LOCUS       NM_004705               3490 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens THAP domain containing 12 (THAP12), transcript variant
            1, mRNA.
ACCESSION   NM_004705
VERSION     NM_004705.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3490)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3490)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3490)
  AUTHORS   Now,H. and Yoo,J.Y.
  TITLE     A protein-kinase, IFN-inducible double-stranded RNA dependent
            inhibitor and repressor of p58 (PRKRIR) enhances type I
            IFN-mediated antiviral response through the stability control of
            RIG-I protein
  JOURNAL   Biochem Biophys Res Commun 413 (3), 487-493 (2011)
   PUBMED   21910972
  REMARK    GeneRIF: PRKRIR provides a novel positive regulator controlling the
            RIG-I-IFN production system through protein stability control.
REFERENCE   4  (bases 1 to 3490)
  AUTHORS   Silva,L.K., Blanton,R.E., Parrado,A.R., Melo,P.S., Morato,V.G.,
            Reis,E.A., Dias,J.P., Castro,J.M., Vasconcelos,P.F., Goddard,K.A.,
            Barreto,M.L., Reis,M.G. and Teixeira,M.G.
  TITLE     Dengue hemorrhagic fever is associated with polymorphisms in JAK1
  JOURNAL   Eur J Hum Genet 18 (11), 1221-1227 (2010)
   PUBMED   20588308
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 3490)
  AUTHORS   Johnatty,S.E., Beesley,J., Chen,X., Macgregor,S., Duffy,D.L.,
            Spurdle,A.B., deFazio,A., Gava,N., Webb,P.M., Rossing,M.A.,
            Doherty,J.A., Goodman,M.T., Lurie,G., Thompson,P.J., Wilkens,L.R.,
            Ness,R.B., Moysich,K.B., Chang-Claude,J., Wang-Gohrke,S.,
            Cramer,D.W., Terry,K.L., Hankinson,S.E., Tworoger,S.S.,
            Garcia-Closas,M., Yang,H., Lissowska,J., Chanock,S.J.,
            Pharoah,P.D., Song,H., Whitemore,A.S., Pearce,C.L., Stram,D.O.,
            Wu,A.H., Pike,M.C., Gayther,S.A., Ramus,S.J., Menon,U.,
            Gentry-Maharaj,A., Anton-Culver,H., Ziogas,A., Hogdall,E.,
            Kjaer,S.K., Hogdall,C., Berchuck,A., Schildkraut,J.M.,
            Iversen,E.S., Moorman,P.G., Phelan,C.M., Sellers,T.A.,
            Cunningham,J.M., Vierkant,R.A., Rider,D.N., Goode,E.L., Haviv,I.
            and Chenevix-Trench,G.
  CONSRTM   Ovarian Cancer Association Consortium; Australian Ovarian Cancer
            Study Group; Australian Cancer Study (Ovarian Cancer)
  TITLE     Evaluation of candidate stromal epithelial cross-talk genes
            identifies association between risk of serous ovarian cancer and
            TERT, a cancer susceptibility 'hot-spot'
  JOURNAL   PLoS Genet 6 (7), e1001016 (2010)
   PUBMED   20628624
  REMARK    GeneRIF: Meta-analysis of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3490)
  AUTHORS   Lu,J., O'Hara,E.B., Trieselmann,B.A., Romano,P.R. and Dever,T.E.
  TITLE     The interferon-induced double-stranded RNA-activated protein kinase
            PKR will phosphorylate serine, threonine, or tyrosine at residue 51
            in eukaryotic initiation factor 2alpha
  JOURNAL   J Biol Chem 274 (45), 32198-32203 (1999)
   PUBMED   10542257
REFERENCE   7  (bases 1 to 3490)
  AUTHORS   Shi,Y., Vattem,K.M., Sood,R., An,J., Liang,J., Stramm,L. and
            Wek,R.C.
  TITLE     Identification and characterization of pancreatic eukaryotic
            initiation factor 2 alpha-subunit kinase, PEK, involved in
            translational control
  JOURNAL   Mol Cell Biol 18 (12), 7499-7509 (1998)
   PUBMED   9819435
REFERENCE   8  (bases 1 to 3490)
  AUTHORS   Gale,M. Jr., Blakely,C.M., Hopkins,D.A., Melville,M.W., Wambach,M.,
            Romano,P.R. and Katze,M.G.
  TITLE     Regulation of interferon-induced protein kinase PKR: modulation of
            P58IPK inhibitory function by a novel protein, P52rIPK
  JOURNAL   Mol Cell Biol 18 (2), 859-871 (1998)
   PUBMED   9447982
REFERENCE   9  (bases 1 to 3490)
  AUTHORS   Polyak,S.J., Tang,N., Wambach,M., Barber,G.N. and Katze,M.G.
  TITLE     The P58 cellular inhibitor complexes with the interferon-induced,
            double-stranded RNA-dependent protein kinase, PKR, to regulate its
            autophosphorylation and activity
  JOURNAL   J Biol Chem 271 (3), 1702-1707 (1996)
   PUBMED   8576172
REFERENCE   10 (bases 1 to 3490)
  AUTHORS   Mellor,H. and Proud,C.G.
  TITLE     A synthetic peptide substrate for initiation factor-2 kinases
  JOURNAL   Biochem Biophys Res Commun 178 (2), 430-437 (1991)
   PUBMED   1677563
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP002360.4, DR005363.1, AF081567.1 and AA765102.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004705.3.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC110304.1, SRR1803613.154733.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA2142348,
                                           SAMEA2146411 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000260045.8/ ENSP00000260045.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               AP002360.4         96584-96750         c
            168-296             DR005363.1         7-135
            297-3197            AF081567.1         1-2901
            3198-3490           AA765102.1         20-312              c
FEATURES             Location/Qualifiers
     source          1..3490
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.5"
     gene            1..3490
                     /gene="THAP12"
                     /gene_synonym="DAP4; P52rIPK; PRKRIR; THAP0"
                     /note="THAP domain containing 12"
                     /db_xref="GeneID:5612"
                     /db_xref="HGNC:HGNC:9440"
                     /db_xref="MIM:607374"
     exon            1..385
                     /gene="THAP12"
                     /gene_synonym="DAP4; P52rIPK; PRKRIR; THAP0"
                     /inference="alignment:Splign:2.1.0"
     CDS             297..2582
                     /gene="THAP12"
                     /gene_synonym="DAP4; P52rIPK; PRKRIR; THAP0"
                     /note="death-associated protein 4; inhibitor of protein
                     kinase PKR; P58IPK-regulatory protein; p58IPK-interacting
                     protein; THAP domain-containing protein 0; 58 kDa
                     interferon-induced protein kinase-interacting protein;
                     protein-kinase, interferon-inducible double stranded RNA
                     dependent inhibitor, repressor of (P58 repressor);
                     testicular tissue protein Li 133; THAP domain-containing
                     protein 12"
                     /codon_start=1
                     /product="52 kDa repressor of the inhibitor of the protein
                     kinase"
                     /protein_id="NP_004696.2"
                     /db_xref="CCDS:CCDS8243.1"
                     /db_xref="GeneID:5612"
                     /db_xref="HGNC:HGNC:9440"
                     /db_xref="MIM:607374"
                     /translation="MPNFCAAPNCTRKSTQSDLAFFRFPRDPARCQKWVENCRRADLE
                     DKTPDQLNKHYRLCAKHFETSMICRTSPYRTVLRDNAIPTIFDLTSHLNNPHSRHRKR
                     IKELSEDEIRTLKQKKIDETSEQEQKHKETNNSNAQNPSEEEGEGQDEDILPLTLEEK
                     ENKEYLKSLFEILILMGKQNIPLDGHEADEIPEGLFTPDNFQALLECRINSGEEVLRK
                     RFETTAVNTLFCSKTQQRQMLEICESCIREETLREVRDSHFFSIITDDVVDIAGEEHL
                     PVLVRFVDESHNLREEFIGFLPYEADAEILAVKFHTMITEKWGLNMEYCRGQAYIVSS
                     GFSSKMKVVASRLLEKYPQAIYTLCSSCALNMWLAKSVPVMGVSVALGTIEEVCSFFH
                     RSPQLLLELDNVISVLFQNSKERGKELKEICHSQWTGRHDAFEILVELLQALVLCLDG
                     INSDTNIRWNNYIAGRAFVLCSAVSDFDFIVTIVVLKNVLSFTRAFGKNLQGQTSDVF
                     FAAGSLTAVLHSLNEVMENIEVYHEFWFEEATNLATKLDIQMKLPGKFRRAHQGNLES
                     QLTSESYYKETLSVPTVEHIIQELKDIFSEQHLKALKCLSLVPSVMGQLKFNTSEEHH
                     ADMYRSDLPNPDTLSAELHCWRIKWKHRGKDIELPSTIYEALHLPDIKFFPNVYALLK
                     VLCILPVMKVENERYENGRKRLKAYLRNTLTDQRSSNLALLNINFDIKHDLDLMVDTY
                     IKLYTSKSELPTDNSETVENT"
     exon            386..506
                     /gene="THAP12"
                     /gene_synonym="DAP4; P52rIPK; PRKRIR; THAP0"
                     /inference="alignment:Splign:2.1.0"
     exon            507..614
                     /gene="THAP12"
                     /gene_synonym="DAP4; P52rIPK; PRKRIR; THAP0"
                     /inference="alignment:Splign:2.1.0"
     exon            615..651
                     /gene="THAP12"
                     /gene_synonym="DAP4; P52rIPK; PRKRIR; THAP0"
                     /inference="alignment:Splign:2.1.0"
     exon            652..3490
                     /gene="THAP12"
                     /gene_synonym="DAP4; P52rIPK; PRKRIR; THAP0"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3467..3472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THAP12"
                     /gene_synonym="DAP4; P52rIPK; PRKRIR; THAP0"
                     /note="hexamer: AATAAA"
     polyA_site      3490
                     /gene="THAP12"
                     /gene_synonym="DAP4; P52rIPK; PRKRIR; THAP0"
                     /note="major polyA site"
ORIGIN      
        1 gcattgtggg aaggaggcgg cagcgtctcg ggcgggcggg aggtgcacca gcggcggcgg
       61 cggcggtaaa tcctcccggc cgctcacagc actgtggagc cgcgtcccca gcccggcctc
      121 ggaccgcggc acccctcctg gccctcgcgg cttctagccc gcccgcccct cccccgcgcg
      181 tcggccctgc cgagccggcc ggccggcctg gctcccctcc ccggccccga cgggcgggcg
      241 gactgccctg aggaggcggg gaggggaggg ctgggccggc cggcgggcgg gcgacgatgc
      301 cgaacttctg cgctgccccc aactgcacgc ggaagagcac gcagtccgac ttggccttct
      361 tcaggttccc gcgggaccct gccagatgcc agaagtgggt ggagaactgt aggagagcag
      421 acttagaaga taaaacacct gatcagctaa ataaacatta tcgattatgt gccaaacatt
      481 ttgagacctc tatgatctgt agaactagtc cttataggac agttcttcga gataatgcaa
      541 taccaacaat atttgatctt accagtcatt tgaacaaccc acatagtaga cacagaaaac
      601 gaataaaaga actgagtgaa gatgaaatca ggacactgaa acagaaaaaa attgatgaaa
      661 cttctgagca ggaacaaaaa cataaagaaa ccaacaatag caatgctcag aaccccagcg
      721 aagaagaggg tgaagggcaa gatgaggaca ttttacctct aacccttgaa gagaaggaaa
      781 acaaagaata cctaaaatct ctatttgaaa tcttgattct gatgggaaag caaaacatac
      841 ctctggatgg acatgaggct gatgaaatcc cagaaggtct ctttactcca gataactttc
      901 aggcactgct ggagtgtcgg ataaattctg gtgaagaggt tctgagaaag cggtttgaga
      961 caacagcagt taacacgttg ttttgttcaa aaacacagca gaggcagatg ctagagatct
     1021 gtgagagctg tattcgagaa gaaactctca gggaagtgag agactcacac ttcttttcca
     1081 ttatcactga cgatgtagtg gacatagcag gggaagagca cctacctgtg ttggtgaggt
     1141 ttgttgatga atctcataac ctaagagagg aatttatagg cttcctgcct tatgaagccg
     1201 atgcagaaat tttggctgtg aaatttcaca ctatgataac tgagaagtgg ggattaaata
     1261 tggagtattg tcgtggccag gcttacattg tctctagtgg attttcttcc aaaatgaaag
     1321 ttgttgcttc tagactttta gagaaatatc cccaagctat ctacacactc tgctcttcct
     1381 gtgccttaaa tatgtggttg gcaaaatcag tacctgttat gggagtatct gttgcattag
     1441 gaacaattga ggaagtttgt tcttttttcc atcgatcacc acaactgctt ttagaacttg
     1501 acaacgtaat ttctgttctt tttcagaaca gtaaagaaag gggtaaagaa ctgaaggaaa
     1561 tctgccattc tcagtggaca ggcaggcatg atgcttttga aattttagtg gaactcctgc
     1621 aagcacttgt tttatgttta gatggtataa atagtgacac aaatattaga tggaataact
     1681 atatagctgg ccgagcattt gtactctgca gtgcagtgtc agattttgat ttcattgtta
     1741 ctattgttgt tcttaaaaat gtcctatctt ttacaagagc ctttgggaaa aacctccagg
     1801 ggcaaacctc tgatgtcttc tttgcggccg gtagcttgac tgcagtactg cattcactca
     1861 acgaagtgat ggaaaatatt gaagtttatc atgaattttg gtttgaggaa gccacaaatt
     1921 tggcaaccaa acttgatatt caaatgaaac tccctgggaa attccgcaga gctcaccagg
     1981 gtaacttgga atctcagcta acctctgaga gttactataa agaaacccta agtgtcccaa
     2041 cagtggagca cattattcag gaacttaaag atatattctc agaacagcac ctcaaagctc
     2101 ttaaatgctt atctctggta ccctcagtca tgggacaact caaattcaat acgtcggagg
     2161 aacaccatgc tgacatgtat agaagtgact tacccaatcc tgacacgctg tcagctgagc
     2221 ttcattgttg gagaatcaaa tggaaacaca gggggaaaga tatagagctt ccgtccacca
     2281 tctatgaagc cctccacctg cctgacatca agttttttcc taatgtgtat gcattgctga
     2341 aggtcctgtg tattcttcct gtgatgaagg ttgagaatga gcggtatgaa aatggacgaa
     2401 agcgtcttaa agcatatttg aggaacactt tgacagacca aaggtcaagt aacttggctt
     2461 tgcttaacat aaattttgat ataaaacacg acctggattt aatggtggac acatatatta
     2521 aactctatac aagtaagtca gagcttccta cagataattc cgaaactgtg gaaaatacct
     2581 aagagacttt taaaaatagg ctttcttata tttgatattt ggaagaaaaa gccgtaaggt
     2641 gtatgtagac cacttaatca ctaaatatct ttgcctatag gactccattg aatacattag
     2701 ccattgataa tctacctgtt taaatggccc ctgtttgaac tctcaagctt tgaagaccta
     2761 cctgttcttc cagaagagaa cgttgaaagt gccatgtttc cttttgcgtg atctctgttg
     2821 atggcactct ggaattgttt cagttaagtc attttagaca tagcatttat tatcactgtg
     2881 gatctctact tgttgggtgt tatgaattct ttgaagaaat atattttgaa gaggtgtggg
     2941 aggaaggaat acattttata aaatgttgta gtgaagccca caattgacct ttgactaata
     3001 ggagttttaa gtatgttaaa aatctatact ggacagttac aagaaattac cggagaaaag
     3061 cttgtgagct caccaaacaa ggatttcagt gtagattttg tctttcttga acttaaagaa
     3121 acaaatgaca aagtttgaat ggaaaagcct gctgttgttc cacatctcgt tgctgtttac
     3181 attcctttgt ggagcctaca tcttcctaag ctttttagca ggtatatgtt gaacacttct
     3241 gtttcatggt tgagacagaa tcagaggcca tggatactga caactgattt gtctgttttt
     3301 tttctctgtc tttttccatg actcttatat actgcctcat cttgatttat aagcaaaacc
     3361 tggaaaacct acaaaataag tgttgtggtt tatctagaaa aatatggaaa atattgctgt
     3421 tatttttggt gaagaaaatc aattttgtat agtttatttc aatctaaata aaatgtgaat
     3481 tttgtttaaa
//
