LOCUS       NM_022065               6091 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens THADA armadillo repeat containing (THADA), transcript
            variant 1, mRNA.
ACCESSION   NM_022065
VERSION     NM_022065.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6091)
  AUTHORS   Katoh,M., Fujii,T., Tabuchi,Y., Shimizu,T. and Sakai,H.
  TITLE     Negative regulation of thyroid adenoma-associated protein (THADA)
            in the cardiac glycoside-induced anti-cancer effect
  JOURNAL   J Physiol Sci 74 (1), 23 (2024)
   PUBMED   38561668
  REMARK    GeneRIF: Negative regulation of thyroid adenoma-associated protein
            (THADA) in the cardiac glycoside-induced anti-cancer effect.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6091)
  AUTHORS   Ustianowski,P., Malinowski,D., Czerewaty,M., Safranow,K.,
            Tarnowski,M., Dziedziejko,V. and Pawlik,A.
  TITLE     THADA, SDHAF4, and MACF1 Gene Polymorphisms and Placental
            Expression in Women with Gestational Diabetes
  JOURNAL   Genes (Basel) 14 (1), 83 (2022)
   PUBMED   36672824
  REMARK    GeneRIF: THADA, SDHAF4, and MACF1 Gene Polymorphisms and Placental
            Expression in Women with Gestational Diabetes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6091)
  AUTHORS   Funk,H.M., DiVita,D.J., Sizemore,H.E., Wehrle,K., Miller,C.L.W.,
            Fraley,M.E., Mullins,A.K., Guy,A.R., Phizicky,E.M. and Guy,M.P.
  TITLE     Identification of a Trm732 Motif Required for 2'-O-methylation of
            the tRNA Anticodon Loop by Trm7
  JOURNAL   ACS Omega 7 (16), 13667-13675 (2022)
   PUBMED   35559166
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6091)
  AUTHORS   Dadachanji,R., Sawant,D., Patil,A. and Mukherjee,S.
  TITLE     Replication study of THADA rs13429458 variant with PCOS
            susceptibility and its related traits in Indian women
  JOURNAL   Gynecol Endocrinol 37 (8), 716-720 (2021)
   PUBMED   33779462
  REMARK    GeneRIF: Replication study of THADA rs13429458 variant with PCOS
            susceptibility and its related traits in Indian women.
REFERENCE   5  (bases 1 to 6091)
  AUTHORS   Morariu,E.M., McCoy,K.L., Chiosea,S.I., Nikitski,A.V., Manroa,P.,
            Nikiforova,M.N. and Nikiforov,Y.E.
  TITLE     Clinicopathologic Characteristics of Thyroid Nodules Positive for
            the THADA-IGF2BP3 Fusion on Preoperative Molecular Analysis
  JOURNAL   Thyroid 31 (8), 1212-1218 (2021)
   PUBMED   33487086
  REMARK    GeneRIF: Clinicopathologic Characteristics of Thyroid Nodules
            Positive for the THADA-IGF2BP3 Fusion on Preoperative Molecular
            Analysis.
REFERENCE   6  (bases 1 to 6091)
  AUTHORS   Grarup,N., Andersen,G., Krarup,N.T., Albrechtsen,A., Schmitz,O.,
            Jorgensen,T., Borch-Johnsen,K., Hansen,T. and Pedersen,O.
  TITLE     Association testing of novel type 2 diabetes risk alleles in the
            JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with
            insulin release, insulin sensitivity, and obesity in a
            population-based sample of 4,516 glucose-tolerant middle-aged Danes
  JOURNAL   Diabetes 57 (9), 2534-2540 (2008)
   PUBMED   18567820
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 6091)
  AUTHORS   Zeggini,E., Scott,L.J., Saxena,R., Voight,B.F., Marchini,J.L.,
            Hu,T., de Bakker,P.I., Abecasis,G.R., Almgren,P., Andersen,G.,
            Ardlie,K., Bostrom,K.B., Bergman,R.N., Bonnycastle,L.L.,
            Borch-Johnsen,K., Burtt,N.P., Chen,H., Chines,P.S., Daly,M.J.,
            Deodhar,P., Ding,C.J., Doney,A.S., Duren,W.L., Elliott,K.S.,
            Erdos,M.R., Frayling,T.M., Freathy,R.M., Gianniny,L., Grallert,H.,
            Grarup,N., Groves,C.J., Guiducci,C., Hansen,T., Herder,C.,
            Hitman,G.A., Hughes,T.E., Isomaa,B., Jackson,A.U., Jorgensen,T.,
            Kong,A., Kubalanza,K., Kuruvilla,F.G., Kuusisto,J., Langenberg,C.,
            Lango,H., Lauritzen,T., Li,Y., Lindgren,C.M., Lyssenko,V.,
            Marvelle,A.F., Meisinger,C., Midthjell,K., Mohlke,K.L.,
            Morken,M.A., Morris,A.D., Narisu,N., Nilsson,P., Owen,K.R.,
            Palmer,C.N., Payne,F., Perry,J.R., Pettersen,E., Platou,C.,
            Prokopenko,I., Qi,L., Qin,L., Rayner,N.W., Rees,M., Roix,J.J.,
            Sandbaek,A., Shields,B., Sjogren,M., Steinthorsdottir,V.,
            Stringham,H.M., Swift,A.J., Thorleifsson,G., Thorsteinsdottir,U.,
            Timpson,N.J., Tuomi,T., Tuomilehto,J., Walker,M., Watanabe,R.M.,
            Weedon,M.N., Willer,C.J., Illig,T., Hveem,K., Hu,F.B., Laakso,M.,
            Stefansson,K., Pedersen,O., Wareham,N.J., Barroso,I.,
            Hattersley,A.T., Collins,F.S., Groop,L., McCarthy,M.I., Boehnke,M.
            and Altshuler,D.
  CONSRTM   Wellcome Trust Case Control Consortium
  TITLE     Meta-analysis of genome-wide association data and large-scale
            replication identifies additional susceptibility loci for type 2
            diabetes
  JOURNAL   Nat Genet 40 (5), 638-645 (2008)
   PUBMED   18372903
  REMARK    GeneRIF: Meta-analysis and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   8  (bases 1 to 6091)
  AUTHORS   Drieschner,N., Belge,G., Rippe,V., Meiboom,M., Loeschke,S. and
            Bullerdiek,J.
  TITLE     Evidence for a 3p25 breakpoint hot spot region in thyroid tumors of
            follicular origin
  JOURNAL   Thyroid 16 (11), 1091-1096 (2006)
   PUBMED   17123335
  REMARK    GeneRIF: intronic sequence of PPAR(gamma) is fused to exon 28 of
            THADA in thyroid tumors of follicular origin including carcinomas
            as well as adenomas
REFERENCE   9  (bases 1 to 6091)
  AUTHORS   Rippe,V., Drieschner,N., Meiboom,M., Murua Escobar,H., Bonk,U.,
            Belge,G. and Bullerdiek,J.
  TITLE     Identification of a gene rearranged by 2p21 aberrations in thyroid
            adenomas
  JOURNAL   Oncogene 22 (38), 6111-6114 (2003)
   PUBMED   12955091
  REMARK    GeneRIF: identification of the target gene of 2p21 aberrations in
            thyroid adenomas tentatively referred to as thyroid
            adenoma-associated gene (THADA); gene spans roughly 365 kbp; based
            on preliminary results, it encodes a death receptor-interacting
            protein [THADA]
REFERENCE   10 (bases 1 to 6091)
  AUTHORS   Bol,S., Belge,G., Rippe,V. and Bullerdiek,J.
  TITLE     Molecular cytogenetic investigations define a subgroup of thyroid
            adenomas with 2p21 breakpoints clustered to a region of less than
            450 kb
  JOURNAL   Cytogenet Cell Genet 95 (3-4), 189-191 (2001)
   PUBMED   12063398
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY149629.1 and BC025773.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 13, 2020 this sequence version replaced NM_022065.4.
            
            Summary: This gene is the target of 2p21 choromosomal aberrations
            in benign thyroid adenomas. Single nucleotide polymorphisms (SNPs)
            in this gene may be associated with type 2 diabetes and polycystic
            ovary syndrome. The encoded protein is likely involved in the death
            receptor pathway and apoptosis. [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). Variants 1, 2 and 8 encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY149629.1, BX648155.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000405975.7/ ENSP00000386088.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6090              AY149629.1         1-6090
            6091-6091           BC025773.1         2312-2312
FEATURES             Location/Qualifiers
     source          1..6091
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p21"
     gene            1..6091
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /note="THADA armadillo repeat containing"
                     /db_xref="GeneID:63892"
                     /db_xref="HGNC:HGNC:19217"
                     /db_xref="MIM:611800"
     exon            1..108
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            109..208
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..5994
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /note="isoform a is encoded by transcript variant 1;
                     thyroid adenoma-associated protein; death
                     receptor-interacting protein; gene inducing thyroid
                     adenomas protein; Trm732 homolog; tRNA
                     (32-2'-O)-methyltransferase regulator THADA"
                     /codon_start=1
                     /product="tRNA (32-2'-O)-methyltransferase regulator THADA
                     isoform a"
                     /protein_id="NP_071348.3"
                     /db_xref="CCDS:CCDS46268.1"
                     /db_xref="GeneID:63892"
                     /db_xref="HGNC:HGNC:19217"
                     /db_xref="MIM:611800"
                     /translation="MGVKKKKEMQVAALTICHQDLETLKSFADVEGKNLASLLLHCVQ
                     LTDGVSQIHYIKQIVPLLEKADKNGMCDPTIQSCLDILAGIYLSLSLKNPLKKVLASS
                     LNSLPDFFLPEAMHRFTSRLQEELNTTDLYSYRKVTDNISSCMENFNLGRASVNNLLK
                     NVLHFLQKSLIEILEENRKCAGNHIIQTQLMNDLLVGIRVSMMLVQKVQDFQGNLWKT
                     SDSPIWQNMCGLLSIFTKVLSDDDLLQTVQSTSGLAIILFIKTMFHPSEKIPHLISSV
                     LLRSVDCTSVPEWFMSSCRSLCCGDISQSAVLFLCQGTLAMLDWQNGSMGRSGEALLL
                     DTAHVLFTLSSQIKEPTLEMFLSRILASWTNSAIQVLESSSPSLTDSLNGNSSIVGRL
                     LEYVYTHWEHPLDALRHQTKIMFKNLLQMHRLTVEGADFVPDPFFVELTESLLRLEWH
                     IKGKYTCLGCLVECIGVEHILAIDKTIPSQILEVMGDQSLVPYASDLLETMFRNHKSH
                     LKSQTAESSWIDQWHETWVSPLLFILCEGNLDQKSYVIDYYLPKLLSYSPESLQYMVK
                     ILQTSIDAKTGQEQSFPSLGSCNSRGALGALMACLRIARAHGHLQSATDTWENLVSDA
                     RIKQGLIHQHCQVRIDTLGLLCESNRSTEIVSMEEMQWIQFFITYNLNSQSPGVRQQI
                     CSLLKKLFCRIQESSQVLYKLEQSKSKREPENELTKQHPSVSLQQYKNFMSSICNSLF
                     EALFPGSSYSTRFSALTILGSIAEVFHVPEGRIYTVYQLSHDIDVGRFQTLMECFTST
                     FEDVKILAFDLLMKLSKTAVHFQDSGKLQGLFQAALELSTSTKPYDCVTASYLLNFLI
                     WQDALPSSLSAYLTQQVACDNGDRPAAVVERNTLMVIKCLMENLEEEVSQAENSLLQA
                     AAAFPMYGRVHCITGALQKLSLNSLQLVSEWRPVVEKLLLMSYRLSTVVSPVIQSSSP
                     EGLIPMDTDSESASRLQMILNEIQPRDTNDYFNQAKILKEHDSFDMKDLNASVVNIDT
                     STEIKGKEVKTCDVTAQMVLVCCWRSMKEVALLLGMLCQLLPMQPVPESSDGLLTVEQ
                     VKEIGDYFKQHLLQSRHRGAFELAYTGFVKLTEVLNRCPNVSLQKLPEQWLWSVLEEI
                     KCSDPSSKLCATRRSAGIPFYIQALLASEPKKGRMDLLKITMKELISLAGPTDDIQST
                     VPQVHALNILRALFRDTRLGENIIPYVADGAKAAILGFTSPVWAVRNSSTLLFSALIT
                     RIFGVKRAKDEHSKTNRMTGREFFSRFPELYPFLLKQLETVANTVDSDMGEPNRHPSM
                     FLLLLVLERLYASPMDGTSSALSMGPFVPFIMRCGHSPVYHSREMAARALVPFVMIDH
                     IPNTIRTLLSTLPSCTDQCFRQNHIHGTLLQVFHLLQAYSDSKHGTNSDFQHELTDIT
                     VCTKAKLWLAKRQNPCLVTRAVYIDILFLLTCCLNRSAKDNQPVLESLGFWEEVRGII
                     SGSELITGFPWAFKVPGLPQYLQSLTRLAIAAVWAAAAKSGERETNVPISFSQLLESA
                     FPEVRSLTLEALLEKFLAAASGLGEKGVPPLLCNMGEKFLLLAMKENHPECFCKILKI
                     LHCMDPGEWLPQTEHCVHLTPKEFLIWTMDIASNERSEIQSVALRLASKVISHHMQTC
                     VENRELIAAELKQWVQLVILSCEDHLPTESRLAVVEVLTSTTPLFLTNPHPILELQDT
                     LALWKCVLTLLQSEEQAVRDAATETVTTAMSQENTCQSTEFAFCQVDASIALALALAV
                     LCDLLQQWDQLAPGLPILLGWLLGESDDLVACVESMHQVEEDYLFEKAEVNFWAETLI
                     FVKYLCKHLFCLLSKSGWRPPSPEMLCHLQRMVSEQCHLLSQFFRELPPAAEFVKTVE
                     FTRLRIQEERTLACLRLLAFLEGKEGEDTLVLSVWDSYAESRQLTLPRTEAAC"
     exon            209..303
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            304..434
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            435..583
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            584..616
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            617..665
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            666..853
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            854..948
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1169
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1861
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..2040
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2196
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2319
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2443
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2595
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            2596..2806
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            2807..2942
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..3079
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            3080..3238
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            3239..3396
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            3397..3506
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            3507..3639
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            3640..3753
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            3754..3876
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            3877..3968
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            3969..4058
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            4059..4190
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            4191..4359
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            4360..4475
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            4476..4570
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            4571..4950
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            4951..5069
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            5070..5142
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            5143..5296
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            5297..5428
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            5429..5598
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     exon            5599..6091
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6068..6073
                     /regulatory_class="polyA_signal_sequence"
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /note="hexamer: CATAAA"
     polyA_site      6091
                     /gene="THADA"
                     /gene_synonym="ARMC13; GITA; Trm732"
                     /note="major polyA site"
ORIGIN      
        1 agtcgaccgt ggaccgcgct gcgagcctcg gagacgccgt agaaggagac ctgcttccgg
       61 gactggacca ggcgcctgcg actcttctca gacgccgacg tgcacgagtg actactatta
      121 attctattta aaatgggtgt aaagaagaag aaagaaatgc aagttgctgc gctgaccatt
      181 tgccatcagg accttgaaac tttgaaatct tttgctgatg tggaagggaa aaatctagct
      241 tctttgctgt tacattgtgt gcaactcacg gatggagtgt cacaaatcca ttatattaaa
      301 cagattgtgc ctctgctgga gaaagcagat aaaaatggca tgtgtgatcc cactattcaa
      361 agttgtttgg atatcttagc aggcatttat ctttctttga gtctaaagaa tcccttgaag
      421 aaagtattgg caagctcact aaatagcctg cctgattttt ttctacctga ggctatgcac
      481 cgttttactt ctcgtcttca ggaagaattg aatactactg acttatactc ttacaggaaa
      541 gttactgaca atatttcttc ctgtatggag aactttaact tgggtagagc aagtgttaat
      601 aatctgctta aaaatgtgct tcattttctg cagaagagtt taattgaaat cctggaagaa
      661 aatagaaaat gtgctggaaa tcatattatt caaacacagt tgatgaatga cttactggta
      721 ggcattagag tttcaatgat gttagtacag aaagtacaag atttccaggg aaatctttgg
      781 aagacttccg attctcccat atggcaaaat atgtgtggat tgctgagtat ttttaccaag
      841 gttttaagcg atgatgatct gttacagact gtacagagca catctggatt agctattatt
      901 ctttttatta agactatgtt tcacccgtct gaaaagattc ctcatttgat tagcagtgtg
      961 ctgcttcgtt cagtggactg caccagtgtc cccgagtggt ttatgagcag ctgcaggagc
     1021 ctctgttgtg gtgacatctc tcagtcagct gtcttattcc tctgtcaggg gacacttgcc
     1081 atgttggact ggcagaacgg aagcatgggt cggagtgggg aggccctgct cttggatact
     1141 gcacatgttt tgttcacctt gagttcacag attaaagagc caacgctgga aatgtttctg
     1201 tctagaatct tagcatcctg gactaattca gccatacaag tccttgaatc aagttccccg
     1261 agcctaacgg acagcctgaa tgggaattca agtatagttg ggagactttt ggaatatgtc
     1321 tatacccatt gggaacatcc attggatgct ctgagacacc aaaccaaaat catgttcaaa
     1381 aaccttctcc aaatgcaccg gctcactgtg gaaggtgcag atttcgtccc tgatcctttc
     1441 tttgtggaat tgactgagag tcttttacga ttggaatggc atattaaagg aaagtacacg
     1501 tgccttggtt gtttggtaga gtgcatagga gttgaacata ttttggctat agataaaact
     1561 attccatctc aaatcttaga ggtgatggga gaccagtcat tggtacctta tgcaagtgac
     1621 ctcttggaaa ccatgtttag aaatcataag agtcatttga aatcccagac tgctgagagt
     1681 tcttggattg accagtggca tgagacttgg gtttctcctc tcctttttat attgtgtgaa
     1741 ggaaacttgg atcaaaaatc ttacgtgatt gattattact tgccaaaatt attaagttac
     1801 agccctgaaa gcttacagta catggtaaag attcttcaga cttctattga tgctaaaact
     1861 ggacaagagc aatctttccc atccttaggg tcttgtaata gcaggggggc tctgggagct
     1921 ttgatggcat gtctgcgaat agctagagct catggacatc ttcagtctgc aactgatacc
     1981 tgggagaacc tcgtgtctga tgcaagaata aagcaaggct taattcatca gcattgccaa
     2041 gtaaggatag atacattagg cttgctttgt gaaagtaatc ggagcacaga aattgtttcc
     2101 atggaagaaa tgcagtggat tcagttcttt attacataca atcttaacag ccagtctcca
     2161 ggagtgcggc aacagatctg ttctcttctt aaaaagttgt tttgtaggat acaggaaagt
     2221 tctcaggtac tttataaatt ggagcagagt aaatccaaac gtgaaccaga gaatgagtta
     2281 accaaacagc acccttctgt ttctttacag cagtataaga atttcatgtc atccatttgt
     2341 aacagtcttt ttgaagcatt gtttcctgga tcttcctact cgactagatt ttcagcttta
     2401 accattttag gttcaatagc tgaagttttt catgtcccag aaggcagaat ttatacagta
     2461 tatcagctga gtcatgatat tgatgttggt cgtttccaaa cactaatgga atgttttacc
     2521 agcacttttg aagacgtgaa aattttagca tttgatcttc tgatgaagtt atcaaaaaca
     2581 gctgtacatt ttcaggattc ggggaaactg caaggcttat ttcaggcagc attggagctc
     2641 agcacaagca ccaaaccata cgactgtgtg acagcttcct acctgctgaa cttcttaatc
     2701 tggcaggatg ctctaccgtc atccttgtct gcctacttaa ctcagcaagt tgcatgtgat
     2761 aatggagata ggcctgctgc tgtggtggaa aggaacacat taatggttat caaatgcttg
     2821 atggaaaatc ttgaggaaga agtatctcag gctgaaaatt ctctgcttca ggcagcagca
     2881 gcatttccaa tgtatgggcg agtccactgt ataacaggag ctttgcagaa gttatctcta
     2941 aacagcctgc agttggtgag cgagtggaga cctgtggtag agaagctcct tttgatgtcc
     3001 tacaggcttt ccactgtggt gtctccagtc attcagagct catcccctga aggcctcatc
     3061 ccaatggaca ctgattcaga gtcagcaagc cgcttacaga tgattctgaa tgagattcag
     3121 cctcgagata ctaatgatta ttttaaccaa gccaaaatat tgaaagaaca tgatagcttt
     3181 gatatgaagg acttgaatgc tagtgtggtg aatattgata cttctacaga aatcaaaggt
     3241 aaagaagtaa aaacatgtga tgtaactgcg cagatggtgc tggtatgttg ttggagaagt
     3301 atgaaggaag ttgctttact tttaggcatg ttgtgccagc ttctgcccat gcagcctgtg
     3361 ccagaatctt ctgatggatt attgacggtg gagcaggtaa aagaaatagg agattacttt
     3421 aaacaacacc ttttgcagtc caggcacaga ggagcatttg aattggctta tactggtttt
     3481 gtgaaactca ctgaagtact aaacaggtgc ccaaatgtga gtctgcaaaa gctgccagaa
     3541 cagtggctat ggagtgtttt agaggaaatt aaatgcagtg atccttcatc taaactctgt
     3601 gctacaaggc gcagtgctgg aattcctttc tacatacagg cactgttggc atctgaacca
     3661 aagaaaggca gaatggattt gttgaaaata acaatgaaag agttaatctc tttggctggg
     3721 cctacagatg acatacagag tacagtcccc caggttcatg ctttaaatat ccttagagca
     3781 ttgttcagag atacgcgcct gggagaaaat attattcctt atgttgctga tggagctaag
     3841 gctgcaattc tgggttttac atcaccggtc tgggcagtgc gaaattcatc cacacttctc
     3901 tttagtgcct tgatcacaag aatttttgga gttaaaaggg caaaggatga acattccaaa
     3961 acaaatagaa tgacagggag agagtttttc tctcgtttcc cagaactcta tccttttctt
     4021 ctcaaacagt tggaaactgt agccaataca gtagacagtg atatgggaga accaaatcgt
     4081 catccaagca tgtttctctt acttttggtg ttggagagac tctacgcttc cccgatggat
     4141 ggtacttctt ctgctctcag catgggacct tttgttccct tcattatgag gtgtggtcac
     4201 tcacctgtct accactcccg tgaaatggca gctcgtgcct tggtcccatt tgttatgata
     4261 gatcacattc ctaataccat tcgaactctg ttgtccacac tccccagctg cactgaccag
     4321 tgtttccggc aaaaccacat tcatgggaca cttctccagg tttttcattt gttgcaagcc
     4381 tactcagact ccaaacacgg aacgaattca gacttccagc acgagctgac tgacatcact
     4441 gtttgtacca aagccaaact ctggctggcc aagaggcaaa atccatgttt ggtgaccaga
     4501 gctgtatata ttgatattct cttcctattg acttgctgcc tcaacagatc tgcaaaggac
     4561 aaccagccag ttctggagag tcttggcttc tgggaggaag tcagagggat tatctcagga
     4621 tcagagctga taacgggatt cccttgggcc ttcaaggtgc caggcctgcc ccagtacctc
     4681 cagagcctca ccagactagc cattgctgca gtgtgggccg cggcagccaa gagtggagag
     4741 cgggagacga atgtccccat ctctttctct cagctgttag aatctgcctt ccctgaagtg
     4801 cgctcactaa cactggaagc cctcttggaa aagttcttag cagcagcctc tggacttgga
     4861 gagaagggcg tgccaccctt gctgtgcaac atgggagaga agttcttatt gttggccatg
     4921 aaggaaaatc acccagaatg cttctgcaag atactgaaaa ttctccactg catggaccct
     4981 ggtgagtggc ttccccagac ggagcactgt gtccatctga ccccaaagga gttcttgatc
     5041 tggacgatgg atattgcttc caatgaaaga tctgaaattc agagtgtagc tctgagactt
     5101 gcttccaaag tcatttccca ccacatgcag acatgtgtgg agaacaggga attgatagct
     5161 gctgagctga agcagtgggt tcagctggtc atcttgtcat gtgaagacca tcttcctaca
     5221 gagtctaggc tggccgtcgt tgaagtcctc accagtacta caccactttt cctcaccaac
     5281 ccccatccta ttcttgagtt gcaggataca cttgctctct ggaagtgtgt ccttaccctt
     5341 ctgcagagtg aggagcaagc tgttagagat gcagccacgg aaaccgtgac aactgccatg
     5401 tcacaagaaa atacctgcca gtcaacagag tttgccttct gccaggtgga tgcctccatc
     5461 gctctggccc tggccctggc cgtcctgtgt gatctgctcc agcagtggga ccagttggcc
     5521 cctggactgc ccatcctgct gggatggctg ttgggagaga gtgatgacct cgtggcctgt
     5581 gtggagagca tgcatcaggt ggaagaagac tacctgtttg aaaaagcaga agtcaacttt
     5641 tgggccgaga ccctgatctt tgtgaaatac ctctgcaagc acctcttctg tctcctctca
     5701 aagtccggct ggcgtccccc aagccctgag atgctctgtc accttcaaag gatggtgtca
     5761 gagcagtgcc acctcctgtc tcagttcttc agagagcttc caccagctgc tgagtttgtg
     5821 aagacagtgg agttcacaag actacgcatt caagaggaaa ggactttggc ttgcttgagg
     5881 ctgctggcct ttttggaagg aaaggaaggg gaagacaccc tagttctcag tgtttgggac
     5941 tcttatgcag aatcgaggca gttaactctt ccaagaacag aagcggcatg ttgaagaaaa
     6001 tctgggggat tgggatgggg gtatgtgtgg atttttcctc cactaaatct gcaggaaaca
     6061 tgttgaacat aaattcaaaa attttatccc a
//
