LOCUS       NM_139214                879 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens TGFB induced factor homeobox 2 like Y-linked
            (TGIF2LY), mRNA.
ACCESSION   NM_139214
VERSION     NM_139214.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 879)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 879)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   3  (bases 1 to 879)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   4  (bases 1 to 879)
  AUTHORS   Ousati Ashtiani,Z., Ayati,M., Modarresi,M.H., Raoofian,R., Sabah
            Goulian,B., Greene,W.K. and Heidari,M.
  TITLE     Association of TGIFLX/Y mRNA expression with prostate cancer
  JOURNAL   Med Oncol 26 (1), 73-77 (2009)
   PUBMED   18663611
  REMARK    GeneRIF: most prostate tumors (73.5%) express at least one of these
            genes (TGIFLX and TGIFLY), although different patterns of mRNA
            expression were observed. These results suggest an association of
            TGIFLX/Y expression with the progression of prostate cancer.
REFERENCE   5  (bases 1 to 879)
  AUTHORS   Aarabi,M., Ousati-Ashtiani,Z., Nazarian,A., Modarressi,M.H. and
            Heidari,M.
  TITLE     Association of TGIFLX/Y mRNA expression with azoospermia in
            infertile men
  JOURNAL   Mol Reprod Dev 75 (12), 1761-1766 (2008)
   PUBMED   18384077
  REMARK    GeneRIF: Association of TGIFLX/Y mRNA expression with azoospermia
            in infertile men.(
REFERENCE   6  (bases 1 to 879)
  AUTHORS   Skaletsky,H., Kuroda-Kawaguchi,T., Minx,P.J., Cordum,H.S.,
            Hillier,L., Brown,L.G., Repping,S., Pyntikova,T., Ali,J., Bieri,T.,
            Chinwalla,A., Delehaunty,A., Delehaunty,K., Du,H., Fewell,G.,
            Fulton,L., Fulton,R., Graves,T., Hou,S.F., Latrielle,P.,
            Leonard,S., Mardis,E., Maupin,R., McPherson,J., Miner,T., Nash,W.,
            Nguyen,C., Ozersky,P., Pepin,K., Rock,S., Rohlfing,T., Scott,K.,
            Schultz,B., Strong,C., Tin-Wollam,A., Yang,S.P., Waterston,R.H.,
            Wilson,R.K., Rozen,S. and Page,D.C.
  TITLE     The male-specific region of the human Y chromosome is a mosaic of
            discrete sequence classes
  JOURNAL   Nature 423 (6942), 825-837 (2003)
   PUBMED   12815422
REFERENCE   7  (bases 1 to 879)
  AUTHORS   Blanco-Arias,P., Sargent,C.A. and Affara,N.A.
  TITLE     The human-specific Yp11.2/Xq21.3 homology block encodes a
            potentially functional testis-specific TGIF-like retroposon
  JOURNAL   Mamm Genome 13 (8), 463-468 (2002)
   PUBMED   12226713
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC019058.4 and AF332223.1.
            
            On Dec 20, 2019 this sequence version replaced NM_139214.2.
            
            Summary: This gene encodes a member of the TALE/TGIF homeobox
            family of transcription factors. This gene lies within the male
            specific region of chromosome Y, in a block of sequence that is
            thought to be the result of a large X-to-Y transposition. The
            C-terminus of this protein is divergent from that of its chromosome
            X homolog (TGIF2LX), suggesting that this protein may act as a
            regulator of TGIF2LX. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF332223.1, AK292609.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000321217.5/ ENSP00000318502.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AC019058.4         35470-35487
            19-868              AF332223.1         1-850
            869-879             AC019058.4         36434-36444
FEATURES             Location/Qualifiers
     source          1..879
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="Y"
                     /map="Yp11.2"
     gene            1..879
                     /gene="TGIF2LY"
                     /gene_synonym="TGIFLY"
                     /note="TGFB induced factor homeobox 2 like Y-linked"
                     /db_xref="GeneID:90655"
                     /db_xref="HGNC:HGNC:18569"
                     /db_xref="MIM:400025"
     exon            1..61
                     /gene="TGIF2LY"
                     /gene_synonym="TGIFLY"
                     /inference="alignment:Splign:2.1.0"
     exon            62..879
                     /gene="TGIF2LY"
                     /gene_synonym="TGIFLY"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..640
                     /gene="TGIF2LY"
                     /gene_synonym="TGIFLY"
                     /note="TGFB-induced factor 2-like, Y-linked; TGIF-like on
                     the Y; TGFB-induced factor 2-like protein, Y-linked;
                     TGF-beta-induced transcription factor 2-like protein"
                     /codon_start=1
                     /product="homeobox protein TGIF2LY"
                     /protein_id="NP_631960.1"
                     /db_xref="CCDS:CCDS14775.1"
                     /db_xref="GeneID:90655"
                     /db_xref="HGNC:HGNC:18569"
                     /db_xref="MIM:400025"
                     /translation="MEAAADGPAETQSPVEKDSPAKTQSPAQDTSIMSRNNADTGRVL
                     ALPEHKKKRKGNLPAESVKILRDWMYKHRFKAYPSEEEKQMLSEKTNLSLLRISNWFI
                     NARRRILPDMLQQRRNDPIIGHKTGKDAHATHLQSTEASVPAKSGPVVQTMYKACPCG
                     PCQRARCQERSNQIRSRPLARSSPE"
ORIGIN      
        1 aaccagctcg gctgttagca actctgttag caaagctgtt tgtctttctc ggaaacaaca
       61 gtaacgataa gcctctttga atatggaggc cgctgcagac ggcccggctg agacccaaag
      121 cccggtggaa aaagacagcc cggcgaagac ccaaagccca gcccaagaca cctcaatcat
      181 gtcgagaaat aacgcagata caggcagagt tcttgcctta ccagagcaca agaagaagcg
      241 caagggaaac ttgccagccg agtccgttaa gatcctccgc gactggatgt ataagcatcg
      301 gtttaaggcc tacccttcag aagaagagaa gcaaatgctg tcagagaaga ccaatttgtc
      361 tttgttgcgg atttctaact ggtttatcaa tgctcgcaga cgcattctcc cggatatgct
      421 tcaacagcgt agaaacgacc ccatcattgg ccacaaaacg ggcaaagatg cccatgccac
      481 ccacctgcag agcaccgagg cgtctgtgcc ggccaagtca gggccagtgg tccagacaat
      541 gtacaaagcc tgcccctgtg gcccttgcca aagggccaga tgtcaagaga gaagcaacca
      601 gatccggagt cggcccctag ccagaagctc accggaatag cccagccaaa gaaaaaggtc
      661 aagatttcta tcacttcccc gtcttctcca gaacttgtgt ctccagagga gtacgccgac
      721 ttcagcagct tcctgctgct agtcgatgca gcagtacaaa cggctgccga gctggagcta
      781 gagaagaagc aagagcctaa tccatgattg atgatgttcc aaaaacccaa gtagtcagtc
      841 ccttgtgtac tgtggtaaac ctgtttatgt tcaccccaa
//
