LOCUS       NM_052955               2322 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens transglutaminase 7 (TGM7), mRNA.
ACCESSION   NM_052955
VERSION     NM_052955.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2322)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2322)
  AUTHORS   Kuramoto,K., Yamasaki,R., Shimizu,Y., Tatsukawa,H. and Hitomi,K.
  TITLE     Phage-displayed peptide library screening for preferred human
            substrate peptide sequences for transglutaminase 7
  JOURNAL   Arch Biochem Biophys 537 (1), 138-143 (2013)
   PUBMED   23876241
  REMARK    GeneRIF: Then, using the most efficient peptide, Z3S, we
            established an in vitro assay system to assess enzymatic activity
            of TG7.
REFERENCE   3  (bases 1 to 2322)
  AUTHORS   Grenard,P., Bates,M.K. and Aeschlimann,D.
  TITLE     Evolution of transglutaminase genes: identification of a
            transglutaminase gene cluster on human chromosome 15q15. Structure
            of the gene encoding transglutaminase X and a novel gene family
            member, transglutaminase Z
  JOURNAL   J Biol Chem 276 (35), 33066-33078 (2001)
   PUBMED   11390390
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF363393.1, BX112796.1 and AC009852.9.
            
            On May 17, 2019 this sequence version replaced NM_052955.2.
            
            Summary: Transglutaminases (TGM; EC 2.3.2.13) are a family of
            structurally and functionally related enzymes that stabilize
            protein assemblies through the formation of gamma-glutamyl-epsilon
            lysine crosslinks. For additional background information on
            transglutaminases, see TGM1 (MIM 190195).[supplied by OMIM, Jul
            2002].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF363393.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2145245 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000452443.3/ ENSP00000389466.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2110              AF363393.1         1-2110
            2111-2312           BX112796.1         167-368
            2313-2322           AC009852.9         110063-110072       c
FEATURES             Location/Qualifiers
     source          1..2322
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.2-q15.3"
     gene            1..2322
                     /gene="TGM7"
                     /gene_synonym="TGMZ"
                     /note="transglutaminase 7"
                     /db_xref="GeneID:116179"
                     /db_xref="HGNC:HGNC:30790"
                     /db_xref="MIM:606776"
     exon            1..15
                     /gene="TGM7"
                     /gene_synonym="TGMZ"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..2138
                     /gene="TGM7"
                     /gene_synonym="TGMZ"
                     /EC_number="2.3.2.13"
                     /note="transglutaminase Z; TGZ; TG(Z); TGase Z; TGase-7"
                     /codon_start=1
                     /product="protein-glutamine gamma-glutamyltransferase Z"
                     /protein_id="NP_443187.1"
                     /db_xref="CCDS:CCDS32213.1"
                     /db_xref="GeneID:116179"
                     /db_xref="HGNC:HGNC:30790"
                     /db_xref="MIM:606776"
                     /translation="MDQVATLRLESVDLQSSRNNKEHHTQEMGVKRLTVRRGQPFYLR
                     LSFSRPFQSQNDHITFVAETGPKPSELLGTRATFFLTRVQPGNVWSASDFTIDSNSLQ
                     VSLFTPANAVIGHYTLKIEISQGQGHSVTYPLGTFILLFNPWSPEDDVYLPSEILLQE
                     YIMRDYGFVYKGHERFITSWPWNYGQFEEDIIDICFEILNKSLYHLKNPAKDCSQRND
                     VVYVCRVVSAMINSNDDNGVLQGNWGEDYSKGVSPLEWKGSVAILQQWSARGGQPVKY
                     GQCWVFASVMCTVMRCLGVPTRVVSNFRSAHNVDRNLTIDTYYDRNAEMLSTQKRDKI
                     WNFHVWNECWMIRKDLPPGYNGWQVLDPTPQQTSSGLFCCGPASVKAIREGDVHLAYD
                     TPFVYAEVNADEVIWLLGDGQAQEILAHNTSSIGKEISTKMVGSDQRQSITSSYKYPE
                     GSPEERAVFMKASRKMLGPQRASLPFLDLLESGGLRDQPAQLQLHLARIPEWGQDLQL
                     LLRIQRVPDSTHPRGPIGLVVRFCAQALLHGGGTQKPFWRHTVRMNLDFGKETQWPLL
                     LPYSNYRNKLTDEKLIRVSGIAEVEETGRSMLVLKDICLEPPHLSIEVSERAEVGKAL
                     RVHVTLTNTLMVALSSCTMVLEGSGLINGQIAKDLGTLVAGHTLQIQLDLYPTKAGPR
                     QLQVLISSNEVKEIKGYKDIFVTVAGAP"
     exon            16..198
                     /gene="TGM7"
                     /gene_synonym="TGMZ"
                     /inference="alignment:Splign:2.1.0"
     exon            199..444
                     /gene="TGM7"
                     /gene_synonym="TGMZ"
                     /inference="alignment:Splign:2.1.0"
     exon            445..563
                     /gene="TGM7"
                     /gene_synonym="TGMZ"
                     /inference="alignment:Splign:2.1.0"
     exon            564..692
                     /gene="TGM7"
                     /gene_synonym="TGMZ"
                     /inference="alignment:Splign:2.1.0"
     exon            693..870
                     /gene="TGM7"
                     /gene_synonym="TGMZ"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1009
                     /gene="TGM7"
                     /gene_synonym="TGMZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1113
                     /gene="TGM7"
                     /gene_synonym="TGMZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1356
                     /gene="TGM7"
                     /gene_synonym="TGMZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1683
                     /gene="TGM7"
                     /gene_synonym="TGMZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1844
                     /gene="TGM7"
                     /gene_synonym="TGMZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..1978
                     /gene="TGM7"
                     /gene_synonym="TGMZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2322
                     /gene="TGM7"
                     /gene_synonym="TGMZ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2294..2299
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGM7"
                     /gene_synonym="TGMZ"
                     /note="hexamer: AATAAA"
     polyA_site      2322
                     /gene="TGM7"
                     /gene_synonym="TGMZ"
                     /note="major polyA site"
ORIGIN      
        1 gggagatgga tcaggtggca accttgcggc ttgagtctgt cgacctgcag agctccagga
       61 acaacaagga gcaccacacg caggagatgg gcgtcaagcg gctcactgtg cgccgcggcc
      121 agcccttcta cctccggctg agcttcagcc gacccttcca gtcccagaac gaccacatca
      181 cctttgtggc tgagaccgga cccaagccgt cagagctgct ggggacccga gccacattct
      241 tcctcacccg ggtccagccc gggaatgtct ggagcgcttc tgatttcacc attgactcca
      301 actctctcca agtttccctt ttcacaccag ccaatgcagt tattggccat tacactctga
      361 aaatagagat ctctcagggc caaggtcaca gtgtgactta cccgctggga actttcatcc
      421 tactttttaa cccttggagt ccagaggacg acgtctacct gccaagtgaa atactgctgc
      481 aggagtatat catgcgagat tatggctttg tttacaaggg tcatgaaaga ttcatcacct
      541 cctggccctg gaactacggg cagtttgaag aggacatcat agacatctgc tttgagatcc
      601 tgaacaagag cctgtatcac ttaaagaacc cggccaaaga ctgttcccag cggaacgacg
      661 tggtgtatgt gtgcagggtg gtgagtgcca tgatcaacag caacgatgac aatggcgtgc
      721 tgcaggggaa ctggggcgag gactactcca aaggggtcag tcctctggag tggaagggca
      781 gtgtggccat cctacagcag tggtcagcca ggggcgggca gcctgtgaag tacggacagt
      841 gctgggtctt cgcctctgtt atgtgcaccg taatgagatg cttaggtgtt ccaacccgtg
      901 ttgtttccaa tttccgttcc gcgcacaacg tggataggaa cttgaccatc gatacgtact
      961 atgaccgaaa tgccgagatg ctgtcaactc agaaacgaga caaaatatgg aacttccacg
     1021 tctggaatga gtgctggatg atccggaaag atctcccacc aggatacaac gggtggcagg
     1081 ttctggaccc cactccccag cagaccagca gtgggctgtt ctgctgtggc cctgcctctg
     1141 tgaaggccat cagggaaggg gatgtccacc tggcctatga cacccctttt gtgtatgccg
     1201 aggtgaacgc cgatgaagtc atttggctcc ttggggatgg ccaggcccag gaaatcctgg
     1261 cccacaacac cagttccatc gggaaggaga tcagcactaa gatggtgggg tcagaccagc
     1321 gccagagcat caccagctcc tacaagtacc cagaaggatc ccctgaggag agagctgtct
     1381 tcatgaaggc ttctcggaaa atgctgggcc cccaaagagc ttctttgccc ttcctggatc
     1441 tcctggagtc tgggggtctt agggatcagc cagcgcagct gcagcttcac ctggccagga
     1501 tacccgagtg gggccaggac ctgcagctgc tgctgcgtat ccagagggtg ccagacagca
     1561 cccaccctcg ggggcccatc ggactggtgg tgcgcttctg tgcacaggcc ctgctgcatg
     1621 ggggtggtac ccagaagccc ttctggaggc acacagtgcg gatgaacctg gactttggga
     1681 aggagacaca gtggccgctc ctcctgccct acagcaatta cagaaacaag ctaacggacg
     1741 aaaagctcat ccgcgtgtct ggcatcgcgg aggttgaaga gacagggagg tccatgctgg
     1801 tcctaaaaga tatctgtctg gagcctcccc acttgtctat tgaggtgtct gagagggctg
     1861 aggtgggcaa ggcgctgaga gtccatgtca ccctcaccaa caccttaatg gtggctctga
     1921 gcagctgcac gatggtgctg gaaggaagcg gcctcatcaa tgggcagata gcaaaggacc
     1981 ttgggactct ggtggccgga cacaccctcc aaattcaact ggacctctac ccgaccaaag
     2041 ctggaccccg ccagctccag gttctcatca gcagcaacga ggtcaaggag atcaaaggct
     2101 acaaggacat cttcgtcact gtggctgggg ctccctgaga cccgccctcc agctgccctc
     2161 cctggcaccc ctgccccacc tggctccttt ctactcctgg ctatgtcgtc ttggctccac
     2221 ctctgtcctc tctctagcct gcctgggaat gaatgaagct ctgttagaaa caccgtgtgc
     2281 tttgggaaga gacaataaag atgtctttat ttatcaccag ca
//
