LOCUS       NM_020457               1876 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens THAP domain containing 11 (THAP11), mRNA.
ACCESSION   NM_020457
VERSION     NM_020457.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1876)
  AUTHORS   Hsiao,C.T., Liao,N.Y., Liao,Y.C. and Lee,Y.C.
  TITLE     THAP11 CAG Repeat Expansion Is Rare or Absent in the Taiwanese
            Cohort with Cerebellar Ataxia
  JOURNAL   Mov Disord 39 (5), 924-925 (2024)
   PUBMED   38757579
  REMARK    GeneRIF: THAP11 CAG Repeat Expansion Is Rare or Absent in the
            Taiwanese Cohort with Cerebellar Ataxia.
REFERENCE   2  (bases 1 to 1876)
  AUTHORS   Liu,A., Liang,J. and Wen,J.
  TITLE     CircNRD1 elevates THAP domain containing 11 through sequestering
            microRNA-421 to inhibit gastric cancer growth and tumorigenesis
  JOURNAL   J Biochem Mol Toxicol 38 (4), e23705 (2024)
   PUBMED   38602237
  REMARK    GeneRIF: CircNRD1 elevates THAP domain containing 11 through
            sequestering microRNA-421 to inhibit gastric cancer growth and
            tumorigenesis.
REFERENCE   3  (bases 1 to 1876)
  AUTHORS   Fearnley,L.G., Rafehi,H., Bennett,M.F. and Bahlo,M.
  TITLE     Exploring THAP11 Repeat Expansion beyond Chinese-Ancestry Cohorts:
            An Examination of 1000 Genomes and UK Biobank Data
  JOURNAL   Mov Disord 38 (12), 2320-2322 (2023)
   PUBMED   38113319
  REMARK    GeneRIF: Exploring THAP11 Repeat Expansion beyond Chinese-Ancestry
            Cohorts: An Examination of 1000 Genomes and UK Biobank Data.
REFERENCE   4  (bases 1 to 1876)
  AUTHORS   Tan,D., Wei,C., Chen,Z., Huang,Y., Deng,J., Li,J., Liu,Y., Bao,X.,
            Xu,J., Hu,Z., Wang,S., Fan,Y., Jiang,Y., Wu,Y., Wu,Y., Wang,S.,
            Liu,P., Zhang,Y., Yang,Z., Jiang,Y., Zhang,H., Hong,D., Zhong,N.,
            Jiang,H. and Xiong,H.
  TITLE     CAG Repeat Expansion in THAP11 Is Associated with a Novel
            Spinocerebellar Ataxia
  JOURNAL   Mov Disord 38 (7), 1282-1293 (2023)
   PUBMED   37148549
  REMARK    GeneRIF: CAG Repeat Expansion in THAP11 Is Associated with a Novel
            Spinocerebellar Ataxia.
REFERENCE   5  (bases 1 to 1876)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1876)
  AUTHORS   DeGrado-Warren,J., Dufford,M., Chen,J., Bartel,P.L., Shattuck,D.
            and Frech,G.C.
  TITLE     Construction and characterization of a normalized yeast two-hybrid
            library derived from a human protein-coding clone collection
  JOURNAL   Biotechniques 44 (2), 265-273 (2008)
   PUBMED   18330356
REFERENCE   7  (bases 1 to 1876)
  AUTHORS   Roussigne,M., Kossida,S., Lavigne,A.C., Clouaire,T., Ecochard,V.,
            Glories,A., Amalric,F. and Girard,J.P.
  TITLE     The THAP domain: a novel protein motif with similarity to the
            DNA-binding domain of P element transposase
  JOURNAL   Trends Biochem Sci 28 (2), 66-69 (2003)
   PUBMED   12575992
REFERENCE   8  (bases 1 to 1876)
  AUTHORS   Ueki,N., Oda,T., Kondo,M., Yano,K., Noguchi,T. and Muramatsu,M.
  TITLE     Selection system for genes encoding nuclear-targeted proteins
  JOURNAL   Nat Biotechnol 16 (13), 1338-1342 (1998)
   PUBMED   9853615
REFERENCE   9  (bases 1 to 1876)
  AUTHORS   Li,S.H., McInnis,M.G., Margolis,R.L., Antonarakis,S.E. and
            Ross,C.A.
  TITLE     Novel triplet repeat containing genes in human brain: cloning,
            expression, and length polymorphisms
  JOURNAL   Genomics 16 (3), 572-579 (1993)
   PUBMED   8325628
REFERENCE   10 (bases 1 to 1876)
  AUTHORS   Sloan,J.L., Carrillo,N., Adams,D. and Venditti,C.P.
  TITLE     Disorders of Intracellular Cobalamin Metabolism
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301503
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ898449.1, BI261822.1 and
            BC012182.1.
            
            On May 17, 2019 this sequence version replaced NM_020457.2.
            
            Summary: The protein encoded by this gene contains a THAP domain,
            which is a conserved DNA-binding domain that has striking
            similarity to the site-specific DNA-binding domain (DBD) of
            Drosophila P element transposases. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC012182.1, SRR1163655.131044.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303596.3/ ENSP00000304689.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                BQ898449.1         11-90
            81-604              BI261822.1         1-524
            605-1876            BC012182.1         574-1845
FEATURES             Location/Qualifiers
     source          1..1876
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..1876
                     /gene="THAP11"
                     /gene_synonym="CTG-B43a; CTG-B45d; HRIHFB2206; MAHCL;
                     RONIN; SCA51"
                     /note="THAP domain containing 11"
                     /db_xref="GeneID:57215"
                     /db_xref="HGNC:HGNC:23194"
                     /db_xref="MIM:609119"
     exon            1..1876
                     /gene="THAP11"
                     /gene_synonym="CTG-B43a; CTG-B45d; HRIHFB2206; MAHCL;
                     RONIN; SCA51"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..1180
                     /gene="THAP11"
                     /gene_synonym="CTG-B43a; CTG-B45d; HRIHFB2206; MAHCL;
                     RONIN; SCA51"
                     /codon_start=1
                     /product="THAP domain-containing protein 11"
                     /protein_id="NP_065190.2"
                     /db_xref="CCDS:CCDS10847.1"
                     /db_xref="GeneID:57215"
                     /db_xref="HGNC:HGNC:23194"
                     /db_xref="MIM:609119"
                     /translation="MPGFTCCVPGCYNNSHRDKALHFYTFPKDAELRRLWLKNVSRAG
                     VSGCFSTFQPTTGHRLCSVHFQGGRKTYTVRVPTIFPLRGVNERKVARRPAGAAAARR
                     RQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSPSASTAQTAQLQPNLVSASAAVLLTL
                     QATVDSSQAPGSVQPAPITPTGEDVKPIDLTVQVEFAAAEGAAAAAAASELQAATAGL
                     EAAECPMGPQLVVVGEEGFPDTGSDHSYSLSSGTTEEELLRKLNEQRDILALMEVKMK
                     EMKGSIRHLRLTEAKLREELREKDRLLAMAVIRKKHGM"
     regulatory      1853..1858
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THAP11"
                     /gene_synonym="CTG-B43a; CTG-B45d; HRIHFB2206; MAHCL;
                     RONIN; SCA51"
                     /note="hexamer: ATTAAA"
     polyA_site      1876
                     /gene="THAP11"
                     /gene_synonym="CTG-B43a; CTG-B45d; HRIHFB2206; MAHCL;
                     RONIN; SCA51"
                     /note="major polyA site"
ORIGIN      
        1 ggggcccact cccgagcgca ggcgggcagc caggcgggcg gcgcggcgcg ggccggcagg
       61 aagcgtattc tgggcacggg gcgccgggcg ggccggctgc gccgagcggc agtggtggga
      121 taccacccaa ggcctcgcgc ggcgccgccc gtcgaggggc gggcggcggc gtagccactg
      181 ggccgtcgaa gagcgcagga ggccggtggg ccgggccggg ccgcgcggcg cagccatgcc
      241 tggctttacg tgctgcgtgc caggctgcta caacaactcg caccgggaca aggcgctgca
      301 cttctacacg tttccaaagg acgctgagtt gcggcgcctc tggctcaaga acgtgtcgcg
      361 tgccggcgtc agtgggtgct tctccacctt ccagcccacc acaggccacc gtctctgcag
      421 cgttcacttc cagggcggcc gcaagaccta cacggtacgc gtccccacca tcttcccgct
      481 gcgcggcgtc aatgagcgca aagtagcgcg cagacccgct ggggccgcgg ccgcccgccg
      541 caggcagcag cagcaacagc agcagcagca gcaacagcag caacagcagc agcagcagca
      601 acagcagcag cagcagcagc agcagcagca gtcctcaccc tctgcctcca ctgcccagac
      661 tgcccagctg cagccgaacc tggtatctgc ttccgcggcc gtgcttctca cccttcaggc
      721 cactgtagac agcagtcagg ctccgggatc cgtacagccg gcgcccatca ctcccactgg
      781 agaagacgtg aagcccatcg atctcacagt gcaagtggag tttgcagccg cagagggcgc
      841 agccgctgcg gccgccgcgt cggagttaca ggctgctacc gcagggctgg aggctgccga
      901 gtgccctatg ggcccccagt tggtggtggt aggggaagag ggcttccctg atactggctc
      961 cgaccattcg tactccttgt cgtcaggcac cacggaggag gagctcctgc gcaagctgaa
     1021 tgagcagcgg gacatcctgg ctctgatgga agtgaagatg aaagagatga aaggcagcat
     1081 tcgccacctg cgtctcactg aggccaagct gcgcgaagaa ctgcgtgaga aggatcggct
     1141 gcttgccatg gctgtcatcc gcaagaagca cggaatgtga actggtgccc cggcagcctg
     1201 ctggactccc agaccccatc cagccagggg accgcaggcc attgttgaac tcctctatac
     1261 tcctgggcac tggttgacag tactgaggct taaggcagct ggactctctt gctggtgacc
     1321 tggcatcctc aattgtttcc tcctgaagtg gaagctgggg ccttagactc tgccctggtg
     1381 acaccagcaa ttatgacttt gtctaccctt cctccccagt tattgttgca gattctggtt
     1441 aagcagaggc ttcagaacca ctgaacttga aacttaccct ctagggatgc aggtgggatg
     1501 tccagggact ataggtttgg gaaaaccata ccttaaggtt ggtcagcagt cagacaactc
     1561 taatgtgtgt agtgataaga gattcaagta acatcagttc tcctcctttt catgcttttc
     1621 cttcccaggt gcagcctgtg attctgatgg ggactggtaa atctgtgcct ctgcctccta
     1681 ggacttattt tcccaggagg ccatttacaa ggggatctgg atgacctgct gatggagatc
     1741 cagcttgcca gggacttagg tttatcctgt tttgtttgct actggttaca aattctattt
     1801 tctgtacaat tagtcagact aaagttttca ctgtgtttgt ttggcaaaac aaattaaaca
     1861 aaaagtaagg ttttta
//
