LOCUS       NM_003245               2643 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens transglutaminase 3 (TGM3), mRNA.
ACCESSION   NM_003245
VERSION     NM_003245.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2643)
  AUTHORS   Hou,J., Mei,K., Wang,D., Ke,S., Chen,X., Shang,J., Li,G., Gao,Y.,
            Xiong,H., Zhang,H., Chen,L., Zhang,W., Deng,Y., Hong,X., Liu,D.A.,
            Hu,T., Guo,W. and Zhan,Y.Y.
  TITLE     TGM1/3-mediated transamidation of Exo70 promotes tumor metastasis
            upon LKB1 inactivation
  JOURNAL   Cell Rep 43 (8), 114604 (2024)
   PUBMED   39146185
  REMARK    GeneRIF: TGM1/3-mediated transamidation of Exo70 promotes tumor
            metastasis upon LKB1 inactivation.
REFERENCE   2  (bases 1 to 2643)
  AUTHORS   Chen,R., Fang,T., Liu,N., Shi,X., Wang,J. and Yu,H.
  TITLE     Transglutaminase 3 suppresses proliferation and cisplatin
            resistance of cervical cancer cells by inactivation of the PI3K/AKT
            pathway
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 397 (4), 2269-2280 (2024)
   PUBMED   37812238
  REMARK    GeneRIF: Transglutaminase 3 suppresses proliferation and cisplatin
            resistance of cervical cancer cells by inactivation of the PI3K/AKT
            pathway.
REFERENCE   3  (bases 1 to 2643)
  AUTHORS   Das,S., Stamnaes,J., Kemppainen,E., Hervonen,K., Lundin,K.E.A.,
            Parmar,N., Jahnsen,F.L., Jahnsen,J., Lindfors,K., Salmi,T.,
            Iversen,R. and Sollid,L.M.
  TITLE     Separate Gut Plasma Cell Populations Produce Auto-Antibodies
            against Transglutaminase 2 and Transglutaminase 3 in Dermatitis
            Herpetiformis
  JOURNAL   Adv Sci (Weinh) 10 (25), e2300401 (2023)
   PUBMED   37424036
  REMARK    GeneRIF: Separate Gut Plasma Cell Populations Produce
            Auto-Antibodies against Transglutaminase 2 and Transglutaminase 3
            in Dermatitis Herpetiformis.
            Erratum:[Adv Sci (Weinh). 2024 Jun;11(21):e2400894. doi:
            10.1002/advs.202400894.. PMID: 38477397]
REFERENCE   4  (bases 1 to 2643)
  AUTHORS   Zhao,K., Ye,F., Gao,P., Zhu,X., Hao,S. and Lou,W.
  TITLE     Circular RNA ciRS-7 promotes laryngeal squamous cell carcinoma
            development by inducing TGM3 hypermethylation via miR-432-5p/DNMT3B
            axis
  JOURNAL   Pathol Res Pract 240, 154193 (2022)
   PUBMED   36356335
  REMARK    GeneRIF: Circular RNA ciRS-7 promotes laryngeal squamous cell
            carcinoma development by inducing TGM3 hypermethylation via
            miR-432-5p/DNMT3B axis.
REFERENCE   5  (bases 1 to 2643)
  AUTHORS   Wu,D., Zhang,R. and Zhan,L.
  TITLE     Transglutaminase 3 expression in hepatocellular carcinoma patients:
            Correlation with tumor features and survival profile
  JOURNAL   Clin Res Hepatol Gastroenterol 46 (3), 101812 (2022)
   PUBMED   34597849
  REMARK    GeneRIF: Transglutaminase 3 expression in hepatocellular carcinoma
            patients: Correlation with tumor features and survival profile.
REFERENCE   6  (bases 1 to 2643)
  AUTHORS   Wang,M., Kim,I.G., Steinert,P.M. and McBride,O.W.
  TITLE     Assignment of the human transglutaminase 2 (TGM2) and
            transglutaminase 3 (TGM3) genes to chromosome 20q11.2
  JOURNAL   Genomics 23 (3), 721-722 (1994)
   PUBMED   7851911
REFERENCE   7  (bases 1 to 2643)
  AUTHORS   Kim,I.G., Lee,S.C., Lee,J.H., Yang,J.M., Chung,S.I. and
            Steinert,P.M.
  TITLE     Structure and organization of the human transglutaminase 3 gene:
            evolutionary relationship to the transglutaminase family
  JOURNAL   J Invest Dermatol 103 (2), 137-142 (1994)
   PUBMED   7913719
REFERENCE   8  (bases 1 to 2643)
  AUTHORS   Kim,I.G., Gorman,J.J., Park,S.C., Chung,S.I. and Steinert,P.M.
  TITLE     The deduced sequence of the novel protransglutaminase E (TGase3) of
            human and mouse
  JOURNAL   J Biol Chem 268 (17), 12682-12690 (1993)
   PUBMED   8099584
REFERENCE   9  (bases 1 to 2643)
  AUTHORS   Rice,R.H. and Green,H.
  TITLE     Relation of protein synthesis and transglutaminase activity to
            formation of the cross-linked envelope during terminal
            differentiation of the cultured human epidermal keratinocyte
  JOURNAL   J Cell Biol 76 (3), 705-711 (1978)
   PUBMED   24643
REFERENCE   10 (bases 1 to 2643)
  AUTHORS   Steck,T.L.
  TITLE     Cross-linking the major proteins of the isolated erythrocyte
            membrane
  JOURNAL   J Mol Biol 66 (2), 295-305 (1972)
   PUBMED   5038456
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC373633.1, BC109076.1,
            BC109075.1 and AI216028.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003245.3.
            
            Summary: Transglutaminases are enzymes that catalyze the
            crosslinking of proteins by epsilon-gamma glutamyl lysine
            isopeptide bonds. While the primary structure of transglutaminases
            is not conserved, they all have the same amino acid sequence at
            their active sites and their activity is calcium-dependent. The
            protein encoded by this gene consists of two polypeptide chains
            activated from a single precursor protein by proteolysis. The
            encoded protein is involved the later stages of cell envelope
            formation in the epidermis and hair follicle. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290324.1, L10386.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147596
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381458.6/ ENSP00000370867.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                DC373633.1         35-74
            41-2135             BC109076.1         1-2095
            2136-2280           BC109075.1         2096-2240
            2281-2431           BC109076.1         2241-2391
            2432-2643           AI216028.1         3-214               c
FEATURES             Location/Qualifiers
     source          1..2643
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..2643
                     /gene="TGM3"
                     /gene_synonym="TGE; UHS2"
                     /note="transglutaminase 3"
                     /db_xref="GeneID:7053"
                     /db_xref="HGNC:HGNC:11779"
                     /db_xref="MIM:600238"
     exon            1..70
                     /gene="TGM3"
                     /gene_synonym="TGE; UHS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..2145
                     /gene="TGM3"
                     /gene_synonym="TGE; UHS2"
                     /EC_number="2.3.2.13"
                     /note="transglutaminase E; TGase E; TG(E); TGase-3; E
                     polypeptide, protein-glutamine-gamma-glutamyltransferase"
                     /codon_start=1
                     /product="protein-glutamine gamma-glutamyltransferase E"
                     /protein_id="NP_003236.3"
                     /db_xref="CCDS:CCDS33435.1"
                     /db_xref="GeneID:7053"
                     /db_xref="HGNC:HGNC:11779"
                     /db_xref="MIM:600238"
                     /translation="MAALGVQSINWQTAFNRQAHHTDKFSSQELILRRGQNFQVLMIM
                     NKGLGSNERLEFIVSTGPYPSESAMTKAVFPLSNGSSGGWSAVLQASNGNTLTISISS
                     PASAPIGRYTMALQIFSQGGISSVKLGTFILLFNPWLNVDSVFMGNHAEREEYVQEDA
                     GIIFVGSTNRIGMIGWNFGQFEEDILSICLSILDRSLNFRRDAATDVASRNDPKYVGR
                     VLSAMINSNDDNGVLAGNWSGTYTGGRDPRSWNGSVEILKNWKKSGFSPVRYGQCWVF
                     AGTLNTALRSLGIPSRVITNFNSAHDTDRNLSVDVYYDPMGNPLDKGSDSVWNFHVWN
                     EGWFVRSDLGPSYGGWQVLDATPQERSQGVFQCGPASVIGVREGDVQLNFDMPFIFAE
                     VNADRITWLYDNTTGKQWKNSVNSHTIGRYISTKAVGSNARMDVTDKYKYPEGSDQER
                     QVFQKALGKLKPNTPFAATSSMGLETEEQEPSIIGKLKVAGMLAVGKEVNLVLLLKNL
                     SRDTKTVTVNMTAWTIIYNGTLVHEVWKDSATMSLDPEEEAEHPIKISYAQYEKYLKS
                     DNMIRITAVCKVPDESEVVVERDIILDNPTLTLEVLNEARVRKPVNVQMLFSNPLDEP
                     VRDCVLMVEGSGLLLGNLKIDVPTLGPKEGSRVRFDILPSRSGTKQLLADFSCNKFPA
                     IKAMLSIDVAE"
     exon            71..244
                     /gene="TGM3"
                     /gene_synonym="TGE; UHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            245..484
                     /gene="TGM3"
                     /gene_synonym="TGE; UHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            485..603
                     /gene="TGM3"
                     /gene_synonym="TGE; UHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            604..732
                     /gene="TGM3"
                     /gene_synonym="TGE; UHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            733..910
                     /gene="TGM3"
                     /gene_synonym="TGE; UHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1046
                     /gene="TGM3"
                     /gene_synonym="TGE; UHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1150
                     /gene="TGM3"
                     /gene_synonym="TGE; UHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1396
                     /gene="TGM3"
                     /gene_synonym="TGE; UHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1705
                     /gene="TGM3"
                     /gene_synonym="TGE; UHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1863
                     /gene="TGM3"
                     /gene_synonym="TGE; UHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..1997
                     /gene="TGM3"
                     /gene_synonym="TGE; UHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2643
                     /gene="TGM3"
                     /gene_synonym="TGE; UHS2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2615..2620
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGM3"
                     /gene_synonym="TGE; UHS2"
                     /note="hexamer: AATAAA"
     polyA_site      2643
                     /gene="TGM3"
                     /gene_synonym="TGE; UHS2"
                     /note="major polyA site"
ORIGIN      
        1 gtctgtcagc actgtccgtg ccattcccag aggagcctga gaagaggcag aggaaggcga
       61 aacatggctg ctctaggagt ccagagtatc aactggcaga cggccttcaa ccgacaagcg
      121 catcacacag acaagttctc cagccaggag ctcatcttgc ggagaggcca aaacttccag
      181 gtcttaatga tcatgaacaa aggccttggc tctaacgaaa gactggagtt cattgtctcc
      241 acagggcctt acccctcaga gtcggccatg acgaaggctg tgtttccact ctccaatggc
      301 agtagtggtg gctggagtgc ggtgcttcag gccagcaatg gcaatactct gactatcagc
      361 atctccagtc ctgccagcgc acccatagga cggtacacaa tggccctcca gatcttctcc
      421 cagggcggca tctcctctgt gaaacttggg acgttcatac tgctttttaa cccctggctg
      481 aatgtggata gcgtctttat gggtaaccac gctgagagag aagagtatgt tcaggaagat
      541 gccggcatca tctttgtggg aagcacaaac cgaattggca tgattggctg gaactttgga
      601 cagtttgaag aagacattct cagcatctgc ctctcaatct tggataggag tctgaatttc
      661 cgccgtgacg ctgctactga tgtggccagc agaaatgacc ccaaatacgt tggccgggtg
      721 ctgagtgcca tgatcaatag caatgatgac aatggtgtgc ttgctgggaa ttggagcggc
      781 acttacaccg gtggccggga cccaaggagc tggaacggca gcgtggagat cctcaaaaat
      841 tggaaaaaat ctggcttcag cccagtccga tatggccagt gctgggtctt tgctgggacc
      901 ctcaacacag cgctgcggtc tttggggatt ccttcccggg tgatcaccaa cttcaactca
      961 gctcatgaca cagaccgaaa tctcagtgtg gatgtgtact acgaccccat gggaaacccc
     1021 ctggacaagg gtagtgatag cgtatggaat ttccatgtct ggaatgaagg ctggtttgtg
     1081 aggtctgacc tgggcccctc gtacggtgga tggcaggtgt tggatgctac cccgcaggaa
     1141 agaagccaag gggtgttcca gtgcggcccc gcttcggtca ttggtgttcg agagggtgat
     1201 gtgcagctga acttcgacat gccctttatc ttcgcggagg ttaatgccga ccgcatcacc
     1261 tggctgtacg acaacaccac tggcaaacag tggaagaatt ccgtgaacag tcacaccatt
     1321 ggcaggtaca tcagcaccaa ggcggtgggc agcaatgctc gcatggacgt cacggacaag
     1381 tacaagtacc cagaaggctc tgaccaggaa agacaagtgt tccaaaaggc tttggggaaa
     1441 cttaaaccca acacgccatt tgccgcgacg tcttcaatgg gtttggaaac agaggaacag
     1501 gagcccagca tcatcgggaa gctgaaggtc gctggcatgc tggcagtagg caaagaagtc
     1561 aacctggtcc tactgctcaa aaacctgagc agggatacga agacagtgac agtgaacatg
     1621 acagcctgga ccatcatcta caacggcacg cttgtacatg aagtgtggaa ggactctgcc
     1681 acaatgtccc tggaccctga ggaagaggca gaacatccca taaagatctc gtacgctcag
     1741 tatgagaagt acctgaagtc agacaacatg atccggatca cagcggtgtg caaggtccca
     1801 gatgagtctg aggtggtggt ggagcgggac atcatcctgg acaaccccac cttgaccctg
     1861 gaggtgctga acgaggctcg tgtgcggaag cctgtgaacg tgcagatgct cttctccaat
     1921 ccactggatg agccggtgag ggactgcgtg ctgatggtgg agggaagcgg cctgctgttg
     1981 ggtaacctga agatcgacgt gccgacccta gggcccaagg aggggtcccg ggtccgtttt
     2041 gatatcctgc cctcccggag tggcaccaag caactgctcg ccgacttctc ctgcaacaag
     2101 ttccctgcaa tcaaggccat gttgtccatc gatgtagccg aatgaagggc gctggtggcc
     2161 tcccgtacaa acttggacaa cacggagcag ggagagctca ccatggaatg aaccccccgc
     2221 ccatgctgtc cggcctggga aaccctctcc atctcccaag gctgccagac atggacctcc
     2281 aggctccagc acatccccct ctcctctccc ccaggttggg gctgggtcca ccctgtccta
     2341 tgacttgatc acttttgcac attccctggc cgcttctccc cagagctgcc tgctctgtga
     2401 gccccacagc cctgctcatt cctcacgccc ttcaatgctg caggatggac tggcccctga
     2461 cccagggact ctccaaacgg gatacaggag agaagctggt ctagactgtt tgctgatccc
     2521 caacctgcac ggggcattcc tgcttctctc tcaggccacc acagagggca ggggatggtt
     2581 agtcacctgc cccagcactc acaccctaac tcaaaataaa tgttaaataa gtgcgatcac
     2641 aca
//
