LOCUS       NM_031435               4432 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens THAP domain containing 2 (THAP2), mRNA.
ACCESSION   NM_031435
VERSION     NM_031435.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4432)
  AUTHORS   Benjamin,D.J., Cesarini,D., van der Loos,M.J., Dawes,C.T.,
            Koellinger,P.D., Magnusson,P.K., Chabris,C.F., Conley,D.,
            Laibson,D., Johannesson,M. and Visscher,P.M.
  TITLE     The genetic architecture of economic and political preferences
  JOURNAL   Proc Natl Acad Sci U S A 109 (21), 8026-8031 (2012)
   PUBMED   22566634
REFERENCE   2  (bases 1 to 4432)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   3  (bases 1 to 4432)
  AUTHORS   Roussigne,M., Kossida,S., Lavigne,A.C., Clouaire,T., Ecochard,V.,
            Glories,A., Amalric,F. and Girard,J.P.
  TITLE     The THAP domain: a novel protein motif with similarity to the
            DNA-binding domain of P element transposase
  JOURNAL   Trends Biochem Sci 28 (2), 66-69 (2003)
   PUBMED   12575992
REFERENCE   4  (bases 1 to 4432)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL136607.1, AC073612.17 and DB301707.1.
            
            On Nov 22, 2018 this sequence version replaced NM_031435.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL136607.1, SRR1660803.217201.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308086.3/ ENSP00000310796.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-805               AL136607.1         302-1106
            806-4414            AC073612.17        27815-31423         c
            4415-4432           DB301707.1         5-22                c
FEATURES             Location/Qualifiers
     source          1..4432
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.1"
     gene            1..4432
                     /gene="THAP2"
                     /note="THAP domain containing 2"
                     /db_xref="GeneID:83591"
                     /db_xref="HGNC:HGNC:20854"
                     /db_xref="MIM:612531"
     exon            1..280
                     /gene="THAP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..896
                     /gene="THAP2"
                     /note="THAP domain containing, apoptosis associated
                     protein 2"
                     /codon_start=1
                     /product="THAP domain-containing protein 2"
                     /protein_id="NP_113623.1"
                     /db_xref="CCDS:CCDS9001.1"
                     /db_xref="GeneID:83591"
                     /db_xref="HGNC:HGNC:20854"
                     /db_xref="MIM:612531"
                     /translation="MPTNCAAAGCATTYNKHINISFHRFPLDPKRRKEWVRLVRRKNF
                     VPGKHTFLCSKHFEASCFDLTGQTRRLKMDAVPTIFDFCTHIKSMKLKSRNLLKKNNS
                     CSPAGPSNLKSNISSQQVLLEHSYAFRNPMEAKKRIIKLEKEIASLRRKMKTCLQKER
                     RATRRWIKATCLVKNLEANSVLPKGTSEHMLPTALSSLPLEDFKILEQDQQDKTLLSL
                     NLKQTKSTFI"
     exon            281..476
                     /gene="THAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            477..4432
                     /gene="THAP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1122..1127
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THAP2"
                     /note="hexamer: AATAAA"
     polyA_site      1145
                     /gene="THAP2"
     regulatory      1654..1659
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THAP2"
                     /note="hexamer: AATAAA"
     polyA_site      1683
                     /gene="THAP2"
                     /note="major polyA site"
     regulatory      4409..4414
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THAP2"
                     /note="hexamer: ATTAAA"
     polyA_site      4432
                     /gene="THAP2"
                     /note="major polyA site"
ORIGIN      
        1 agtcggccat attaataaag agaaagggaa ggctgaccgt ccttcgcctc cgcccccaca
       61 tacacacccc ttcttcccac tccgctctca cgactaagct ctcacgatta aggcacgcct
      121 gcctcgattg tccagcctct gccagaagaa agcttagcag ccagcgcctc agtagagacc
      181 taagggcgct gaatgagtgg gaaagggaaa tgccgaccaa ttgcgctgcg gcgggctgtg
      241 ccactaccta caacaagcac attaacatca gcttccacag gtttcctttg gatcctaaaa
      301 gaagaaaaga atgggttcgc ctggttaggc gcaaaaattt tgtgccagga aaacacactt
      361 ttctttgttc aaagcacttt gaagcctcct gttttgacct aacaggacaa actcgacgac
      421 ttaaaatgga tgctgttcca accatttttg atttttgtac ccatataaag tctatgaaac
      481 tcaagtcaag gaatcttttg aagaaaaaca acagttgttc tccagctgga ccatctaatt
      541 taaaatcaaa cattagtagt cagcaagtac tacttgaaca cagctatgcc tttaggaatc
      601 ctatggaggc aaaaaagagg atcattaaac tggaaaaaga aatagcaagc ttaagaagaa
      661 aaatgaaaac ttgcctacaa aaggaacgca gagcaactcg aagatggatc aaagccacgt
      721 gtttggtaaa gaatttagaa gcaaatagtg tattacctaa aggtacatca gaacacatgt
      781 taccaactgc cttaagcagt cttcctttgg aagattttaa gatccttgaa caagatcaac
      841 aagataaaac actgctaagt ctaaatctaa aacagaccaa gagtaccttc atttaaattt
      901 agcttgcaca gagcttgatg cctatccttc attcttttca gaagtaaaga taattatggc
      961 acttatgcca aaattcatta tttaataaag ttttacttga agtaacatta ctgaatttgt
     1021 gaagacttga ttacaaaaga ataaaaaact tcatatggaa attttatttg aaaatgagtg
     1081 gaagtgcctt acattagaat tacggactta aaaattttgc taataaattg tgtgtttgaa
     1141 aggtgttttt tgtttttgtc tttttaaact actgttaaaa gaacagctta tgataagtaa
     1201 tatgtttaac ttagagaaga attttttcct gtaccaaagt tggcatattg cattctaaat
     1261 aagatgctaa ataagagtta accaacattc aacatgacct taaaactgct gggttttgta
     1321 ttaattaaat tataattggc actgtgattt gaaaaattta tagaaaaaaa ggtacagggc
     1381 aagtttttaa attaaaactt tctatatttt gttttaccag taaaagtgag cttatcatgg
     1441 cctctctcat aagaatgatt ttaaaatagg ttgtaaaata ttttgaaaat atttgaatgt
     1501 gaagtaccat tgagtcatcc aaactaggta aggcctcaag tactttaaac tagtaaaatc
     1561 tagtagctga taatattcac ctaagtaagt gttgtaaaat aattcagagt tcaggaccta
     1621 gcttagataa atgtatacta ctctttttct cataataaaa atcttacatt tccaacttca
     1681 aaattggtgc ttccatattt gttgataacc aaaactccta aggttttttg ttttcttttt
     1741 aactactttc caaatgcata ctatacctca gaaatagtgt atcaatatag tgggcttttt
     1801 ttttcctctt cataaaccca cagtaaaatt taatcacagg aaactactta tatcttcaca
     1861 ctttgtattg ataacttaaa atggcatcag tttatcttag acatcagctt gctttttatc
     1921 tcctttttta gtgagtgaaa tagagcaact agcatgcctg tgttcccagc tacttgggag
     1981 gctaaggtgg gaagatcaat tgaacctagg aggttgaggc tatagtgagc tgtgattgca
     2041 cgactgcact ccagcctggg caatggagtg agactcctgt ctctaaaaca gcaacaacaa
     2101 aaataaagca accatagtgc ataagggaaa ttaaatgttc cctatagaaa tatgtgtatg
     2161 tctgtgatag tggtatgcaa atgctaatta ttttataaaa taaaagttca gaactattct
     2221 tatcattgcc acttgaacaa ttaaagggtt tgctttattt cactaatgtt taataggaac
     2281 cctttgcttc aaacagcttt gttgaaatca tgtaaaaatt tgttaataga gaatcaagtt
     2341 atttaactca acttatttaa ttcaagcttg tgatactaac atacaaaggt agcataaacc
     2401 aagtcataaa ttgctgtaat ctttcctgta aagtaatagc tacttcatga tttttttaaa
     2461 aatttcattt ttttgctatt taggattgca tttgcttggc tcctagtaac aattctttta
     2521 cagtattagc actctcttta ctaaggaatg cctcccaagg aaatgcaaag gtaggaaaag
     2581 tctcttagaa tgcccatgag gtatttaaaa cagatattta tgaaaatctt tttgtgaatg
     2641 ttataaatct tgctagttat tttatcttta tcttaagtat tagatgtagt tccttggaat
     2701 tgtcattaca tatttatttt tttctagtat ggtttcaaat aactttttgc caacatataa
     2761 tcatcatcaa acattcactg accatatcta ttttataact caaaataagt tggacaaata
     2821 atcattttaa taaaaactat tttttccaag tataaccact gtcatgtggt tcacccttca
     2881 ccccagatac aaaacactta tttgtgtagc ccagttccca tctacagtaa taccttgaaa
     2941 ccttaataaa ttttaaaaat cataaaaata aaatattgta aaatacaaca aattttggac
     3001 aaggttactt catcttcatt cattattacc tgacagtatt aaactactac tcaataattt
     3061 tagagtaaac ttttctgtgt tttctccgtg attttcattg tgctgtcctg acaacatgct
     3121 ccaaactctt tgcatcaaat tgttttatta acatacattt gtctacctta aaactagctt
     3181 tattcacaga gaaaaaccta aaaggagtct attaaaatgc tgctttcagt ttgatagttt
     3241 tttttttaat cactctgacc ataaactaac tgaaattata atggattttt tttcctctcc
     3301 cggtcacaac acagatcttc tgttcatttg ttctctgtct actgggcacc aacctctaca
     3361 aagaaccagc caaaggctag gtacttgata taaaaaggaa tattacatta ttttctgccc
     3421 tcaagttgct ctatctcctg aaagaaacaa gtaatattta taatacaata tgataaatgc
     3481 tacaaaagaa atagctgtaa agtcctttgg taaatgctgt tgaattggaa ttcagtaaga
     3541 actataaact gtagaccttt ttataatcaa atgcttttgt cttgaaacaa aacagattcc
     3601 tccttatatt gacttagcaa aggaggtaca aggacattgg catttgacct gaattatggt
     3661 gttttattga atgagctata agacaacatt tttacccttt aaaatgaaca ctgaacaaat
     3721 gtgttaatgg tatctttgtt aaaaggaaaa catagctata aataaaatac tacatcgaaa
     3781 tccagcactg gagttcattt gaaatttgat attttgtgta aaataacaaa cctattaaca
     3841 cagattttta aaataactca gaatcgtata aagcactttg gtacttattt gttctctttt
     3901 cccttacatt ctgtgtggta ggtggtatta tctctgattt acacatgaag acatccttgt
     3961 taatgcaatt tatttattca ttcgggcatt tactgtgtgc caacttgcaa aaggaataga
     4021 aatgtctgtg atctagatag ttctagattg aacatagatt ttctgccaac aaatcctctc
     4081 tgctgttcac attatccttt gtttaacgta tgaaccaggt tactaaaata ggataaatca
     4141 tgtgtcttaa aatatgaaaa tagtaaagtc tttgaggtca cttgatcttc tctaagtaga
     4201 ctttataata ttgtgtttta tctcatttct caatattaga atacgggtag attttaattt
     4261 tgctataata taggaaatgg ttcatctttg taccaaaata ttgcattctt ctgatattta
     4321 gacagttgga aactttctaa aattgaggat tttgtagtgt atactaaata attgcatatt
     4381 caaaaaaatg tattctgagt atggtgatat taaacatttt tccccaagga aa
//
