LOCUS       NM_003241               3391 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens transglutaminase 4 (TGM4), mRNA.
ACCESSION   NM_003241
VERSION     NM_003241.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3391)
  AUTHORS   Ye,L., Sanders,A.J. and Jiang,W.G.
  TITLE     Transglutaminase-4 (Prostate Transglutaminase), a Potential
            Biological Factor and Clinical Indicator for the Diagnosis and
            Prognosis of Prostate Cancer
  JOURNAL   Anticancer Res 43 (1), 291-296 (2023)
   PUBMED   36585193
  REMARK    GeneRIF: Transglutaminase-4 (Prostate Transglutaminase), a
            Potential Biological Factor and Clinical Indicator for the
            Diagnosis and Prognosis of Prostate Cancer.
            Review article
REFERENCE   2  (bases 1 to 3391)
  AUTHORS   Csoban-Szabo,Z., Becsi,B., El Alaoui,S., Fesus,L.,
            Korponay-Szabo,I.R. and Kiraly,R.
  TITLE     Biochemical Characterisation of Human Transglutaminase 4
  JOURNAL   Int J Mol Sci 22 (22), 12448 (2021)
   PUBMED   34830327
  REMARK    GeneRIF: Biochemical Characterisation of Human Transglutaminase 4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3391)
  AUTHORS   Drabovich,A.P., Saraon,P., Drabovich,M., Karakosta,T.D.,
            Dimitromanolakis,A., Hyndman,M.E., Jarvi,K. and Diamandis,E.P.
  TITLE     Multi-omics Biomarker Pipeline Reveals Elevated Levels of
            Protein-glutamine Gamma-glutamyltransferase 4 in Seminal Plasma of
            Prostate Cancer Patients
  JOURNAL   Mol Cell Proteomics 18 (9), 1807-1823 (2019)
   PUBMED   31249104
  REMARK    GeneRIF: TGM4 is elevated in the seminal plasma of prostate cancer
            patients.
REFERENCE   4  (bases 1 to 3391)
  AUTHORS   Landegren,N., Sharon,D., Shum,A.K., Khan,I.S., Fasano,K.J.,
            Hallgren,A., Kampf,C., Freyhult,E., Ardesjo-Lundgren,B.,
            Alimohammadi,M., Rathsman,S., Ludvigsson,J.F., Lundh,D.,
            Motrich,R., Rivero,V., Fong,L., Giwercman,A., Gustafsson,J.,
            Perheentupa,J., Husebye,E.S., Anderson,M.S., Snyder,M. and Kampe,O.
  TITLE     Transglutaminase 4 as a prostate autoantigen in male subfertility
  JOURNAL   Sci Transl Med 7 (292), 292ra101 (2015)
   PUBMED   26084804
  REMARK    GeneRIF: TGM4 is a prostatic secretory molecule with critical role
            in male reproduction.
REFERENCE   5  (bases 1 to 3391)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3391)
  AUTHORS   Davies,G., Ablin,R.J., Mason,M.D. and Jiang,W.G.
  TITLE     Expression of the prostate transglutaminase (TGase-4) in prostate
            cancer cells and its impact on the invasiveness of prostate cancer
  JOURNAL   J Exp Ther Oncol 6 (3), 257-264 (2007)
   PUBMED   17552366
  REMARK    GeneRIF: transglutaminase 4 has a relatively wide profile of
            expression in human cancer cell lines
REFERENCE   7  (bases 1 to 3391)
  AUTHORS   Dubbink,H.J., de Waal,L., van Haperen,R., Verkaik,N.S., Trapman,J.
            and Romijn,J.C.
  TITLE     The human prostate-specific transglutaminase gene (TGM4): genomic
            organization, tissue-specific expression, and promoter
            characterization
  JOURNAL   Genomics 51 (3), 434-444 (1998)
   PUBMED   9721214
REFERENCE   8  (bases 1 to 3391)
  AUTHORS   Dubbink,H.J., Verkaik,N.S., Faber,P.W., Trapman,J., Schroder,F.H.
            and Romijn,J.C.
  TITLE     Tissue specific and androgen-regulated expression of human
            prostate-specific transglutaminase
  JOURNAL   Biochem J 315 (Pt 3) (Pt 3), 901-908 (1996)
   PUBMED   8645175
REFERENCE   9  (bases 1 to 3391)
  AUTHORS   Gentile,V., Grant,F.J., Porta,R. and Baldini,A.
  TITLE     Localization of the human prostate transglutaminase (type IV) gene
            (TGM4) to chromosome 3p21.33-p22 by fluorescence in situ
            hybridization
  JOURNAL   Genomics 27 (1), 219-220 (1995)
   PUBMED   7665178
REFERENCE   10 (bases 1 to 3391)
  AUTHORS   Grant,F.J., Taylor,D.A., Sheppard,P.O., Mathewes,S.L., Lint,W.,
            Vanaja,E., Bishop,P.D. and O'Hara,P.J.
  TITLE     Molecular cloning and characterization of a novel transglutaminase
            cDNA from a human prostate cDNA library
  JOURNAL   Biochem Biophys Res Commun 203 (2), 1117-1123 (1994)
   PUBMED   7916568
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA870110.1, L34840.1, BF678064.1, BC007003.1 and AC098649.2.
            
            On May 17, 2019 this sequence version replaced NM_003241.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK312936.1, BC007003.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146411, SAMEA2153427
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296125.9/ ENSP00000296125.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                DA870110.1         3-29
            28-2987             L34840.1           1-2960
            2988-2994           BF678064.1         515-521
            2995-2997           BC007003.1         2992-2994
            2998-3391           AC098649.2         192922-193315
FEATURES             Location/Qualifiers
     source          1..3391
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..3391
                     /gene="TGM4"
                     /gene_synonym="hTGP; TGP"
                     /note="transglutaminase 4"
                     /db_xref="GeneID:7047"
                     /db_xref="HGNC:HGNC:11780"
                     /db_xref="MIM:600585"
     exon            1..90
                     /gene="TGM4"
                     /gene_synonym="hTGP; TGP"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..2126
                     /gene="TGM4"
                     /gene_synonym="hTGP; TGP"
                     /EC_number="2.3.2.13"
                     /note="prostate-specific transglutaminase; TG(P); TGase P;
                     TGase-4; fibrinoligase; transglutaminase P; prostate
                     transglutaminase; transglutaminase 4 (prostate)"
                     /codon_start=1
                     /product="protein-glutamine gamma-glutamyltransferase 4"
                     /protein_id="NP_003232.2"
                     /db_xref="CCDS:CCDS2723.1"
                     /db_xref="GeneID:7047"
                     /db_xref="HGNC:HGNC:11780"
                     /db_xref="MIM:600585"
                     /translation="MMDASKELQVLHIDFLNQDNAVSHHTWEFQTSSPVFRRGQVFHL
                     RLVLNQPLQSYHQLKLEFSTGPNPSIAKHTLVVLDPRTPSDHYNWQATLQNESGKEVT
                     VAVTSSPNAILGKYQLNVKTGNHILKSEENILYLLFNPWCKEDMVFMPDEDERKEYIL
                     NDTGCHYVGAARSIKCKPWNFGQFEKNVLDCCISLLTESSLKPTDRRDPVLVCRAMCA
                     MMSFEKGQGVLIGNWTGDYEGGTAPYKWTGSAPILQQYYNTKQAVCFGQCWVFAGILT
                     TVLRALGIPARSVTGFDSAHDTERNLTVDTYVNENGEKITSMTHDSVWNFHVWTDAWM
                     KRPDLPKGYDGWQAVDATPQERSQGVFCCGPSPLTAIRKGDIFIVYDTRFVFSEVNGD
                     RLIWLVKMVNGQEELHVISMETTSIGKNISTKAVGQDRRRDITYEYKYPEGSSEERQV
                     MDHAFLLLSSEREHRRPVKENFLHMSVQSDDVLLGNSVNFTVILKRKTAALQNVNILG
                     SFELQLYTGKKMAKLCDLNKTSQIQGQVSEVTLTLDSKTYINSLAILDDEPVIRGFII
                     AEIVESKEIMASEVFTSFQYPEFSIELPNTGRIGQLLVCNCIFKNTLAIPLTDVKFSL
                     ESLGISSLQTSDHGTVQPGETIQSQIKCTPIKTGPKKFIVKLSSKQVKEINAQKIVLI
                     TK"
     exon            91..264
                     /gene="TGM4"
                     /gene_synonym="hTGP; TGP"
                     /inference="alignment:Splign:2.1.0"
     exon            265..371
                     /gene="TGM4"
                     /gene_synonym="hTGP; TGP"
                     /inference="alignment:Splign:2.1.0"
     exon            372..501
                     /gene="TGM4"
                     /gene_synonym="hTGP; TGP"
                     /inference="alignment:Splign:2.1.0"
     exon            502..620
                     /gene="TGM4"
                     /gene_synonym="hTGP; TGP"
                     /inference="alignment:Splign:2.1.0"
     exon            621..728
                     /gene="TGM4"
                     /gene_synonym="hTGP; TGP"
                     /inference="alignment:Splign:2.1.0"
     exon            729..903
                     /gene="TGM4"
                     /gene_synonym="hTGP; TGP"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1042
                     /gene="TGM4"
                     /gene_synonym="hTGP; TGP"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1146
                     /gene="TGM4"
                     /gene_synonym="hTGP; TGP"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1398
                     /gene="TGM4"
                     /gene_synonym="hTGP; TGP"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1677
                     /gene="TGM4"
                     /gene_synonym="hTGP; TGP"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1847
                     /gene="TGM4"
                     /gene_synonym="hTGP; TGP"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..1984
                     /gene="TGM4"
                     /gene_synonym="hTGP; TGP"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..3391
                     /gene="TGM4"
                     /gene_synonym="hTGP; TGP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2981..2986
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGM4"
                     /gene_synonym="hTGP; TGP"
                     /note="hexamer: ATTAAA"
     polyA_site      3002
                     /gene="TGM4"
                     /gene_synonym="hTGP; TGP"
                     /note="major polyA site"
ORIGIN      
        1 accgactgtg tggaagcacc aggcatcaga gatagagtct tccctggcat tgcaggagag
       61 aatctgaagg gatgatggat gcatcaaaag agctgcaagt tctccacatt gacttcttga
      121 atcaggacaa cgccgtttct caccacacat gggagttcca aacgagcagt cctgtgttcc
      181 ggcgaggaca ggtgtttcac ctgcggctgg tgctgaacca gcccctacaa tcctaccacc
      241 aactgaaact ggaattcagc acagggccga atcctagcat cgccaaacac accctggtgg
      301 tgctcgaccc gaggacgccc tcagaccact acaactggca ggcaaccctt caaaatgagt
      361 ctggcaaaga ggtcacagtg gctgtcacca gttcccccaa tgccatcctg ggcaagtacc
      421 aactaaacgt gaaaactgga aaccacatcc ttaagtctga agaaaacatc ctataccttc
      481 tcttcaaccc atggtgtaaa gaggacatgg ttttcatgcc tgatgaggac gagcgcaaag
      541 agtacatcct caatgacacg ggctgccatt acgtgggggc tgccagaagt atcaaatgca
      601 aaccctggaa ctttggtcag tttgagaaaa atgtcctgga ctgctgcatt tccctgctga
      661 ctgagagctc cctcaagccc acagatagga gggaccccgt gctggtgtgc agggccatgt
      721 gtgctatgat gagctttgag aaaggccagg gcgtgctcat tgggaattgg actggggact
      781 acgaaggtgg cacagcccca tacaagtgga caggcagtgc cccgatcctg cagcagtact
      841 acaacacgaa gcaggctgtg tgctttggcc agtgctgggt gtttgctggg atcctgacta
      901 cagtgctgag agcgttgggc atcccagcac gcagtgtgac aggcttcgat tcagctcacg
      961 acacagaaag gaacctcacg gtggacacct atgtgaatga gaatggcgag aaaatcacca
     1021 gtatgaccca cgactctgtc tggaatttcc atgtgtggac ggatgcctgg atgaagcgac
     1081 cggatctgcc caagggctac gacggctggc aggctgtgga cgcaacgccg caggagcgaa
     1141 gccagggtgt cttctgctgt gggccatcac cactgaccgc catccgcaaa ggtgacatct
     1201 ttattgtcta tgacaccaga ttcgtcttct cagaagtgaa tggtgacagg ctcatctggt
     1261 tggtgaagat ggtgaatggg caggaggagt tacacgtaat ttcaatggag accacaagca
     1321 tcgggaaaaa catcagcacc aaggcagtgg gccaagacag gcggagagat atcacctatg
     1381 agtacaagta tccagaaggc tcctctgagg agaggcaggt catggatcat gccttcctcc
     1441 ttctcagttc tgagagggag cacagacgac ctgtaaaaga gaactttctt cacatgtcgg
     1501 tacaatcaga tgatgtgctg ctgggaaact ctgttaattt caccgtgatt cttaaaagga
     1561 agaccgctgc cctacagaat gtcaacatct tgggctcctt tgaactacag ttgtacactg
     1621 gcaagaagat ggcaaaactg tgtgacctca ataagacctc gcagatccaa ggtcaagtat
     1681 cagaagtgac tctgaccttg gactccaaga cctacatcaa cagcctggct atattagatg
     1741 atgagccagt tatcagaggt ttcatcattg cggaaattgt ggagtctaag gaaatcatgg
     1801 cctctgaagt attcacgtct ttccagtacc ctgagttctc tatagagttg cctaacacag
     1861 gcagaattgg ccagctactt gtctgcaatt gtatcttcaa gaataccctg gccatccctt
     1921 tgactgacgt caagttctct ttggaaagcc tgggcatctc ctcactacag acctctgacc
     1981 atgggacggt gcagcctggt gagaccatcc aatcccaaat aaaatgcacc ccaataaaaa
     2041 ctggacccaa gaaatttatc gtcaagttaa gttccaaaca agtgaaagag attaatgctc
     2101 agaagattgt tctcatcacc aagtagcctt gtctgatgct gtggagcctt agttgagatt
     2161 tcagcatttc ctaccttgtg cttagctttc agattatgga tgattaaatt tgatgactta
     2221 tatgagggca gattcaagag ccagcaggtc aaaaaggcca acacaaccat aagcagccag
     2281 acccacaagg ccaggtcctg tgctatcaca gggtcacctc ttttacagtt agaaacacca
     2341 gccgaggcca cagaatccca tccctttcct gagtcatggc ctcaaaaatc agggccacca
     2401 ttgtctcaat tcaaatccat agatttcgaa gccacagagt ctctccctgg agcagcagac
     2461 tatgggcagc ccagtgctgc cacctgctga cgacccttga gaagctgcca tatcttcagg
     2521 ccatgggttc accagccctg aaggcacctg tcaactggag tgctctctca gcactgggat
     2581 gggcctgata gaagtgcatt ctcctcctat tgcctccatt ctcctctctc tatccctgaa
     2641 atccaggaag tccctctcct ggtgctccaa gcagtttgaa gcccaatctg caaggacatt
     2701 tctcaagggc catgtggttt tgcagacaac cctgtcctca ggcctgaact caccatagag
     2761 acccatgtca gcaaacggtg accagcaaat cctcttccct tattctaaag ctgccccttg
     2821 ggagactcca gggagaaggc attgcttcct ccctggtgtg aactctttct ttggtattcc
     2881 atccactatc ctggcaactc aaggctgctt ctgttaactg aagcctgctc cttcttgttc
     2941 tgccctccag agatttgctc aaatgatcaa taagctttaa attaaactct acttcaagaa
     3001 aactctgtgg tccctgagtc cttttttctt tatgccaata agcttcttaa atgtgctggc
     3061 ggtttatgca gtcacttggg gagccatgga atcctttgat ctccccaggc aaggtgctct
     3121 gaggagttgg cttctttatt gtctgttcag tacatccaac ccctctctca aaggctgtca
     3181 ccccaactgg atacacaccc tggcaaaggc acgtagcttg aatgagggtt attttgtgtc
     3241 taattcacag gagagtcatg ggtgggatac ctgtcatcct ctgcctttcc agctgtccaa
     3301 gtgaaaaaaa cctcaatcct ggtcaccctt gcccaagttg cccacatccc tggcatacag
     3361 taggtgttca ataaatgttt attgaaggaa a
//
