LOCUS       NM_006464               6050 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens trans-golgi network protein 2 (TGOLN2), transcript
            variant 1, mRNA.
ACCESSION   NM_006464
VERSION     NM_006464.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6050)
  AUTHORS   Gerashchenko,T., Skitchenko,R., Korobeynikova,A., Kuanysheva,K.,
            Khozyainova,A., Vorobiev,R., Rodionov,E., Miller,S.,
            Topolnitsky,E., Shefer,N., Anisimenko,M., Zhuikova,L., Vashisth,M.,
            Pankova,O., Perelmuter,V., Rezapova,V., Artomov,M. and Denisov,E.
  TITLE     Whole-exome sequencing reveals an association of rs112065068 in
            TGOLN2 gene with distant metastasis of non-small cell lung cancer
  JOURNAL   Gene 920, 148507 (2024)
   PUBMED   38670394
  REMARK    GeneRIF: Whole-exome sequencing reveals an association of
            rs112065068 in TGOLN2 gene with distant metastasis of non-small
            cell lung cancer.
REFERENCE   2  (bases 1 to 6050)
  AUTHORS   Lujan,P., Garcia-Cabau,C., Wakana,Y., Vera Lillo,J.,
            Rodilla-Ramirez,C., Sugiura,H., Malhotra,V., Salvatella,X.,
            Garcia-Parajo,M.F. and Campelo,F.
  TITLE     Sorting of secretory proteins at the trans-Golgi network by human
            TGN46
  JOURNAL   Elife 12, 91708 (2024)
   PUBMED   38466628
  REMARK    GeneRIF: Sorting of secretory proteins at the trans-Golgi network
            by human TGN46.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6050)
  AUTHORS   Liang,X.H., Nichols,J.G., De Hoyos,C.L., Sun,H., Zhang,L. and
            Crooke,S.T.
  TITLE     Golgi-58K can re-localize to late endosomes upon cellular uptake of
            PS-ASOs and facilitates endosomal release of ASOs
  JOURNAL   Nucleic Acids Res 49 (14), 8277-8293 (2021)
   PUBMED   34244781
  REMARK    GeneRIF: Golgi-58K can re-localize to late endosomes upon cellular
            uptake of PS-ASOs and facilitates endosomal release of ASOs.
REFERENCE   4  (bases 1 to 6050)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 6050)
  AUTHORS   Yeaman,C., Ayala,M.I., Wright,J.R., Bard,F., Bossard,C., Ang,A.,
            Maeda,Y., Seufferlein,T., Mellman,I., Nelson,W.J. and Malhotra,V.
  TITLE     Protein kinase D regulates basolateral membrane protein exit from
            trans-Golgi network
  JOURNAL   Nat Cell Biol 6 (2), 106-112 (2004)
   PUBMED   14743217
REFERENCE   6  (bases 1 to 6050)
  AUTHORS   Wang,J. and Howell,K.E.
  TITLE     The luminal domain of TGN38 interacts with integrin beta 1 and is
            involved in its trafficking
  JOURNAL   Traffic 1 (9), 713-723 (2000)
   PUBMED   11208159
REFERENCE   7  (bases 1 to 6050)
  AUTHORS   Stephens,D.J. and Banting,G.
  TITLE     Direct interaction of the trans-Golgi network membrane protein,
            TGN38, with the F-actin binding protein, neurabin
  JOURNAL   J Biol Chem 274 (42), 30080-30086 (1999)
   PUBMED   10514494
REFERENCE   8  (bases 1 to 6050)
  AUTHORS   Stephens,D.J. and Banting,G.
  TITLE     Specificity of interaction between adaptor-complex medium chains
            and the tyrosine-based sorting motifs of TGN38 and lgp120
  JOURNAL   Biochem J 335 (Pt 3) (Pt 3), 567-572 (1998)
   PUBMED   9794796
REFERENCE   9  (bases 1 to 6050)
  AUTHORS   Kain,R., Angata,K., Kerjaschki,D. and Fukuda,M.
  TITLE     Molecular cloning and expression of a novel human trans-Golgi
            network glycoprotein, TGN51, that contains multiple
            tyrosine-containing motifs
  JOURNAL   J Biol Chem 273 (2), 981-988 (1998)
   PUBMED   9422759
REFERENCE   10 (bases 1 to 6050)
  AUTHORS   Ponnambalam,S., Girotti,M., Yaspo,M.L., Owen,C.E., Perry,A.C.,
            Suganuma,T., Nilsson,T., Fried,M., Banting,G. and Warren,G.
  TITLE     Primate homologues of rat TGN38: primary structure, expression and
            functional implications
  JOURNAL   J Cell Sci 109 (Pt 3), 675-685 (1996)
   PUBMED   8907712
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL710137.1, BC008461.1,
            AC093162.5 and AA723637.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006464.3.
            
            Summary: This gene encodes a type I integral membrane protein that
            is localized to the trans-Golgi network, a major sorting station
            for secretory and membrane proteins. The encoded protein cycles
            between early endosomes and the trans-Golgi network, and may play a
            role in exocytic vesicle formation. Alternatively spliced
            transcript variants encoding multiple isoforms have been observed
            for this gene. [provided by RefSeq, Oct 2011].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.41145.1,
                                           SRR1803617.1762.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377386.8/ ENSP00000366603.3
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-337               AL710137.1         297-633
            338-1460            BC008461.1         338-1460
            1461-5889           AC093162.5         57735-62163         c
            5890-6050           AA723637.1         17-177              c
FEATURES             Location/Qualifiers
     source          1..6050
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p11.2"
     gene            1..6050
                     /gene="TGOLN2"
                     /gene_synonym="hTGN46; hTGN48; hTGN51; TGN38; TGN46;
                     TGN48; TGN51; TTGN2"
                     /note="trans-golgi network protein 2"
                     /db_xref="GeneID:10618"
                     /db_xref="HGNC:HGNC:15450"
                     /db_xref="MIM:603062"
     exon            1..73
                     /gene="TGOLN2"
                     /gene_synonym="hTGN46; hTGN48; hTGN51; TGN38; TGN46;
                     TGN48; TGN51; TTGN2"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1341
                     /gene="TGOLN2"
                     /gene_synonym="hTGN46; hTGN48; hTGN51; TGN38; TGN46;
                     TGN48; TGN51; TTGN2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; trans-Golgi network integral membrane protein
                     2; TGN38 homolog; trans-Golgi network protein TGN51;
                     trans-Golgi network glycoprotein 46; trans-Golgi network
                     glycoprotein 48; trans-Golgi network glycoprotein 51"
                     /codon_start=1
                     /product="trans-Golgi network integral membrane protein 2
                     isoform 1 precursor"
                     /protein_id="NP_006455.2"
                     /db_xref="CCDS:CCDS46351.1"
                     /db_xref="GeneID:10618"
                     /db_xref="HGNC:HGNC:15450"
                     /db_xref="MIM:603062"
                     /translation="MRFVVALVLLNVAAAGAVPLLATESVKQEEAGVRPSAGNVSTHP
                     SLSQRPGGSTKSHPEPQTPKDSPSKSSAEAQTPEDTPNKSGAEAKTQKDSSNKSGAEA
                     KTQKGSTSKSGSEAQTTKDSTSKSHPELQTPKDSTGKSGAEAQTPEDSPNRSGAEAKT
                     QKDSPSKSGSEAQTTKDVPNKSGADGQTPKDGSSKSGAEDQTPKDVPNKSGAEKQTPK
                     DGSNKSGAEEQGPIDGPSKSGAEEQTSKDSPNKVVPEQPSRKDHSKPISNPSDNKELP
                     KADTNQLADKGKLSPHAFKTESGEETDLISPPQEEVKSSEPTEDVEPKEAEDDDTGPE
                     EGSPPKEEKEKMSGSASSENREGTLSDSTGSEKDDLYPNGSGNGSAESSHFFAYLVTA
                     AILVAVLYIAHHNKRKIIAFVLEGKRSKVTRRPKASDYQRLDQKS"
     exon            74..1251
                     /gene="TGOLN2"
                     /gene_synonym="hTGN46; hTGN48; hTGN51; TGN38; TGN46;
                     TGN48; TGN51; TTGN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1335
                     /gene="TGOLN2"
                     /gene_synonym="hTGN46; hTGN48; hTGN51; TGN38; TGN46;
                     TGN48; TGN51; TTGN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..6050
                     /gene="TGOLN2"
                     /gene_synonym="hTGN46; hTGN48; hTGN51; TGN38; TGN46;
                     TGN48; TGN51; TTGN2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6026..6031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGOLN2"
                     /gene_synonym="hTGN46; hTGN48; hTGN51; TGN38; TGN46;
                     TGN48; TGN51; TTGN2"
                     /note="hexamer: AATAAA"
     polyA_site      6050
                     /gene="TGOLN2"
                     /gene_synonym="hTGN46; hTGN48; hTGN51; TGN38; TGN46;
                     TGN48; TGN51; TTGN2"
                     /note="major polyA site"
ORIGIN      
        1 agagggcgga agcgctatcc gagcaggatg cggttcgtgg ttgccttggt cctcctgaac
       61 gtcgcagcgg cgggagccgt gccgctcttg gccaccgaaa gcgtcaagca agaagaagct
      121 ggagtacggc cttctgcagg aaacgtctcc acccacccca gcttgagcca acggcctgga
      181 ggctctacca agtcgcatcc ggagccgcag actccaaaag acagccctag caagtcgagt
      241 gcggaggcgc agaccccaga agacaccccc aacaagtcgg gtgcggaggc aaagacccaa
      301 aaagacagct ccaacaagtc gggtgcggag gcaaagaccc aaaaaggcag cactagcaag
      361 tcgggttcgg aggcgcagac cacaaaagac agcactagta agtcgcatcc ggagctgcag
      421 actccaaaag acagcactgg caaatcgggt gcggaggcgc agaccccaga agacagcccc
      481 aacaggtcgg gtgcggaggc aaagacccaa aaagacagcc ctagcaagtc aggttcggag
      541 gcgcagacca caaaagatgt ccctaataag tcgggtgcgg acggccagac cccaaaagac
      601 ggctccagca agtcgggtgc ggaggatcag accccaaaag acgtccctaa caagtcgggt
      661 gcggagaagc agactccaaa agacggctct aacaagtccg gtgcagagga gcagggccca
      721 atagacgggc ccagcaagtc gggtgcggag gagcagacct caaaagacag ccctaacaag
      781 gtggttccag agcagccttc ccggaaagac cattccaagc ccatctccaa cccttctgat
      841 aacaaggagc tccccaaggc tgacacaaac cagcttgctg acaaagggaa gctttctcct
      901 catgctttca aaaccgaatc tggggaggaa actgacctca tttctccccc gcaggaggaa
      961 gttaagtctt cagagcctac tgaggatgtg gagcccaaag aggctgaaga tgatgataca
     1021 ggacccgagg agggctcacc gcccaaagaa gagaaagaaa agatgtccgg ttctgcctcc
     1081 agtgagaacc gtgaagggac actttcggat tccacgggta gcgagaagga tgacctttat
     1141 ccgaacggtt ctggaaatgg cagcgcggag agcagccact tctttgcata tctggtgact
     1201 gcagccattc ttgtggctgt cctctatatc gctcatcaca acaagcggaa gatcattgct
     1261 tttgtcctgg aaggaaaaag atctaaagtc acccggcggc caaaggccag tgactaccaa
     1321 cgtttggacc agaagtccta acagaatggt atattcctct ggaaaaagat gaacgtcacc
     1381 aatggattgt gctgctctcg tttcagcttt gatttttttg tccttgagaa ccttgtcctc
     1441 cctgctgatt tgtttctaaa tcaaaagaaa tgaagaaaaa agtactgtga cctgagagac
     1501 accctcctct agaatttagt ggcgggtctg ggctggcaga ggtagggggc tgctttgggc
     1561 tttgcacctg cactttggtg acattgttct tctgtgttcc ctttatttat gctggtggct
     1621 tccatccgtt cctcctctga gggtgagtgg aggggtatat ggaaacacgg ctatgaccaa
     1681 agggagatcc cagcctgggc aggctgcgct gctgaccacc ctccctgggg cccgggctct
     1741 gtaggaaagt tggtccttga ctgtggcatt gcactctgca ctgtttctct ctgcagacct
     1801 aggggaaaac tgcaggtgga agtgcttttc tactaaggcc tcttactttg ggggggatgt
     1861 gccctacaga agacatagaa gatggggaaa tgccaatggg caaagagcta ctttgaatac
     1921 ataattctct tcaaagactt cagcagcaaa ccaaaacagc aggttaaaaa aaaagatgct
     1981 tttttgggtg caagtctaac ctgtctagca tgagatcttc ttgattttct gattatttta
     2041 tgtagcttga gacaaagtga atcaacttcc acttagttgt accgagcata aaacagaact
     2101 tgggcttcct ggcagtgagg ccactgtccc atcacagatt tttaaaataa atatgatttg
     2161 aagtagtgtg atctttcaca caatcatact cagtaggaac tttttgaaat agggcaagtt
     2221 tatgtttcat gcgagaaaac atgaaggagg gttttggttt tggtctgcag tttttccaaa
     2281 gggcttttat gagatacatt tcccacaaag tccattttgc ctttgttgcc taaaacagac
     2341 aaaatagact tagatttatt aatagaaact atactctctg ccaattttac ctcagtgtat
     2401 ttaatggtcc tttaatctga tataagatgc caagggtatt tgataaaaat tcttcttcca
     2461 tgccatgtca ggagttaata caaatgaaga aattccgtgg gttcccctgg gataagtgag
     2521 ggtagtgtct tggacaacac tattgtttga aggtttatct tttctaatca tgctctaccg
     2581 cattgtagag agcctaaaga gagttgtttc tgagctgatc tcagggaaat acaaataact
     2641 tgggagatga gggaaataag atgaattctg tgctgtcaag gcagtaagtc tgaagaaagg
     2701 accatgcttc ttatattatc ttccaccttg cttaaaacag cccatagctt tgagttgaca
     2761 ttttcattct tggcggatag cctactttat gaaggtaagg aatgaactcc tacccttctt
     2821 gggtcattct ctgtactgat gcgttagtct tataatactt tgcaccaacc tgaggaatct
     2881 tctaggcttc tctagcatcc cctaagactg tggctatttc acgtctctct ccctgcctgc
     2941 cttccttttc ccttcctttc ccctcctcat gttttctggt tgtgcccatc tgtaccagct
     3001 cctttccatc caccttcgta tgcacccaga tttttctgtt cccatctgtc ctatttgtta
     3061 ttcatcccgc tgctcaactt ctccagtatg ttgcttccct taagttgcca ttcattctct
     3121 tcatgacttt tactaactca cttcggtctc tgtctgtcaa ctaaactttt ctaaaggtta
     3181 ccagttatcc aatcaccaaa tccatggctt tttctcaaag cttagtcttg tccttggcag
     3241 aactggacac tattgaccat ccaaatggaa attccccttt cttggtgtct ctgacaaatg
     3301 gtcctttgcc ttatcttgtg ctggtggtga agaggccctc aaagccaggc ctctctattc
     3361 ctttgactgt ctcctcagcc attaacccat tcttcatcct cggagtgagt gattcccaag
     3421 tctttgtctt ggcttaatcc ctaaagaacc cagttctgct ggtatcgaat agttcagctt
     3481 ggttgtcatt gaaaggaatt tctctcttct gtccatcagc ctgtccctcc caactgtcta
     3541 ggacagtctt cggtcaccta aattcctaac tgcagacttt tgcccttttt ctctctcatc
     3601 accaaagtcc catccatttt tttttaataa aagatcctca gctacagtct ttccattttc
     3661 cttgcttctc ttattgcaca cccccagccc attttgcttc tctcttggat tttgtttttt
     3721 cagatccaca tttattgggt ttcctgtcca gcttcttgga aaggagctca ctcttggaaa
     3781 gactgatctt tccaaaatat tttccctggt ctgaagcttt ggtgtgaact tctcaaggct
     3841 tagagaatcc agttacagac cttttggggt tcaggatgct atagattgac accctcctgc
     3901 ctgtttttct ctgcatccca acctggccaa ggcccctcct gtggggtgcc catctgtgcc
     3961 tttattccgg ctgtgccctc gactttccag cttcccatgt ttctttggtt aggtttctct
     4021 cccttccttc tttctccttc cccaatccgc ctgtttcgtc agggcccagt ttgtttcctc
     4081 atacaccttc ctcactaccc caccccacat ggttgactct ttccctcagc tccaccagct
     4141 cttcatcatg ccactcattt cagaacttga gcaaaacagg gcagtcagga tctgatgtct
     4201 ttctggtctc cctaagaaaa ctaagctctt gagggacagc ccttggcaat gctttcctat
     4261 ctgctgatca tggtgacctt ccttaggact tccagagttc agttccttct ggcagagagg
     4321 ttttctttct ccatgccata tggatgtgac tcaaatgagg ggtcccacag cttttcctgg
     4381 ctaccacttg ctgtgacctt atacatgttg gggtttgctc ttaaagagga gagcaggaag
     4441 aaaggttggt ttcagaaacc aagagggtcg gcagtggacg cgtacatttt gtcacggagt
     4501 ccacagagct gagcttttga gcagactctg agaagtatca ttgcttgtgt tgaaagaata
     4561 caacaggatt taagtttctc tttagaaatt gcactgaaga aaggccgggc gcggtggctc
     4621 cccctgtaat cccagcgctt tgggaggccg aggcgggggg atcacgaggt caagagatcg
     4681 agaccatcct ggccaacatg gtgaaacccc gtctctaata aaaatacaaa aattagccgg
     4741 gcatggtgac gtgcacctgt agtcccagct actagatagg ctgaggcagg agaattgctt
     4801 gaatccggga ggcggaggtt gcagtgagcc gagatcgtgc cactgaactc caacctgcca
     4861 atagagcgag actccgtctc aaaaaaaaaa aaaaaaaaga aagaaatagc attgaagaaa
     4921 ataccgcaca tcagaggaaa gcttattttc tgcatggtgt cttttcaaag atagaatatt
     4981 tgaagcatgt tttctagcga ttgtgtggat gagggtgagc tggctgaggc atcgctcaag
     5041 ctggggggtg gtgtgtaaga agcacgtgga gccacaagag gcacctccta tagtcagcta
     5101 agggcttccc tttctgcgcc cagcttttgg gtgaagggtg atttctatta gacacatctg
     5161 tgcttcagtc atagatgtta atagaggaag cagttttcct gctgcagatt cctgaataga
     5221 gttgctgaaa gagtctactt ctggactcag gggaagttga aggccagtct gtgtagaaag
     5281 gctgaggcaa cggggaaaga cctgacagct agttacatac gctctgacat agtactccca
     5341 tgatggcttc cagtgacaca tgtgctgata gaattctaaa cctctggaat ttccctgctg
     5401 gcgacttcta tggccgttga ctgtacaggg taacctgatg ccagatgcta tgggcgtgat
     5461 gagaactaga gcattgcagc atggaggaaa ctgtgaggca ccagatcctg tgcttctgca
     5521 ggccattttc tgaaaacccc tgttaggaag gttggatttg gcgtgacttg cttgagcaag
     5581 agtcctgggg agagattttg aggtttaatt taacggtata tccagagcta acagtgactc
     5641 aactcgtcta gttctgcaag tcagatgtac acttagagtc tctctgtgaa gggtttgggt
     5701 ctgagctgta tagtatgtca aactgccagt aagccagccc ctcaccctct gatagatatt
     5761 cctttaatgc accagacttc atgtttgata aatgattaat ggttgaaatt gtttctcttc
     5821 ttttgtgttt tcccagttaa tagatggtca ctgtttccac aatgttttat actttcagct
     5881 ttttgtaact taactataat tacttaattt tattttttta aagcttgttg tggtctaatg
     5941 agaagtattt ttcagtgcat aatgtttttc tgagcttctg taaatgccat cccaatgtgg
     6001 tttggttttg ttgaacagaa accaaaataa atttcaaaat gttaaagcaa
//
