LOCUS       NM_001195752            1358 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens THAP domain containing 3 (THAP3), transcript variant
            1, mRNA.
ACCESSION   NM_001195752 XM_005263532
VERSION     NM_001195752.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1358)
  AUTHORS   Wang,Z.H., Wang,J., Liu,F., Sun,S., Zheng,Q., Hu,X., Yin,Z.,
            Xie,C., Wang,H., Wang,T., Zhang,S. and Wang,Y.P.
  TITLE     THAP3 recruits SMYD3 to OXPHOS genes and epigenetically promotes
            mitochondrial respiration in hepatocellular carcinoma
  JOURNAL   FEBS Lett 598 (12), 1513-1531 (2024)
   PUBMED   38664231
  REMARK    GeneRIF: THAP3 recruits SMYD3 to OXPHOS genes and epigenetically
            promotes mitochondrial respiration in hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 1358)
  AUTHORS   Qin,Y., Huttlin,E.L., Winsnes,C.F., Gosztyla,M.L., Wacheul,L.,
            Kelly,M.R., Blue,S.M., Zheng,F., Chen,M., Schaffer,L.V., Licon,K.,
            Backstrom,A., Vaites,L.P., Lee,J.J., Ouyang,W., Liu,S.N., Zhang,T.,
            Silva,E., Park,J., Pitea,A., Kreisberg,J.F., Gygi,S.P., Ma,J.,
            Harper,J.W., Yeo,G.W., Lafontaine,D.L.J., Lundberg,E. and Ideker,T.
  TITLE     A multi-scale map of cell structure fusing protein images and
            interactions
  JOURNAL   Nature 600 (7889), 536-542 (2021)
   PUBMED   34819669
REFERENCE   3  (bases 1 to 1358)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1358)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1358)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1358)
  AUTHORS   Mazars,R., Gonzalez-de-Peredo,A., Cayrol,C., Lavigne,A.C.,
            Vogel,J.L., Ortega,N., Lacroix,C., Gautier,V., Huet,G., Ray,A.,
            Monsarrat,B., Kristie,T.M. and Girard,J.P.
  TITLE     The THAP-zinc finger protein THAP1 associates with coactivator
            HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3
            dystonias
  JOURNAL   J Biol Chem 285 (18), 13364-13371 (2010)
   PUBMED   20200153
REFERENCE   7  (bases 1 to 1358)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   8  (bases 1 to 1358)
  AUTHORS   Roussigne,M., Kossida,S., Lavigne,A.C., Clouaire,T., Ecochard,V.,
            Glories,A., Amalric,F. and Girard,J.P.
  TITLE     The THAP domain: a novel protein motif with similarity to the
            DNA-binding domain of P element transposase
  JOURNAL   Trends Biochem Sci 28 (2), 66-69 (2003)
   PUBMED   12575992
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL031447.4.
            
            On or before Apr 22, 2021 this sequence version replaced
            XM_005263532.4, NM_001195752.1.
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and it encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR12921934.1533359.1,
                                           SRR7410570.6361.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AL031447.4         75931-76017         c
            88-230              AL031447.4         75593-75735         c
            231-423             AL031447.4         72194-72386         c
            424-486             AL031447.4         70532-70594         c
            487-591             AL031447.4         68390-68494         c
            592-1358            AL031447.4         67323-68089         c
FEATURES             Location/Qualifiers
     source          1..1358
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.31"
     gene            1..1358
                     /gene="THAP3"
                     /note="THAP domain containing 3"
                     /db_xref="GeneID:90326"
                     /db_xref="HGNC:HGNC:20855"
                     /db_xref="MIM:612532"
     exon            1..87
                     /gene="THAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            88..230
                     /gene="THAP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..873
                     /gene="THAP3"
                     /note="isoform 1 is encoded by transcript variant 1; THAP
                     domain-containing protein 3; THAP domain containing,
                     apoptosis associated protein 3"
                     /codon_start=1
                     /product="THAP domain-containing protein 3 isoform 1"
                     /protein_id="NP_001182681.1"
                     /db_xref="CCDS:CCDS55573.1"
                     /db_xref="GeneID:90326"
                     /db_xref="HGNC:HGNC:20855"
                     /db_xref="MIM:612532"
                     /translation="MPKSCAARQCCNRYSSRRKQLTFHRFPFSRPELLKEWVLNIGRG
                     NFKPKQHTVICSEHFRPECFSAFGNRKNLKHNAVPTVFAFQDPTQVRENTDPASERGN
                     ASSSQKEKVLPEAGAGEDSPGRNMDTALEELQLPPNAEGHVKQVSPRRPQATEAVGRP
                     TGPAGLRRTPNKQPSDHSYALLDLDSLKKKLFLTLKENEKLRKRLQAQRLVMRRMSSR
                     LRACKGHQGLQARLGPEQQS"
     exon            231..423
                     /gene="THAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            424..486
                     /gene="THAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            487..591
                     /gene="THAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            592..1358
                     /gene="THAP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1340..1345
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THAP3"
                     /note="hexamer: AATAAA"
     polyA_site      1358
                     /gene="THAP3"
                     /note="major polyA site"
ORIGIN      
        1 ccagttgtcc aagcctgtga gtggctatgc gtcctggttg ggtgctcaaa gcaaggaggt
       61 gaaaggcgac cagcattggc gaatggggtc cctcccctct ccgcaggccc cgccgccgcc
      121 gccatctttg ttgggggcag ccaggcctgg ctcgagatgc cgaagtcgtg cgcggcccgg
      181 cagtgctgca accgctacag cagccgcagg aagcagctca ccttccaccg gtttccgttc
      241 agccgcccgg agctgctgaa ggaatgggtg ctgaacatcg gccggggcaa cttcaagccc
      301 aagcagcaca cggtcatctg ctccgagcac ttccggccag agtgcttcag cgcctttgga
      361 aaccgcaaga acctaaagca caatgccgtg cccacggtgt tcgcctttca ggaccccaca
      421 caggtgaggg agaacacaga ccctgccagt gagagaggaa atgccagctc ttctcagaaa
      481 gaaaaggtcc tccctgaggc gggggccgga gaggacagtc ctgggagaaa catggacact
      541 gcacttgaag agcttcagtt gcccccaaat gccgaaggcc acgtaaaaca ggtctcgcca
      601 cggaggccgc aagcaacaga ggctgttggc cggccgactg gccctgcagg cctgagaagg
      661 acccccaaca agcagccatc tgatcacagc tatgcccttt tggacttaga ttccctgaag
      721 aaaaaactct tcctcactct gaaggaaaat gaaaagctcc ggaagcgctt gcaggcccag
      781 aggctggtga tgcgaaggat gtccagccgc ctccgtgctt gcaaagggca ccagggactc
      841 caggccagac ttgggccaga gcagcagagc tgagccccac aggctccgga cgcagaggtg
      901 gcagtggcac cagggccggc agagctttgg agctctggct gtggacattt ttgtctgctg
      961 tggacactga gaaagttggc catgaggcct gcttggccgg ggatcgagac agtagccaag
     1021 ctccccggcg agagccccaa tgccgtctgg gggacgttta gaggcgtggc actaggagtg
     1081 cacatctgtg agcatgacaa gcttatcctc ccatggtaac agaagtccag gctgaggctg
     1141 attctggacg ctgtcctttc agcacacgca gagcaaagat cgttggaagc cccagtgtgg
     1201 gagatgctcc tcagggagga agccatgtga gggggctggc tctgtggcgg gtgagtggtc
     1261 ccctcctcca tcagcctgga cagccgctcg gggttctaag gagtgactcc tgtcccggcc
     1321 tggtgtgagt gggcagtgta ataaagtgtc tttctata
//
