LOCUS       NM_020147               2047 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens THAP domain containing 10 (THAP10), mRNA.
ACCESSION   NM_020147
VERSION     NM_020147.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2047)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2047)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2047)
  AUTHORS   Li,Y., Ning,Q., Shi,J., Chen,Y., Jiang,M., Gao,L., Huang,W.,
            Jing,Y., Huang,S., Liu,A., Hu,Z., Liu,D., Wang,L., Nervi,C.,
            Dai,Y., Zhang,M.Q. and Yu,L.
  TITLE     A novel epigenetic AML1-ETO/THAP10/miR-383 mini-circuitry
            contributes to t(8;21) leukaemogenesis
  JOURNAL   EMBO Mol Med 9 (7), 933-949 (2017)
   PUBMED   28539478
  REMARK    GeneRIF: Altogether, these results revealed an unexpected and
            important epigenetic mini-circuit of AML1-ETO/THAP10/miR-383 in
            t(8;21) acute myeloid leukaemia, in which epigenetic suppression of
            THAP10 predicts a poor clinical outcome and represents a novel
            therapeutic target.
REFERENCE   4  (bases 1 to 2047)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   5  (bases 1 to 2047)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   6  (bases 1 to 2047)
  AUTHORS   De Souza Santos,E., De Bessa,S.A., Netto,M.M. and Nagai,M.A.
  TITLE     Silencing of LRRC49 and THAP10 genes by bidirectional promoter
            hypermethylation is a frequent event in breast cancer
  JOURNAL   Int J Oncol 33 (1), 25-31 (2008)
   PUBMED   18575747
  REMARK    GeneRIF: transcripts of LRRC49/THAP10 bidirectional gene pair are
            co-regulated by estrogen and that hypermethylation of the
            bidirectional promoter region simultaneously silences both genes.
REFERENCE   7  (bases 1 to 2047)
  AUTHORS   Roussigne,M., Kossida,S., Lavigne,A.C., Clouaire,T., Ecochard,V.,
            Glories,A., Amalric,F. and Girard,J.P.
  TITLE     The THAP domain: a novel protein motif with similarity to the
            DNA-binding domain of P element transposase
  JOURNAL   Trends Biochem Sci 28 (2), 66-69 (2003)
   PUBMED   12575992
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA272000.1, BC027857.1 and
            AC090868.4.
            
            On Nov 22, 2018 this sequence version replaced NM_020147.3.
            
            Summary: This gene encodes a member of a family of proteins sharing
            an N-terminal Thanatos-associated domain. The Thanatos-associated
            domain contains a zinc finger signature similar to DNA-binding
            domains. This gene is part of a bidirectional gene pair on the long
            arm of chromosome 15 that is regulated by estrogen and may play a
            role in breast cancer. [provided by RefSeq, Nov 2010].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072414.1, SRR1660807.211441.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000249861.9/ ENSP00000249861.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                DA272000.1         1-19
            20-1599             BC027857.1         1-1580
            1600-1600           AC090868.4         24147-24147
            1601-2047           BC027857.1         1582-2028
FEATURES             Location/Qualifiers
     source          1..2047
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q23"
     gene            1..2047
                     /gene="THAP10"
                     /note="THAP domain containing 10"
                     /db_xref="GeneID:56906"
                     /db_xref="HGNC:HGNC:23193"
                     /db_xref="MIM:612538"
     exon            1..590
                     /gene="THAP10"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..935
                     /gene="THAP10"
                     /codon_start=1
                     /product="THAP domain-containing protein 10"
                     /protein_id="NP_064532.1"
                     /db_xref="CCDS:CCDS10237.1"
                     /db_xref="GeneID:56906"
                     /db_xref="HGNC:HGNC:23193"
                     /db_xref="MIM:612538"
                     /translation="MPARCVAAHCGNTTKSGKSLFRFPKDRAVRLLWDRFVRGCRADW
                     YGGNDRSVICSDHFAPACFDVSSVIQKNLRFSQRLRLVAGAVPTLHRVPAPAPKRGEE
                     GDQAGRLDTRGELQAARHSEAAPGPVSCTRPRAGKQAAASQITCENELVQTQPHADNP
                     SNTVTSVPTHCEEGPVHKSTQISLKRPRHRSVGIQAKVKAFGKRLCNATTQTEELWSR
                     TSSLFDIYSSDSETDTDWDIKSEQSDLSYMAVQVKEETC"
     exon            591..738
                     /gene="THAP10"
                     /inference="alignment:Splign:2.1.0"
     exon            739..2047
                     /gene="THAP10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1883..1888
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THAP10"
                     /note="hexamer: AATAAA"
     polyA_site      1906
                     /gene="THAP10"
                     /note="major polyA site"
     regulatory      2025..2030
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THAP10"
                     /note="hexamer: AATAAA"
     polyA_site      2047
                     /gene="THAP10"
                     /note="major polyA site"
ORIGIN      
        1 agatcgccac ttccggtgac cagaggtagg gaaggaaaca atcccgaccc ggagtggaca
       61 ggtgaggagg ggaggacttg cctcgccgag gccgctgcga ggagcgtgcc caagggcgaa
      121 ggtccaggga acccggctcc cgcgcaccga agacggccgc catgccggcc cgttgtgtgg
      181 ccgcccactg cggcaacacc accaagtctg ggaagtcgct gttccgcttt cccaaggacc
      241 gggccgtgcg gctgctctgg gaccgcttcg tgcggggttg ccgcgccgac tggtacggag
      301 gcaatgaccg ctcggtcatc tgctctgacc actttgcccc agcctgtttt gacgtctctt
      361 cggttatcca gaagaacctg cgcttctccc agcgcctgag gctggtggca ggcgccgtgc
      421 ccaccctgca ccgggtgccc gccccggcac ctaagagggg agaggaggga gaccaagcag
      481 gccgcctgga cacgcgagga gagctccagg cagccaggca ttctgaggct gccccaggtc
      541 cagtctcctg tacacgcccc cgagctggga agcaggctgc agcttcacag attacgtgtg
      601 aaaatgaact tgtgcaaacc caaccccatg ctgataatcc atctaatact gtcacttcag
      661 tacctactca ctgtgaagaa ggcccagtgc ataaaagtac acaaatttct ttgaaaaggc
      721 cccgtcaccg tagtgtgggt attcaagcca aagtgaaagc gtttggaaaa agactgtgta
      781 atgcaactac tcagacagag gaattgtggt ctagaacttc ctctctcttt gacatttact
      841 ccagtgattc agaaacagat acagactggg atatcaagag tgaacagagt gatttgtctt
      901 atatggctgt acaggtgaaa gaagaaacat gttaaaaact caacatcaaa tgctctgatg
      961 tgctatagat tttcaaatct ttactcacat aattatctct ttgctattgt aaatctttca
     1021 cttcaagata atttgacagt tgagtatcag cataatttgt ttagctctaa ggcaaaagtt
     1081 tgcttgcttg ccaacacaat gaagataata cctacccaca aacatcccta ttctctactt
     1141 tcaccttttt ttttctttta atccttttgg tagaaatcag gttacaaagc aaaaccacaa
     1201 tatcagcaac acttcctaat caaaattaag cattgaatat ttgtttaagc ttagttcaga
     1261 agcaacgctc ctacaggact tgacatttgc tagttagaat atccctactc ttctaaataa
     1321 tttgaaagta tagagcagta acacagtaac agtgagcaca gccaagcctg acactactaa
     1381 atgatttggt agtgaagcca ggacatctac ccttgactat tttttatgtt atttatttat
     1441 tagtttgtcc atttgtaaca tgtatagatc tgtcctgtga gcatttctga tgaatctatg
     1501 gttcttacag aaatttttca aaggaatcaa tttagagata gagttttcat atacttacat
     1561 taacttatta atgaaatctg tttgcatcag tgcttactgc gacacattaa ttagcttgat
     1621 taatttagat tagaatcatt aacatcatga aaaataaaag tactacattt ctaacgtatt
     1681 cccattgcag gtgttaggta ttttttctgt caacacctct cttttgaatt ctacatttga
     1741 gaaataagca tggaaatatt agctgccccg tctgccattc accaggaaaa atttctatgg
     1801 caattttgta ccatgaagta aactgttaca atagtttctg agaagcatac tataactctg
     1861 atcttccatt gagaataaca aaaataaata tcaattttac acctcatatg tcttcttagt
     1921 tctgaatgat tagaagaact tgcatgtatt tttatcctag aaggtttaaa taatacatca
     1981 aagttatttt cttccaaatg taattttatg tctgctttaa ggaaaataaa ataaaatatt
     2041 aatagga
//
