LOCUS       NM_001195753            1361 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens THAP domain containing 3 (THAP3), transcript variant
            3, mRNA.
ACCESSION   NM_001195753
VERSION     NM_001195753.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1361)
  AUTHORS   Wang,Z.H., Wang,J., Liu,F., Sun,S., Zheng,Q., Hu,X., Yin,Z.,
            Xie,C., Wang,H., Wang,T., Zhang,S. and Wang,Y.P.
  TITLE     THAP3 recruits SMYD3 to OXPHOS genes and epigenetically promotes
            mitochondrial respiration in hepatocellular carcinoma
  JOURNAL   FEBS Lett 598 (12), 1513-1531 (2024)
   PUBMED   38664231
  REMARK    GeneRIF: THAP3 recruits SMYD3 to OXPHOS genes and epigenetically
            promotes mitochondrial respiration in hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 1361)
  AUTHORS   Qin,Y., Huttlin,E.L., Winsnes,C.F., Gosztyla,M.L., Wacheul,L.,
            Kelly,M.R., Blue,S.M., Zheng,F., Chen,M., Schaffer,L.V., Licon,K.,
            Backstrom,A., Vaites,L.P., Lee,J.J., Ouyang,W., Liu,S.N., Zhang,T.,
            Silva,E., Park,J., Pitea,A., Kreisberg,J.F., Gygi,S.P., Ma,J.,
            Harper,J.W., Yeo,G.W., Lafontaine,D.L.J., Lundberg,E. and Ideker,T.
  TITLE     A multi-scale map of cell structure fusing protein images and
            interactions
  JOURNAL   Nature 600 (7889), 536-542 (2021)
   PUBMED   34819669
REFERENCE   3  (bases 1 to 1361)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1361)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1361)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1361)
  AUTHORS   Mazars,R., Gonzalez-de-Peredo,A., Cayrol,C., Lavigne,A.C.,
            Vogel,J.L., Ortega,N., Lacroix,C., Gautier,V., Huet,G., Ray,A.,
            Monsarrat,B., Kristie,T.M. and Girard,J.P.
  TITLE     The THAP-zinc finger protein THAP1 associates with coactivator
            HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3
            dystonias
  JOURNAL   J Biol Chem 285 (18), 13364-13371 (2010)
   PUBMED   20200153
REFERENCE   7  (bases 1 to 1361)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   8  (bases 1 to 1361)
  AUTHORS   Roussigne,M., Kossida,S., Lavigne,A.C., Clouaire,T., Ecochard,V.,
            Glories,A., Amalric,F. and Girard,J.P.
  TITLE     The THAP domain: a novel protein motif with similarity to the
            DNA-binding domain of P element transposase
  JOURNAL   Trends Biochem Sci 28 (2), 66-69 (2003)
   PUBMED   12575992
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC092427.1, BM931707.1 and BU624154.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001195753.1.
            
            Transcript Variant: This variant (3) contains a different 5' exon
            and uses a different splice site, compared to variant 1. The
            resulting protein (isoform 3) is longer by 1 amino acid when it is
            compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092427.1, SRR18074967.3287438.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000054650.9/ ENSP00000054650.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-835               BC092427.1         4-838
            836-1176            BM931707.1         252-592
            1177-1361           BU624154.1         38-222              c
FEATURES             Location/Qualifiers
     source          1..1361
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.31"
     gene            1..1361
                     /gene="THAP3"
                     /note="THAP domain containing 3"
                     /db_xref="GeneID:90326"
                     /db_xref="HGNC:HGNC:20855"
                     /db_xref="MIM:612532"
     exon            1..87
                     /gene="THAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            88..230
                     /gene="THAP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..876
                     /gene="THAP3"
                     /note="isoform 3 is encoded by transcript variant 3; THAP
                     domain-containing protein 3; THAP domain containing,
                     apoptosis associated protein 3"
                     /codon_start=1
                     /product="THAP domain-containing protein 3 isoform 3"
                     /protein_id="NP_001182682.1"
                     /db_xref="CCDS:CCDS55572.1"
                     /db_xref="GeneID:90326"
                     /db_xref="HGNC:HGNC:20855"
                     /db_xref="MIM:612532"
                     /translation="MPKSCAARQCCNRYSSRRKQLTFHRFPFSRPELLKEWVLNIGRG
                     NFKPKQHTVICSEHFRPECFSAFGNRKNLKHNAVPTVFAFQDPTQQVRENTDPASERG
                     NASSSQKEKVLPEAGAGEDSPGRNMDTALEELQLPPNAEGHVKQVSPRRPQATEAVGR
                     PTGPAGLRRTPNKQPSDHSYALLDLDSLKKKLFLTLKENEKLRKRLQAQRLVMRRMSS
                     RLRACKGHQGLQARLGPEQQS"
     exon            231..423
                     /gene="THAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            424..489
                     /gene="THAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            490..594
                     /gene="THAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            595..1361
                     /gene="THAP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1343..1348
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THAP3"
                     /note="hexamer: AATAAA"
     polyA_site      1361
                     /gene="THAP3"
                     /note="major polyA site"
ORIGIN      
        1 ccagttgtcc aagcctgtga gtggctatgc gtcctggttg ggtgctcaaa gcaaggaggt
       61 gaaaggcgac cagcattggc gaatggggtc cctcccctct ccgcaggccc cgccgccgcc
      121 gccatctttg ttgggggcag ccaggcctgg ctcgagatgc cgaagtcgtg cgcggcccgg
      181 cagtgctgca accgctacag cagccgcagg aagcagctca ccttccaccg gtttccgttc
      241 agccgcccgg agctgctgaa ggaatgggtg ctgaacatcg gccggggcaa cttcaagccc
      301 aagcagcaca cggtcatctg ctccgagcac ttccggccag agtgcttcag cgcctttgga
      361 aaccgcaaga acctaaagca caatgccgtg cccacggtgt tcgcctttca ggaccccaca
      421 cagcaggtga gggagaacac agaccctgcc agtgagagag gaaatgccag ctcttctcag
      481 aaagaaaagg tcctccctga ggcgggggcc ggagaggaca gtcctgggag aaacatggac
      541 actgcacttg aagagcttca gttgccccca aatgccgaag gccacgtaaa acaggtctcg
      601 ccacggaggc cgcaagcaac agaggctgtt ggccggccga ctggccctgc aggcctgaga
      661 aggaccccca acaagcagcc atctgatcac agctatgccc ttttggactt agattccctg
      721 aagaaaaaac tcttcctcac tctgaaggaa aatgaaaagc tccggaagcg cttgcaggcc
      781 cagaggctgg tgatgcgaag gatgtccagc cgcctccgtg cttgcaaagg gcaccaggga
      841 ctccaggcca gacttgggcc agagcagcag agctgagccc cacaggctcc ggacgcagag
      901 gtggcagtgg caccagggcc ggcagagctt tggagctctg gctgtggaca tttttgtctg
      961 ctgtggacac tgagaaagtt ggccatgagg cctgcttggc cggggatcga gacagtagcc
     1021 aagctccccg gcgagagccc caatgccgtc tgggggacgt ttagaggcgt ggcactagga
     1081 gtgcacatct gtgagcatga caagcttatc ctcccatggt aacagaagtc caggctgagg
     1141 ctgattctgg acgctgtcct ttcagcacac gcagagcaaa gatcgttgga agccccagtg
     1201 tgggagatgc tcctcaggga ggaagccatg tgagggggct ggctctgtgg cgggtgagtg
     1261 gtcccctcct ccatcagcct ggacagccgc tcggggttct aaggagtgac tcctgtcccg
     1321 gcctggtgtg agtgggcagt gtaataaagt gtctttctat a
//
