSSQKEKVLPEAGAGEDSPGRNMDTALEELQLPPNAEGHVKQIP"
     exon            111..303
                     /gene="THAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            304..369
                     /gene="THAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            370..474
                     /gene="THAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            475..1123
                     /gene="THAP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1105..1110
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THAP3"
                     /note="hexamer: AATAAA"
     polyA_site      1123
                     /gene="THAP3"
                     /note="major polyA site"
ORIGIN      
        1 gccatctttg ttgggggcag ccaggcctgg ctcgagatgc cgaagtcgtg cgcggcccgg
       61 cagtgctgca accgctacag cagccgcagg aagcagctca ccttccaccg gtttccgttc
      121 agccgcccgg agctgctgaa ggaatgggtg ctgaacatcg gccggggcaa cttcaagccc
      181 aagcagcaca cggtcatctg ctccgagcac ttccggccag agtgcttcag cgcctttgga
      241 aaccgcaaga acctaaagca caatgccgtg cccacggtgt tcgcctttca ggaccccaca
      301 cagcaggtga gggagaacac agaccctgcc agtgagagag gaaatgccag ctcttctcag
      361 aaagaaaagg tcctccctga ggcgggggcc ggagaggaca gtcctgggag aaacatggac
      421 actgcacttg aagagcttca gttgccccca aatgccgaag gccacgtaaa acagattccc
      481 tgaagaaaaa actcttcctc actctgaagg aaaatgaaaa gctccggaag cgcttgcagg
      541 cccagaggct ggtgatgcga aggatgtcca gccgcctccg tgcttgcaaa gggcaccagg
      601 gactccaggc cagacttggg ccagagcagc agagctgagc cccacaggct ccggacgcag
      661 aggtggcagt ggcaccaggg ccggcagagc tttggagctc tggctgtgga catttttgtc
      721 tgctgtggac actgagaaag ttggccatga ggcctgcttg gccggggatc gagacagtag
      781 ccaagctccc cggcgagagc cccaatgccg tctgggggac gtttagaggc gtggcactag
      841 gagtgcacat ctgtgagcat gacaagctta tcctcccatg gtaacagaag tccaggctga
      901 ggctgattct ggacgctgtc ctttcagcac acgcagagca aagatcgttg gaagccccag
      961 tgtgggagat gctcctcagg gaggaagcca tgtgaggggg ctggctctgt ggcgggtgag
     1021 tggtcccctc ctccatcagc ctggacagcc gctcggggtt ctaaggagtg actcctgtcc
     1081 cggcctggtg tgagtgggca gtgtaataaa gtgtctttct ata
//
